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Intersection of pathological tau and microglia at the synapse
scientific article published on 05 July 2019
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scholarly article
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Europe PubMed Central
PMCID
6612163
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31277708%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 April 2020
review article
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Europe PubMed Central
title
Intersection of pathological tau and microglia at the synapse
(English)
1 reference
stated in
Europe PubMed Central
PMCID
6612163
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31277708%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 April 2020
main subject
microglia
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author
Adriana-Natalia Murgoci
series ordinal
2
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Europe PubMed Central
PMCID
6612163
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31277708%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 April 2020
Q91660734
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMCID
6612163
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31277708%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 April 2020
author name string
Thomas Vogels
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1
1 reference
stated in
Europe PubMed Central
PMCID
6612163
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31277708%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 April 2020
publication date
5 July 2019
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Europe PubMed Central
PMCID
6612163
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31277708%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 April 2020
published in
Acta Neuropathologica Communications
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Europe PubMed Central
PMCID
6612163
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31277708%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 April 2020
volume
7
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stated in
Europe PubMed Central
PMCID
6612163
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31277708%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 April 2020
issue
1
1 reference
stated in
Europe PubMed Central
PMCID
6612163
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31277708%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 April 2020
page(s)
109
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Europe PubMed Central
PMCID
6612163
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31277708%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 April 2020
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Unconventional Secretion Mediates the Trans-cellular Spreading of Tau
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Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer's disease and PART.
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Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates.
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The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity
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Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain.
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23 February 2021
Cerebrovascular inflammation is associated with tau pathology in Guam parkinsonism dementia.
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23 February 2021
Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs).
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23 February 2021
Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice.
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23 February 2021
Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways.
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23 February 2021
Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction.
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23 February 2021
Prion-like protein aggregates exploit the RHO GTPase to cofilin-1 signaling pathway to enter cells.
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23 February 2021
Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion
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23 February 2021
Normal aging induces A1-like astrocyte reactivity.
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23 February 2021
Phos-tau peptide immunization of amyloid-tg-mice reduced non-mutant phos-tau pathology, improved cognition and reduced amyloid plaques.
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23 February 2021
Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development.
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23 February 2021
A transcriptomic atlas of aged human microglia.
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23 February 2021
Activated forms of astrocytes with higher GLT-1 expression are associated with cognitive normal subjects with Alzheimer pathology in human brain.
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23 February 2021
TREM2 Ameliorates Neuronal Tau Pathology Through Suppression of Microglial Inflammatory Response.
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23 February 2021
Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease.
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23 February 2021
Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations
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23 February 2021
The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain
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23 February 2021
Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1.
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23 February 2021
Galectin-8-mediated selective autophagy protects against seeded tau aggregation
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23 February 2021
What is the evidence that tau pathology spreads through prion-like propagation?
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23 February 2021
The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy
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23 February 2021
Prophylactic Active Tau Immunization Leads to Sustained Reduction in Both Tau and Amyloid-β Pathologies in 3xTg Mice.
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23 February 2021
Microglia in Alzheimer's disease
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23 February 2021
Astrocytes in mouse models of tauopathies acquire early deficits and lose neurosupportive functions.
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23 February 2021
Atypical, non-standard functions of the microtubule associated Tau protein
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23 February 2021
Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease
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23 February 2021
Overexpression of 5-Lipoxygenase Worsens the Phenotype of a Mouse Model of Tauopathy
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23 February 2021
Brain 5-lipoxygenase over-expression worsens memory, synaptic integrity, and tau pathology in the P301S mice
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23 February 2021
Cell Biology of Astrocyte-Synapse Interactions.
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23 February 2021
TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy
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23 February 2021
The roles of inflammation and immune mechanisms in Alzheimer's disease
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23 February 2021
Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain
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23 February 2021
TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy
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23 February 2021
Absence of microglial CX3CR1 impairs the synaptic integration of adult-born hippocampal granule neurons
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23 February 2021
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
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23 February 2021
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
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23 February 2021
Inhibition of IL-1β Signaling Normalizes NMDA-Dependent Neurotransmission and Reduces Seizure Susceptibility in a Mouse Model of Creutzfeldt-Jakob Disease.
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23 February 2021
The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology
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23 February 2021
A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease.
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23 February 2021
Absence of CX3CR1 impairs the internalization of Tau by microglia.
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23 February 2021
Identification of the Tau phosphorylation pattern that drives its aggregation.
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23 February 2021
Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football.
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23 February 2021
Transcriptomic analysis of purified human cortical microglia reveals age-associated changes.
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23 February 2021
Glial contributions to neurodegeneration in tauopathies
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23 February 2021
Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway
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23 February 2021
Synaptoimmunology - roles in health and disease.
