(Q36960535)

17 August 2017

1 reference

title

Maximising use of in vitro ADMET tools to predict in vivo bioavailability and safety (English)

1 reference

17 August 2017

1 reference

Jianling Wang

1

1 reference

17 August 2017

Laszlo Urban

series ordinal

2

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17 August 2017

Dejan Bojanic

series ordinal

3

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17 August 2017

language of work or name

English

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publication date

1 October 2007

1 reference

Expert Opinion on Drug Metabolism & Toxicology

17 August 2017

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17 August 2017

3

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17 August 2017

641-665

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17 August 2017

5

1 reference

The price of innovation: new estimates of drug development costs

17 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

R&D technology investments: misguided and expensive or a better way to discover medicines?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Screening for human ADME/Tox drug properties in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

The road map to oral bioavailability: an industrial perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

High-throughput in vitro profiling assays: lessons learnt from experiences at Novartis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

In vitro ADME medium/high-throughput screening in drug preclinical development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Biological assay challenges from compound solubility: strategies for bioassay optimization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Avoiding physicochemical artefacts in early ADME-Tox experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Improving the hit-to-lead process: data-driven assessment of drug-like and lead-like screening hits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Integrity profiling of high throughput screening hits using LC-MS and related techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Streamlined system for purifying and quantifying a diverse library of compounds and the effect of compound concentration measurements on the accurate interpretation of biological assay results

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

A high-throughput screening method for the determination of aqueous drug solubility using laser nephelometry in microtiter plates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Improvement of "hit-to-lead" optimization by integration of in vitro HTS experimental models for early determination of pharmacokinetic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Highly selective inhibition of human CYP3Aa in vitro by azamulin and evidence that inhibition is irreversible

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Comparison of chromatographic and spectroscopic methods used to rank compounds for aqueous solubility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

A specific mechanism of nonspecific inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Screening in a spirit haunted world

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

High-throughput assays for promiscuous inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

A detergent-based assay for the detection of promiscuous inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Identification and Prediction of Promiscuous Aggregating Inhibitors among Known Drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

NMR-based quality control approach for the identification of false positives and false negatives in high throughput screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

High-throughput pKa screening and prediction amenable for ADME profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

A rapid method for pKa determination of drugs using pressure-assisted capillary electrophoresis with photodiode array detection in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

High-throughput measurement of pKa values in a mixed-buffer linear pH gradient system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

High throughput physicochemical profiling for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Comparison of a miniaturized shake-flask solubility method with automated potentiometric acid/base titrations and calculated solubilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Miniature device for aqueous and non-aqueous solubility measurements during drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Accuracy of calculated pH-dependent aqueous drug solubility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Forecasting the in vivo performance of four low solubility drugs from their in vitro dissolution data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

In vitro-in vivo correlations for lipophilic, poorly water-soluble drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Forecasting the oral absorption behavior of poorly soluble weak bases using solubility and dissolution studies in biorelevant media

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Predicting the precipitation of poorly soluble weak bases upon entry in the small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Estimation of intragastric solubility of drugs: in what medium?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Effect of buffer media composition on the solubility and effective permeability coefficient of ibuprofen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Dissolution media simulating the intralumenal composition of the small intestine: physiological issues and practical aspects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Canine intestinal contents vs. simulated media for the assessment of solubility of two weak bases in the human small intestinal contents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Biorelevant dissolution media as a predictive tool for glyburide a class II drug.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

pH-metric solubility. 2: correlation between the acid-base titration and the saturation shake-flask solubility-pH methods.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Chasing equilibrium: measuring the intrinsic solubility of weak acids and bases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Current industrial practices of assessing permeability and P-glycoprotein interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Drug absorption in vitro model: filter-immobilized artificial membranes. 2. Studies of the permeability properties of lactones in Piper methysticum Forst

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Optimized conditions of bio-mimetic artificial membrane permeation assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Acid-base cosolvent method for determining aqueous permeability of amiodarone, itraconazole, tamoxifen, terfenadine and other very insoluble molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

In vitro permeability of poorly aqueous soluble compounds using different solubilizers in the PAMPA assay with liquid chromatography/mass spectrometry detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

PAMPA - excipient classification gradient map.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

A novel high-throughput automated chip-based nanoelectrospray tandem mass spectrometric method for PAMPA sample analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Intestinal and blood-brain drug transport: beyond involvement of a single transport function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Caco-2 replace or refine?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Intestinal solute carriers: an overview of trends and strategies for improving oral drug absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Development of a 7-day, 96-well Caco-2 permeability assay with high-throughput direct UV compound analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Paraben transport and metabolism in the biomimetic artificial membrane permeability assay (BAMPA) and 3-day and 21-day Caco-2 cell systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

