(Q38237519)

31 August 2017

Biological metals and metal-targeting compounds in major neurodegenerative diseases (English)

1 reference

31 August 2017

1 reference

Ashley I Bush

2

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author name string

Kevin J Barnham

series ordinal

1

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31 August 2017

7 August 2014

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31 August 2017

Chemical Society Reviews

1 reference

31 August 2017

43

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31 August 2017

19

1 reference

31 August 2017

6727-6749

1 reference

Oxygen toxicity, oxygen radicals, transition metals and disease

31 August 2017

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Aging: a theory based on free radical and radiation chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The neurobiology of zinc in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Copper in the brain and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Molecular and genetic features of zinc transporters in physiology and pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

ZnT-3, a putative transporter of zinc into synaptic vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Zinc-specific autometallographic in vivo selenium methods: tracing of zinc-enriched (ZEN) terminals, ZEN pathways, and pools of zinc ions in a multitude of other ZEN cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Visualization of transmitter release with zinc fluorescence detection at the mouse hippocampal mossy fibre synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Stimulation-induced uptake and release of zinc in hippocampal slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Release of endogenous Zn2+ from brain tissue during activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The actions of synaptically released zinc at hippocampal mossy fiber synapses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Synaptic release of zinc from brain slices: factors governing release, imaging, and accurate calculation of concentration

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Zinc in the physiology and pathology of the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The neurophysiology and pathology of brain zinc

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Structural basis of NR2B-selective antagonist recognition by N-methyl-D-aspartate receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Vesicular zinc promotes presynaptic and inhibits postsynaptic long-term potentiation of mossy fiber-CA3 synapse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Synaptically released zinc triggers metabotropic signaling via a zinc-sensing receptor in the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Intracellular zinc inhibits KCC2 transporter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The bioinorganic chemistry of apoptosis: potential inhibitory zinc binding sites in caspase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Convergent Ca2+ and Zn2+ signaling regulates apoptotic Kv2.1 K+ currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Growth inhibitory factor prevents neurite extension and the death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Prion protein facilitates uptake of zinc into neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

An architectural framework that may lie at the core of the postsynaptic density

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Rapid induction of Alzheimer A beta amyloid formation by zinc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Role of the P-Type ATPases, ATP7A and ATP7B in brain copper homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

ATP7A (Menkes protein) functions in axonal targeting and synaptogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Affinity gradients drive copper to cellular destinations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Calcium-dependent copper redistributions in neuronal cells revealed by a fluorescent copper sensor and X-ray fluorescence microscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Evidence for release of copper in the brain: depolarization-induced release of newly taken-up 67copper

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Nerve endings from rat brain tissue release copper upon depolarization. A possible role in regulating neuronal excitability

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Methods for studying synaptosomal copper release

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

NMDA receptor activation mediates copper homeostasis in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Copper modulation of NMDA responses in mouse and rat cultured hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The effects of copper ions on glutamate receptors in cultured rat cortical neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Inhibition of delayed rectifier K+ currents by copper in acutely dissociated rat hippocampal CA1 neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Effects of copper on A-type potassium currents in acutely dissociated rat hippocampal CA1 neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Formation of carnosine-Cu(II) complexes prevents and reverts the inhibitory action of copper in P2X4 and P2X7 receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Neuromodulator role of zinc and copper during prolonged ATP applications to P2X4 purinoceptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Extracellular histidine residues identify common structural determinants in the copper/zinc P2X2 receptor modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X7 purinergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Biphasic effects of copper on neurotransmission in rat hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Aging results in copper accumulations in glial fibrillary acidic protein-positive cells in the subventricular zone

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Elevated cortical zinc in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

In vivo reduction of amyloid-beta by a mutant copper transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Iron levels in the human brain: a post-mortem study of anatomical region differences and age-related changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Brain ferritin iron may influence age- and gender-related risks of neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Gender and iron genes may modify associations between brain iron and memory in healthy aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Elevated labile Cu is associated with oxidative pathology in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Metal binding dictates conformation and function of the amyloid precursor protein (APP) E2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Copper promotes the trafficking of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Alzheimer disease beta-amyloid activity mimics cholesterol oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Combined deletions of amyloid precursor protein and amyloid precursor-like protein 2 reveal different effects on mouse brain metal homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Deficiency of the copper chaperone for superoxide dismutase increases amyloid-β production

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Copper, iron and zinc in Alzheimer's disease senile plaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Immersion autometallographic tracing of zinc ions in Alzheimer beta-amyloid plaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Amyloid plaques in PSAPP mice bind less metal than plaques in human Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Copper is required for oncogenic BRAF signalling and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

4-Hydroxynonenal disrupts zinc export in primary rat cortical cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Increased amount of zinc in the hippocampus and amygdala of Alzheimer's diseased brains: a proton-induced X-ray emission spectroscopic analysis of cryostat sections from autopsy material.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Zinc homeostasis in the brain of adult rats fed zinc-deficient diet.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn2+ in cognitively intact aged individuals with Alzheimer's disease neuropathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Metal swap between Zn7-metallothionein-3 and amyloid-beta-Cu protects against amyloid-beta toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

