(Q38225786)

31 August 2017

title

Defective autophagy in Parkinson's disease: lessons from genetics (English)

1 reference

31 August 2017

0 references

1 reference

H Zhang

1

1 reference

31 August 2017

C Duan

series ordinal

2

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31 August 2017

H Yang

series ordinal

3

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31 August 2017

publication date

4 July 2014

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31 August 2017

published in

Molecular Neurobiology

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31 August 2017

volume

51

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31 August 2017

issue

1

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31 August 2017

page(s)

89-104

1 reference

https://scigraph.springernature.com/pub.10.1007/s12035-014-8787-5

31 August 2017

exact match

0 references

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Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration.

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LAMP2A as a therapeutic target in Parkinson disease

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Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy

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21 January 2018

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21 January 2018

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21 January 2018

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Lewy body-like α-synuclein aggregates resist degradation and impair macroautophagy

21 January 2018

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The Parkinson disease protein α-synuclein inhibits autophagy

21 January 2018

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α-Synuclein impairs macroautophagy: implications for Parkinson's disease.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development

21 January 2018

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Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Loss of PINK1 enhances neurodegeneration in a mouse model of Parkinson's disease triggered by mitochondrial stress.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Genetic mutations and functions of PINK1.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Aconitase causes iron toxicity in Drosophila pink1 mutants

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Silencing of PINK1 induces mitophagy via mitochondrial permeability transition in dopaminergic MN9D cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Mitophagy and Parkinson's disease: be eaten to stay healthy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease

21 January 2018

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The parkin protein as a therapeutic target in Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Parkin is protective against proteotoxic stress in a transgenic zebrafish model

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Enhanced parkin levels favor ER-mitochondria crosstalk and guarantee Ca(2+) transfer to sustain cell bioenergetics.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Mitochondrial biology and Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Mitochondrial autophagy as a compensatory response to PINK1 deficiency

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

The kinase domain of mitochondrial PINK1 faces the cytoplasm

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Molecular signaling toward mitophagy and its physiological significance.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

LC3 binds externalized cardiolipin on injured mitochondria to signal mitophagy in neurons: implications for Parkinson disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Mitochondria directly donate their membrane to form autophagosomes during a novel mechanism of parkin-associated mitophagy.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

FBXO7 immunoreactivity in α-synuclein-containing inclusions in Parkinson disease and multiple system atrophy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Pathogenic lysosomal depletion in Parkinson's disease

21 January 2018

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Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions.

21 January 2018

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In silico and functional studies of the regulation of the glucocerebrosidase gene

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Defective quality control mechanisms and accumulation of damaged mitochondria link Gaucher and Parkinson diseases

21 January 2018

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Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage

21 January 2018

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21 January 2018

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Neuroinflammation and α-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction

21 January 2018

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Exploring the link between glucocerebrosidase mutations and parkinsonism

21 January 2018

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Lysosomal impairment in Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration.

21 January 2018

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ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies

21 January 2018

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Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity

21 January 2018

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ATP13A2 regulates mitochondrial bioenergetics through macroautophagy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Lysosome-dependent pathways as a unifying theme in Parkinson's disease.

21 January 2018

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Lysosomal dysfunction in Parkinson disease: ATP13A2 gets into the groove

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

LRRK2 in Parkinson's disease: protein domains and functional insights

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation

21 January 2018

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Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Kinases and kinase signaling pathways: potential therapeutic targets in Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Dangerous duet: LRRK2 and α-synuclein jam at CMA.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Interplay of LRRK2 with chaperone-mediated autophagy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Regulation of autophagy by LRRK2 in Caenorhabditis elegans

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Neuronal autophagy and neurodegenerative diseases

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Synaptic dysfunction in genetic models of Parkinson's disease: a role for autophagy?

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Inhibition of LRRK2 kinase activity stimulates macroautophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

DJ-1 protects dopaminergic neurons against rotenone-induced apoptosis by enhancing ERK-dependent mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

DJ-1, a cancer and Parkinson's disease associated protein, regulates autophagy through JNK pathway in cancer cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

DJ-1 regulation of mitochondrial function and autophagy through oxidative stress

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Lewy-like aggregation of α-synuclein reduces protein phosphatase 2A activity in vitro and in vivo

21 January 2018

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Alpha-synuclein overexpression increases phospho-protein phosphatase 2A levels via formation of calmodulin/Src complex

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model

21 January 2018

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Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.

21 January 2018

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21 January 2018

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Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

21 January 2018

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ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

The parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Therapeutic effects of rapamycin on MPTP-induced Parkinsonism in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Roles of autophagy in MPP+-induced neurotoxicity in vivo: the involvement of mitochondria and α-synuclein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

How Parkinsonian toxins dysregulate the autophagy machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Dopaminergic cell damage and vulnerability to MPTP in Pink1 knockdown zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Parkin-knockout mice did not display increased vulnerability to intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Autophagic death of adult hippocampal neural stem cells following insulin withdrawal

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-8787-5

The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy

21 January 2018

1 reference

12 December 2020

The oxidation states of DJ-1 dictate the cell fate in response to oxidative stress triggered by 4-hpr: autophagy or apoptosis?

1 reference

12 December 2020

Oxidation of survival factor MEF2D in neuronal death and Parkinson's disease

1 reference

12 December 2020

DJ-1 upregulates tyrosine hydroxylase gene expression by activating its transcriptional factor Nurr1 via the ERK1/2 pathway

1 reference

12 December 2020

Evidence for gender differences in cognition, emotion and quality of life in Parkinson's disease?

1 reference

12 December 2020

Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy

1 reference

12 December 2020

Shared and cell type-specific mitochondrial defects and metabolic adaptations in primary cells from PINK1-deficient mice

1 reference

12 December 2020

The role of autophagy in Parkinson's disease.

1 reference

12 December 2020

Dopamine oxidation and autophagy

1 reference

12 December 2020

Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation

1 reference

12 December 2020

Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

1 reference

12 December 2020

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

1 reference

12 December 2020

Accumulation of the parkin substrate, FAF1, plays a key role in the dopaminergic neurodegeneration

1 reference

12 December 2020

Phospholipase D1 regulates autophagic flux and clearance of α-synuclein aggregates

1 reference

12 December 2020

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

1 reference

12 December 2020

The role of oxidative stress in Parkinson's disease

1 reference

12 December 2020

Parkin and PINK1: much more than mitophagy

1 reference

12 December 2020

Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson's disease

1 reference

12 December 2020

Parkinson's disease-associated human ATP13A2 (PARK9) deficiency causes zinc dyshomeostasis and mitochondrial dysfunction

1 reference

12 December 2020

10.1007/S12035-014-8787-5

Identifiers

DOI

1 reference

Dimensions Publication ID

31 August 2017

1044584565

0 references

1 reference