(Q38043975)

27 August 2017

Role of cholesterol in APP metabolism and its significance in Alzheimer's disease pathogenesis (English)

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27 August 2017

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M Maulik

1

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27 August 2017

D Westaway

series ordinal

2

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27 August 2017

J H Jhamandas

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3

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27 August 2017

S Kar

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4

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27 August 2017

16 September 2012

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27 August 2017

Molecular Neurobiology

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27 August 2017

47

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27 August 2017

1

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27 August 2017

37-63

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https://scigraph.springernature.com/pub.10.1007/s12035-012-8337-y

27 August 2017

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cites work

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

1 reference

12 December 2020

Reduced risk of incident AD with elective statin use in a clinical trial cohort

1 reference

12 December 2020

Genetic association of CYP46 and risk for Alzheimer's disease

1 reference

12 December 2020

Statins in unconventional secretion of insulin-degrading enzyme and degradation of the amyloid-β peptide

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12 December 2020

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12 December 2020

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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12 December 2020

DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice

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12 December 2020

The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease

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12 December 2020

ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein

1 reference

12 December 2020

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons

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12 December 2020

Lipid imbalance in the neurological disorder, Niemann-Pick C disease

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12 December 2020

Neuropathology of Alzheimer's disease and mild cognitive impairment

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12 December 2020

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides

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12 December 2020

Structural correlates of cognition in dementia: quantification and assessment of synapse change.

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12 December 2020

Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats.

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12 December 2020

Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

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12 December 2020

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

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12 December 2020

Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's disease

1 reference

12 December 2020

Statins promote potent systemic antioxidant effects through specific inflammatory pathways

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12 December 2020

The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease.

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12 December 2020

Cholesterol is increased in the exofacial leaflet of synaptic plasma membranes of human apolipoprotein E4 knock-in mice

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12 December 2020

The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice.

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12 December 2020

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

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12 December 2020

Statins and the risk of dementia

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12 December 2020

Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study.

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12 December 2020

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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12 December 2020

ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

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12 December 2020

Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease

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12 December 2020

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

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12 December 2020

Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease

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12 December 2020

Alzheimer's disease: synaptic dysfunction and Abeta

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12 December 2020

The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease

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12 December 2020

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

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12 December 2020

Seladin-1 transcription is linked to neuronal degeneration in Alzheimer's disease

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12 December 2020

Risk factors and differential diagnosis of Alzheimer's disease

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12 December 2020

The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

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12 December 2020

Amyloid precursor protein trafficking, processing, and function

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12 December 2020

Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain.

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12 December 2020

Lipid Rafts: Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes

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12 December 2020

Acceleration of amyloid fibril formation by specific binding of Abeta-(1-40) peptide to ganglioside-containing membrane vesicles

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12 December 2020

Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells.

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12 December 2020

Presenilins are essential for regulating neurotransmitter release

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12 December 2020

Inhibition of β-amyloid1-42 internalization attenuates neuronal death by stabilizing the endosomal-lysosomal system in rat cortical cultured neurons

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12 December 2020

Niemann-Pick disease type C.

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12 December 2020

Linking lipids to Alzheimer's disease: cholesterol and beyond

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12 December 2020

Treatment with controlled-release lovastatin decreases serum concentrations of human beta-amyloid (A beta) peptide

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12 December 2020

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

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12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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12 December 2020

The non-amyloidogenic pathway: structure and function of alpha-secretases

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12 December 2020

Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease

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12 December 2020

PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling

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12 December 2020

Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro

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12 December 2020

Risk factors for dementia

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12 December 2020

Alzheimer's disease genetics: current knowledge and future challenges

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12 December 2020

Protein sensors for membrane sterols

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12 December 2020

Amyloid beta oligomerization is induced by brain lipid rafts

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12 December 2020

Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis

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12 December 2020

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

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12 December 2020

Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells

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12 December 2020

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

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12 December 2020

Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County Study.

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12 December 2020

Characterization of beta-amyloid peptide from human cerebrospinal fluid

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12 December 2020

Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease

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12 December 2020

Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice.

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12 December 2020

Cholesterol potentiates beta-amyloid-induced toxicity in human neuroblastoma cells: involvement of oxidative stress

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12 December 2020

APP intracellular domain is increased and soluble Abeta is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease

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12 December 2020

β-amyloid inhibits protein prenylation and induces cholesterol sequestration by impairing SREBP-2 cleavage.