A laser microprobe mass analysis of brain aluminum and iron in dementia pugilistica: comparison with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

In vivo evaluation of brain iron in Alzheimer's disease and normal subjects using MRI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Cortical phase changes in Alzheimer's disease at 7T MRI: a novel imaging marker

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Increased brain iron coincides with early plaque formation in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Iron overload accelerates neuronal amyloid-β production and cognitive impairment in transgenic mice model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Iron deposits in post-mortem brains of patients with neurodegenerative and cerebrovascular diseases: a semi-quantitative 7.0 T magnetic resonance imaging study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Quantitative assessment of subcortical atrophy and iron content in progressive supranuclear palsy and parkinsonian variant of multiple system atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The novel multi-target iron chelating-radical scavenging compound M30 possesses beneficial effects on major hallmarks of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Effects of hemochromatosis and transferrin gene mutations on iron dyshomeostasis, liver dysfunction and on the risk of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Genetic and biochemical markers in patients with Alzheimer's disease support a concerted systemic iron homeostasis dysregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

An anemia of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Active site environment of heme-bound amyloid β peptide associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Analogues of oxy-heme Aβ: reactive intermediates relevant to Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Copper and heme-mediated Abeta toxicity: redox chemistry, Abeta oxidations and anti-ROS compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Interactions between amyloid-β and hemoglobin: implications for amyloid plaque formation in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Peripheral clearance of amyloid beta peptide by complement C3-dependent adherence to erythrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Blood-borne amyloid-beta dimer correlates with clinical markers of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Red cell perturbations by amyloid beta-protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Elevation of serum copper levels in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

d-penicillamine reduces serum oxidative stress in Alzheimer's disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Value of serum nonceruloplasmin copper for prediction of mild cognitive impairment conversion to Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The metallobiology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The redox chemistry of the Alzheimer's disease amyloid beta peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Electrochemical and homogeneous electron transfers to the Alzheimer amyloid-beta copper complex follow a preorganization mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Redox reactions of copper complexes formed with different beta-amyloid peptides and their neuropathological [correction of neuropathalogical] relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The catalytically active copper-amyloid-Beta state: coordination site responsible for reactive oxygen species production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Bifunctional compounds for controlling metal-mediated aggregation of the aβ42 peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Design of small molecules that target metal-A{beta} species and regulate metal-induced A{beta} aggregation and neurotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Zinc-amyloid beta interactions on a millisecond time-scale stabilize non-fibrillar Alzheimer-related species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Distinct effects of Zn2+, Cu2+, Fe3+, and Al3+ on amyloid-beta stability, oligomerization, and aggregation: amyloid-beta destabilization promotes annular protofibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

New insights on how metals disrupt amyloid beta-aggregation and their effects on amyloid-beta cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Zn2+-Aβ40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates aβ pathology in a Drosophila model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Role of metal ions in the self-assembly of the Alzheimer's amyloid-β peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The second Cu(II)-binding site in a proton-rich environment interferes with the aggregation of amyloid-beta(1-40) into amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Cu(II) mediates kinetically distinct, non-amyloidogenic aggregation of amyloid-beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Copper prevents amyloid-β(1-42) from forming amyloid fibrils under near-physiological conditions in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Substoichiometric levels of Cu2+ ions accelerate the kinetics of fiber formation and promote cell toxicity of amyloid-{beta} from Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Neurodegenerative diseases and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

New evidence that the Alzheimer beta-amyloid peptide does not spontaneously form free radicals: an ESR study using a series of spin-traps.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Redox processes of methionine relevant to beta-amyloid oxidation and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Metals and amyloid-beta in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Anti-inflammatory drugs and Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Copper ions strongly activate the phosphoinositide-3-kinase/Akt pathway independent of the generation of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Alanine-2 carbonyl is an oxygen ligand in Cu2+ coordination of Alzheimer's disease amyloid-beta peptide--relevance to N-terminally truncated forms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Pleomorphic copper coordination by Alzheimer's disease amyloid-beta peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Deprotonation of the Asp1-Ala2 peptide bond induces modification of the dynamic copper(II) environment in the amyloid-beta peptide near physiological pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Importance of dynamical processes in the coordination chemistry and redox conversion of copper amyloid-beta complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The heterogeneous nature of Cu2+ interactions with Alzheimer's amyloid-β peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Biophysical studies of the amyloid β-peptide: interactions with metal ions and small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The challenges of determining metal-protein affinities

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Copper and zinc binding to amyloid-beta: coordination, dynamics, aggregation, reactivity and metal-ion transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Cu(II) affinity for the Alzheimer's peptide: tyrosine fluorescence studies revisited.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The elevated copper binding strength of amyloid-β aggregates allows the sequestration of copper from albumin: a pathway to accumulation of copper in senile plaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Zinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic states

