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The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging
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instance of
scholarly article
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review article
1 reference
stated in
Europe PubMed Central
title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging
(English)
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main subject
cell biology
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sirolimus
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based on heuristic
inferred from title
author
Brian K Kennedy
series ordinal
1
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stated in
Europe PubMed Central
PMCID
4910876
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27304501%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 June 2020
Dudley W Lamming
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
4910876
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27304501%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 June 2020
author name string
Brian K Kennedy
series ordinal
1
0 references
Dudley W Lamming
series ordinal
2
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language of work or name
English
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publication date
14 June 2016
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published in
Cell Metabolism
1 reference
stated in
Europe PubMed Central
PMCID
4910876
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27304501%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 June 2020
volume
23
1 reference
stated in
Europe PubMed Central
PMCID
4910876
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27304501%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 June 2020
issue
6
1 reference
stated in
Europe PubMed Central
PMCID
4910876
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27304501%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 June 2020
page(s)
990-1003
1 reference
stated in
Europe PubMed Central
PMCID
4910876
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27304501%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 June 2020
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
The Biology of Aging: Citizen Scientists and Their Pets as a Bridge Between Research on Model Organisms and Human Subjects
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29 September 2017
Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
mTOR is necessary for proper satellite cell activity and skeletal muscle regeneration
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
mTORC2 regulates cardiac response to stress by inhibiting MST1.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Diminished mTOR signaling: a common mode of action for endocrine longevity factors.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Metabolism. Differential regulation of mTORC1 by leucine and glutamine
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
mTOR inhibition improves immune function in the elderly
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Fasting levels of hepatic p-S6 are increased in old mice
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Catecholamine-induced lipolysis causes mTOR complex dissociation and inhibits glucose uptake in adipocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Leptin signaling
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Rapamycin-induced metabolic defects are reversible in both lean and obese mice
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
DEP domain-containing mTOR-interacting protein in the rat brain: distribution of expression and potential implication
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Influence of mTOR in energy and metabolic homeostasis.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Characterization of Cre recombinase models for the study of adipose tissue
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
mTOR controls kidney epithelia in health and disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Mammalian target of rapamycin signaling in cardiac physiology and disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
A role for Raptor phosphorylation in the mechanical activation of mTOR signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
XPLN is an endogenous inhibitor of mTORC2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Rapamycin Modulates Markers of Mitochondrial Biogenesis and Fatty Acid Oxidation in the Adipose Tissue of db/db Mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
A Central role for mTOR in lipid homeostasis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
IKK interacts with rictor and regulates mTORC2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Late-life rapamycin treatment reverses age-related heart dysfunction.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Mechanisms regulating skeletal muscle growth and atrophy
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Adaptive thermogenesis in adipocytes: is beige the new brown?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Lessons on conditional gene targeting in mouse adipose tissue
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Human β-cell proliferation and intracellular signaling: driving in the dark without a road map.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Rapamycin slows aging in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
A unifying model for mTORC1-mediated regulation of mRNA translation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
The metabolic footprint of aging in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
TOR on the brain.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Structure of the human mTOR complex I and its implications for rapamycin inhibition.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
mTOR complex 2 in adipose tissue negatively controls whole-body growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Control of liver glycogen synthase activity and intracellular distribution by phosphorylation.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
29 September 2017
Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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29 September 2017
The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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2 June 2018
LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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2 June 2018
Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
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2 June 2018
REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
2 June 2018
Complications of mammalian target of rapamycin inhibitor anticancer treatment among patients with tuberous sclerosis complex are common and occasionally life-threatening
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
2 June 2018
Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
2 June 2018
Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
2 June 2018
The TSC-mTOR pathway regulates macrophage polarization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
2 June 2018
Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
2 June 2018
Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
27 November 2018
Rapamycin inhibition of eosinophil differentiation attenuates allergic airway inflammation in mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
27 November 2018
MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
27 November 2018
Dynamic Visualization of mTORC1 Activity in Living Cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
27 November 2018
Tuberous sclerosis complex 1-mechanistic target of rapamycin complex 1 signaling determines brown-to-white adipocyte phenotypic switch.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
27 November 2018
Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
27 November 2018
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
27 November 2018
MTORC1 determines autophagy through ULK1 regulation in skeletal muscle.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
27 November 2018
Signalling pathways regulating muscle mass in ageing skeletal muscle: the role of the IGF1-Akt-mTOR-FoxO pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
27 November 2018
mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
27 November 2018
TOR-driven aging: speeding car without brakes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
27 November 2018
The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4910876
retrieved
27 November 2018
Identifiers
DOI
10.1016/J.CMET.2016.05.009
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3881346
stated in
Europe PubMed Central
PMCID
4910876
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27304501%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 June 2020
Fatcat ID
release_5xegfkuhojaglkdqgwizk4dmzm
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/5xegfkuhojaglkdqgwizk4dmzm
retrieved
24 November 2022
based on heuristic
mapped directly with Wikidata item
OpenCitations bibliographic resource ID
3881346
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3881346
PMCID
4910876
1 reference
stated in
Europe PubMed Central
PMCID
4910876
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27304501%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 June 2020
PubMed ID
27304501
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3881346
stated in
Europe PubMed Central
PMCID
4910876
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27304501%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 June 2020
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