(Q37880875)

24 August 2017

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title

Pharmacogenetics of drug transporters in the enterohepatic circulation (English)

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24 August 2017

Bruno Stieger

1

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24 August 2017

Peter J Meier

series ordinal

2

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24 August 2017

publication date

1 May 2011

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24 August 2017

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24 August 2017

volume

12

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24 August 2017

issue

5

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24 August 2017

page(s)

611-631

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Transporters and drug therapy: implications for drug disposition and disease

24 August 2017

cites work

1 reference

Blood-brain barrier transporters and response to CNS-active drugs

21 January 2018

1 reference

Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense

21 January 2018

1 reference

Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs

21 January 2018

1 reference

Niemann-Pick C1-Like 1 (NPC1L1) Protein in Intestinal and Hepatic Cholesterol Transport

21 January 2018

1 reference

Biochemical aspects of X-linked adrenoleukodystrophy.

21 January 2018

1 reference

Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs

21 January 2018

1 reference

Pharmacogenetics of drug transporters

21 January 2018

1 reference

The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology.

21 January 2018

1 reference

Pharmacogenetics of membrane transporters: an update on current approaches

21 January 2018

1 reference

Pharmacogenomics of membrane transporters: past, present and future

21 January 2018

1 reference

Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney

21 January 2018

1 reference

21 January 2018

Bile salt transporters

1 reference

Enterohepatic transport of bile salts and genetics of cholestasis

21 January 2018

1 reference

The role of the sodium-taurocholate cotransporting polypeptide (NTCP) and of the bile salt export pump (BSEP) in physiology and pathophysiology of bile formation

21 January 2018

1 reference

Description and simulation of a physiological pharmacokinetic model for the metabolism and enterohepatic circulation of bile acids in man. Cholic acid in healthy man

21 January 2018

1 reference

Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans

21 January 2018

1 reference

Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters

21 January 2018

1 reference

Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients

21 January 2018

1 reference

The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics.

21 January 2018

1 reference

Cyclosporin A, but not tacrolimus, inhibits the biliary excretion of mycophenolic acid glucuronide possibly mediated by multidrug resistance-associated protein 2 in rats

21 January 2018

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Measurement of sodium ion concentration in the unstirred layer of rat small intestine by polymer Na+-sensitive electrodes

21 January 2018

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Pharmacogenetics of intestinal absorption.

21 January 2018

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The biological and clinical role of drug transporters at the intestinal barrier

21 January 2018

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Membrane transporters in drug development

21 January 2018

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Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family

21 January 2018

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Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines.

21 January 2018

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Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications

21 January 2018

1 reference

21 January 2018

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Intestinal drug transporter expression and the impact of grapefruit juice in humans

21 January 2018

1 reference

ABC multidrug transporters: target for modulation of drug pharmacokinetics and drug-drug interactions

21 January 2018

1 reference

Transport of drugs by proton-coupled peptide transporters: pearls and pitfalls

21 January 2018

1 reference

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

21 January 2018

1 reference

Implications of genetic polymorphisms in drug transporters for pharmacotherapy

21 January 2018

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P-glycoprotein: Tissue Distribution, Substrates, and Functional Consequences of Genetic Variations

21 January 2018

1 reference

Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCC2 and their impact on drug disposition

21 January 2018

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Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

21 January 2018

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ABCC2/Abcc2: a multispecific transporter with dominant excretory functions.

21 January 2018

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Drug transport by breast cancer resistance protein.

21 January 2018

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In Vitro and In Vivo Evidence for the Importance of Breast Cancer Resistance Protein Transporters (BCRP/MXR/ABCP/ABCG2)

21 January 2018

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Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

21 January 2018

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Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study

21 January 2018

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Multidrug resistance-associated proteins 3, 4, and 5.

21 January 2018

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Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family

21 January 2018

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Impact of OATP transporters on pharmacokinetics

21 January 2018

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Hepatic OATP and OCT uptake transporters: their role for drug-drug interactions and pharmacogenetic aspects

21 January 2018

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Uptake transporters of the human OATP family: molecular characteristics, substrates, their role in drug-drug interactions, and functional consequences of polymorphisms

21 January 2018

1 reference

In Vitro and In Vivo Evidence of the Importance of Organic Anion Transporters (OATs) in Drug Therapy

21 January 2018

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Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy

21 January 2018

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Interplay of drug metabolism and transport: a real phenomenon or an artifact of the site of measurement?

