(Q38167610)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24292194%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

title

Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24292194%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24292194%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Dong-Kug Choi

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24292194%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

author name string

In-Su Kim

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24292194%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Sandeep Vasant More

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24292194%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Byung-Wook Kim

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24292194%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

publication date

1 January 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24292194%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

published in

Natural Product Reports

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24292194%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

volume

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24292194%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24292194%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

page(s)

109-139

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24292194%20AND%20SRC:MED&resulttype=core&format=json

Free radicals, metals and antioxidants in oxidative stress-induced cancer

2 March 2020

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The role of free radicals in the aging brain and Parkinson's Disease: convergence and parallelism

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Neuroinflammation and oxidative stress: co-conspirators in the pathology of Parkinson's disease

21 January 2018

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Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription.

21 January 2018

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Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

21 January 2018

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Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

21 January 2018

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Cell respiration and formation of reactive oxygen species: facts and artefacts

21 January 2018

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Endothelial cell apoptosis in angiogenesis and vessel regression

21 January 2018

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Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

21 January 2018

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Uncovering the beginning of diabetes: the cellular redox status and oxidative stress as starting players in hyperglycemic damage.

21 January 2018

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Nuclear factor erythroid 2-related factor 2 signaling in Parkinson disease: a promising multi therapeutic target against oxidative stress, neuroinflammation and cell death.

21 January 2018

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Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene

21 January 2018

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Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

21 January 2018

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Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome

21 January 2018

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Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds

21 January 2018

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Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles

21 January 2018

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Nrf2-Keap1 defines a physiologically important stress response mechanism

21 January 2018

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 January 2018

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Natural products to drugs: natural product derived compounds in clinical trials

21 January 2018

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The evolving role of natural products in drug discovery

21 January 2018

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Vegetables, fruit, and cancer prevention: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Inhibition of carcinogenesis by isothiocyanates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Brain foods: the effects of nutrients on brain function

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Promising therapeutics with natural bioactive compounds for improving learning and memory--a review of randomized trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: therapeutic implications for Parkinson's disease explained via in silico studies

21 January 2018

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Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Resveratrol protects primary rat hepatocytes against oxidative stress damage: activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Effect of diallyl sulfide on in vitro and in vivo Nrf2-mediated pulmonic antioxidant enzyme expression via activation ERK/p38 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease

21 January 2018

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Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.

21 January 2018

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Toward clinical application of the Keap1-Nrf2 pathway

21 January 2018

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Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.

21 January 2018

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Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1

21 January 2018

1 reference

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Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

21 January 2018

1 reference

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The cytoprotective role of the Keap1-Nrf2 pathway

21 January 2018

1 reference

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Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

21 January 2018

1 reference

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Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

21 January 2018

1 reference

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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

21 January 2018

1 reference

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Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

21 January 2018

1 reference

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Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.

21 January 2018

1 reference

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Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nitric oxide-induced transcriptional up-regulation of protective genes by Nrf2 via the antioxidant response element counteracts apoptosis of neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

NO signaling in ARE-mediated gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

CR6-interacting factor 1 (CRIF1) regulates NF-E2-related factor 2 (NRF2) protein stability by proteasome-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals

21 January 2018

1 reference

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Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2

21 January 2018

1 reference

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Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress

21 January 2018

1 reference

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Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2.

21 January 2018

1 reference

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Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2: a novel mechanism in Nrf2 activation

21 January 2018

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GSK-3beta down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress.

21 January 2018

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Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

21 January 2018

1 reference

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Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2 signaling in coordinated activation of antioxidant gene expression

21 January 2018

1 reference

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21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Activation of the Nrf2-ARE signaling pathway: a promising strategy in cancer prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Chemoprotection against cancer by phase 2 enzyme induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2, a multi-organ protector?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Linkage analysis of susceptibility to hyperoxia. Nrf2 is a candidate gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Neuronal sensitivity to kainic acid is dependent on the Nrf2-mediated actions of the antioxidant response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

A crucial role of Nrf2 in in vivo defense against oxidative damage by an environmental pollutant, pentachlorophenol

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2: friend or foe for chemoprevention?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Expression of Nrf2 in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nuclear factor erythroid 2-related factor 2 protects against beta amyloid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

