(Q85159440)

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A quantitative framework and strategies for management and evaluation of metabolic drug-drug interactions in oncology drug development: new molecular entities as object drugs

scientific article published on 01 November 2010

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scholarly article

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Europe PubMed Central

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15 February 2020

A quantitative framework and strategies for management and evaluation of metabolic drug-drug interactions in oncology drug development: new molecular entities as object drugs (English)

1 reference

Europe PubMed Central

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15 February 2020

drug interaction

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Lisa L. von Moltke

3

object named as

Lisa L von Moltke

1 reference

Europe PubMed Central

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15 February 2020

author name string

Karthik Venkatakrishnan

1

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15 February 2020

Michael D Pickard

2

1 reference

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15 February 2020

publication date

1 November 2010

1 reference

Europe PubMed Central

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15 February 2020

Clinical Pharmacokinetics

1 reference

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15 February 2020

49

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15 February 2020

11

1 reference

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15 February 2020

703-727

1 reference

Europe PubMed Central

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15 February 2020

https://scigraph.springernature.com/pub.10.2165/11536740-000000000-00000

0 references

A proposal for a pharmacokinetic interaction significance classification system (PISCS) based on predicted drug exposure changes and its potential application to alert classifications in product labelling

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apparent high CYP3A5 expression is required for significant metabolism of vincristine by human cryopreserved hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of sandwich-cultured human hepatocytes to predict biliary clearance of angiotensin II receptor blockers and HMG-CoA reductase inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of ignoring extraction ratio when predicting drug-drug interactions, fraction metabolized, and intestinal first-pass contribution

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic variability in CYP3A5 and its possible consequences.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicting drug disposition via application of a Biopharmaceutics Drug Disposition Classification System

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of ixabepilone: a first in class epothilone B analogue in late-phase clinical development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane transporters in drug development

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tamoxifen pharmacogenomics: the role of CYP2D6 as a predictor of drug response

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

General framework for the prediction of oral drug interactions caused by CYP3A4 induction from in vivo information

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of parallel pathways of drug elimination and multiple cytochrome P450 involvement on drug-drug interactions: CYP2D6 paradigm.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug interactions evaluation: an integrated part of risk assessment of therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective metabolism of vincristine in vitro by CYP3A5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro-in vivo correlation of hepatobiliary drug clearance in humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of Temafloxacin and Ciprofloxacin on the Pharmacokinetics of Caffeine†

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of cytochrome P450 3A4 inhibition on the pharmacokinetics of docetaxel

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recogn

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preirradiation paclitaxel in glioblastoma multiforme: efficacy, pharmacology, and drug interactions. New Approaches to Brain Tumor Therapy Central Nervous System Consortium

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of CYP3A5 expression on vincristine metabolism with human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping and in vitro-in vivo extrapolation of drug clearance and drug-drug interaction potentia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug interaction studies: study design, data analysis, and implications for dosing and labeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinically relevant pharmacology of selective serotonin reuptake inhibitors. An overview with emphasis on pharmacokinetics and effects on oxidative drug metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 reaction-phenotyping: an industrial perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of ketoconazole on exposure to temsirolimus following intravenous infusion of temsirolimus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: studies with cDNA and oligonucleotide expression arrays

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of ethnicity in variability in response to drugs: focus on clinical pharmacology studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New era in drug interaction evaluation: US Food and Drug Administration update on CYP enzymes, transporters, and the guidance process

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

So many studies, too few subjects: establishing functional relevance of genetic polymorphisms on pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Application of CYP3A4 in vitro data to predict clinical drug-drug interactions; predictions of compounds as objects of interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential--towards a consensus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Limited influence of UGT1A1*28 and no effect of UGT2B7*2 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I clinical and pharmacokinetic study of irinotecan in adults with recurrent malignant glioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

General framework for the quantitative prediction of CYP3A4-mediated oral drug interactions based on the AUC increase by coadministration of standard drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo induction of cytochrome p450: a survey of the current practices and recommendations: a pharmaceutical research and manufacturers of america perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of intestinal first-pass drug metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The drug transporter-metabolism alliance: uncovering and defining the interplay

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

'In silico' simulations to assess the 'in vivo' consequences of 'in vitro' metabolic drug-drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential role of intestinal first-pass metabolism in the prediction of drug–drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic interaction between ketoconazole and imatinib mesylate (Glivec) in healthy subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of race on vincristine-associated neurotoxicity in pediatric acute lymphoblastic leukemia patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of CYP3A4 inhibition on the steady-state pharmacokinetics of imatinib

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome P450 3A4 substrate, in patients with chronic myeloid leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of pharmacokinetic drug-drug interactions using human hepatocyte suspension in plasma and cytochrome P450 phenotypic data. II. In vitro-in vivo correlation with ketoconazole

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: qualitative relationships, quantitative predictions, and the rank-order approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CYP3A5 genotype markedly influences the pharmacokinetics of tacrolimus and sirolimus in kidney transplant recipients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unexpected effect of rifampin on the pharmacokinetics of linezolid: in silico and in vitro approaches to explain its mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Towards a quantitative framework for the prediction of DDIs arising from cytochrome P450 induction

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanistic modeling of hepatic transport from cells to whole body: application to napsagatran and fexofenadine

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

What is the objective of the mass balance study? A retrospective analysis of data in animal and human excretion studies employing radiolabeled drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of the CYP3A inhibitor ketoconazole on the pharmacokinetics and pharmacodynamics of bortezomib in patients with advanced solid tumors: a prospective, multicenter, open-label, randomized, two-way crossover drug-drug interaction study

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A global examination of allometric scaling for predicting human drug clearance and the prediction of large vertical allometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Should pharmacogenomic studies be required for new drug approval?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Simcyp population-based ADME simulator

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of UGTs active against SAHA and association between SAHA glucuronidation activity phenotype with UGT genotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maximal inhibition of intestinal first-pass metabolism as a pragmatic indicator of intestinal contribution to the drug-drug interactions for CYP3A4 cleared drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase-1 trial of gefitinib and temozolomide in patients with malignant glioma: a North American brain tumor consortium study

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug-drug, drug-dietary supplement, and drug-citrus fruit and other food interactions: what have we learned?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase 1 pharmacokinetic and drug-interaction study of dasatinib in patients with advanced solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of pharmacokinetic profile of valsartan in human based on in vitro uptake transport data

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinically Relevant Pharmacology of Selective Serotonin Reuptake Inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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