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12 December 2020

Abeta-degrading enzymes: modulators of Alzheimer's disease pathogenesis and targets for therapeutic intervention

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12 December 2020

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

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12 December 2020

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

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12 December 2020

Membrane cholesterol interferes with neuronal apoptosis induced by soluble oligomers but not fibrils of amyloid-beta peptide

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12 December 2020

Abeta polymerization through interaction with membrane gangliosides.

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12 December 2020

ADAMs family members as amyloid precursor protein alpha-secretases

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12 December 2020

Reduction in cholesterol and sialic acid content protects cells from the toxic effects of beta-amyloid peptides

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12 December 2020

Genetics of Alzheimer's disease: new evidences for an old hypothesis?

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12 December 2020

Probing the origins of increased activity of the E22Q "Dutch" mutant Alzheimer's beta-amyloid peptide

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12 December 2020

Biochemistry and molecular biology of amyloid beta-protein and the mechanism of Alzheimer's disease

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12 December 2020

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12 December 2020

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

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12 December 2020

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

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12 December 2020

Amyloid precursor protein processing and Alzheimer's disease

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12 December 2020

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

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12 December 2020

Squalestatin protects neurons and reduces the activation of cytoplasmic phospholipase A2 by Abeta(1-42).

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12 December 2020

Greasing the wheels of Abeta clearance in Alzheimer's disease: the role of lipids and apolipoprotein E.

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12 December 2020

Structure of genes encoding steroidogenic enzymes

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12 December 2020

3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity.

1 reference

12 December 2020

A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.

1 reference

12 December 2020

Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal

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12 December 2020

ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins

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12 December 2020

Recent advances in membrane microdomains: rafts, caveolae, and intracellular cholesterol trafficking

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12 December 2020

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

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12 December 2020

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

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12 December 2020

Localization of mature neprilysin in lipid rafts

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12 December 2020

Tau protein in normal and Alzheimer's disease brain.

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12 December 2020

High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice.

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12 December 2020

Plasma membrane cholesterol controls the cytotoxicity of Alzheimer's disease AbetaP (1-40) and (1-42) peptides.

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12 December 2020

Human neprilysin is capable of degrading amyloid beta peptide not only in the monomeric form but also the pathological oligomeric form

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12 December 2020

Aβ internalization by neurons and glia

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12 December 2020

Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice

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12 December 2020

Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

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12 December 2020

Statin therapy for Alzheimer's disease: will it work?

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12 December 2020

Cerebrospinal fluid Abeta40 and Abeta42: natural course and clinical usefulness

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12 December 2020

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

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12 December 2020

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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12 December 2020

High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus.

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12 December 2020

Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis

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12 December 2020

Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol.

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12 December 2020

Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.

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12 December 2020

Modulation of ABCA1 by an LXR agonist reduces β-amyloid levels and improves outcome after traumatic brain injury

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12 December 2020

Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan

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12 December 2020

gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease

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12 December 2020

Neuronal receptors as targets for the action of amyloid-beta protein (Aβ) in the brain

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12 December 2020

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

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12 December 2020

Consequences of NPC1 and NPC2 loss of function in mammalian neurons

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12 December 2020

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

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12 December 2020

Beta-amyloid precursor protein cleavage by a membrane-bound protease

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12 December 2020

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

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12 December 2020

Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid

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12 December 2020

Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

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12 December 2020

Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study.

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12 December 2020

Mechanisms for cellular cholesterol transport: defects and human disease

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12 December 2020

Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro

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12 December 2020

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.

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12 December 2020

Statins, incident Alzheimer disease, change in cognitive function, and neuropathology

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12 December 2020

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

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12 December 2020

Mutant genes in familial Alzheimer's disease and transgenic models

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12 December 2020

Cholinergic activity and amyloid precursor protein metabolism

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12 December 2020

Assembly and activation of the γ-secretase complex: roles of presenilin cofactors

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12 December 2020

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance

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12 December 2020

Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid beta-peptide deposition in homozygous APP(V717F) transgenic mice.

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12 December 2020

Transplanted astrocytes internalize deposited beta-amyloid peptides in a transgenic mouse model of Alzheimer's disease.

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12 December 2020

Neurofibrillary tangles and tau phosphorylation.

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12 December 2020

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

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12 December 2020

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

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12 December 2020

Cholesterol homeostasis and function in neurons of the central nervous system

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12 December 2020

Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism

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12 December 2020

Intracellular amyloid-beta in Alzheimer's disease

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12 December 2020

Statin Use and the Risk of Incident Dementia

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12 December 2020

Increased amyloid- levels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet

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12 December 2020

Mechanisms of neurofibrillary degeneration and the formation of neurofibrillary tangles.

