(Q38066149)

28 August 2017

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title

The 11q13-q14 amplicon: clinicopathological correlations and potential drivers (English)

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28 August 2017

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2

Jorge S Reis-Filho

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28 August 2017

Paul M Wilkerson

1

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28 August 2017

publication date

10 December 2012

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Genes, Chromosomes and Cancer

28 August 2017

published in

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28 August 2017

volume

52

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28 August 2017

issue

4

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28 August 2017

page(s)

333-355

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Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase

28 August 2017

cites work

1 reference

Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1

21 January 2018

1 reference

Oesophageal cancer and amplification of the human cyclin D gene CCND1/PRAD1.

21 January 2018

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Role of cyclin D1 in ErbB2-positive breast cancer and tamoxifen resistance

21 January 2018

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Targeting cyclin D1, a downstream effector of INI1/hSNF5, in rhabdoid tumors

21 January 2018

1 reference

Clinical application of fluorescence in situ hybridization for chromosome 11q13 analysis in head and neck cancer

21 January 2018

1 reference

Gene amplification in cancer

21 January 2018

1 reference

Using functional genetics to understand breast cancer biology

21 January 2018

1 reference

p21-activated Kinase-1 Signaling Mediates Cyclin D1 Expression in Mammary Epithelial and Cancer Cells

21 January 2018

1 reference

Chromosomal imbalances in primary and metastatic melanomas revealed by comparative genomic hybridization

21 January 2018

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Cyclin D1 in mammary carcinoma

21 January 2018

1 reference

CCND1 and FGFR1 coamplification results in the colocalization of 11q13 and 8p12 sequences in breast tumor nuclei.

21 January 2018

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Detailed map of a region commonly amplified at 11q13-->q14 in human breast carcinoma

21 January 2018

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A role for the scaffolding adapter GAB2 in breast cancer

21 January 2018

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Common variation in EMSY and risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs

21 January 2018

1 reference

Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer

21 January 2018

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The landscape of somatic copy-number alteration across human cancers

21 January 2018

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Nuclear localized phosphorylated FADD induces cell proliferation and is associated with aggressive lung cancer

21 January 2018

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Prognostic value of CCND1 gene status in sporadic breast tumours, as determined by real-time quantitative PCR assays

21 January 2018

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Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line

21 January 2018

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Focal amplification and oncogene dependency of GAB2 in breast cancer

21 January 2018

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Biology of the p21-activated kinases

21 January 2018

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Three-dimensional maps of all chromosomes in human male fibroblast nuclei and prometaphase rosettes

21 January 2018

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Association of INT2/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis

21 January 2018

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Functional viability profiles of breast cancer

21 January 2018

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Amplification of EMSY, a novel oncogene on 11q13, in high grade ovarian surface epithelial carcinomas

21 January 2018

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Co-amplification of CCND1 and EMSY is associated with an adverse outcome in ER-positive tamoxifen-treated breast cancers.

21 January 2018

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Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein

21 January 2018

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Gain of 11q/cyclin D1 overexpression is an essential early step in skin cancer development and causes abnormal tissue organization and differentiation

21 January 2018

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Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E.

21 January 2018

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Identification and validation of prognostic markers in breast cancer with the complementary use of array-CGH and tissue microarrays

21 January 2018

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Expression and tyrosine phosphorylation of EMS1 in human breast cancer cell lines

21 January 2018

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Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing

21 January 2018

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Prognostic impact of array-based genomic profiles in esophageal squamous cell cancer

21 January 2018

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Crystal structure of the ENT domain of human EMSY.

21 January 2018

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Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas

21 January 2018

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GAB2 amplifications refine molecular classification of melanoma

21 January 2018

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Using array-comparative genomic hybridization to define molecular portraits of primary breast cancers.

21 January 2018

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p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model.

