(Q39688289)

14 September 2017

Functional interdependence of BRD4 and DOT1L in MLL leukemia (English)

1 reference

14 September 2017

1 reference

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Enid Yi Ni Lam

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Isabelle Becher

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Chun Yew Fong

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Chen-Fang Weng

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Y-C Chan

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

David Smil

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Peter J. Brown

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Marnie Blewitt

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Tony Kouzarides

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Brian Huntly

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Ricky W Johnstone

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Gerard Drewes

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Cheryl Arrowsmith

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Laura MacPherson

13

0 references

Aoife Ward Gahlawat

Aoife Ward

7

0 references

Sarah-Jane Dawson

Sarah-Jane Dawson

27

0 references

Mark A. Dawson

Mark A Dawson

31

0 references

Rab K Prinjha

30

Rab K Prinjha

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

4

Dave Lugo

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

author name string

Omer Gilan

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Ester Cannizzaro

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Gerard Joberty

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Meike Wiese

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Sarah Ftouni

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Dean Tyler

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Kym Stanley

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Margherita Ghisi

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Christopher Carpenter

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Neil Garton

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Paola Grandi

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

publication date

13 June 2016

1 reference

Nature Structural & Molecular Biology

14 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

volume

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

page(s)

673-681

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27294782%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nsmb.3249

8 June 2020

exact match

0 references

1 reference

Cancer epigenetics: from mechanism to therapy

21 January 2018

1 reference

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

21 January 2018

1 reference

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

21 January 2018

1 reference

Drugging Chromatin in Cancer: Recent Advances and Novel Approaches.

21 January 2018

1 reference

Targeting epigenetic readers in cancer.

21 January 2018

1 reference

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition

21 January 2018

1 reference

Prolonged administration of azacitidine with or without entinostat for myelodysplastic syndrome and acute myeloid leukemia with myelodysplasia-related changes: results of the US Leukemia Intergroup trial E1905.

21 January 2018

1 reference

Results of phase 2 randomized study of low-dose decitabine with or without valproic acid in patients with myelodysplastic syndrome and acute myelogenous leukemia

21 January 2018

1 reference

Altered Hox expression and segmental identity in Mll-mutant mice

21 January 2018

1 reference

Mll has a critical role in fetal and adult hematopoietic stem cell self-renewal.

21 January 2018

1 reference

Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors

21 January 2018

1 reference

Recent progress toward epigenetic therapies: the example of mixed lineage leukemia

21 January 2018

1 reference

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

21 January 2018

1 reference

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

21 January 2018

1 reference

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

21 January 2018

1 reference

The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells

21 January 2018

1 reference

Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes

21 January 2018

1 reference

The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling

21 January 2018

1 reference

AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia

21 January 2018

1 reference

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

21 January 2018

1 reference

A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification

21 January 2018

1 reference

Misguided transcriptional elongation causes mixed lineage leukemia

21 January 2018

1 reference

A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription

21 January 2018

1 reference

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

21 January 2018

1 reference

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

21 January 2018

1 reference

DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.

21 January 2018

1 reference

Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

21 January 2018

1 reference

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

21 January 2018

1 reference

BET inhibitor resistance emerges from leukaemia stem cells

21 January 2018

1 reference

The diverse functions of Dot1 and H3K79 methylation.

21 January 2018

1 reference

Selective inhibition of tumor oncogenes by disruption of super-enhancers

21 January 2018

1 reference

What are super-enhancers?

21 January 2018

1 reference

lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs.

21 January 2018

1 reference

Proteogenomic characterization and mapping of nucleosomes decoded by Brd and HP1 proteins.

21 January 2018

1 reference

Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation

21 January 2018

1 reference

The language of histone crosstalk

21 January 2018

1 reference

The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia

21 January 2018

1 reference

Differences in specificity and selectivity between CBP and p300 acetylation of histone H3 and H3/H4.

21 January 2018

1 reference

BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia

21 January 2018

1 reference

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.

21 January 2018

1 reference

Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation.

21 January 2018

1 reference

DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis

21 January 2018

1 reference

Regulation of chromatin by histone modifications

21 January 2018

1 reference

Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia

21 January 2018

1 reference

The emerging roles of DOT1L in leukemia and normal development

21 January 2018

1 reference

The mechanisms behind the therapeutic activity of BET bromodomain inhibition

21 January 2018

1 reference

Primary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro

21 January 2018

1 reference

Getting up to speed with transcription elongation by RNA polymerase II

21 January 2018

1 reference

Transcriptional elongation checkpoint control in development and disease

21 January 2018

1 reference

Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells.

21 January 2018

1 reference

Tracking cancer drugs in living cells by thermal profiling of the proteome

21 January 2018

1 reference

High-resolution enabled TMT 8-plexing.

21 January 2018

1 reference

Targeted data acquisition for improved reproducibility and robustness of proteomic mass spectrometry assays

21 January 2018

1 reference

Measuring and managing ratio compression for accurate iTRAQ/TMT quantification.

21 January 2018

1 reference

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

21 January 2018

1 reference

Differential expression analysis for sequence count data

21 January 2018

1 reference

ROAST: rotation gene set tests for complex microarray experiments

21 January 2018

1 reference

Fast gapped-read alignment with Bowtie 2

21 January 2018

1 reference

Model-based analysis of ChIP-Seq (MACS)

21 January 2018

1 reference

Integrative genomics viewer

21 January 2018

1 reference

BEDTools: a flexible suite of utilities for comparing genomic features

21 January 2018

1 reference

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

21 January 2018

1 reference

GenomicTools: a computational platform for developing high-throughput analytics in genomics.

21 January 2018

1 reference

Inferring direct DNA binding from ChIP-seq

21 January 2018

1 reference

Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis

21 January 2018

1 reference

Delayed fragmentation and optimized isolation width settings for improvement of protein identification and accuracy of isobaric mass tag quantification on Orbitrap-type mass spectrometers

31 March 2020

1 reference

Metabolic labeling of newly transcribed RNA for high resolution gene expression profiling of RNA synthesis, processing and decay in cell culture

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27294782