(Q38263008)

1 September 2017

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title

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium (English)

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1 September 2017

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25

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1 September 2017

26

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1 September 2017

44

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1 September 2017

Dan Cojocari

47

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Marianne Koritzinsky

Marianne Koritzinsky

45

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Jochen Kieninger

Jochen Kieninger

19

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Kasper M Rouschop

Kasper M Rouschop

43

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Francesca M. Buffa

Francesca M Buffa

24

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Kjersti Flatmark

12

Kjersti Flatmark

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1 September 2017

33

Jan Alsner

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1 September 2017

13

Heidi Lyng

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1 September 2017

34

Jacques Pouyssegur

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1 September 2017

11

Anne H Ree

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1 September 2017

17

Agnes Görlach

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1 September 2017

2

Peter Ebbesen

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1 September 2017

4

Kaye J Williams

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1 September 2017

5

Ludwig Dubois

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1 September 2017

27

Claudiu T Supuran

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1 September 2017

32

Jens Overgaard

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1 September 2017

36

Nathalie Mazure

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1 September 2017

41

Silvia Pastorekova

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1 September 2017

46

Hilda Mujcic

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1 September 2017

Erik O Pettersen

1

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1 September 2017

Roben G Gieling

3

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1 September 2017

Philippe Lambin

6

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1 September 2017

Carol Ward

7

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1 September 2017

James Meehan

8

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1 September 2017

Ian H Kunkler

9

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1 September 2017

Simon P Langdon

10

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1 September 2017

Maria J Calzada

14

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1 September 2017

Luis Del Peso

15

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1 September 2017

Manuel O Landazuri

16

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1 September 2017

Hubert Flamm

18

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1 September 2017

Gerald Urban

20

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1 September 2017

Andreas Weltin

21

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1 September 2017

Dean C Singleton

22

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1 September 2017

Syed Haider

23

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1 September 2017

Isabella Moser

28

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1 September 2017

Gerhard Jobst

29

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1 September 2017

Morten Busk

30

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1 September 2017

Kasper Toustrup

31

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1 September 2017

Johanna Chiche

35

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1 September 2017

Ibtissam Marchiq

37

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1 September 2017

Scott Parks

38

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1 September 2017

Afshan Ahmed

39

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1 September 2017

Margaret Ashcroft

40

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1 September 2017

Yihai Cao

42

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1 September 2017

publication date

27 October 2014

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Journal of Enzyme Inhibition and Medicinal Chemistry

1 September 2017

published in

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1 September 2017

volume

30

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1 September 2017

issue

5

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1 September 2017

page(s)

689-721

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Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells

1 September 2017

cites work

1 reference

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Fluctuating and diffusion-limited hypoxia in hypoxia-induced metastasis

21 January 2018

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Defining normoxia, physoxia and hypoxia in tumours-implications for treatment response

21 January 2018

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The histological structure of some human lung cancers and the possible implications for radiotherapy

21 January 2018

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Hypoxia in cancer: significance and impact on clinical outcome

21 January 2018

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Hypoxia and hypoxia-inducible factors: master regulators of metastasis

21 January 2018

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Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Regulation of tumor initiation and metastatic progression by Eph receptor tyrosine kinases.

21 January 2018

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Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2.

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2014.966704

EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis

21 January 2018

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Autocrine stimulation of clear-cell renal carcinoma cell migration in hypoxia via HIF-independent suppression of thrombospondin-1.

21 January 2018

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A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Therapies using anti-angiogenic peptide mimetics of thrombospondin-1.

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Transient potential receptor channel 4 controls thrombospondin-1 secretion and angiogenesis in renal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Cooperativity of stress-responsive transcription factors in core hypoxia-inducible factor binding regions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

A role for insulator elements in the regulation of gene expression response to hypoxia

21 January 2018

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https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Carbonic anhydrase IX: regulation and role in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Phosphorylation of carbonic anhydrase IX controls its ability to mediate extracellular acidification in hypoxic tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Carbonic anhydrase IX interacts with bicarbonate transporters in lamellipodia and increases cell migration via its catalytic domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Carbonic anhydrase IX as an anticancer therapy target: preclinical evaluation of internalizing monoclonal antibody directed to catalytic domain

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Inhibition of carbonic anhydrase IX: a new strategy against cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

NDUFA4 is a subunit of complex IV of the mammalian electron transport chain

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxia signalling through mTOR and the unfolded protein response in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The hypoxic proteome is influenced by gene-specific changes in mRNA translation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The unfolded protein response: from stress pathway to homeostatic regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Two phases of disulfide bond formation have differing requirements for oxygen.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Protein folding and modification in the mammalian endoplasmic reticulum.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Regulation of autophagy by ATF4 in response to severe hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Autophagy is required during cycling hypoxia to lower production of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Patterns of somatic mutation in human cancer genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Comprehensive molecular portraits of human breast tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