21 January 2018

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Aggressiveness of HNSCC tumors depends on expression levels of cortactin, a gene in the 11q13 amplicon

21 January 2018

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BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation

21 January 2018

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EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases

21 January 2018

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Cortactin modulates RhoA activation and expression of Cip/Kip cyclin-dependent kinase inhibitors to promote cell cycle progression in 11q13-amplified head and neck squamous cell carcinoma cells.

21 January 2018

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Distinct sets of genetic alterations in melanoma

21 January 2018

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Cortactin signalling and dynamic actin networks

21 January 2018

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Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure

21 January 2018

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Cortactin gene amplification and expression in breast cancer: a chromogenic in situ hybridisation and immunohistochemical study

21 January 2018

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Amplification of chromosome band 11q13 and a role for cyclin D1 in human breast cancer

21 January 2018

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CCND1 amplification and cyclin D1 expression in breast cancer and their relation with proteomic subgroups and patient outcome

21 January 2018

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Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor

21 January 2018

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PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro

21 January 2018

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Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation.

21 January 2018

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Nuclear transcription factor-kappaB as a target for cancer drug development

21 January 2018

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Systematic identification of genomic markers of drug sensitivity in cancer cells

21 January 2018

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Amplicon mapping and expression profiling identify the Fas-associated death domain gene as a new driver in the 11q13.3 amplicon in laryngeal/pharyngeal cancer

21 January 2018

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Cortactin expression predicts poor survival in laryngeal carcinoma

21 January 2018

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Anatomic site-specific patterns of gene copy number gains in skin, mucosal, and uveal melanomas detected by fluorescence in situ hybridization

21 January 2018

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Chromosomal alterations in squamous cell carcinomas of the head and neck: window to the biology of disease

21 January 2018

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Validation of cyclin D1/CDK4 as an anticancer drug target in MCF-7 breast cancer cells: Effect of regulated overexpression of cyclin D1 and siRNA-mediated inhibition of endogenous cyclin D1 and CDK4 expression

21 January 2018

1 reference

Hallmarks of Cancer: The Next Generation

21 January 2018

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Identification of biomarkers in human head and neck tumor cell lines that predict for in vitro sensitivity to gefitinib

21 January 2018

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Signal therapy of breast cancers by the HDAC inhibitor FK228 that blocks the activation of PAK1 and abrogates the tamoxifen-resistance

21 January 2018

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Prognostic significance of cortactin levels in head and neck squamous cell carcinoma: comparison with epidermal growth factor receptor status

21 January 2018

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ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium

21 January 2018

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Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients

21 January 2018

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Characterisation of amplification patterns and target genes at chromosome 11q13 in CCND1-amplified sporadic and familial breast tumours.

21 January 2018

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Gab2-mediated signaling promotes melanoma metastasis

21 January 2018

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EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer

21 January 2018

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Array-based comparative genomic hybridization analysis identified cyclin D1 as a target oncogene at 11q13.3 in nasopharyngeal carcinoma

21 January 2018

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Utilizing RNA interference to enhance cancer drug discovery

21 January 2018

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Gene amplification profiling of esophageal squamous cell carcinomas by DNA array CGH.

21 January 2018

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MYEOV, a gene at 11q13, is coamplified with CCND1, but epigenetically inactivated in a subset of esophageal squamous cell carcinomas

21 January 2018

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Oral cancer overexpressed 1 (ORAOV1): a regulator for the cell growth and tumor angiogenesis in oral squamous cell carcinoma

21 January 2018

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Oral cancer overexpressed 1 (ORAOV1) regulates cell cycle and apoptosis in cervical cancer HeLa cells

21 January 2018

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Identification of novel gene amplifications in breast cancer and coexistence of gene amplification with an activating mutation of PIK3CA

21 January 2018

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The concept of synthetic lethality in the context of anticancer therapy

21 January 2018

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RNA interference-based functional dissection of the 17q12 amplicon in breast cancer reveals contribution of coamplified genes

21 January 2018

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High-resolution genomic analysis of the 11q13 amplicon in breast cancers identifies synergy with 8p12 amplification, involving the mTOR targets S6K2 and 4EBP1.