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12 December 2020

Regulation of beta-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer's disease

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12 December 2020

Endocytic pathways mediating oligomeric Abeta42 neurotoxicity.

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12 December 2020

ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease

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12 December 2020

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

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12 December 2020

Cholesterol protects PC12 cells from beta-amyloid induced calcium disordering and cytotoxicity.

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12 December 2020

Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide Secretion

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12 December 2020

Serum lipoprotein levels, statin use, and cognitive function in older women

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12 December 2020

TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

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12 December 2020

Transcriptional regulation of cholesterol 24-hydroxylase by histone deacetylase inhibitors.

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12 December 2020

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

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12 December 2020

The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress

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12 December 2020

Raft disorganization leads to reduced plasmin activity in Alzheimer's disease brains

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12 December 2020

Molecular pathogenesis of apolipoprotein E-mediated amyloidosis in late-onset Alzheimer's disease

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12 December 2020

Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid-Alzheimer's disease relationships?

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12 December 2020

Cleavage of amyloid beta peptide during constitutive processing of its precursor

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12 December 2020

Amyloid beta-protein assembly and Alzheimer disease

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12 December 2020

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

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12 December 2020

Function of beta-amyloid in cholesterol transport: a lead to neurotoxicity

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12 December 2020

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

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12 December 2020

Comparative lipidomic analysis of mouse and human brain with Alzheimer disease.

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12 December 2020

The amyloid-beta peptide and its role in Alzheimer's disease

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12 December 2020

Interactions of Npc1 and amyloid accumulation/deposition in the APP/PS1 mouse model of Alzheimer's

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12 December 2020

A detergent-insoluble membrane compartment contains A beta in vivo.

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12 December 2020

Changes in cerebral blood volume and amyloid pathology in aged Alzheimer APP/PS1 mice on a docosahexaenoic acid (DHA) diet or cholesterol enriched Typical Western Diet (TWD).

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12 December 2020

Beta-amyloid monomers are neuroprotective.

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12 December 2020

Brain cholesterol: long secret life behind a barrier.

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12 December 2020

Genesis of Alzheimer's disease

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12 December 2020

Current perspectives on statins

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12 December 2020

Association of Alzheimer disease pathology with abnormal lipid metabolism: the Hisayama Study.

1 reference

12 December 2020

Seladin-1/DHCR24 protects neuroblastoma cells against Abeta toxicity by increasing membrane cholesterol content

1 reference

12 December 2020

Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis and neurotoxicity.

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12 December 2020

Abeta-degrading enzymes in Alzheimer's disease.

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12 December 2020

The Alzheimer's disease beta-secretase enzyme, BACE1.

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12 December 2020

Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells.

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12 December 2020

Differential effects of lovastatin treatment on brain cholesterol levels in normal and apoE-deficient mice

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12 December 2020

Effects of cholesterol depletion and increased lipid unsaturation on the properties of endocytic membranes.

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12 December 2020

Human apolipoprotein E4 accelerates beta-amyloid deposition in APPsw transgenic mouse brain.

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12 December 2020

Regulation of amyloid precursor protein cleavage.

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12 December 2020

Point substitution in the central hydrophobic cluster of a human beta-amyloid congener disrupts peptide folding and abolishes plaque competence

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12 December 2020

Statins reduce amyloid-beta production through inhibition of protein isoprenylation

1 reference

12 December 2020

Mechanisms of amyloid-Beta Peptide uptake by neurons: the role of lipid rafts and lipid raft-associated proteins

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12 December 2020

Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology

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12 December 2020

Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels.

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12 December 2020

Oligomer-specific Abeta toxicity in cell models is mediated by selective uptake

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12 December 2020

ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.

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12 December 2020

Anti-apoptotic effect of atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, on cardiac myocytes through protein kinase C activation

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12 December 2020

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

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12 December 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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12 December 2020

Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration

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12 December 2020

The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

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12 December 2020

Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic mice

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12 December 2020

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.

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12 December 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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12 December 2020

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

1 reference

12 December 2020

Role of amyloid beta in lipid homeostasis.

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12 December 2020

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

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12 December 2020

Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons.

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12 December 2020

Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein

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12 December 2020

Cholesterol, lipid rafts, and disease

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12 December 2020

Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice

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12 December 2020

The genetic epidemiology of neurodegenerative disease

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12 December 2020

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

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12 December 2020

Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.