New and better protocols for a short-term Caco-2 cell culture system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Comparison of in vitro models for the prediction of compound absorption across the human intestinal mucosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Utility of 96 well Caco-2 cell system for increased throughput of P-gp screening in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Effect of bovine serum albumin on drug permeability estimation across Caco-2 monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Impact of extracellular protein binding on passive and active drug transport across Caco-2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Evaluation of drug interactions with P-glycoprotein in drug discovery: in vitro assessment of the potential for drug-drug interactions with P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Functional role of P-glycoprotein in limiting peroral drug absorption: optimizing drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Pharmacological strategies for overcoming multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Modulation of oral drug bioavailability: from preclinical mechanism to therapeutic application

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Current methodologies used for evaluation of intestinal permeability and absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Strategies for absorption screening in drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Saturable absorptive transport of the hydrophilic organic cation ranitidine in Caco-2 cells: role of pH-dependent organic cation uptake system and P-glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Functional role of P-glycoprotein in limiting intestinal absorption of drugs: contribution of passive permeability to P-glycoprotein mediated efflux transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Methodologies to study the induction of rat hepatic and intestinal cytochrome P450 3A at the mRNA, protein, and catalytic activity level.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

P-glycoprotein-mediated intestinal and biliary digoxin transport in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Functional interaction of intestinal CYP3A4 and P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Role of P-glycoprotein in pharmacokinetics: clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Intestinal metabolism promotes regional differences in apical uptake of indinavir: coupled effect of P-glycoprotein and cytochrome P450 3A on indinavir membrane permeability in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Enzymatic activities in the microsomes prepared from rat small intestinal epithelial cells by differential procedures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Creation of polarized cells coexpressing CYP3A4, NADPH cytochrome P450 reductase and MDR1/P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Application of drug delivery technologies in lead candidate selection and optimization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Preclinical formulations for discovery and toxicology: physicochemical challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Intestinal drug efflux: formulation and food effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Nanosizing: a formulation approach for poorly-water-soluble compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Preparation and evaluation of nanosuspensions for enhancing the dissolution of poorly soluble drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

A high-throughput combinatorial approach for the discovery of a cremophor EL-free paclitaxel formulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

The use of in vitro metabolic stability for rapid selection of compounds in early discovery based on their expected hepatic extraction ratios

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Predicting in vivo drug interactions from in vitro drug discovery data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Complexities of glucuronidation affecting in vitro in vivo extrapolation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

High-throughput screening of inhibitory potential of nine cytochrome P450 enzymes in vitro using liquid chromatography/tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

CYP induction-mediated drug interactions: in vitro assessment and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Advances in predicting CYP-mediated drug interactions in the drug discovery setting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Inhibition and induction of human cytochrome P450 (CYP) enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Quantitative PCR assay for cytochromes P450 2B and 3A induction in rat precision-cut liver slices: correlation study with induction in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

PXR, CAR and drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Induction of drug metabolism: the role of nuclear receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

hERG potassium channels and cardiac arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: lessons learned from the bromfenac experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Timing of new black box warnings and withdrawals for prescription medications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Molecular and cellular mechanisms of cardiac arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Validation of a [3H]astemizole binding assay in HEK293 cells expressing HERG K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Understanding the Structure−Activity Relationship of the Human Ether-a-go-go-Related Gene Cardiac K+ Channel. A Model for Bad Behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Idiosyncratic drug hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Method to estimate the rate and extent of intestinal absorption in conscious rats using an absorption probe and portal blood sampling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Dissecting the energy needs of the body.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Human and animal hepatocytes in vitro with extrapolation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Concordance of the toxicity of pharmaceuticals in humans and in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

New technologies and screening strategies for hepatotoxicity: use of in vitro models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

In vitro methods to study chemically-induced hepatotoxicity: a literature review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Validation of an in vitro screen for phospholipidosis using a high-content biology platform

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Prediction of drug-induced intrahepatic cholestasis: in vitro screening and QSAR analysis of drugs inhibiting the human bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

In vitro zonation and toxicity in a hepatocyte bioreactor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Hematotoxicity testing by cell clonogenic assay in drug development and preclinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

High-throughput in vitro hemotoxicity testing and in vitro cross-platform comparative toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Evaluation of neurotoxic potential by use of in vitro systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

A paradigm for examining toxicant effects on viability, structure, and axonal transport of neurons in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Predictive value of in vitro safety studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

High-specificity and high-sensitivity genotoxicity assessment in a human cell line: validation of the GreenScreen HC GADD45a-GFP genotoxicity assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Strategy of utilizing in vitro and in vivo ADME tools for lead optimization and drug candidate selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Implementation of an ADME enabling selection and visualization tool for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Hit and lead generation: beyond high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

High-throughput drug discovery: what can we expect from HTS?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

QT prolongation through hERG K(+) channel blockade: current knowledge and strategies for the early prediction during drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

Experimental Design on Single-Time-Point High-Throughput Microsomal Stability Assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.5.641

21 January 2018

Identifiers

DOI

10.1517/17425255.3.5.641

1 reference

17 August 2017

1 reference