21 January 2018

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Role of Gab2 in mammary tumorigenesis and metastasis.

21 January 2018

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Revisiting the ERK/Src cortactin switch

21 January 2018

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Genetic alterations of CCND1 and EMSY in breast cancers

21 January 2018

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Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer.

21 January 2018

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Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins

21 January 2018

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Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis

21 January 2018

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Inhibition of cyclin D1 expression by androgen receptor in breast cancer cells--identification of a novel androgen response element

21 January 2018

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Characterization of candidate gene copy number alterations in the 11q13 region along with BRAF and NRAS mutations in human melanoma.

21 January 2018

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Targeting cyclins and cyclin-dependent kinases in cancer: lessons from mice, hopes for therapeutic applications in human

21 January 2018

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The mutation spectrum revealed by paired genome sequences from a lung cancer patient

21 January 2018

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Down-regulation of the oncogene cyclin D1 increases migratory capacity in breast cancer and is linked to unfavorable prognostic features

21 January 2018

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Frequency, prognostic impact, and subtype association of 8p12, 8q24, 11q13, 12p13, 17q12, and 20q13 amplifications in breast cancers

21 January 2018

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Net1 and Myeov: computationally identified mediators of gastric cancer

21 January 2018

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Cyclin D1 induction of cellular migration requires p27(KIP1).

21 January 2018

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Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling

21 January 2018

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Indicators of homologous recombination deficiency in breast cancer and association with response to neoadjuvant chemotherapy.

21 January 2018

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Downregulation of p21-activated kinase-1 inhibits the growth of gastric cancer cells involving cyclin B1

21 January 2018

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Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint

21 January 2018

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Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes

21 January 2018

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Gene products of chromosome 11q and their association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer

21 January 2018

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Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance.

21 January 2018

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A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton

21 January 2018

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The genomic profile of HER2-amplified breast cancers: the influence of ER status

21 January 2018

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Genomics and the continuum of cancer care

21 January 2018

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Amplification and overexpression of the KIT gene is associated with progression in the seminoma subtype of testicular germ cell tumors of adolescents and adults

21 January 2018

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Active p21-activated kinase 1 rescues MCF10A breast epithelial cells from undergoing anoikis

21 January 2018

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Chromosome 11q13 amplification in head and neck squamous cell carcinoma. Association with poor prognosis

21 January 2018

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ArrayCGH-based classification of neuroblastoma into genomic subgroups

21 January 2018

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The GAB2 signaling scaffold promotes anchorage independence and drives a transcriptional response associated with metastatic progression of breast cancer

21 January 2018

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Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cells

21 January 2018

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ETV4 and Myeov knockdown impairs colon cancer cell line proliferation and invasion

21 January 2018

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Tiling path genomic profiling of grade 3 invasive ductal breast cancers

21 January 2018

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An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers

21 January 2018

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Functional characterization of the 19q12 amplicon in grade III breast cancers

21 January 2018

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A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

21 January 2018

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The association of CCND1 overexpression and cisplatin resistance in testicular germ cell tumors and other cancers

21 January 2018

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Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

21 January 2018

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Cyclin D1, EMS1 and 11q13 amplification in breast cancer

21 January 2018

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Overexpression of EMS1/cortactin in NIH3T3 fibroblasts causes increased cell motility and invasion in vitro

21 January 2018

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Co-amplification of 8p12 and 11q13 in breast cancers is not the result of a single genomic event.

21 January 2018

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Evaluation of immunohistochemical expression of p53, p21, p27, cyclin D1, and Ki67 in oral and oropharyngeal squamous cell carcinoma.

21 January 2018

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c-Myc or cyclin D1 mimics estrogen effects on cyclin E-Cdk2 activation and cell cycle reentry

21 January 2018

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Genomic instability of human mammary epithelial cells overexpressing a truncated form of EMSY.