21 January 2018

1 reference

Cell entry and export of nucleoside analogues

21 January 2018

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In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney

21 January 2018

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Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy

21 January 2018

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Does the absence of ABCC6 (multidrug resistance protein 6) in patients with Pseudoxanthoma elasticum prevent the liver from providing sufficient vitamin K to the periphery?

21 January 2018

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A human transporter protein that mediates the final excretion step for toxic organic cations

21 January 2018

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The apical conjugate efflux pump ABCC2 (MRP2).

21 January 2018

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The bile salt export pump

21 January 2018

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Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin

21 January 2018

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Role of the bile salt export pump, BSEP, in acquired forms of cholestasis

21 January 2018

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Genetic determinants of drug-induced cholestasis and intrahepatic cholestasis of pregnancy

21 January 2018

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Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development

21 January 2018

1 reference

The spectrum of liver diseases related to ABCB4 gene mutations: pathophysiology and clinical aspects

21 January 2018

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ABCG5/G8 polymorphisms and markers of cholesterol metabolism: systematic review and meta-analysis

21 January 2018

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Progressive familial intrahepatic cholestasis type 1.

21 January 2018

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Transport of nucleoside analogs across the plasma membrane: a clue to understanding drug-induced cytotoxicity

21 January 2018

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Catalog of 238 variations among six human genes encoding solute carriers ( hSLCs) in the Japanese population

21 January 2018

1 reference

Genetic polymorphisms in human proton-dependent dipeptide transporter PEPT1: implications for the functional role of Pro586.

21 January 2018

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Genetic variants of the human dipeptide transporter PEPT1.

21 January 2018

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Implications of ABC transporters on the disposition of typical veterinary medicinal products

21 January 2018

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The MDR1 (ABCB1) gene polymorphism and its clinical implications

21 January 2018

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Functional implications of genetic polymorphisms in the multidrug resistance gene MDR1 (ABCB1).

21 January 2018

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Clinical aspects of the MDR1 (ABCB1) gene polymorphism

21 January 2018

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Single nucleotide polymorphisms in human P-glycoprotein: its impact on drug delivery and disposition

21 January 2018

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ABCB1 pharmacogenetics: progress, pitfalls, and promise

21 January 2018

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Emerging new technologies in Pharmacogenomics: rapid SNP detection, molecular dynamic simulation, and QSAR analysis methods to validate clinically important genetic variants of human ABC Transporter ABCB1 (P-gp/MDR1).

21 January 2018

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A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function.

21 January 2018

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21 January 2018

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Impact of genetic polymorphisms of transporters on the pharmacokinetic, pharmacodynamic and toxicological properties of anionic drugs

21 January 2018

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Meta-analysis of the influence of MDR1 C3435T polymorphism on digoxin pharmacokinetics and MDR1 gene expression

21 January 2018

1 reference

Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysis

21 January 2018

1 reference

ABCB1 C3435T polymorphism and the risk of resistance to antiepileptic drugs in epilepsy: a systematic review and meta-analysis

21 January 2018

1 reference

Multidrug resistance 1 gene in inflammatory bowel disease: a meta-analysis

21 January 2018

1 reference

Association between two polymorphisms of ABCB1 and breast cancer risk in the current studies: a meta-analysis.

21 January 2018

1 reference

The drug transporter-metabolism alliance: uncovering and defining the interplay

21 January 2018

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Interplay of transporters and enzymes in drug and metabolite processing.

21 January 2018

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Garlic extract induces intestinal P-glycoprotein, but exhibits no effect on intestinal and hepatic CYP3A4 in humans

21 January 2018

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Herbal modulation of P-glycoprotein

21 January 2018

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Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism

21 January 2018

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Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs

21 January 2018

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Hepatic drug transporters and nuclear receptors: regulation by therapeutic agents

21 January 2018

1 reference

Xenobiotic, bile acid, and cholesterol transporters: function and regulation.

21 January 2018

1 reference

Genetic associations: false or true?