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23 February 2021
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease
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23 February 2021
Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue
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23 February 2021
Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer's Disease and Related Tauopathies
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23 February 2021
An environment-dependent transcriptional network specifies human microglia identity
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23 February 2021
Sleep Loss Promotes Astrocytic Phagocytosis and Microglial Activation in Mouse Cerebral Cortex
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23 February 2021
Reduced gliotransmitter release from astrocytes mediates tau-induced synaptic dysfunction in cultured hippocampal neurons.
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23 February 2021
Prion-like Spreading in Tauopathies
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23 February 2021
CX3CR1+ monocytes modulate learning and learning-dependent dendritic spine remodeling via TNF-α.
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23 February 2021
AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy
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23 February 2021
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro
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23 February 2021
Roles of tau protein in health and disease
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23 February 2021
Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model
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23 February 2021
Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain
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23 February 2021
Tau-mediated synaptic damage in Alzheimer's disease
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23 February 2021
Neurotoxic reactive astrocytes are induced by activated microglia
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23 February 2021
The release and trans-synaptic transmission of Tau via exosomes
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23 February 2021
Tau passive immunization inhibits not only tau but also Aβ pathology
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23 February 2021
Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset
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23 February 2021
Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology.
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23 February 2021
17q21.31 duplication causes prominent tau-related dementia with increased MAPT expression.
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23 February 2021
Widespread tau seeding activity at early Braak stages.
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23 February 2021
Microglia show altered morphology and reduced arborization in human brain during aging and Alzheimer's disease.
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23 February 2021
Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy
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23 February 2021
Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies
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23 February 2021
Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy.
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23 February 2021
Loss of Bin1 Promotes the Propagation of Tau Pathology.
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23 February 2021
Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration
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23 February 2021
Tau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases.
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23 February 2021
Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases.
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23 February 2021
The MAPT gene is differentially methylated in the progressive supranuclear palsy brain.
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23 February 2021
Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes
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23 February 2021
Microglia contact induces synapse formation in developing somatosensory cortex.
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23 February 2021
Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement.
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23 February 2021
Inhomogeneous distribution of Iba-1 characterizes microglial pathology in Alzheimer's disease.
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23 February 2021
Neuronal activity enhances tau propagation and tau pathology in vivo.
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23 February 2021
Imatinib methanesulfonate reduces hyperphosphorylation of tau following repeated peripheral exposure to lipopolysaccharide.
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23 February 2021
Age-related myelin degradation burdens the clearance function of microglia during aging.
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23 February 2021
The age-related neuroinflammatory environment promotes macrophage activation, which negatively impacts synaptic function
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23 February 2021
Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic Cells by Astrocytes
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23 February 2021
Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation
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23 February 2021
Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization
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23 February 2021
Complement and microglia mediate early synapse loss in Alzheimer mouse models.
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23 February 2021
Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner
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23 February 2021
Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathy
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23 February 2021
Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease.
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23 February 2021
Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex.
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23 February 2021
Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina
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23 February 2021
Alzheimer's disease
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23 February 2021
TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice
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23 February 2021
Microglial brain region-dependent diversity and selective regional sensitivities to aging.
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23 February 2021
Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease.
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23 February 2021
Tau Oligomers: The Toxic Player at Synapses in Alzheimer's Disease
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23 February 2021
Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo.
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23 February 2021
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23 February 2021
Tau in physiology and pathology
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23 February 2021
Association of APOE with tau-tangle pathology with and without β-amyloid
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23 February 2021
Depletion of microglia and inhibition of exosome synthesis halt tau propagation
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23 February 2021
Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline.
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23 February 2021
Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice
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23 February 2021
Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice
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23 February 2021
Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake
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23 February 2021
Loss of tau rescues inflammation-mediated neurodegeneration
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23 February 2021
Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody.
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23 February 2021
Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging
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23 February 2021
Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis.
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23 February 2021
Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation.
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23 February 2021
Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models
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23 February 2021
Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain
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23 February 2021
Anti-tau antibody reduces insoluble tau and decreases brain atrophy
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23 February 2021
Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an Alzheimer's disease mouse model.
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23 February 2021
Pharmacologic inhibition of 5-lipoxygenase improves memory, rescues synaptic dysfunction, and ameliorates tau pathology in a transgenic model of tauopathy
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23 February 2021
Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy
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23 February 2021
A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology
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23 February 2021
SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.
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23 February 2021
NFκB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease
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23 February 2021
Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury
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23 February 2021
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors.
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23 February 2021
Conformation determines the seeding potencies of native and recombinant Tau aggregates
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23 February 2021
Lost after translation: missorting of Tau protein and consequences for Alzheimer disease
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23 February 2021
Microglia display modest phagocytic capacity for extracellular tau oligomers
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23 February 2021
Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway
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23 February 2021
Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis
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23 February 2021
Synaptic change in the posterior cingulate gyrus in the progression of Alzheimer's disease
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23 February 2021
Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus.
