(Q37671826)

21 August 2017

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title

Mitigating permeability-mediated risks in drug discovery (English)

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21 August 2017

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Jianling Wang

1

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PubMed ID

20064074

21 August 2017

Suzanne Skolnik

series ordinal

2

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PubMed ID

20064074

21 August 2017

language of work or name

English

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publication date

1 February 2010

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Expert Opinion on Drug Metabolism & Toxicology

21 August 2017

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21 August 2017

6

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21 August 2017

171-187

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21 August 2017

2

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Comprehensive assessment of ADMET risks in drug discovery

21 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Recent advances in high throughput screening for ADME properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Drug absorption in vitro model: filter-immobilized artificial membranes. 2. Studies of the permeability properties of lactones in Piper methysticum Forst

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Recent advances in computational prediction of drug absorption and permeability in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Permeability through DOPC/dodecane membranes: measurement and LFER modelling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Relationships between structure and high-throughput screening permeability of diverse drugs with artificial membranes: application to prediction of Caco-2 cell permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

QSAR application for the prediction of compound permeability with in silico descriptors in practical use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

A novel high-throughput automated chip-based nanoelectrospray tandem mass spectrometric method for PAMPA sample analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Artificial membrane assays to assess permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Optimized conditions of bio-mimetic artificial membrane permeation assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

PAMPA--a drug absorption in vitro model 11. Matching the in vivo unstirred water layer thickness by individual-well stirring in microtitre plates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

PAMPA--a drug absorption in vitro model. 5. Unstirred water layer in iso-pH mapping assays and pKa(flux)--optimized design (pOD-PAMPA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Modelling of the blood-brain barrier in drug discovery and development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

High throughput artificial membrane permeability assay for blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Comparison of blood-brain barrier permeability assays: in situ brain perfusion, MDR1-MDCKII and PAMPA-BBB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Rapid screening of blood-brain barrier penetration of drugs using the immobilized artificial membrane phosphatidylcholine column chromatography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Strategies to assess blood-brain barrier penetration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Intestinal drug absorption and bioavailability: beyond involvement of single transport function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Caco-2 replace or refine?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Intestinal solute carriers: an overview of trends and strategies for improving oral drug absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Paraben transport and metabolism in the biomimetic artificial membrane permeability assay (BAMPA) and 3-day and 21-day Caco-2 cell systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

A modified fast (4 day) 96-well plate Caco-2 permeability assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Development of a 7-day, 96-well Caco-2 permeability assay with high-throughput direct UV compound analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Permeability for intestinal absorption: Caco-2 assay and related issues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Current industrial practices of assessing permeability and P-glycoprotein interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Variability in Caco-2 and MDCK cell-based intestinal permeability assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Optimisation of the caco-2 permeability assay using experimental design methodology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Evaluation of drug interactions with P-glycoprotein in drug discovery: in vitro assessment of the potential for drug-drug interactions with P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Functional role of P-glycoprotein in limiting peroral drug absorption: optimizing drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Current methodologies used for evaluation of intestinal permeability and absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Strategies for absorption screening in drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Biopharmaceutics classification system: validation and learnings of an in vitro permeability assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Exploring the role of different drug transport routes in permeability screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Evaluation of the MDR-MDCK cell line as a permeability screen for the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

In vitro models for the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

The use of in vitro cell culture models for mechanistic studies and as permeability screens for the blood-brain barrier in the pharmaceutical industry--background and current status in the drug discovery process.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

New approaches to in vitro models of blood-brain barrier drug transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Comparison of in vitro BBMEC permeability and in vivo CNS uptake by microdialysis sampling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Methods to assess drug permeability across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Modeling gastrointestinal drug absorption requires more in vivo biopharmaceutical data: experience from in vivo dissolution and permeability studies in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Increased understanding of intestinal drug permeability determined by the LOC-I-GUT approach using multislice computed tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Animal data: the contributions of the Ussing Chamber and perfusion systems to predicting human oral drug delivery in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Comparison between permeability coefficients in rat and human jejunum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Segmental dependent transport of low permeability compounds along the small intestine due to P-glycoprotein: the role of efflux transport in the oral absorption of BCS class III drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Effect of pentobarbital anaesthesia on intestinal absorption and hepatic first-pass metabolism of oxacillin in rats, evaluated by portal-systemic concentration difference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Method to estimate the rate and extent of intestinal absorption in conscious rats using an absorption probe and portal blood sampling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Influence of anesthetic regimens on intestinal absorption in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Regional intestinal absorption and biliary excretion of fluvastatin in the rat: possible involvement of mrp2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Application of compartmental modeling to an examination of in vitro intestinal permeability data: assessing the impact of tissue uptake, P-glycoprotein, and CYP3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Animal models for studying transport across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Maximising use of in vitro ADMET tools to predict in vivo bioavailability and safety

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

The influence of drug-like concepts on decision-making in medicinal chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Drug-like properties and the causes of poor solubility and poor permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Permeability evaluation of peptidic HCV protease inhibitors in Caco-2 cells-correlation with in vivo absorption predicted in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

The role of permeability in drug ADME/PK, interactions and toxicity--presentation of a permeability-based classification system (PCS) for prediction of ADME/PK in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Applied Introduction to Multivariate Methods Used in Drug Discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903436486

Blood-brain barrier-specific properties of a human adult brain endothelial cell line

21 January 2018

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1096/FJ.04-3458FJE

Identifiers

DOI

10.1517/17425250903436486

1 reference

21 August 2017

1 reference

PubMed ID

20064074