(Q37943792)

25 August 2017

title

Modulation of hypoxia-inducible factors (HIF) from an integrative pharmacological perspective (English)

1 reference

25 August 2017

1 reference

Francisco Javier Rodríguez-Jiménez

series ordinal

1

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25 August 2017

Victoria Moreno-Manzano

series ordinal

2

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25 August 2017

publication date

8 October 2011

1 reference

Cellular and Molecular Life Sciences

25 August 2017

published in

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25 August 2017

volume

69

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25 August 2017

issue

4

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25 August 2017

page(s)

519-534

1 reference

https://scigraph.springernature.com/pub.10.1007/s00018-011-0813-4

25 August 2017

exact match

0 references

cites work

Role of oxygen in cancer: looking beyond hypoxia

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Review: hypoxia-inducible factor-1 (HIF-1): a novel transcription factor in immune reactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Oxygen-dependent and -independent regulation of HIF-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Signal transduction to hypoxia-inducible factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Targeting HIF-1 for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Regulation of HIF-1alpha at the transcriptional level

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Hypoxia-inducible factor (HIF)-3alpha is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

An operational definition of epigenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Tumor-associated CpG demethylation augments hypoxia-induced effects by positive autoregulation of HIF-1α.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1alpha gene locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

HIF1A gene transcription is dependent on a core promoter sequence encompassing activating and inhibiting sequences located upstream from the transcription initiation site and cis elements located within the 5'UTR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

The transcription factor Egr1 regulates the HIF-1alpha gene during hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

GL331 inhibits HIF-1alpha expression in a lung cancer model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Flavopiridol downregulates hypoxia-mediated hypoxia-inducible factor-1alpha expression in human glioma cells by a proteasome-independent pathway: implications for in vivo therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Hypoxia causes downregulation of mismatch repair system and genomic instability in stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Factors interacting with HIF-1alpha mRNA: novel therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

MicroRNA-22 regulates hypoxia signaling in colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Tristetraprolin regulates the stability of HIF-1alpha mRNA during prolonged hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Androgens regulate the binding of endogenous HuR to the AU-rich 3'UTRs of HIF-1alpha and EGF mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Antitumoral activity of rapamycin mediated through inhibition of HIF-1alpha and VEGF in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Quercetin suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) through inhibiting protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Quercetin activates an angiogenic pathway, hypoxia inducible factor (HIF)-1-vascular endothelial growth factor, by inhibiting HIF-prolyl hydroxylase: a structural analysis of quercetin for inhibiting HIF-prolyl hydroxylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Genistein inhibited hypoxia-inducible factor-1alpha expression induced by hypoxia and cobalt chloride in human retinal pigment epithelium cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Silibinin inhibits expression of HIF-1alpha through suppression of protein translation in prostate cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Wondonin, a novel compound, inhibits hypoxia-induced angiogenesis through hypoxia-inducible factor 1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Schedule-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Cell type-specific, topoisomerase II-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation by NSC 644221.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Novel delivery of SN38 markedly inhibits tumor growth in xenografts, including a camptothecin-11-refractory model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Inhibition of hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis by DNA damage inducing agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Regulation of HIF-1alpha stability through S-nitrosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Effects of histone deacetylase inhibitors on HIF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Intermittent hypoxia changes HIF-1alpha phosphorylation pattern in endothelial cells: unravelling of a new PKA-dependent regulation of HIF-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Compound C prevents Hypoxia-Inducible Factor-1α protein stabilization by regulating the cellular oxygen availability via interaction with Mitochondrial Complex I

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Compound C inhibits hypoxic activation of HIF-1 independent of AMPK

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

HSP90 and the chaperoning of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Novel thioredoxin inhibitors paradoxically increase hypoxia-inducible factor-alpha expression but decrease functional transcriptional activity, DNA binding, and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Tipifarnib: farnesyl transferase inhibition at a crossroads

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Suppression of hypoxia inducible factor-1alpha (HIF-1alpha) by YC-1 is dependent on murine double minute 2 (Mdm2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Hypoxia induces a novel signature of chromatin modifications and global repression of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

A role for cofactor-cofactor and cofactor-histone interactions in targeting p300, SWI/SNF and Mediator for transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Regulation of higher-order chromatin structures by nucleosome-remodelling factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

SWI/SNF regulates the cellular response to hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Transcriptome remodeling in hypoxic inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Epigenetics, the epicenter of the hypoxic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Histone deacetylase inhibitors for epigenetic therapy of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Epigenetic regulation of immune escape genes in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Rational development of histone deacetylase inhibitors as anticancer agents: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1alpha activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Hypoxia upregulates the histone demethylase JMJD1A via HIF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Role of hypoxia-inducible factors in epigenetic regulation via histone demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Hypoxia causes epigenetic gene regulation in macrophages by attenuating Jumonji histone demethylase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Transcriptional regulation by histone ubiquitination and deubiquitination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Identification of novel small-molecule inhibitors of hypoxia-inducible factor-1 transactivation and DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

NF-κB suppresses HIF-1α response by competing for P300 binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Amphotericin B blunts erythropoietin response to hypoxia by reinforcing FIH-mediated repression of HIF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Specific inhibition of hypoxia-inducible factor (HIF)-1 alpha activation and of vascular endothelial growth factor (VEGF) production by flavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