In vivo modulation of the Parkinsonian phenotype by Nrf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Comparative analysis of superoxide dismutase activity between acute pharmacological models and a transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Efficacy of fumaric acid esters in the R6/2 and YAC128 models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nuclear erythroid 2-related factor 2-antioxidative response element signaling pathway in motor cortex and spinal cord in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Gastrodin protect primary cultured rat hippocampal neurons against amyloid-beta peptide-induced neurotoxicity via ERK1/2-Nrf2 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Licochalcone E activates Nrf2/antioxidant response element signaling pathway in both neuronal and microglial cells: therapeutic relevance to neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2:INrf2 (Keap1) signaling in oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Chemoprevention studies of the flavonoids quercetin and rutin in normal and azoxymethane-treated mouse colon.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Polymeric black tea polyphenols induce phase II enzymes via Nrf2 in mouse liver and lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Transcription factor Nrf2/MafK regulates rat placental glutathione S-transferase gene during hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Dual roles of Nrf2 in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Active efflux system for cisplatin in cisplatin-resistant human KB cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Role of the Nrf2-antioxidant system in cytotoxicity mediated by anticancer cisplatin: implication to cancer cell resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

The Nrf2-Keap1-ARE signaling pathway: The regulation and dual function of Nrf2 in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

NRF2 and cancer: the good, the bad and the importance of context.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Ethanol-induced HO-1 and NQO1 are differentially regulated by HIF-1alpha and Nrf2 to attenuate inflammatory cytokine expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Involvement of the electrophile responsive element and p53 in the activation of hepatic stellate cells as a response to electrophile menadione

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nuclear factor-eythroid 2-related factor 2 prevents alcohol-induced fulminant liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Keap1 degradation by autophagy for the maintenance of redox homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2-mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKCδ-GSK3β pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Experimental therapeutics of Nrf2 as a target for prevention of bacterial exacerbations in COPD

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Vitamin E prevents NRF2 suppression by allergens in asthmatic alveolar macrophages in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Molecular mechanisms involved in enhancing HO-1 expression: de-repression by heme and activation by Nrf2, the "one-two" punch

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Heme oxygenase-1 prevents airway mucus hypersecretion induced by cigarette smoke in rodents and humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

2',4',6'-tris(methoxymethoxy) chalcone protects against trinitrobenzene sulfonic acid-induced colitis and blocks tumor necrosis factor-alpha-induced intestinal epithelial inflammation via heme oxygenase 1-dependent and independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2-deficient female mice develop lupus-like autoimmune nephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Heme oxygenase 1 is required for mammalian iron reutilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Induction of cellular antioxidative stress genes through heterodimeric transcription factor Nrf2/small Maf by antirheumatic gold(I) compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Oxidative stress and diabetic complications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

The Keap1-Nrf2 system prevents onset of diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Defective Nrf2-dependent redox signalling contributes to microvascular dysfunction in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

The role of peroxidases in the pathogenesis of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Oxidative stress and hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Oxidative stress in heart failure: what are we missing?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Low serum glutathione peroxidase activity is associated with increased cardiovascular mortality in individuals with low HDLc's

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Hydrogen sulfide mediates cardioprotection through Nrf2 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

4-hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via the Nrf2-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Induction of antioxidant and detoxification response by oxidants in cardiomyocytes: evidence from gene expression profiling and activation of Nrf2 transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Protective effect of green tea polyphenol EGCG against neuronal damage and brain edema after unilateral cerebral ischemia in gerbils

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Polyphenol amentoflavone affords neuroprotection against neonatal hypoxic-ischemic brain damage via multiple mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Polyphenols in cerebral ischemia: novel targets for neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2 protects against airway disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

The Nrf2 pathway in the progression of renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Role of NRF2 in protection against hyperoxic lung injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2 is essential for protection against acute pulmonary injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Dibenzoylmethane activates Nrf2-dependent detoxification pathway and inhibits benzo(a)pyrene induced DNA adducts in lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

A possible role of nrf2 in prevention of renal oxidative damage by ferric nitrilotriacetate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Neurohormetic phytochemicals: Low-dose toxins that induce adaptive neuronal stress responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Hormetic dietary phytochemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

The rise of antioxidant signaling--the evolution and hormetic actions of Nrf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

The role of Keap1 in cellular protective responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

The electrophile counterattack response: protection against neoplasia and toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

The potency of inducers of NAD(P)H:(quinone-acceptor) oxidoreductase parallels their efficiency as substrates for glutathione transferases. Structural and electronic correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Irreversible inhibitors of serine, cysteine, and threonine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Neuroscience and hormesis: overview and general findings

