(Q38601445)

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Impact of Insulin Degrading Enzyme and Neprilysin in Alzheimer's Disease Biology: Characterization of Putative Cognates for Therapeutic Applications

scientific article published on 19 September 2015

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 September 2017

Impact of Insulin Degrading Enzyme and Neprilysin in Alzheimer's Disease Biology: Characterization of Putative Cognates for Therapeutic Applications (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

Alzheimer's disease

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disease biology

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based on heuristic

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author name string

Niraj Kumar Jha

1

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

Saurabh Kumar Jha

2

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Europe PubMed Central

PubMed publication ID

4 September 2017

Dhiraj Kumar

3

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

Noopur Kejriwal

4

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

Renu Sharma

5

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

Rashmi K Ambasta

6

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Europe PubMed Central

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4 September 2017

Pravir Kumar

7

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Europe PubMed Central

PubMed publication ID

4 September 2017

publication date

19 September 2015

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Europe PubMed Central

PubMed publication ID

4 September 2017

Journal of Alzheimer's Disease

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Europe PubMed Central

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4 September 2017

48

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Europe PubMed Central

PubMed publication ID

4 September 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

891-917

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

Molecular mechanisms of neurodegeneration in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry

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21 January 2018

Role of tau protein in both physiological and pathological conditions.

1 reference

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21 January 2018

Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Alzheimer's disease is type 3 diabetes-evidence reviewed

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Effects of insulin on cultured rat brain cells: stimulation of ornithine decarboxylase activity

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Potential roles of insulin and IGF-1 in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Effect of insulin on GABAergic development in the embryonic chick retina

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

High glucose-induced oxidative stress and mitochondrial dysfunction in neurons.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: an update

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Common pathological processes in Alzheimer disease and type 2 diabetes: a review

1 reference

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21 January 2018

Insulin resistance, affective disorders, and Alzheimer's disease: review and hypothesis

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Insulin and cognitive function in an elderly population. The Rotterdam Study.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Hyperinsulinemia and risk of Alzheimer disease.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: new cues into the human disease?

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Effects of Alzheimer's amyloid-beta and tau protein on mitochondrial function -- role of glucose metabolism and insulin signalling

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Insulin and the insulin receptor in experimental models of learning and memory.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Insulin signaling in the central nervous system: learning to survive

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Insulin is a two-edged knife on the brain

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Purification of endopeptidase-24.11 ('enkephalinase') from pig brain by immunoadsorbent chromatography

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase).

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11): multiple miniexons and separate 5' untranslated regions

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Engineering Neprilysin Activity and Specificity to Create a Novel Therapeutic for Alzheimer’s Disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Structural analysis of neprilysin with various specific and potent inhibitors

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Age-dependent decline of neprilysin in Alzheimer's disease and normal brain: inverse correlation with A beta levels.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Membrane Localization of Endopeptidase‐24.11 and Peptidyl Dipeptidase A (Angiotensin Converting Enzyme) in the Pig Brain: A Study Using Subcellular Fractionation and Electron Microscopic Immunocytochemistry

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Effects of hypoxia and oxidative stress on expression of neprilysin in human neuroblastoma cells and rat cortical neurones and astrocytes

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

An immunohistochemical study of endopeptidase-24.11 ("enkephalinase") in the pig nervous system

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Neuropeptide Y and its receptors as potential therapeutic drug targets

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Alterations within the endogenous opioid system in mice with targeted deletion of the neutral endopeptidase ('enkephalinase') gene

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Metabolism of amyloid β peptide and pathogenesis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Amyloid-degrading enzymes as therapeutic targets in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Metabolism of amyloid-beta peptide and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Meta-analysis of the association between two neprilysin gene polymorphisms and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Determination of hypoxic effect on neprilysin activity in human neuroblastoma SH-SY5Y cells using a novel HPLC method

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Oxidized neprilysin in aging and Alzheimer's disease brains

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Substitution of potential metal-coordinating amino acid residues in the zinc-binding site of endopeptidase-24.11.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Post-translational myristoylation: Fat matters in cellular life and death

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Effects of glycosylation on the stability of protein pharmaceuticals

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Analysis Tool Web Services from the EMBL-EBI.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

SCOP: a structural classification of proteins database

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Inhibitors of neprilysin: design, pharmacological and clinical applications.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Dali server: conservation mapping in 3D

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme †

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Insulin degradation: mechanisms, products, and significance

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Endoplasmic reticulum-localized amyloid beta-peptide is degraded in the cytosol by two distinct degradation pathways

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Insulin-degrading enzyme exists inside of rat liver peroxisomes and degrades oxidized proteins

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Genetic aspects of Alzheimer disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Amylin and its analogs: a friend or foe for the treatment of Alzheimer's disease?

