(Q38094984)

28 August 2017

The senescence hypothesis of disease progression in Alzheimer disease: an integrated matrix of disease pathways for FAD and SAD. (English)

1 reference

28 August 2017

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Sally Hunter

1

0 references

Carol Brayne

series ordinal

3

object named as

Carol Brayne

1 reference

28 August 2017

Thomas Arendt

2

1 reference

28 August 2017

3 April 2013

1 reference

28 August 2017

Molecular Neurobiology

1 reference

28 August 2017

48

1 reference

28 August 2017

556-570

1 reference

28 August 2017

3

1 reference

https://scigraph.springernature.com/pub.10.1007/s12035-013-8445-3

28 August 2017

0 references

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The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

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Cholesterol homeostasis failure as a unifying cause of synaptic degeneration

21 January 2018

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Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease

21 January 2018

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Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease

21 January 2018

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Mitochondrial dysfunction, apoptotic cell death, and Alzheimer's disease

21 January 2018

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The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review

21 January 2018

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The cholinergic hypothesis of geriatric memory dysfunction

21 January 2018

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Calcium and neurodegeneration

21 January 2018

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Calcium dysregulation in Alzheimer's disease

21 January 2018

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Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity

21 January 2018

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Changing perspectives regarding late-life dementia.

21 January 2018

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Time for a change in the research paradigm for Alzheimer's disease: the value of a chaotic matrix modeling approach.

21 January 2018

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Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems

21 January 2018

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Reimagining Alzheimer's disease--an age-based hypothesis

21 January 2018

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Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

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Pathologic heterogeneity of Alzheimer's disease.

21 January 2018

1 reference

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Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study

21 January 2018

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Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).

21 January 2018

1 reference

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The elephant in the room - healthy brains in later life, epidemiology and public health

21 January 2018

1 reference

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Impact of cellular senescence signature on ageing research

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Senescence; an endogenous anticancer mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Cellular senescence: a double-edged sword in the fight against cancer

21 January 2018

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Hallmarks of senescence in carcinogenesis and cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Autophagy in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Senescent cells as a source of inflammatory factors for tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The roles of TNF in brain dysfunction and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Kinetics of the neuroinflammation-oxidative stress correlation in rat brain following the injection of fibrillar amyloid-beta onto the hippocampus in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Aberrant expression of nNOS in pyramidal neurons in Alzheimer's disease is highly co-localized with p21ras and p16INK4a.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Neurodegeneration and plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Identification of 3-nitrotyrosine-modified brain proteins by redox proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Oxidative stress signalling in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Oxidative imbalance in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Oxidative damage is the earliest event in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Inflammation, the complement system and the diseases of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Antioxidant approaches for the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Oxidative stress, perturbed calcium homeostasis, and immune dysfunction in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Oxidative stress and cerebrovascular dysfunction in mouse models of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Cerebral hypoperfusion, capillary degeneration, and development of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: involvement of oxidative stress and mitogen-activated protein kinase cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Insights into CNS ageing from animal models of senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Oxidative stress in Alzheimer's disease brain: new insights from redox proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Amyloid beta: the alternate hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The amyloid hypothesis: let sleeping dogmas lie?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Amyloid beta-peptide(1-42) contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Oxidative stress in neurodegenerative diseases: mechanisms and therapeutic perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Inflammation and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Macrophage migration inhibitory factor in mild cognitive impairment and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Evidence linking neuronal cell death to autoimmunity in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Yin and Yang: complement activation and regulation in Alzheimer’s disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Inflammaging as a prodrome to Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Neuroinflammation and ageing: current theories and an overview of the data

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

NSAIDs for the Chemoprevention of Alzheimer’s Disease

21 January 2018

2 references

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

21 January 2018

12 December 2020

NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Amyloid-beta peptides induce cell proliferation and macrophage colony-stimulating factor expression via the PI3-kinase/Akt pathway in cultured Ra2 microglial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The role of microglia in amyloid clearance from the AD brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Cells of monocyte/microglial lineage are involved in both microvessel amyloidosis and fibrillar plaque formation in APPsw tg mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Glial cell dysregulation: a new perspective on Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

RAGE, LDL receptor, and LRP1 expression in the brains of SAMP8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Apolipoprotein E protects cultured pericytes and astrocytes from D-Abeta(1-40)-mediated cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Astrocyte lipoproteins, effects of apoE on neuronal function, and role of apoE in amyloid-beta deposition in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Astrocytes accumulate Aβ42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Selective targeting of perivascular macrophages for clearance of beta-amyloid in cerebral amyloid angiopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Mechanisms of cell signaling and inflammation in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Apolipoprotein E structural requirements for the formation of SDS-stable complexes with beta-amyloid-(1-40): the role of salt bridges

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Apolipoprotein gene and its interaction with the environmentally driven risk factors: molecular, genetic and epidemiological studies of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Interaction with amyloid beta peptide compromises the lipid binding function of apolipoprotein E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

