(Q34318188)

1 August 2017

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title

The evolution of the TOR pathway and its role in cancer (English)

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1 August 2017

E M Beauchamp

1

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1 August 2017

L C Platanias

series ordinal

2

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1 August 2017

language of work or name

English

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publication date

17 December 2012

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1 August 2017

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1 August 2017

32

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1 August 2017

34

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1 August 2017

3923-3932

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https://scigraph.springernature.com/pub.10.1038/onc.2012.567

1 August 2017

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cites work

With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

A Putative Sirolimus (Rapamycin) Effector Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

mTOR signaling in growth control and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

mTOR and cancer: insights into a complex relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

21 January 2018

The two TORCs and Akt.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Molecular mechanisms of mTOR-mediated translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Role of the Akt pathway in mRNA translation of interferon-stimulated genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Mechanisms of type-I- and type-II-interferon-mediated signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Identification of a conserved motif required for mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

The crosstalk of mTOR/S6K1 and Hedgehog pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Upstream and downstream of mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Regulation of translation initiation in eukaryotes: mechanisms and biological targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Regulation of eIF-4E BP1 phosphorylation by mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Akt regulates growth by directly phosphorylating Tsc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

AMPK and mTOR in cellular energy homeostasis and drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

TOR signaling in growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Large-scale characterization of HeLa cell nuclear phosphoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Regulation of TORC1 by Rag GTPases in nutrient response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

The mTOR (mammalian target of rapamycin) kinase maintains integrity of mTOR complex 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Integrity of mTORC2 is dependent on the rictor Gly-934 site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

TOR controls translation initiation and early G1 progression in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Sch9 is a major target of TORC1 in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

TOR2 is required for organization of the actin cytoskeleton in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Genetics: influence of TOR kinase on lifespan in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

A role for autophagy in the extension of lifespan by dietary restriction in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Amino acid regulation of TOR complex 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Regulation of membrane traffic by phosphoinositide 3-kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Drosophila S6 kinase: a regulator of cell size

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

An emerging role of mTOR in lipid biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Negative regulatory effects of Mnk kinases in the generation of chemotherapy-induced antileukemic responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

The TOR pathway: a target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

The role of LKB1 in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

The LKB1 tumor suppressor negatively regulates mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Identification and characterization of the tuberous sclerosis gene on chromosome 16

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Deconvoluting the context-dependent role for autophagy in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Distinct clinical characteristics of tuberous sclerosis complex patients with no mutation identified

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Tumorigenic activity and therapeutic inhibition of Rheb GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

p53-dependent translational control of senescence and transformation via 4E-BPs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Activated eIF4E-binding Protein Slows G1 Progression and Blocks Transformation by c-myc without Inhibiting Cell Growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

TOR complex 2 is needed for cell cycle progression and anchorage-independent growth of MCF7 and PC3 tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

PRR5 encodes a conserved proline-rich protein predominant in kidney: analysis of genomic organization, expression, and mutation status in breast and colorectal carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.567

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

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Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

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Survival of acute myeloid leukemia cells requires PI3 kinase activation

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Dissecting the genomic complexity underlying medulloblastoma

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Subgroup-specific structural variation across 1,000 medulloblastoma genomes

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Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

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Novel mutations target distinct subgroups of medulloblastoma.

21 January 2018

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Molecular subgroups of medulloblastoma: the current consensus

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Clonal selection drives genetic divergence of metastatic medulloblastoma

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Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

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1 reference

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PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

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Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth

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1 reference

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Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

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1 reference

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Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome

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1 reference

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Medulloblastoma comprises four distinct molecular variants

21 January 2018

1 reference

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An animal model of MYC-driven medulloblastoma

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Sirolimus: its discovery, biological properties, and mechanism of action

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Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma

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Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

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Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial

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Everolimus for advanced pancreatic neuroendocrine tumors.

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Emerging roles for mammalian target of rapamycin inhibitors in the treatment of solid tumors and hematological malignancies

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Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer

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Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study

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PTEN loss does not predict for response to RAD001 (Everolimus) in a glioblastoma orthotopic xenograft test panel

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

21 January 2018

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

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Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition

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An overview of the mTOR pathway as a target in cancer therapy.

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Dual mTORC2/mTORC1 targeting results in potent suppressive effects on acute myeloid leukemia (AML) progenitors

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Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells

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Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia

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A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

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NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

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BRAFV600E negatively regulates the AKT pathway in melanoma cell lines

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The Rapamycin and FKBP12 Target (RAFT) Displays Phosphatidylinositol 4-Kinase Activity

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The tuberous sclerosis gene on chromosome 9q34 acts as a growth suppressor

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Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E

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Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor.

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Rictor regulates cell migration by suppressing RhoGDI2.

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Functional characterization of glycine N-methyltransferase and its interactive protein DEPDC6/DEPTOR in hepatocellular carcinoma

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Identification of mTOR as a novel bifunctional target in chronic myeloid leukemia: dissection of growth-inhibitory and VEGF-suppressive effects of rapamycin in leukemic cells.

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31 March 2020

Identifiers

DOI

10.1038/ONC.2012.567

1 reference

Dimensions Publication ID

1 August 2017

0 references

1 reference