(Q38331206)

2 September 2017

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title

The role of DNA damage responses in p53 biology (English)

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2 September 2017

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Daniel Speidel

1

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2 September 2017

language of work or name

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25 January 2015

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2 September 2017

published in

Archives of Toxicology

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2 September 2017

volume

89

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2 September 2017

issue

4

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2 September 2017

page(s)

501-517

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https://scigraph.springernature.com/pub.10.1007/s00204-015-1459-z

2 September 2017

exact match

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cites work

p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene

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https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

DNA substrate dependence of p53-mediated regulation of double-strand break repair

21 January 2018

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Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms.

21 January 2018

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Acquisition of p53 mutations in response to the non-genotoxic p53 activator Nutlin-3.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p21 delays tumor onset by preservation of chromosomal stability

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Metabolic regulation by p53 family members.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Deconstructing p53 transcriptional networks in tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Unravelling mechanisms of p53-mediated tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

A role for p53 in DNA end rejoining by human cell extracts

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53-mediated activation of miRNA34 candidate tumor-suppressor genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Radioresistant MTp53-expressing rat embryo cell transformants exhibit increased DNA-dsb rejoining during exposure to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Awakening guardian angels: drugging the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Radiation-induced cell cycle arrest compromised by p21 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Another fork in the road--life or death decisions by the tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

ATM activates p53 by regulating MDM2 oligomerization and E3 processivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Resistance acquisition to MDM2 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Thymocyte apoptosis induced by p53-dependent and independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Intact p53-dependent responses in miR-34-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Transcriptional regulation of thymine DNA glycosylase (TDG) by the tumor suppressor protein p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Inhibition of DNA replication factor RPA by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Definition of a consensus binding site for p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53 in recombination and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Coordinated regulation of cell cycle transcripts by p53-Inducible microRNAs, miR-192 and miR-215.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Molecular subtypes of breast cancer in relation to paclitaxel response and outcomes in women with metastatic disease: results from CALGB 9342

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

A microRNA component of the p53 tumour suppressor network

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

microRNAs join the p53 network--another piece in the tumour-suppression puzzle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

A rapid and optimization-free procedure allows the in vivo detection of subtle cell cycle and ploidy alterations in tissues by flow cytometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Timed somatic deletion of p53 in mice reveals age-associated differences in tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

The Regulation of Multiple p53 Stress Responses is Mediated through MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

The p53/microRNA network in cancer: experimental and bioinformatics approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Tumor spectrum analysis in p53-mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Wild-type p53 inhibits replication-associated homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Mutational landscape and significance across 12 major cancer types

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Identification of p53 as a sequence-specific DNA-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Drugging the p53 pathway: understanding the route to clinical efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Cancer. p53, guardian of the genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Mechanism and regulation of human non-homologous DNA end-joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53 activates Fanconi anemia group C gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Suppression of high-fidelity double-strand break repair in mammalian chromosomes by pifithrin-alpha, a chemical inhibitor of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53 is required for radiation-induced apoptosis in mouse thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

The oncogenic roles of p53 mutants in mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

G1 cell-cycle control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Checkpoint control and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53 has a direct apoptogenic role at the mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

PUMA, a novel proapoptotic gene, is induced by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

A ribonucleotide reductase gene is a transcriptional target of p53 and p73

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Structural and functional involvement of p53 in BER in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

WAF1 retards S-phase progression primarily by inhibition of cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Effect of wild-type, S15D and R175H p53 proteins on DNA end joining in vitro: potential mechanism of DNA double-strand break repair modulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

TP53 mutations in human cancers: origins, consequences, and clinical use

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Genetic networks lead and follow tumor development: microRNA regulation of cell cycle and apoptosis in the p53 pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

The G(2) checkpoint is maintained by redundant pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Genetic determinants of p53-induced apoptosis and growth arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Transcriptional activation of miR-34a contributes to p53-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Hypermutation in human cancer genomes: footprints and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

TIS21/BTG2/PC3 is expressed through PKC-delta pathway and inhibits binding of cyclin B1-Cdc2 and its activity, independent of p53 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Specific in vitro binding of p53 to the promoter region of the human mismatch repair gene hMSH2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

DNA binding cooperativity of p53 modulates the decision between cell-cycle arrest and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53: traffic cop at the crossroads of DNA repair and recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Implication of p53 in base excision DNA repair: in vivo evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Transcription-independent p53 apoptosis: an alternative route to death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Dissection of transcriptional and non-transcriptional p53 activities in the response to genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p21(waf1/cip1)-null human fibroblasts are deficient in nucleotide excision repair downstream the recruitment of PCNA to DNA repair sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Radiation-induced senescence-like growth arrest requires TP53 function but not telomere shortening

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Constitutive expression of the cyclin-dependent kinase inhibitor p21 is transcriptionally regulated by the tumor suppressor protein p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Mechanisms of G2 arrest in response to overexpression of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Mutant p53 and the response to chemotherapy and radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Human cells compromised for p53 function exhibit defective global and transcription-coupled nucleotide excision repair, whereas cells compromised for pRb function are defective only in global repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Gadd45a suppresses Ras-driven mammary tumorigenesis by activation of c-Jun NH2-terminal kinase and p38 stress signaling resulting in apoptosis and senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Gadd45a functions as a promoter or suppressor of breast cancer dependent on the oncogenic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

A novel p53-inducible gene coding for a microtubule-localized protein with G2-phase-specific expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Outcomes of p53 activation--spoilt for choice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53 in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Blinded by the Light: The Growing Complexity of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53 modulation of TFIIH-associated nucleotide excision repair activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

GADD45 induction of a G2/M cell cycle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p21 is a universal inhibitor of cyclin kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

p53 induced by ionizing radiation mediates DNA end-jointing activity, but not apoptosis of thyroid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

PUMA induces the rapid apoptosis of colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Replication of damaged DNA in vitro is blocked by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

A role for p53 in base excision repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

The role of p53 in base excision repair following genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

Apaf-1 is a transcriptional target for E2F and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1459-Z

10.1007/S00204-015-1459-Z

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

2 September 2017

1019146511

0 references

1 reference