LRP and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

LRP in amyloid-beta production and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Functional role of lipoprotein receptors in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

ApoE promotes the proteolytic degradation of Abeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The effect of oxidative stress on accumulation of apolipoprotein E3 and E4 in a cell culture model of beta-amyloid angiopathy (CAA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Role of apoe/Abeta interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Acetylcholinesterase inhibitors, neuropsychiatric symptoms, and Alzheimer's disease subtypes: an alternate hypothesis to global cognitive enhancement

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The significance of the cholinergic system in the brain during aging and in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The cholinergic system in aging and neuronal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Acetylcholine esterase activity in mild cognitive impairment and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Deficits of the cholinergic system in early AD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Cholinergic markers in elderly patients with early signs of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Cholinergic and glutamatergic alterations beginning at the early stages of Alzheimer disease: participation of the phospholipase A2 enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Tau phosphorylation in Alzheimer's disease: pathogen or protector?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

A novel perspective on tau in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Phosphorylated tau and the neurodegenerative foldopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

A neuroprotective role for the DNA damage checkpoint in tauopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Tubulin-independent tau in Alzheimer's disease and cancer: implications for disease pathogenesis and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Innervation of cerebral blood vessels: morphology, plasticity, age-related, and Alzheimer's disease-related neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Nicotine-mediated cell proliferation and angiogenesis: new twists to an old story

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The blood-brain barrier and cerebrovascular pathology in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Review: cerebral microvascular pathology in ageing and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Cerebral microvascular pathology in aging and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Cerebral amyloid angiopathy and its relationship to Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Two types of sporadic cerebral amyloid angiopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Lymphatic drainage of the brain and the pathophysiology of neurological disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Role of perivascular cells and myocytes in vascular amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Neurovascular mechanisms of Alzheimer's neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Abeta peptides accelerate the senescence of endothelial cells in vitro and in vivo, impairing angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Neuronal life-and-death signaling, apoptosis, and neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Mitochondrial alterations, oxidative stress and neuroinflammation in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Are paradoxical cell cycle activities in neurons and glia related to the metabolic theory of Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

mTOR: dissecting regulation and mechanism of action to understand human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Physical activity and risk of cognitive decline: a meta-analysis of prospective studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Exercise and the nitric oxide vasodilator system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Effects of exercise on brain function: role of free radicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Beneficial effects of moderate voluntary physical exercise and its biological mechanisms on brain health

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

BMP signaling mediates effects of exercise on hippocampal neurogenesis and cognition in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Exercise tames the wild side of the Myc network: a hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Applicability and effects of physical exercise on physical and cognitive functions and activities of daily living among people with dementia: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Oxidative stress and inflammation in brain aging: nutritional considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Cognitive reserve and the neurobiology of cognitive aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Role of common and rare APP DNA sequence variants in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Apo E genotypes and risk of dementia in Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Duplication of amyloid precursor protein (APP), but not prion protein (PRNP) gene is a significant cause of early onset dementia in a large UK series

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

APP locus duplication in a Finnish family with dementia and intracerebral haemorrhage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Phenotype associated with APP duplication in five families.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Notch and the p53 clan of transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Notch 1 interacts with the amyloid precursor protein in a Numb-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: implications for Alzheimer disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Implication of APP secretases in notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Alzheimer's disease and Notch signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Do c-Jun, c-Fos, and amyloid precursor protein play a role in neuronal death or survival?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The ups and downs of Wnt signaling in prevalent neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Wnt signaling in Alzheimer's disease: up or down, that is the question

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Vital elements of the Wnt-Frizzled signaling pathway in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Two sides of the same coin: Wnt signaling in neurodegeneration and neuro-oncology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Wnt signaling in neuroprotection and stem cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

A common biological mechanism in cancer and Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Gamma-secretase activity is not involved in presenilin-mediated regulation of beta-catenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Presenilin 1 independently regulates beta-catenin stability and transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Amyloid precursor protein modulates beta-catenin degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Oligomeric Abeta in Alzheimer's disease: relationship to plaque and tangle pathology, APOE genotype and cerebral amyloid angiopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Differential physiologic responses of alpha7 nicotinic acetylcholine receptors to beta-amyloid1-40 and beta-amyloid1-42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Amyloid beta-protein (Abeta)1-40 protects neurons from damage induced by Abeta1-42 in culture and in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Antioxidant protection and neurodegenerative disease: the role of amyloid-beta and tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Abeta to physiologically relevant proteolytic degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Pathogenic effects of cerebral amyloid angiopathy mutations in the amyloid beta-protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Genotype-phenotype relationships of presenilin-1 mutations in Alzheimer's disease: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Variations in the neuropathology of familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Notch: from neural development to neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