21 January 2018

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Gene expression profiling in breast cancer: classification, prognostication, and prediction

21 January 2018

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Cyclin D1 protein overexpression and CCND1 amplification in breast carcinomas: an immunohistochemical and chromogenic in situ hybridisation analysis

21 January 2018

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FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas

21 January 2018

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Distinctive clinicopathological associations of amplification of the cortactin gene at 11q13 in head and neck squamous cell carcinomas

21 January 2018

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A census of amplified and overexpressed human cancer genes

21 January 2018

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Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma

21 January 2018

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The involvement of the chromosome 11q13 region in human malignancies: Cyclin D1 and EMS1 are two new candidate oncogenes-a review

21 January 2018

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First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations

21 January 2018

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Suppression of cancer cell growth by promoting cyclin D1 degradation

21 January 2018

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Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: its association with clinicopathologic features.

21 January 2018

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PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling

21 January 2018

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ZNF703 gene amplification at 8p12 specifies luminal B breast cancer

21 January 2018

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Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion.

21 January 2018

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Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas

21 January 2018

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Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes

21 January 2018

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Cyclin D1 overexpression is a negative predictive factor for tamoxifen response in postmenopausal breast cancer patients

21 January 2018

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Complex landscapes of somatic rearrangement in human breast cancer genomes

21 January 2018

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21 January 2018

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Constitutive activation of the mitogen-activated protein kinase signaling pathway in acral melanomas

21 January 2018

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Proliferation of cancer cells despite CDK2 inhibition.

21 January 2018

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The death effector domain protein family: regulators of cellular homeostasis

21 January 2018

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Aberrant expression of cortactin in head and neck squamous cell carcinoma cells is associated with enhanced cell proliferation and resistance to the epidermal growth factor receptor inhibitor gefitinib

21 January 2018

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FADD: a regulator of life and death

21 January 2018

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Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets

21 January 2018

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FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer

21 January 2018

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

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A role for FADD in T cell activation and development

21 January 2018

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PAK1 hyperactivation is sufficient for mammary gland tumor formation

21 January 2018

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Cortactin in tumor invasiveness

21 January 2018

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Challenges translating breast cancer gene signatures into the clinic

21 January 2018

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Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapy

21 January 2018

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21 January 2018

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Functional characterization of EMSY gene amplification in human cancers

21 January 2018

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Chromosome 11Q13 amplification in head and neck squamous cell carcinoma

21 January 2018

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Function, regulation and pathological roles of the Gab/DOS docking proteins

21 January 2018

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ORAOV1 is amplified in oral squamous cell carcinoma.

21 January 2018

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GAB2 induces tumor angiogenesis in NRAS-driven melanoma.

21 January 2018

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Development of small-molecule inhibitors of the group I p21-activated kinases, emerging therapeutic targets in cancer

21 January 2018

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Amplification and overexpression of the EMS 1 oncogene, a possible prognostic marker, in human hepatocellular carcinoma

21 January 2018

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Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

21 January 2018

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FADD-deficient T cells exhibit a disaccord in regulation of the cell cycle machinery

21 January 2018

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FADD and its phosphorylation

21 January 2018

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CDK-independent activation of estrogen receptor by cyclin D1

21 January 2018

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Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development

21 January 2018

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MYEOV: A candidate gene for DNA amplification events occurring centromeric toCCND1in breast cancer

21 January 2018

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Patterns of dna amplification at band q13 of chromosome 11 in human breast cancer

21 January 2018

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Amplification of the BRCA2 Pathway Gene EMSY in Sporadic Breast Cancer Is Related to Negative Outcome

21 January 2018

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Cortactin Overexpression Regulates Actin-Related Protein 2/3 Complex Activity, Motility, and Invasion in Carcinomas with Chromosome 11q13 Amplification