New small molecule inhibitors of UPR activation demonstrate that PERK, but not IRE1α signaling is essential for promoting adaptation and survival to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Structural determinants of PERK inhibitor potency and selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The unfolded protein response signals through high-order assembly of Ire1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (P

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Pharmacological brake-release of mRNA translation enhances cognitive memory

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Superoxide flux in endothelial cells via the chloride channel-3 mediates intracellular signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Superoxide and derived reactive oxygen species in the regulation of hypoxia-inducible factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Trends in oxidative aging theories

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Redox signaling through NADPH oxidases: involvement in vascular proliferation and coagulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

NOX5 variants are functionally active in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Regulation of Nox and Duox enzymatic activity and expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Receptor activation of NADPH oxidases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The hypoxia-inducible factor-2alpha is stabilized by oxidative stress involving NOX4.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hepatocyte growth factor-activated NF-kappaB regulates HIF-1 activity and ODC expression, implicated in survival, differently in different carcinoma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Inhibition of endothelial nitric oxyde synthase increases capillary formation via Rac1-dependent induction of hypoxia-inducible factor-1α and plasminogen activator inhibitor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1 and NADPH oxidase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Aiding and abetting roles of NOX oxidases in cellular transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

NAD(P)H oxidases regulate HIF-2alpha protein expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Nox4 is critical for hypoxia-inducible factor 2-alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

JunD reduces tumor angiogenesis by protecting cells from oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Vitamin C is dispensable for oxygen sensing in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Regulation of HIF-1alpha at the transcriptional level

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Regulation of hypoxia-inducible factor-1alpha by NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The β3-integrin binding protein β3-endonexin is a novel negative regulator of hypoxia-inducible factor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Reciprocal regulation of Rac1 and PAK-1 by HIF-1alpha: a positive-feedback loop promoting pulmonary vascular remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The expression of the NADPH oxidase subunit p22phox is regulated by a redox-sensitive pathway in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Targeting mitochondria as a therapeutic target in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Functional integrity of nuclear factor kappaB, phosphatidylinositol 3'-kinase, and mitogen-activated protein kinase signaling allows tumor necrosis factor alpha-evoked Bcl-2 expression to provoke internal ribosome entry site-dependent translation of

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Stabilization of HIF-2α through redox regulation of mTORC2 activation and initiation of mRNA translation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

NADPH oxidase and heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

NADPH oxidases as a source of oxidative stress and molecular target in ischemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Intermittent hypoxia-induced cognitive deficits are mediated by NADPH oxidase activity in a murine model of sleep apnea

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

HIF-1 alpha signaling is augmented during intermittent hypoxia by induction of the Nrf2 pathway in NOX1-expressing adenocarcinoma A549 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

NADPH oxidase subunit 4 mediates cycling hypoxia-promoted radiation resistance in glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

NADPH oxidase 2 regulates bone marrow microenvironment following hindlimb ischemia: role in reparative mobilization of progenitor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Human urotensin II is a novel activator of NADPH oxidase in human pulmonary artery smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxic pulmonary hypertension: role of superoxide and NADPH oxidase (gp91phox).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Impact of mitochondria and NADPH oxidases on acute and sustained hypoxic pulmonary vasoconstriction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The NADPH oxidase subunit NOX4 is a new target gene of the hypoxia-inducible factor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Inhibition of reactive oxygen species by Lovastatin downregulates vascular endothelial growth factor expression and ameliorates blood-retinal barrier breakdown in db/db mice: role of NADPH oxidase 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Pericellular oxygen monitoring with integrated sensor chips for reproducible cell culture experiments.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Thin-film microbiosensors for glucose-lactate monitoring

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Destructive cycles: the role of genomic instability and adaptation in carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Oxidative stress and cancer: have we moved forward?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Free Radical Increases in Cancer: Evidence That There Is Not a Real Increase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Biosensors based on the energy metabolism of living cells: The physical chemistry and cell biology of extracellular acidification

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

A microphysiometer for simultaneous measurement of changes in extracellular glucose, lactate, oxygen, and acidification rate

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Non-invasive measurement of cell membrane associated proton gradients by ion-sensitive field effect transistor arrays for microphysiological and bioelectronical applications

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Simultaneous measurement of cellular respiration and acidification with a single CMOS ISFET.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Monitoring of cellular signalling and metabolism with modular sensor-technique: the PhysioControl-Microsystem (PCM).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Functional cellular assays with multiparametric silicon sensor chips

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Online monitoring of cell metabolism for studying pharmacodynamic effects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Cell culture monitoring for drug screening and cancer research: a transparent, microfluidic, multi-sensor microsystem

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The complete automation of cell culture: improvements for high-throughput and high-content screening

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Adapting Cell-Based Assays to the High Throughput Screening Platform: Problems Encountered and Lessons Learned