21 January 2018

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Genetic associations in large versus small studies: an empirical assessment

21 January 2018

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Replication in Genome-Wide Association Studies

21 January 2018

1 reference

The ABCG2 transporter and its relations with the pharmacokinetics, drug interaction and lipid-lowering effects of statins

21 January 2018

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Additive effects of drug transporter genetic polymorphisms on irinotecan pharmacokinetics/pharmacodynamics in Japanese cancer patients

21 January 2018

1 reference

Single nucleotide polymorphism in ABCG2 is associated with irinotecan-induced severe myelosuppression

21 January 2018

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ABCG2 pharmacogenetics: ethnic differences in allele frequency and assessment of influence on irinotecan disposition

21 January 2018

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Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical outcome in patients with advanced non-small cell lung cancer.

21 January 2018

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Role of pharmacogenetics in irinotecan therapy

21 January 2018

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High-dose methotrexate in pediatric acute lymphoblastic leukemia: impact of ABCC2 polymorphisms on plasma concentrations.

21 January 2018

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Association of ATP-binding cassette, sub-family C, number 2 (ABCC2) genotype with pharmacokinetics of irinotecan in Japanese patients with metastatic colorectal cancer treated with irinotecan plus infusional 5-fluorouracil/leucovorin (FOLFIRI).

21 January 2018

1 reference

Irinotecan-induced diarrhea: functional significance of the polymorphic ABCC2 transporter protein

21 January 2018

1 reference

Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients

21 January 2018

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MRP2 haplotypes confer differential susceptibility to toxic liver injury

21 January 2018

1 reference

Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes.

21 January 2018

1 reference

Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver

21 January 2018

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Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3).

21 January 2018

1 reference

Polymorphisms in transporter and phase II metabolism genes as potential modifiers of the predisposition to and treatment outcome of de novo acute myeloid leukemia in Israeli ethnic groups

21 January 2018

1 reference

Polymorphisms in ABCG2, ABCC3 and CNT1 genes and their possible impact on chemotherapy outcome of lung cancer patients

21 January 2018

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Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance

21 January 2018

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Efflux and uptake transporters as determinants of statin response.

21 January 2018

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3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) and genetic variability (single nucleotide polymorphisms) in a hepatic drug uptake transporter: what's it all about?

21 January 2018

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Pharmacogenomics of human OATP transporters

21 January 2018

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The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy.

21 January 2018

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Transporter pharmacogenetics and statin toxicity

21 January 2018

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Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans

21 January 2018

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Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation

21 January 2018

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Agents and mechanisms of toxic myopathy

21 January 2018

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SLCO1B1 variants and statin-induced myopathy--a genomewide study

21 January 2018

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Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake

21 January 2018

1 reference

Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis

21 January 2018

1 reference

Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response

21 January 2018

1 reference

The effects of the SLCO2B1 c.1457C > T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans

21 January 2018

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Impact of regulatory polymorphisms in organic anion transporter genes in the human liver.

21 January 2018

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Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics

21 January 2018

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Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

21 January 2018

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OCT1 (SLC22A1) R61C polymorphism and response to imatinib treatment in chronic myeloid leukemia patients

21 January 2018

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Functional analysis of human organic cation transporter OCT3 (SLC22A3) polymorphisms.

21 January 2018

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The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.

21 January 2018

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Association of the SLC22A1, SLC22A2, and SLC22A3 genes encoding organic cation transporters with diabetic nephropathy and hypertension

21 January 2018

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The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene

21 January 2018

1 reference

6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4.

21 January 2018

1 reference

Clinical and genetic determinants of intracellular tenofovir diphosphate concentrations in HIV-infected patients

21 January 2018

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The effect of lopinavir/ritonavir on the renal clearance of tenofovir in HIV-infected patients

21 January 2018

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Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study

21 January 2018

1 reference

Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia

21 January 2018

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Multidrug resistance-associated protein 4 (MRP4) gene polymorphisms and treatment response in adult acute lymphoblastic leukemia

21 January 2018

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Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients

21 January 2018

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The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease

21 January 2018

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Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function

21 January 2018

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Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity.

21 January 2018

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Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study

21 January 2018

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Pharmacogenetics of anticoagulants

21 January 2018

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Meta-analysis in genome-wide association studies

21 January 2018

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HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

21 January 2018

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Pharmacogenetics of drug-induced liver injury

21 January 2018

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Expression and membrane localization of MCT isoforms along the length of the human intestine

21 January 2018

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Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter

21 January 2018

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Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas

21 January 2018

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Isolation of a family of organic anion transporters from human liver and kidney

21 January 2018

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Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate

21 January 2018

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Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry

21 January 2018

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Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide

21 January 2018

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Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

21 January 2018

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Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver

21 January 2018

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Functional variants of OCTN cation transporter genes are associated with Crohn disease

21 January 2018

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Gene and protein expression of P-glycoprotein, MRP1, MRP2, and CYP3A4 in the small and large human intestine.