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Flavonoids: antioxidants or signalling molecules?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Consequences of quercetin methylation for its covalent glutathione and DNA adduct formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Pro-oxidant activity of flavonoids induces EpRE-mediated gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Multitargeted cancer prevention by quercetin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Dihydroquercetin (DHQ) induced HO-1 and NQO1 expression against oxidative stress through the Nrf2-dependent antioxidant pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Upregulation of heme oxygenase-1 by Epigallocatechin-3-gallate via the phosphatidylinositol 3-kinase/Akt and ERK pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Fisetin induces Nrf2-mediated HO-1 expression through PKC-δ and p38 in human umbilical vein endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Kaempferol suppresses cisplatin-induced apoptosis via inductions of heme oxygenase-1 and glutamate-cysteine ligase catalytic subunit in HEI-OC1 cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Naringenin-7-O-glucoside protects against doxorubicin-induced toxicity in H9c2 cardiomyocytes by induction of endogenous antioxidant enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Effects of sappanchalcone on the cytoprotection and anti-inflammation via heme oxygenase-1 in human pulp and periodontal ligament cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Isoorientin induces Nrf2 pathway-driven antioxidant response through phosphatidylinositol 3-kinase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Genistein as a neuroprotective antioxidant attenuates redox imbalance induced by beta-amyloid peptides 25-35 in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Genistein attenuates ischemic oxidative damage and behavioral deficits via eNOS/Nrf2/HO-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Neuroprotective effects of dehydroglyasperin C through activation of heme oxygenase-1 in mouse hippocampal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescens var. crispa f. viridis).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Lucidone suppresses hepatitis C virus replication by Nrf2-mediated heme oxygenase-1 induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Okanin, a chalcone found in the genus Bidens, and 3-penten-2-one inhibit inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Phloretamide, an apple phenolic compound, activates the Nrf2/ARE pathway in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Oral administration of naturally occurring coumarins leads to altered phase I and II enzyme activities and reduced DNA adduct formation by polycyclic aromatic hydrocarbons in various tissues of SENCAR mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

In vitro absorption and metabolism of a citrus chemopreventive agent, auraptene, and its modifying effects on xenobiotic enzyme activities in mouse livers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Dual anti-oxidative effects of fraxetin isolated from Fraxinus rhinchophylla

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Mining and engineering natural-product biosynthetic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Antioxidant activities of oleanolic acid in vitro: possible role of Nrf2 and MAP kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2-dependent neuroprotective activity of diterpenoids isolated from Sideritis spp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

The coffee diterpene kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

ent-kaur-16-en-19-oic Acid, isolated from the roots of Aralia continentalis, induces activation of Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Kaurane diterpenes from Sideritis spp. exert a cytoprotective effect against oxidative injury that is associated with modulation of the Nrf2 system

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Involvement of Nrf2 signaling pathway in the neuroprotective activity of natural kaurane diterpenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Celastrol induces expression of heme oxygenase-1 through ROS/Nrf2/ARE signaling in the HaCaT cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Costunolide inhibits production of tumor necrosis factor-alpha and interleukin-6 by inducing heme oxygenase-1 in RAW264.7 macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Pulchellamin G, an amino acid-sesquiterpene lactone, from Saussurea pulchella suppresses lipopolysaccharide-induced inflammatory responses via heme oxygenase-1 expression in murine peritoneal macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Isoalantolactone from Inula helenium caused Nrf2-mediated induction of detoxifying enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Schisandra chinensis α-iso-cubebenol induces heme oxygenase-1 expression through PI3K/Akt and Nrf2 signaling and has anti-inflammatory activity in Porphyromonas gingivalis lipopolysaccharide-stimulated macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Cinnamaldehyde enhances Nrf2 nuclear translocation to upregulate phase II detoxifying enzyme expression in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Caffeic acid phenethyl ester and curcumin: a novel class of heme oxygenase-1 inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Z-ligustilide activates the Nrf2/HO-1 pathway and protects against cerebral ischemia-reperfusion injury in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Characterization of bioactive thiophenes from the dichloromethane extract of Echinops grijisii as Michael addition acceptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

PYDDT, a novel phase 2 enzymes inducer, activates Keap1-Nrf2 pathway via depleting the cellular level of glutathione.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

On the mechanisms of induction of cancer-protective enzymes: a unifying proposal

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Two-step mechanism of induction of the gene expression of a prototypic cancer-protective enzyme by diphenols.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

