(Q37820330)

23 August 2017

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title

APP transgenic mice: their use and limitations (English)

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23 August 2017

Claudia Balducci

1

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23 August 2017

Gianluigi Forloni

series ordinal

2

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23 August 2017

publication date

9 December 2010

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23 August 2017

published in

NeuroMolecular Medicine

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23 August 2017

volume

13

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23 August 2017

issue

2

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23 August 2017

page(s)

117-137

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LTP maintenance and its protein synthesis-dependence

23 August 2017

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Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein

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21 January 2018

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Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondria

21 January 2018

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Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

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Pathways by which Abeta facilitates tau pathology

21 January 2018

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Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice

21 January 2018

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Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance

21 January 2018

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Neocortical synaptic bouton number is maintained despite robust amyloid deposition in APP23 transgenic mice.

21 January 2018

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Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

21 January 2018

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

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Active and passive immunotherapy for neurodegenerative disorders

21 January 2018

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Expression of APP in brains of transgenic mice containing the entire human APP gene.

21 January 2018

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Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor

21 January 2018

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Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model

21 January 2018

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Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

21 January 2018

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Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

21 January 2018

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Activity-dependent regulation of NR2B translation contributes to metaplasticity in mouse visual cortex

21 January 2018

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A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease

21 January 2018

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Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation

21 January 2018

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Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.

21 January 2018

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Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.

21 January 2018

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Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Application of MRS to mouse models of neurodegenerative illness

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Plasticity in the human central nervous system

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

In vivo MRI and histological evaluation of brain atrophy in APP/PS1 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Senile plaques do not induce susceptibility effects in T2*-weighted MR microscopic images.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Release of acetylcholinesterase (AChE) from beta-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Behavioral deficits in APP(V717F) transgenic mice deficient for the apolipoprotein E gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Transgenic mouse models of Alzheimer's disease: how useful have they been for therapeutic development?

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Altered APP processing in PDAPP (Val717 --> Phe) transgenic mice yields extended-length Abeta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Expression of amyloid precursor protein mRNAs in endothelial, neuronal and glial cells: modulation by interleukin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

The clinical use of structural MRI in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Presence of sodium dodecyl sulfate-stable amyloid beta-protein dimers in the hippocampus CA1 not exhibiting neurofibrillary tangle formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Techniques for brain imaging in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Reduced corpus callosum, fornix and hippocampus in PDAPP transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Intraneuronal Abeta42 accumulation in human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Various dendritic abnormalities are associated with fibrillar amyloid deposits in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

The genetics of neurodegenerative diseases

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Cognitive correlates of Abeta deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

APP transgenic mouse models and their use in drug discovery to evaluate amyloid- lowering therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Therapeutic potential of gamma-secretase inhibitors and modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Magnetic resonance imaging of Alzheimer's pathology in the brains of living transgenic mice: a new tool in Alzheimer's disease research

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

BCL-xL regulates synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

APP processing and synaptic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Progressive age-related impairment of cognitive behavior in APP23 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Behavioral phenotypes of amyloid-based genetically modified mouse models of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Intracellular amyloid-beta in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

The neurobiological basis of spontaneous alternation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Subcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Longitudinal neuroanatomical changes determined by deformation-based morphometry in a mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Hyperaccumulation of FAD-linked presenilin 1 variants in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Genetic background regulates -amyloid precursor protein processing and -amyloid deposition in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Working memory impairment in a transgenic amyloid precursor protein TgCRND8 mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Longitudinal regional brain volume changes quantified in normal aging and Alzheimer's APP x PS1 mice using MRI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Neurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Pathways towards and away from Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Mitochondria in neuroplasticity and neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Developments of a water-maze procedure for studying spatial learning in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Place navigation impaired in rats with hippocampal lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Hippocampal hypometabolism predicts cognitive decline from normal aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Oral vaccination with a viral vector containing Abeta cDNA attenuates age-related Abeta accumulation and memory deficits without causing inflammation in a mouse Alzheimer model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Neuroscience: Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Proteomic analysis for protein carbonyl as an indicator of oxidative damage in senescence-accelerated mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

A dynamic relationship between intracellular and extracellular pools of Abeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

The radial arm maze as a tool in behavioral pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Cerebral hemorrhage after passive anti-Abeta immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Characterization of amyloid beta peptides from brain extracts of transgenic mice overexpressing the London mutant of human amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Morphological and biochemical analyses of amyloid plaque core proteins purified from Alzheimer disease brain tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

APP transgenic mice: the effect of active and passive immunotherapy in cognitive tasks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Mice expressing the Swedish APP mutation on a 129 genetic background demonstrate consistent behavioral deficits and pathological markers of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Tau suppression in a neurodegenerative mouse model improves memory function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Regulation of NMDA receptor trafficking by amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Recognition memory and the medial temporal lobe: a new perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