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12 December 2020

Variants of CYP46A1 may interact with age and APOE to influence CSF Abeta42 levels in Alzheimer's disease

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12 December 2020

The role of apolipoprotein E in Alzheimer's disease

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12 December 2020

Altered levels and distribution of amyloid precursor protein and its processing enzymes in Niemann-Pick type C1-deficient mouse brains

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12 December 2020

Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

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12 December 2020

Neuronal membrane cholesterol loss enhances amyloid peptide generation

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12 December 2020

Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism

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12 December 2020

Alzheimer's disease: genes, proteins, and therapy

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12 December 2020

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

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12 December 2020

gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.

1 reference

12 December 2020

How cholesterol constrains glycolipid conformation for optimal recognition of Alzheimer's beta amyloid peptide (Abeta1-40).

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12 December 2020

Association of aortic atherosclerosis with cerebral beta-amyloidosis and learning deficits in a mouse model of Alzheimer's disease.

1 reference

12 December 2020

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

12 December 2020

Apolipoprotein E in Alzheimer's disease and other neurological disorders

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12 December 2020

Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study.

1 reference

12 December 2020

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

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12 December 2020

Therapeutic potential of statins in Alzheimer's disease.

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12 December 2020

Cholesterol Depletion of Enterocytes

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12 December 2020

Effects of lovastatin and pravastatin on amyloid processing and inflammatory response in TgCRND8 brain

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12 December 2020

Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship

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12 December 2020

Lipid rafts: at a crossroad between cell biology and physics.

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12 December 2020

Examining the levels of ganglioside and cholesterol in cell membrane on attenuation the cytotoxicity of beta-amyloid peptide

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12 December 2020

Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation

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12 December 2020

Mitochondrial cholesterol loading exacerbates amyloid beta peptide-induced inflammation and neurotoxicity

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12 December 2020

Intramembrane proteolysis by gamma-secretase

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12 December 2020

Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease

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12 December 2020

Expression of ABCG1, but not ABCA1, correlates with cholesterol release by cerebellar astroglia

1 reference

12 December 2020

Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people.

1 reference

12 December 2020

The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo

1 reference

12 December 2020

Amyloid precursor protein, although partially detergent-insoluble in mouse cerebral cortex, behaves as an atypical lipid raft protein

1 reference

12 December 2020

Regulation of cerebral cholesterol metabolism in Alzheimer disease

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12 December 2020

Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study

1 reference

12 December 2020

Membrane rafts in Alzheimer's disease beta-amyloid production

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12 December 2020

A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice.

1 reference

12 December 2020

Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability

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12 December 2020

Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages

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12 December 2020

Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol.

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12 December 2020

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

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12 December 2020

Regulation of tau phosphorylation in Alzheimer's disease

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12 December 2020

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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12 December 2020

Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease

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12 December 2020

Formation of toxic Abeta(1-40) fibrils on GM1 ganglioside-containing membranes mimicking lipid rafts: polymorphisms in Abeta(1-40) fibrils

1 reference

12 December 2020

On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

1 reference

12 December 2020

The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.

1 reference

12 December 2020

Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover

1 reference

12 December 2020

Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease

1 reference

12 December 2020

The influence of simvastatin, atorvastatin and high-cholesterol diet on acetylcholinesterase activity, amyloid beta and cholesterol synthesis in rat brain

1 reference

12 December 2020

Effects of lipids and aging on the neurotoxicity and neuronal loss caused by intracerebral injections of the amyloid-beta peptide in the rat.

1 reference

12 December 2020

Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization

1 reference

12 December 2020

Genome-wide analysis of genetic loci associated with Alzheimer disease

1 reference

12 December 2020

Recent advances in brain cholesterol dynamics: transport, domains, and Alzheimer's disease

1 reference

12 December 2020

Direct and potent regulation of gamma-secretase by its lipid microenvironment

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12 December 2020

Axonal amyloid precursor protein expressed by neurons in vitro is present in a membrane fraction with caveolae-like properties.

1 reference

12 December 2020

Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease

1 reference

12 December 2020

ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-beta pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis

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12 December 2020

ApoE promotes the proteolytic degradation of Abeta

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12 December 2020

Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities

1 reference

12 December 2020

The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo.

1 reference

12 December 2020

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

12 December 2020

Cholesterol and statins in Alzheimer's disease: current controversies

1 reference

12 December 2020

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

12 December 2020

The role of cholesterol in the biosynthesis of beta-amyloid

1 reference

12 December 2020

Plaque-bearing mice with reduced levels of oligomeric amyloid-beta assemblies have intact memory function.