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Insulin clearance in obesity

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Insulin-degrading enzyme: embarking on amyloid destruction.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Beta-endorphin 1-31 biotransformation and cAMP modulation in inflammation

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Identification of gamma-endorphin-generating enzyme as insulin-degrading enzyme

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Reduced amyloid-β degradation in early Alzheimer's disease but not in the APPswePS1dE9 and 3xTg-AD mouse models

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Transformation of amyloid β(1-40) oligomers into fibrils is characterized by a major change in secondary structure

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

The effect of amyloid associated proteins on the expression of genes involved in amyloid-β clearance by adult human astrocytes.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Structure, function, and regulation of insulin-degrading enzyme

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Substrate activation of insulin-degrading enzyme (insulysin). A potential target for drug development.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Insulin stimulates postsynaptic density-95 protein translation via the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Signaling by insulin-like growth factor 1 in brain

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Role of insulin and insulin receptor in learning and memory

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Insulin-like growth factor-I enhances transforming growth factor-beta-induced extracellular matrix protein production through the P38/activating transcription factor-2 signaling pathway in keloid fibroblasts

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

The role of insulin, insulin growth factor, and insulin-degrading enzyme in brain aging and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged

1 reference

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21 January 2018

Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Trafficking and proteolytic processing of APP

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Alzheimer's disease and the amyloid-beta peptide

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

The Aβ-clearance protein transthyretin, like neprilysin, is epigenetically regulated by the amyloid precursor protein intracellular domain.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid β (Aβ) peptide catabolism and functionality.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

ApoE promotes the proteolytic degradation of Abeta

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Alzheimer's disease: strategies for disease modification

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Neprilysin protects human neuronal progenitor cells against impaired development caused by amyloid-beta peptide

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Circulating neprilysin clears brain amyloid

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Mechanisms of Amyloid-β Peptide Clearance: Potential Therapeutic Targets for Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Recombinant soluble neprilysin reduces amyloid-beta accumulation and improves memory impairment in Alzheimer's disease mice

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Recombinant adeno-associated viral vectors as therapeutic agents to treat neurological disorders.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Herpes simplex virus RNAi and neprilysin gene transfer vectors reduce accumulation of Alzheimer's disease-related amyloid-beta peptide in vivo

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

AAV9: a potential blood-brain barrier buster

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Aβ-degrading enzymes: potential for treatment of Alzheimer disease.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Nitric oxide decreases the enzymatic activity of insulin degrading enzyme in APP/PS1 mice.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Interleukin-34 selectively enhances the neuroprotective effects of microglia to attenuate oligomeric amyloid-β neurotoxicity

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Loss of interleukin receptor-associated kinase 4 signaling suppresses amyloid pathology and alters microglial phenotype in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Long-term immunomodulatory effect of amniotic stem cells in an Alzheimer's disease model

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Degradation of amyloid beta by human induced pluripotent stem cell-derived macrophages expressing Neprilysin-2.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

PF-04494700, an oral inhibitor of receptor for advanced glycation end products (RAGE), in Alzheimer disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, an

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Effect of sodium valproate administration on brain neprilysin expression and memory in rats

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Valproic acid reduces neuritic plaque formation and improves learning deficits in APP(Swe) /PS1(A246E) transgenic mice via preventing the prenatal hypoxia-induced down-regulation of neprilysin.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Propranolol reduces cognitive deficits, amyloid and tau pathology in Alzheimer's transgenic mice

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Neuropep-1 ameliorates learning and memory deficits in an Alzheimer's disease mouse model, increases brain-derived neurotrophic factor expression in the brain, and causes reduction of amyloid beta plaques.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Somatostatin modulates insulin-degrading-enzyme metabolism: implications for the regulation of microglia activity in AD

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Cysteine 904 is required for maximal insulin degrading enzyme activity and polyanion activation

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

BRI2 protein regulates β-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE).

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

[A drug targeting intracellular amyloid-β and oxidative stress: apomorphine].

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Estrogen stimulates degradation of beta-amyloid peptide by up-regulating neprilysin

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

An Aβ42 uptake and degradation via Rg3 requires an activation of caveolin, clathrin and Aβ-degrading enzymes in microglia.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Ginsenoside Rg1 decreases Aβ(1-42) level by upregulating PPARγ and IDE expression in the hippocampus of a rat model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Enhancement of neutral endopeptidase activity in SK-N-SH cells by green tea extract

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Mechanisms and effects of curcumin on spatial learning and memory improvement in APPswe/PS1dE9 mice

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Possible role of resveratrol targeting estradiol and neprilysin pathways in lipopolysaccharide model of Alzheimer disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Norepinephrine promotes microglia to uptake and degrade amyloid beta peptide through upregulation of mouse formyl peptide receptor 2 and induction of insulin-degrading enzyme.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Protective actions of sex steroid hormones in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Androgens activate mitogen-activated protein kinase signaling: role in neuroprotection

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Estrogen regulates neprilysin activity in rat brain

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Androgens regulate neprilysin expression: role in reducing beta-amyloid levels.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Nobiletin, a flavone from Citrus depressa, induces gene expression and increases the protein level and activity of neprilysin in SK-N-SH cells

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Sevoflurane alters the expression of receptors and enzymes involved in Aβ clearance in rats

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Impaired amyloid β-degrading enzymes in brain of streptozotocin-induced diabetic rats

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Thiorphan-induced neprilysin inhibition raises amyloid beta levels in rabbit cortex and cerebrospinal fluid

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

NEP-like endopeptidases and Alzheimer's disease [corrected].

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Neprilysin activity and expression are controlled by nicastrin

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Ketamine reduces amyloid β-protein degradation by suppressing neprilysin expression in primary cultured astrocytes

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Spinorphin, an endogenous inhibitor of enkephalin-degrading enzymes, potentiates leu-enkephalin-induced anti-allodynic and antinociceptive effects in mice

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Copper downregulates neprilysin activity through modulation of neprilysin degradation.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

In vitro Pb exposure disturbs the balance between Aβ production and elimination: the role of AβPP and neprilysin

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Leptin inhibits amyloid β-protein degradation through decrease of neprilysin expression in primary cultured astrocytes.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Structure–Activity Relationship Study of Opiorphin, a Human Dual Ectopeptidase Inhibitor with Antinociceptive Properties

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150379

21 January 2018

Identifiers

10.3233/JAD-150379

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

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