The molecular basis of the prevention of Alzheimer's disease through healthy nutrition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Reduced brain volumes in mice expressing APP-Austrian mutation but not in mice expressing APP-Swedish-Austrian mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Intraneuronal amyloid beta and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Age-dependent cognitive decline in the APP23 model precedes amyloid deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Drug discovery in dementia: the role of rodent models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Noninvasive in vivo MRI detection of neuritic plaques associated with iron in APP[V717I] transgenic mice, a model for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

A beta oligomers - a decade of discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

The mouse C1q A-chain sequence alters beta-amyloid-induced complement activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Independent effects of intra- and extracellular Abeta on learning-related gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Impaired eyeblink conditioning and decreased hippocampal volume in PDAPP V717F mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: digital morphometric analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Inflammation in neurodegenerative disease--a double-edged sword

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

NMDA receptor-dependent signaling pathways that underlie amyloid beta-protein disruption of LTP in the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Neuron loss in APP transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-010-8141-7

Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.

21 January 2018

1 reference

12 December 2020

Amyloid plaque imaging in vivo: current achievement and future prospects.

1 reference

12 December 2020

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

12 December 2020

Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.

1 reference

12 December 2020

Reciprocal control of inflammatory cytokines, IL-1 and IL-6, and β-amyloid production in cultures

1 reference

12 December 2020

Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome.

1 reference

12 December 2020

The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component.

1 reference

12 December 2020

Glial conditioned medium alters the expression of amyloid precursor protein in SH-SY5Y neuroblastoma cells

1 reference

12 December 2020

From aging to Alzheimer's disease: unveiling "the switch" with the senescence-accelerated mouse model (SAMP8).

1 reference

12 December 2020

Biological markers for early detection and pharmacological treatment of Alzheimer's disease

1 reference

12 December 2020

Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

1 reference

12 December 2020

Amidation of beta-amyloid peptide strongly reduced the amyloidogenic activity without alteration of the neurotoxicity.

1 reference

12 December 2020

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

1 reference

12 December 2020

New biochemical insights to unravel the pathogenesis of Alzheimer's lesions.

1 reference

12 December 2020

Elevated A beta and apolipoprotein E in A betaPP transgenic mice and its relationship to amyloid accumulation in Alzheimer's disease

1 reference

12 December 2020

TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs

1 reference

12 December 2020

Behavioral models of memory and amnesia

1 reference

12 December 2020

Abeta deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer's disease

1 reference

12 December 2020

Both N-terminal and C-terminal fragments of presenilin 1 colocalize with neurofibrillary tangles in neurons and dystrophic neurites of senile plaques in Alzheimer's disease

1 reference

12 December 2020

Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein.

1 reference

12 December 2020

APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.

1 reference

12 December 2020

Transgenic mice for the amyloid precursor protein 695 isoform have impaired spatial memory

1 reference

12 December 2020

Neurodegenerative changes associated with beta-amyloid deposition in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes

1 reference

12 December 2020

Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease

1 reference

12 December 2020

MR microimaging of amyloid plaques in Alzheimer's disease transgenic mice

1 reference

12 December 2020

Cerebrospinal fluid biomarkers for Alzheimer's disease

1 reference

12 December 2020

Of mice and men: The relevance of transgenic mice Abeta immunizations to Alzheimer's disease

1 reference

12 December 2020

Immunohistochemical visualization of amyloid-beta protein precursor and amyloid-beta in extra- and intracellular compartments in the human brain

1 reference

12 December 2020

The evolution of A beta peptide burden in the APP23 transgenic mice: implications for A beta deposition in Alzheimer disease

1 reference

12 December 2020

Multiphoton in vivo imaging of amyloid in animal models of Alzheimer's disease

1 reference

12 December 2020

Cognitive deficits associated with alteration of synaptic metaplasticity precede plaque deposition in AβPP23 transgenic mice.

1 reference

12 December 2020

Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease.

1 reference

12 December 2020

Inflammation-dependent cerebral deposition of serum amyloid a protein in a mouse model of amyloidosis.

1 reference

12 December 2020

Reversible memory loss in a mouse transgenic model of Alzheimer's disease

1 reference

12 December 2020

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model

1 reference

12 December 2020

Mitochondrial abnormalities in Alzheimer's disease.

1 reference

12 December 2020

Effect of a carboxy-terminal fragment of the Alzheimer's amyloid precursor protein on expression of proinflammatory cytokines in rat glial cells

1 reference

12 December 2020

Treatment of Alzheimer's disease: the role of symptomatic agents in an era of disease-modifying therapies

1 reference

12 December 2020

10.1007/S12017-010-8141-7

Identifiers

DOI

1 reference

23 August 2017

1 reference