21 January 2018

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Association of cyclinD1 copy number changes with histological type in ovarian tumors

21 January 2018

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Increased p21-activated kinase-1 expression is associated with invasive potential in uveal melanoma

21 January 2018

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Regulatable Expression of p21-activated Kinase-1 Promotes Anchorage-independent Growth and Abnormal Organization of Mitotic Spindles in Human Epithelial Breast Cancer Cells

21 January 2018

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High-throughput tissue microarray analysis of 11q13 gene amplification (CCND1, FGF3, FGF4, EMS1) in urinary bladder cancer

21 January 2018

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Cyclin D1 protein expression and function in human breast cancer

21 January 2018

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Prognostic relevance of gene amplifications and coamplifications in breast cancer

21 January 2018

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7 January 2021

Expression of EMSY gene in sporadic ovarian cancer

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7 January 2021

Genetic Interactions in Cancer Progression and Treatment

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7 January 2021

Personalizing therapy for ovarian cancer: BRCAness and beyond

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7 January 2021

Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer

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7 January 2021

Amplification of 11q13 in ovarian carcinoma

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7 January 2021

Genome-wide profiling of oral squamous cell carcinoma

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7 January 2021

Analysis of different deleted regions in chromosome 11 and their interrelations in early- and late-onset breast tumors: association with cyclin D1 amplification and survival

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7 January 2021

Cyclin gene amplification and overexpression in breast and ovarian cancers: Evidence for the selection ofcyclin D1 in breast andcyclin E in ovarian tumors

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7 January 2021

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

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7 January 2021

Abnormal expression of cell cycle regulatory proteins in ductal and lobular carcinomas of the breast

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7 January 2021

EMS1 amplification can occur independently of CCND1 or INT-2 amplification at 11q13 and may identify different phenotypes in primary breast cancer

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7 January 2021

EMS1 gene expression in primary breast cancer: relationship to cyclin D1 and oestrogen receptor expression and patient survival

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7 January 2021

Adverse effect of adjuvant tamoxifen in premenopausal breast cancer with cyclin D1 gene amplification

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7 January 2021

Cyclin-D1-gene amplification is a more potent prognostic factor than its protein over-expression in human head-and-neck squamous-cell carcinoma

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7 January 2021

Detection of copy number amplification of cyclin D1 (CCND1) and cortactin (CTTN) in oral carcinoma and oral brushed samples from areca chewers

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7 January 2021

Frequent amplification of 8q24, 11q, 17q, and 20q-specific genes in pancreatic cancer

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7 January 2021

Rearrangements and increased expression of cyclin D1 (CCND1) in neuroblastoma

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7 January 2021

Bio-pathologic Characteristics Related to Chromosome 11 Aneusomy and Cyclin D1 Gene Status in Surgically Resected Stage I and II Breast Cancer: Identification of an Adverse Prognostic Profile

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7 January 2021

Frequent amplification of 11q13 DNA markers is associated with lymph node involvement in human head and neck squamous cell carcinomas

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7 January 2021

Amplification of 11q13 DNA markers in head and neck squamous cell carcinomas: correlation with clinical outcome

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7 January 2021

Next-generation sequencing applied to molecular diagnostics

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7 January 2021

Clinical significance of cyclin D1 expression in patients with node-positive breast carcinoma treated with adjuvant therapy

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7 January 2021

The landscape of cancer genes and mutational processes in breast cancer

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7 January 2021

Cyclin D1 overexpression in invasive breast cancers: correlation with cyclin-dependent kinase 4 and oestrogen receptor overexpression, and lack of correlation with mitotic activity

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7 January 2021

Markers for assessment of nodal metastasis in laryngeal carcinoma

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7 January 2021

Cortactin overexpression inhibits ligand-induced down-regulation of the epidermal growth factor receptor

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7 January 2021

Identifiers

DOI

10.1002/GCC.22037

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28 August 2017

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