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Tau protein: relevance to Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Copper- and iron-induced differential fibril formation in α-synuclein: TEM study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Alpha-synuclein and its role in metal binding: relevance to Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Alpha-synuclein is a cellular ferrireductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Site-specific copper-catalyzed oxidation of α-synuclein: tightening the link between metal binding and protein oxidative damage in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Unique copper-induced oligomers mediate alpha-synuclein toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Copper binding regulates intracellular alpha-synuclein localisation, aggregation and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Iron-binding characteristics of neuromelanin of the human substantia nigra.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Amyloid beta and neuromelanin--toxic or protective molecules? The cellular context makes the difference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Transcranial ultrasound as a risk marker for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Motor phenotype and magnetic resonance measures of basal ganglia iron levels in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Individual dopaminergic neurons show raised iron levels in Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Substantia nigra hyperechogenicity with LRRK2 G2019S mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Substantia nigra hyperechogenicity correlates with clinical status and number of Parkin mutated alleles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Transcranial ultrasound in different monogenetic subtypes of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Loss of iron triggers PINK1/Parkin-independent mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Total iron-binding capacity calculated from serum transferrin concentration or serum iron concentration and unsaturated iron-binding capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Ceruloplasmin gene expression in the murine central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Novel bifunctional drugs targeting monoamine oxidase inhibition and iron chelation as an approach to neuroprotection in Parkinson's disease and other neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal dopamine depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Chronic intranasal deferoxamine ameliorates motor defects and pathology in the α-synuclein rAAV Parkinson's model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Therapeutic targets and potential of the novel brain- permeable multifunctional iron chelator-monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Targeting chelatable iron as a therapeutic modality in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Zn²⁺ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Parkinson's disease-associated human ATP13A2 (PARK9) deficiency causes zinc dyshomeostasis and mitochondrial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Alterations in levels of iron, ferritin, and other trace metals in neurodegenerative diseases affecting the basal ganglia. The Royal Kings and Queens Parkinson's Disease Research Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Increased basal ganglia iron levels in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Myelin breakdown and iron changes in Huntington's disease: pathogenesis and treatment implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Alterations in brain transition metals in Huntington disease: an evolving and intricate story

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Mechanisms of copper ion mediated Huntington's disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Iron accumulates in Huntington's disease neurons: protection by deferoxamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The changing scene of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

How do ALS-associated mutations in superoxide dismutase 1 promote aggregation of the protein?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Overexpression of Abeta is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in an amyotrophic lateral sclerosis mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Metallothionein proteins expression, copper and zinc concentrations, and lipid peroxidation level in a rodent model for amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The efficacy of trientine or ascorbate alone compared to that of the combined treatment with these two agents in familial amyotrophic lateral sclerosis model mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Ammonium tetrathiomolybdate delays onset, prolongs survival, and slows progression of disease in a mouse model for amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Monomerized Cu, Zn-superoxide dismutase induces oxidative stress through aberrant Cu binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Structural Characterization of Zinc-deficient Human Superoxide Dismutase and Implications for ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

SOD1 aggregation and ALS: role of metallation states and disulfide status

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

ALS-causing SOD1 mutations promote production of copper-deficient misfolded species

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Elevated serum ferritin is associated with reduced survival in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

A systematic review of the clinical effectiveness of donepezil, rivastigmine and galantamine on cognition, quality of life and adverse events in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Stoichiometry and conditional stability constants of Cu(II) or Zn(II) clioquinol complexes; implications for Alzheimer's and Huntington's disease therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Multitarget-directed benzylideneindanone derivatives: anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Multi-target, neuroprotective and neurorestorative M30 improves cognitive impairment and reduces Alzheimer's-like neuropathology and age-related alterations in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Sequestration of copper from beta-amyloid promotes selective lysis by cyclen-hybrid cleavage agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Inhibition of Cu-amyloid-β by using bifunctional peptides with β-sheet breaker and chelator moieties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Development of bifunctional stilbene derivatives for targeting and modulating metal-amyloid-β species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Small molecule modulators of copper-induced Abeta aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Design, selection, and characterization of thioflavin-based intercalation compounds with metal chelating properties for application in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Combating Alzheimer's disease with multifunctional molecules designed for metal passivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective-neurorestorative moieties for Alzheimer's therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Efficacy and toxicity of clioquinol treatment and A-beta42 inoculation in the APP/PSI mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Clioquinol decreases amyloid-beta burden and reduces working memory impairment in a transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Werner coordination chemistry and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Copper-64-diacetyl-bis(N4-methylthiosemicarbazone): An agent for radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Bis(thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Metal ions and intrinsically disordered proteins and peptides: from Cu/Zn amyloid-β to general principles

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Metal binding sites in amyloid oligomers: Complexes and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

An iron–dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Bioinorganic chemistry of copper coordination to alpha-synuclein: Relevance to Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Genetically Decreased Spinal Cord Copper Concentration Prolongs Life in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

Is ALS caused by an altered oxidative activity of mutant superoxide dismutase?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4CS00138A

21 January 2018

Identifiers

DOI

10.1039/C4CS00138A

1 reference

31 August 2017

1 reference

PubMed ID

25099276