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23 February 2021
Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain
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23 February 2021
Ectosomes: a new mechanism for non-exosomal secretion of tau protein
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23 February 2021
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.
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23 February 2021
Microglial phagocytosis of live neurons
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23 February 2021
Vaccination with Sarkosyl insoluble PHF-tau decrease neurofibrillary tangles formation in aged tau transgenic mouse model: a pilot study.
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23 February 2021
Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds
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23 February 2021
Obesity elicits interleukin 1-mediated deficits in hippocampal synaptic plasticity
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23 February 2021
Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior.
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23 February 2021
Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1.
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23 February 2021
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.
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23 February 2021
Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis.
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23 February 2021
Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways
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23 February 2021
TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement
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23 February 2021
The microglial sensome revealed by direct RNA sequencing
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23 February 2021
Expression of Tau40 induces activation of cultured rat microglial cells
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23 February 2021
Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.
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23 February 2021
Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy
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23 February 2021
Homeostatic and injury-induced microglia behavior in the aging brain
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23 February 2021
Tau oligomers and fibrils induce activation of microglial cells
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23 February 2021
A dramatic increase of C1q protein in the CNS during normal aging.
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23 February 2021
Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds
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23 February 2021
Repeated immunization of mice with phosphorylated-tau peptides causes neuroinflammation.
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23 February 2021
Tau passive immunotherapy in mutant P301L mice: antibody affinity versus specificity
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23 February 2021
Chronic neuron- and age-selective down-regulation of TNF receptor expression in triple-transgenic Alzheimer disease mice leads to significant modulation of amyloid- and Tau-related pathologies
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23 February 2021
Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model
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23 February 2021
Physiological release of endogenous tau is stimulated by neuronal activity.
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23 February 2021
Complement activation fragment C5a receptors, CD88 and C5L2, are associated with neurofibrillary pathology
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23 February 2021
The influence of 5-lipoxygenase on Alzheimer's disease-related tau pathology: in vivo and in vitro evidence
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23 February 2021
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.
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23 February 2021
Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons
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23 February 2021
Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation.
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23 February 2021
Deficiency of the microglial receptor CX3CR1 impairs postnatal functional development of thalamocortical synapses in the barrel cortex.
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23 February 2021
Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice
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23 February 2021
Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice
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23 February 2021
Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
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23 February 2021
Paired helical filaments from Alzheimer disease brain induce intracellular accumulation of Tau protein in aggresomes
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23 February 2021
Trans-cellular propagation of Tau aggregation by fibrillar species
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23 February 2021
Immunomodulation of memory-impairing protein tau in Alzheimer's disease.
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23 February 2021
Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways
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23 February 2021
Propagation of tau pathology in a model of early Alzheimer's disease
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23 February 2021
Sialic acid on the neuronal glycocalyx prevents complement C1 binding and complement receptor-3-mediated removal by microglia
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23 February 2021
Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice
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23 February 2021
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model
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23 February 2021
Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease
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23 February 2021
Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.
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23 February 2021
Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration
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23 February 2021
Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain
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23 February 2021
Misfolded truncated protein τ induces innate immune response via MAPK pathway.
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23 February 2021
Synaptic pruning by microglia is necessary for normal brain development
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23 February 2021
Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease
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23 February 2021
Lipopolysaccharide-induced tau phosphorylation and kinase activity--modulation, but not mediation, by corticotropin-releasing factor receptors
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23 February 2021
Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain
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23 February 2021
Complement in the brain.
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23 February 2021
Inflammation induced by infection potentiates tau pathological features in transgenic mice
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23 February 2021
The acetylation of tau inhibits its function and promotes pathological tau aggregation
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23 February 2021
Anti-inflammatory impact of minocycline in a mouse model of tauopathy.
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23 February 2021
Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles
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23 February 2021
Synaptic loss in the inferior temporal gyrus in mild cognitive impairment and Alzheimer's disease
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23 February 2021
Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission
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23 February 2021
Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease
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23 February 2021
Presence of reactive microglia and neuroinflammatory mediators in a case of frontotemporal dementia with P301S mutation
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23 February 2021
First transgenic rat model developing progressive cortical neurofibrillary tangles
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23 February 2021
Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model
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23 February 2021
Microglial interactions with synapses are modulated by visual experience
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23 February 2021
Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease
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23 February 2021
Regulation of tau pathology by the microglial fractalkine receptor
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23 February 2021
LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice
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23 February 2021
Tau truncation is a productive posttranslational modification of neurofibrillary degeneration in Alzheimer's disease
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23 February 2021
Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice.
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23 February 2021
Human truncated tau is using a different mechanism from amyloid-beta to damage the blood-brain barrier
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23 February 2021
Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease
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23 February 2021
Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease
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PubMed Central
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23 February 2021
Accumulation of tau induced in neurites by microglial proinflammatory mediators
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23 February 2021
Propagation of tau misfolding from the outside to the inside of a cell.