21 January 2018

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The effect of rifampin treatment on intestinal expression of human MRP transporters

21 January 2018

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Tissue distribution and induction of human multidrug resistant protein 3

21 January 2018

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Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane

21 January 2018

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Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane

21 January 2018

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MRP6 (ABCC6) detection in normal human tissues and tumors.

21 January 2018

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Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily

21 January 2018

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A novel human multidrug resistance gene MDR1 variant G571A (G191R) modulates cancer drug resistance and efflux transport

21 January 2018

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Quantitative structure--activity relationship analysis and molecular dynamics simulation to functionally validate nonsynonymous polymorphisms of human ABC transporter ABCB1 (P-glycoprotein/MDR1).

21 January 2018

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A novel MDR1 G1199T variant alters drug resistance and efflux transport activity of P-glycoprotein in recombinant Hek cells

21 January 2018

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A novel MDR1 GT1292-3TG (Cys431Leu) genetic variation and its effect on P-glycoprotein biologic functions

21 January 2018

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Identification of functionally variant MDR1 alleles among European Americans and African Americans

21 January 2018

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MDR1 polymorphisms G2677T in exon 21 and C3435T in exon 26 fail to affect rhodamine 123 efflux in peripheral blood lymphocytes

21 January 2018

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In-vitro transport characteristics discriminate wild-type ABCB1 (MDR1) from ALA893SER and ALA893THR polymorphisms

21 January 2018

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Plasma LDL cholesterol has no impact on P-glycoprotein (MDR1/ABCB1) activity in human peripheral blood mononuclear cells

21 January 2018

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Single nucleotide polymorphisms result in impaired membrane localization and reduced atpase activity in multidrug transporter ABCG2.

21 January 2018

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Functional analysis of SNPs variants of BCRP/ABCG2.

21 January 2018

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Single nucleotide polymorphisms modify the transporter activity of ABCG2.

21 January 2018

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Association of enzyme and transporter genotypes with the pharmacokinetics of imatinib

21 January 2018

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Re-evaluation and functional classification of non-synonymous single nucleotide polymorphisms of the human ATP-binding cassette transporter ABCG2.

21 January 2018

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Association of variant ABCG2 and the pharmacokinetics of epidermal growth factor receptor tyrosine kinase inhibitors in cancer patients.

21 January 2018

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In vitro evaluation of photosensitivity risk related to genetic polymorphisms of human ABC transporter ABCG2 and inhibition by drugs

21 January 2018

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The 315-316 deletion determines the BXP-21 antibody epitope but has no effect on the function of wild type ABCG2 or the Q141K variant.

21 January 2018

1 reference

Breast cancer resistance protein (BCRP)-mediated glyburide transport: effect of the C421A/Q141K BCRP single-nucleotide polymorphism.

21 January 2018

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Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2.

21 January 2018

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Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-binding cassette transmembrane transporter subfamily C member 3.

21 January 2018

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Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity

21 January 2018

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Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8).

21 January 2018

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Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1

21 January 2018

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Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences

21 January 2018

1 reference

Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions

21 January 2018

1 reference

Novel mutations of the extraneuronal monoamine transporter gene in children and adolescents with obsessive-compulsive disorder

21 January 2018

1 reference

Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms

21 January 2018

1 reference

Predisposition to epilepsy--does the ABCB1 gene play a role?

21 January 2018

1 reference

Associations of allelic variants of the multidrug resistance gene (ABCB1 or MDR1) and Inflammatory Bowel Disease and their effects on disease behavior: A case-control and meta-analysis study

21 January 2018

1 reference

Could polymorphisms in ATP-binding cassette C3/multidrug resistance associated protein 3 (ABCC3/MRP3) modify colorectal cancer risk?

21 January 2018

1 reference

In situ hybridization and immunolocalization of concentrative and equilibrative nucleoside transporters in the human intestine, liver, kidneys, and placenta

21 January 2018

1 reference

Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach

21 January 2018

1 reference

Polymorphisms in the BRCA1 and ABCB1 genes modulate menopausal hormone therapy associated breast cancer risk in postmenopausal women

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/PGS.11.53

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24 August 2017

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