(Q46190066)

20 December 2017

title

CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine (English)

1 reference

20 December 2017

Martin Kampmann

1

0 references

publication date

16 October 2017

1 reference

20 December 2017

published in

ACS Chemical Biology

1 reference

20 December 2017

Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood

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A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

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The mTOR Complex Controls HIV Latency

3 November 2018

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Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.

3 November 2018

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Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR-Cas9 library

3 November 2018

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Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants

3 November 2018

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Prospective functional classification of all possible missense variants in PPARG.

3 November 2018

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Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells

3 November 2018

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Systematic mapping of functional enhancer-promoter connections with CRISPR interference

3 November 2018

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Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers

3 November 2018

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Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.

3 November 2018

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High-throughput Phenotyping of Lung Cancer Somatic Mutations

3 November 2018

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CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter.

3 November 2018

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CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions.

3 November 2018

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Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

3 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Comparison of Cas9 activators in multiple species

3 November 2018

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CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes.

3 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

3 November 2018

1 reference

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CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Repurposing the CRISPR-Cas9 system for targeted DNA methylation

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Next-generation libraries for robust RNA interference-based genome-wide screens.

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers.

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Functional annotation of native enhancers with a Cas9-histone demethylase fusion.

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Highly efficient Cas9-mediated transcriptional programming

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

A protein-tagging system for signal amplification in gene expression and fluorescence imaging

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Genome-scale CRISPR-Cas9 knockout screening in human cells

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Genetic screens in human cells using the CRISPR-Cas9 system

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Orthogonal Cas9 proteins for RNA-guided gene regulation and editing

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

CRISPR RNA-guided activation of endogenous human genes

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

RNA-guided gene activation by CRISPR-Cas9-based transcription factors

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

RNA-programmed genome editing in human cells

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

RNA-guided human genome engineering via Cas9

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Multiplex genome engineering using CRISPR/Cas systems

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Molecular biology. Use and abuse of RNAi to study mammalian gene function

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

3 November 2018

1 reference

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A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

The dose can make the poison: lessons learned from adverse in vivo toxicities caused by RNAi overexpression

3 November 2018

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A public genome-scale lentiviral expression library of human ORFs

3 November 2018

1 reference

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Haploid genetic screens in human cells identify host factors used by pathogens

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Global mapping of the yeast genetic interaction network

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

RNA interference in human cells is restricted to the cytoplasm

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Systematic genetic analysis with ordered arrays of yeast deletion mutants

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Systematic determination of the packaging limit of lentiviral vectors

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Krüppel-associated boxes are potent transcriptional repression domains

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

A Robust Toolkit for Functional Profiling of the Yeast Genome

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886776

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent

1 December 2018

1 reference

19 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1016/J.MOLCEL.2017.09.012

Identifiers

DOI

10.1021/ACSCHEMBIO.7B00657

1 reference

20 December 2017

PMC publication ID

5886776

0 references

1 reference

20 December 2017