1 reference

12 December 2020

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

1 reference

12 December 2020

Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels

1 reference

12 December 2020

Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis

1 reference

12 December 2020

Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies

1 reference

12 December 2020

ACAT inhibition and amyloid beta reduction

1 reference

12 December 2020

Presenilin: running with scissors in the membrane

1 reference

12 December 2020

Alpha-secretase cleavage of the amyloid precursor protein: proteolysis regulated by signaling pathways and protein trafficking

1 reference

12 December 2020

Modulation of amyloid precursor protein cleavage by cellular sphingolipids

1 reference

12 December 2020

Simvastatin affects cell motility and actin cytoskeleton distribution of microglia

1 reference

12 December 2020

Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity

1 reference

12 December 2020

Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease

1 reference

12 December 2020

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

1 reference

12 December 2020

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

1 reference

12 December 2020

Internalization of beta-amyloid peptide by primary neurons in the absence of apolipoprotein E.

1 reference

12 December 2020

Molecular biology and genetics of Alzheimer's disease

1 reference

12 December 2020

Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Abeta and insulin degradation

1 reference

12 December 2020

Lipid rafts as a membrane-organizing principle

1 reference

12 December 2020

Structural transitions associated with the interaction of Alzheimer beta-amyloid peptides with gangliosides.

1 reference

12 December 2020

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

1 reference

12 December 2020

Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology

1 reference

12 December 2020

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

1 reference

12 December 2020

The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted

1 reference

12 December 2020

Association between statin use and Alzheimer's disease

1 reference

12 December 2020

Cholesterol in Alzheimer's disease: unresolved questions.

1 reference

12 December 2020

Mutant human APP exacerbates pathology in a mouse model of NPC and its reversal by a β-cyclodextrin.

1 reference

12 December 2020

Joe Goldstein and Mike Brown: from cholesterol homeostasis to new paradigms in membrane biology

1 reference

12 December 2020

Lysosomal membrane damage in soluble Abeta-mediated cell death in Alzheimer's disease

1 reference

12 December 2020

Lipid rafts are primary mediators of amyloid oxidative attack on plasma membrane

1 reference

12 December 2020

Brain cholesterol in normal and pathological aging

1 reference

12 December 2020

Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

1 reference

12 December 2020

Tangle-bearing neurons contain more free cholesterol than adjacent tangle-free neurons.

1 reference

12 December 2020

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

1 reference

12 December 2020

The pathogenesis of senile plaques

1 reference

12 December 2020

Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism.

1 reference

12 December 2020

Cholesterol for synthesis of myelin is made locally, not imported into brain

1 reference

12 December 2020

The cholesterol transport inhibitor U18666a regulates amyloid precursor protein metabolism and trafficking in N2aAPP "Swedish" cells

1 reference

12 December 2020

The selective Alzheimer's disease indicator-1 gene (Seladin-1/DHCR24) is a liver X receptor target gene

1 reference

12 December 2020

Genotype and phenotype in Alzheimer's disease

1 reference

12 December 2020

Intronic CYP46 polymorphism along with ApoE genotype in sporadic Alzheimer Disease: from risk factors to disease modulators

1 reference

12 December 2020

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

1 reference

12 December 2020

Statins inhibit A beta-neurotoxicity in vitro and A beta-induced vasoconstriction and inflammation in rat aortae

1 reference

12 December 2020

Time course of biosynthetic cholesterol in the adult rat brain.

1 reference

12 December 2020

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

1 reference

12 December 2020

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

1 reference

12 December 2020

Membrane cholesterol content plays a key role in the neurotoxicity of β-amyloid: implications for Alzheimer's disease.

1 reference

12 December 2020

Apolipoprotein E receptors in the nervous system

1 reference

12 December 2020

Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis.

1 reference

12 December 2020

The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice.

1 reference

12 December 2020

MEGF10 functions as a receptor for the uptake of amyloid-β.

1 reference

12 December 2020

Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling

1 reference

12 December 2020

Novel N-terminal cleavage of APP precludes Abeta generation in ACAT-defective AC29 cells

1 reference

12 December 2020

10.1007/S12035-012-8337-Y

Identifiers

DOI

1 reference

Dimensions Publication ID

27 August 2017

1010996510

0 references

Fatcat ID

release_b7k5ho7ypndrfiu3kqk7huubi4

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/b7k5ho7ypndrfiu3kqk7huubi4

24 November 2022

mapped directly with Wikidata item

1 reference