(-)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Comparison of (-)-epigallocatechin-3-gallate elicited liver and small intestine gene expression profiles between C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2-Keap1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Synthesis and structure identification of thiol conjugates of (-)-epigallocatechin gallate and their urinary levels in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Cajaninstilbene acid (CSA) exerts cytoprotective effects against oxidative stress through the Nrf2-dependent antioxidant pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Danshensu protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Ferulic acid protects human umbilical vein endothelial cells from radiation induced oxidative stress by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Lithospermic acid B protects β-cells from cytokine-induced apoptosis by alleviating apoptotic pathways and activating anti-apoptotic pathways of Nrf2-HO-1 and Sirt1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Piceatannol induces heme oxygenase-1 expression in human mammary epithelial cells through activation of ARE-driven Nrf2 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Rottlerin induces heme oxygenase-1 (HO-1) up-regulation through reactive oxygen species (ROS) dependent and PKC delta-independent pathway in human colon cancer HT29 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Triphlorethol-A induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K/Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

1, 5-Dicaffeoylquinic acid-mediated glutathione synthesis through activation of Nrf2 protects against OGD/reperfusion-induced oxidative stress in astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Protective mechanisms of 3-caffeoyl, 4-dihydrocaffeoyl quinic acid from Salicornia herbacea against tert-butyl hydroperoxide-induced oxidative damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Ginsenoside Rb1 protects against 6-hydroxydopamine-induced oxidative stress by increasing heme oxygenase-1 expression through an estrogen receptor-related PI3K/Akt/Nrf2-dependent pathway in human dopaminergic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Strongylophorine-8, a pro-electrophilic compound from the marine sponge Petrosia (Strongylophora) corticata, provides neuroprotection through Nrf2/ARE pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

The chemical diversity and distribution of glucosinolates and isothiocyanates among plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Potent induction of carcinogen defence enzymes with sulforaphane, a putative prostate cancer chemopreventive agent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Differential responses from seven mammalian cell lines to the treatments of detoxifying enzyme inducers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Modest induction of phase 2 enzyme activity in the F-344 rat prostate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Role of phase 2 enzyme induction in chemoprotection by dithiolethiones

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Induction of cellular glutathione and glutathione S-transferase by 3H-1,2-dithiole-3-thione in rat aortic smooth muscle A10 cells: protection against acrolein-induced toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Induction of cellular glutathione-linked enzymes and catalase by the unique chemoprotective agent, 3H-1,2-dithiole-3-thione in rat cardiomyocytes affords protection against oxidative cell injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Generation of superoxide from reaction of 3H-1,2-dithiole-3-thione with thiols: implications for dithiolethione chemoprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Effects of organosulfur compounds from garlic oil on the antioxidation system in rat liver and red blood cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Antithrombotic and anticancer effects of garlic-derived sulfur compounds: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Ajoene, a stable garlic by-product, has an antioxidant effect through Nrf2-mediated glutamate-cysteine ligase induction in HepG2 cells and primary hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Diallyl sulfide induces heme oxygenase-1 through MAPK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated aldehyde acrolein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Fucoxanthin enhances HO-1 and NQO1 expression in murine hepatic BNL CL.2 cells through activation of the Nrf2/ARE system partially by its pro-oxidant activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Identification of 3-hydroxy-beta-damascone and related carotenoid-derived aroma compounds as novel potent inducers of Nrf2-mediated phase 2 response with concomitant anti-inflammatory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Structure activity relationship of carotenoid derivatives in activation of the electrophile/antioxidant response element transcription system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Homocysteine and alpha-lipoic acid regulate p44/42 MAP kinase phosphorylation in NIH/3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

4-Ketopinoresinol, a novel naturally occurring ARE activator, induces the Nrf2/HO-1 axis and protects against oxidative stress-induced cell injury via activation of PI3K/AKT signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Induction of antioxidant and phase 2 drug-metabolizing enzymes by falcarindiol isolated from Notopterygium incisum extract, which activates the Nrf2/ARE pathway, leads to cytoprotection against oxidative and electrophilic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene compound

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Effects of monascin on anti-inflammation mediated by Nrf2 activation in advanced glycation end product-treated THP-1 monocytes and methylglyoxal-treated wistar rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in H9c2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

The alpha-methylene-gamma-butyrolactone moiety in dehydrocostus lactone is responsible for cytoprotective heme oxygenase-1 expression through activation of the nuclear factor E2-related factor 2 in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

E-cadherin inhibits nuclear accumulation of Nrf2: implications for chemoresistance of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

ERRbeta: a potent inhibitor of Nrf2 transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Caveolin-1 inhibits expression of antioxidant enzymes through direct interaction with nuclear erythroid 2 p45-related factor-2 (Nrf2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Phosphorylation of tyrosine 568 controls nuclear export of Nrf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

RXRα inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Genetic analysis of cytoprotective functions supported by graded expression of Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Ochratoxin A impairs Nrf2-dependent gene expression in porcine kidney tubulus cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H

Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70065H