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23 February 2021
Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathy.
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23 February 2021
Pronounced microgliosis and neurodegeneration in aged rats after tau gene transfer
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23 February 2021
The effects of IL-1 receptor antagonist on beta amyloid mediated depression of LTP in the rat CA1 in vivo
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23 February 2021
Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease.
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23 February 2021
Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice
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23 February 2021
Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells
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23 February 2021
Microglial activation in brain lesions with tau deposits: comparison of human tauopathies and tau transgenic mice TgTauP301L.
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23 February 2021
The classical complement cascade mediates CNS synapse elimination
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23 February 2021
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life.
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23 February 2021
Neuronal 'On' and 'Off' signals control microglia
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23 February 2021
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
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23 February 2021
The P2Y12 receptor regulates microglial activation by extracellular nucleotides
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23 February 2021
Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein.
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23 February 2021
Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo.
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23 February 2021
Impaired glutamate transport in a mouse model of tau pathology in astrocytes.
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23 February 2021
Beta-amyloid inhibition of long-term potentiation is mediated via tumor necrosis factor
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23 February 2021
Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.
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23 February 2021
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in progressive supranuclear palsy
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23 February 2021
Complement activation in very early Alzheimer disease
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23 February 2021
ATP mediates rapid microglial response to local brain injury in vivo
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23 February 2021
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
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23 February 2021
Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration.
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23 February 2021
Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice
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23 February 2021
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in corticobasal degeneration
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23 February 2021
Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration
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23 February 2021
Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway.
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23 February 2021
Dystrophic microglia in the aging human brain.
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23 February 2021
Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway
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23 February 2021
Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure
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23 February 2021
Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: potential significance for tau protein phosphorylation
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23 February 2021
Complement activation by neurofibrillary tangles in Alzheimer's disease.
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23 February 2021
Microglial activation parallels system degeneration in progressive supranuclear palsy and corticobasal degeneration
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23 February 2021
Regional distribution of cortical microglia parallels that of neurofibrillary tangles in Alzheimer's disease.
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23 February 2021
Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure
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23 February 2021
Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease
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23 February 2021
Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue.
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23 February 2021
Association of an extended haplotype in the tau gene with progressive supranuclear palsy.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6612163
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23 February 2021
A nucleated assembly mechanism of Alzheimer paired helical filaments
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6612163
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23 February 2021
Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6612163
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23 February 2021
Molecular and cellular characterization of the membrane attack complex, C5b-9, in Alzheimer's disease
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6612163
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23 February 2021
Glial-neuronal interactions in Alzheimer disease: progressive association of IL-1alpha+ microglia and S100beta+ astrocytes with neurofibrillary tangle stages.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6612163
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23 February 2021
Microglial cell activation in aging and Alzheimer disease: partial linkage with neurofibrillary tangle burden in the hippocampus
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6612163
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23 February 2021
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6612163
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23 February 2021
Neurofibrillary tangles of Guam parkinson-dementia are associated with reactive microglia and complement proteins.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6612163
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23 February 2021
Role of complement in the aetiology of Pick's disease?
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PubMed Central
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23 February 2021
Localization and cell association of C1q in Alzheimer's disease brain
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6612163
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23 February 2021
Microglial reaction in Pick's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6612163
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23 February 2021
Ultrastructural localization of complement membrane attack complex (MAC)-like immunoreactivity in brains of patients with Alzheimer's disease.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6612163
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23 February 2021
Investigation of tau-2 positive microglia-like cells in the subcortical nuclei of human neurodegenerative disorders.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6612163
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23 February 2021
Senile dementia of Alzheimer type: astroglial reaction to extracellular neurofibrillary tangles in the hippocampus. An immunocytochemical and electron-microscopic study.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6612163
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23 February 2021
Immune system response in Alzheimer's disease.
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23 February 2021
Activation of the classical complement pathway in brain tissue of Alzheimer patients
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6612163
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23 February 2021
Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6612163
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23 February 2021
Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity.
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6612163
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23 February 2021
Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia.
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6612163
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23 February 2021
Microglia are associated with the extracellular neurofibrillary tangles of Alzheimer disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6612163
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23 February 2021
Neuropathological stageing of Alzheimer-related changes
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stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6612163
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23 February 2021
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6612163
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23 February 2021
Identifiers
DOI
10.1186/S40478-019-0754-Y
1 reference
stated in
Europe PubMed Central
PMCID
6612163
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31277708%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 April 2020
PMCID
6612163
1 reference
stated in
Europe PubMed Central
PMCID
6612163
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31277708%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 April 2020
PubMed ID
31277708
1 reference
stated in
Europe PubMed Central
PMCID
6612163
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31277708%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 April 2020
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