AMP-activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target gene expression under hypoxic conditions in DU145 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Flavonoids induce HIF-1alpha but impair its nuclear accumulation and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Silibinin inhibits hypoxia-inducible factor-1alpha and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Noscapine sensitizes chemoresistant ovarian cancer cells to cisplatin through inhibition of HIF-1α.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Hypoxia-inducible factor 1: a new hope to counteract neurodegeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Regulation of cardiovascular development and physiology by hypoxia-inducible factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Angiogenesis in ischemic and neoplastic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Vasculogenesis, angiogenesis, and arteriogenesis: mechanisms of blood vessel formation and remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Hypoxia inducible factor 1 (HIF-1) and cardioprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Dibenzoylmethane, a natural dietary compound, induces HIF-1 alpha and increases expression of VEGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Effects of deferoxamine-activated hypoxia-inducible factor-1 on the brainstem after subarachnoid hemorrhage in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Deferoxamine prevents cardiac hypertrophy and failure in the gerbil model of iron-induced cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Capsaicin regulates vascular endothelial cell growth factor expression by modulation of hypoxia inducing factor-1alpha in human malignant melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Interaction of the human cytomegalovirus particle with the host cell induces hypoxia-inducible factor 1 alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Mersalyl: a diuretic with antiviral properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

UCN-01, a protein kinase C inhibitor, inhibits endothelial cell proliferation and angiogenic hypoxic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0813-4

Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: implications for physiological and therapeutic modulation of enzyme activity

21 January 2018

1 reference

12 December 2020

Potent and sustained inhibition of HIF-1α and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effects

1 reference

12 December 2020

Hypoxia and hypoxia-inducible factor in renal disease

1 reference

12 December 2020

Noscapine inhibits hypoxia-mediated HIF-1alpha expression andangiogenesis in vitro: a novel function for an old drug.

1 reference

12 December 2020

Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the trans-activation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1alpha

1 reference

12 December 2020

The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.

1 reference

12 December 2020

Hemin, an iron-binding porphyrin, inhibits HIF-1α induction through its binding with heat shock protein 90.

1 reference

12 December 2020

Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors

1 reference

12 December 2020

Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response

1 reference

12 December 2020

Functional regulation of HIF-1α under normoxia--is there more than post-translational regulation?

1 reference

12 December 2020

Hypoxic preconditioning augments efficacy of human endothelial progenitor cells for therapeutic neovascularization

1 reference

12 December 2020

Antitumor agent PX-12 inhibits HIF-1α protein levels through an Nrf2/PMF-1-mediated increase in spermidine/spermine acetyl transferase

1 reference

12 December 2020

Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells

1 reference

12 December 2020

Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway.

1 reference

12 December 2020

Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity

1 reference

12 December 2020

Mutual regulation of hypoxic and retinoic acid related signalling in tubular proximal cells

1 reference

12 December 2020

Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway

1 reference

12 December 2020

Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway

1 reference

12 December 2020

The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis

1 reference

12 December 2020

The flavonoid quercetin induces hypoxia-inducible factor-1alpha (HIF-1alpha) and inhibits cell proliferation by depleting intracellular iron

1 reference

12 December 2020

FM19G11: A new modulator of HIF that links mTOR activation with the DNA damage checkpoint pathways

1 reference

12 December 2020

Astragaloside IV stimulates angiogenesis and increases hypoxia-inducible factor-1α accumulation via phosphatidylinositol 3-kinase/Akt pathway

1 reference

12 December 2020

Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

1 reference

12 December 2020

Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha.

1 reference

12 December 2020

RTEF-1, an upstream gene of hypoxia-inducible factor-1α, accelerates recovery from ischemia.

1 reference

12 December 2020

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

1 reference

12 December 2020

Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice

1 reference

12 December 2020

Intestinal hypoxia-inducible factor-2alpha (HIF-2alpha) is critical for efficient erythropoiesis

1 reference

12 December 2020

Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1

1 reference

12 December 2020

Degeneration of capsaicin sensitive sensory nerves enhances myocardial injury in acute myocardial infarction in rats

1 reference

12 December 2020

The hypoxia-associated factor switches cells from HIF-1α- to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion

1 reference

12 December 2020

In vitro hypoxic preconditioning of embryonic stem cells as a strategy of promoting cell survival and functional benefits after transplantation into the ischemic rat brain

1 reference

12 December 2020

Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells.

1 reference

12 December 2020

Honokiol inhibits hypoxia-inducible factor-1 pathway.

1 reference

12 December 2020

Negative and positive regulation of HIF-1: a complex network

1 reference

12 December 2020

Inducible expression of hypoxia-inducible factor 1alpha (HIF-1alpha) as a tool for studying HIF-1alpha-dependent gene regulation during normoxia in vitro

1 reference

12 December 2020

Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.

1 reference

12 December 2020

von Hippel Lindau tumor suppressor and HIF-1alpha: new targets of NSAIDs inhibition of hypoxia-induced angiogenesis

1 reference

12 December 2020

10.1007/S00018-011-0813-4

Identifiers

DOI

1 reference

25 August 2017

1 reference