A systems biology approach to Down syndrome: identification of Notch/Wnt dysregulation in a model of stem cells aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Notch activation induces endothelial cell senescence and pro-inflammatory response: implication of Notch signaling in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Cholesterol in Alzheimer's disease: unresolved questions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Microglia and neuroprotection: from in vitro studies to therapeutic applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Microglia: scapegoat, saboteur, or something else?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

A second look into the oxidant mechanisms in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Alzheimer's disease and Alzheimer's dementia: distinct but overlapping entities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Copernicus revisited: amyloid beta in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Education, the brain and dementia: neuroprotection or compensation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8445-3

Age and Histopathologic Heterogeneity in Alzheimer's Disease

21 January 2018

1 reference

12 December 2020

Amyloid-β peptide: Dr. Jekyll or Mr. Hyde?

1 reference

12 December 2020

Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation--a pharmacological fMRI study

1 reference

12 December 2020

The cholinergic pathology in Alzheimer's disease--discrepancies between clinical experience and pathophysiological findings

1 reference

12 December 2020

Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain

1 reference

12 December 2020

Capillary CAA and perivascular Aβ-deposition: two distinct features of Alzheimer's disease pathology

1 reference

12 December 2020

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease

1 reference

12 December 2020

Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease.

1 reference

12 December 2020

Stress in the brain: novel cellular mechanisms of injury linked to Alzheimer's disease

1 reference

12 December 2020

Pin1: a new genetic link between Alzheimer's disease, cancer and aging.

1 reference

12 December 2020

Apolipoprotein E4, cholinergic integrity and the pharmacogenetics of Alzheimer's disease

1 reference

12 December 2020

Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture

1 reference

12 December 2020

Enhanced apoptosis, oxidative stress and mitochondrial dysfunction in lymphocytes as potential biomarkers for Alzheimer's disease

1 reference

12 December 2020

Cholinesterase inhibitors for Alzheimer's disease

1 reference

12 December 2020

Correlates of response to acetylcholinesterase inhibitor therapy in Alzheimer's disease.

1 reference

12 December 2020

Induction of p21ras in Alzheimer pathology.

1 reference

12 December 2020

Memantine: a review of studies into its safety and efficacy in treating Alzheimer's disease and other dementias.

1 reference

12 December 2020

Targeting WNT, protein kinase B, and mitochondrial membrane integrity to foster cellular survival in the nervous system

1 reference

12 December 2020

Say NO to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type

1 reference

12 December 2020

Cortical tissue of patients with hereditary cerebral hemorrhage with amyloidosis (Dutch) contains various extracellular matrix deposits.

1 reference

12 December 2020

Insulin and cholesterol pathways in neuronal function, memory and neurodegeneration

1 reference

12 December 2020

Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

1 reference

12 December 2020

Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration

1 reference

12 December 2020

Altered immune responses in apolipoprotein E-deficient mice

1 reference

12 December 2020

Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications.

1 reference

12 December 2020

Cross-talk between apolipoprotein E and cytokines

1 reference

12 December 2020

Redox proteomics identification of oxidatively modified brain proteins in Alzheimer's disease and mild cognitive impairment: insights into the progression of this dementing disorder.

1 reference

12 December 2020

Beta amyloid angiogenic activity in vitro and in vivo.

1 reference

12 December 2020

Epigenetic mechanisms in Alzheimer's disease

1 reference

12 December 2020

The role of diet in cognitive decline

1 reference

12 December 2020

Diversity of Abeta deposits in the aged brain: a window on molecular heterogeneity?

1 reference

12 December 2020

A review: inflammatory process in Alzheimer's disease, role of cytokines.

1 reference

12 December 2020

An insight into the role of autophagy in cell responses in the aging and neurodegenerative brain.

1 reference

12 December 2020

Pathogenic effects of D23N Iowa mutant amyloid beta -protein

1 reference

12 December 2020

The role and therapeutic potential of monocytic cells in Alzheimer's disease.

1 reference

12 December 2020

Assessing the toxicity of tau aggregation.

1 reference

12 December 2020

Oxidative processes in the brain and non-neuronal tissues as biomarkers of Alzheimer's disease

1 reference

12 December 2020

Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins.

1 reference

12 December 2020

Genetic aspects of Alzheimer's disease.

1 reference

12 December 2020

Role of α7-nicotinic acetylcholine receptor in normal and cancer stem cells

1 reference

12 December 2020

Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein

1 reference

12 December 2020

Reactive Oxygen Species Mediate Cellular Damage in Alzheimer Disease.

1 reference

12 December 2020

Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments

1 reference

12 December 2020

Mitochondrial abnormalities in Alzheimer's disease.

1 reference

12 December 2020

10.1007/S12035-013-8445-3

Identifiers

DOI

1 reference

PubMed ID

23546742

Dimensions Publication ID

28 August 2017

0 references

1 reference

PubMed ID

23546742