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Effect of microculture on cell metabolism and biochemistry: do cells get stressed in microchannels?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Development of a fed-batch culture process for enhanced production of recombinant human antithrombin by Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Bioprocess development for the production of mouse-human chimeric anti-epidermal growth factor receptor vIII antibody C12 by suspension culture of recombinant Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Biosensor arrays for simultaneous measurement of glucose, lactate, glutamate, and glutamine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Targeting the hypoxia-inducible factor (HIF) pathway in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Activation of a unique p53-dependent DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Live or let die: the cell's response to p53

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Growth factor-mediated induction of HDM2 positively regulates hypoxia-inducible factor 1alpha expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Nutlin-3 radiosensitizes hypoxic prostate cancer cells independent of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

MDM2 inhibitors for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1alpha and Hdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Treatment of kidney cancer: insights provided by the VHL tumor-suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The VHL/HIF axis in clear cell renal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

p53 stabilization and transactivation by a von Hippel-Lindau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Glycolysis inhibition for anticancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Cancer metastasis: building a framework

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Carbonic anhydrase IX, MN/CA IX: analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Interfering with pH regulation in tumours as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Selection of Carbonic Anhydrase IX Inhibitors from One Million DNA-Encoded Compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: a new concept of dual targeting drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Sensors and regulators of intracellular pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Disrupting proton dynamics and energy metabolism for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Carbon dioxide-sensing in organisms and its implications for human disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Monocarboxylate transporter MCT1 is a target for immunosuppression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Quantitative in vivo characterization of intracellular and extracellular pH profiles in heterogeneous tumors: a novel method enabling multiparametric pH analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Monocarboxylic acid transport

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Tumor-derived lactic acid modulates dendritic cell activation and antigen expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Recent developments in targeting carbonic anhydrase IX for cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in Vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Dithiocarbamates strongly inhibit the β-class carbonic anhydrases from Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Mouse models of advanced spontaneous metastasis for experimental therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

[18F]-FLT positron emission tomography can be used to image the response of sensitive tumors to PI3-kinase inhibition with the novel agent GDC-0941.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

A new mouse model for the study of human breast cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Carbonic anhydrase IX as a target for metastatic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Molecular aspects of tumour hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Expression of hypoxia-inducible factor 1 alpha in thyroid carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxia-induced metastasis model in embryonic zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Best practices in cancer nanotechnology: perspective from NCI nanotechnology alliance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

When failure should be the option

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Molecularly targeted cancer therapy: some lessons from the past decade

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

A primary xenograft model of small-cell lung cancer reveals irreversible changes in gene expression imposed by culture in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Tumour evolution inferred by single-cell sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Modelling glandular epithelial cancers in three-dimensional cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Unraveling the microenvironmental influences on the normal mammary gland and breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Distinctive alterations of invasiveness, drug resistance and cell-cell organization in 3D-cultures of MCF-7, a human breast cancer cell line, and its multidrug resistant variant

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Modeling tissue morphogenesis and cancer in 3D.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The third dimension bridges the gap between cell culture and live tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Modeling tissue-specific signaling and organ function in three dimensions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Three-dimensional neuroblastoma cell culture: proteomic analysis between monolayer and multicellular tumor spheroids

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Capturing complex 3D tissue physiology in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Multicellular tumor spheroids: an underestimated tool is catching up again.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Recent advances in three-dimensional multicellular spheroid culture for biomedical research

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Collagen density promotes mammary tumor initiation and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

A molecular signature of metastasis in primary solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Experimental anti-tumor therapy in 3-D: spheroids--old hat or new challenge?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Drug penetration in solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

What's wrong with our cancer models?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Guidelines for preclinical and early phase clinical assessment of novel radiosensitisers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Modelling breast cancer: one size does not fit all.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Contributions of human tumor xenografts to anticancer drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Gene expression profiles can predict panitumumab monotherapy responsiveness in human tumor xenograft models

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

How genetically engineered mouse tumor models provide insights into human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The mighty mouse: genetically engineered mouse models in cancer drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxia in models of lung cancer: implications for targeted therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Location, location, location-makes all the difference for hypoxia in lung tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Strategies for optimizing the response of cancer and normal tissues to radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Generation of a mouse model of Von Hippel-Lindau kidney disease leading to renal cancers by expression of a constitutively active mutant of HIF1α.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Global gene expression profiling confirms the molecular fidelity of primary tumor-based orthotopic xenograft mouse models of medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Molecular profiling of patient-derived breast cancer xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Genome remodelling in a basal-like breast cancer metastasis and xenograft

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Patient-derived tumor xenografts: transforming clinical samples into mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Targeting of Rac GTPases blocks the spread of intact human breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Short term culture of breast cancer tissues to study the activity of the anticancer drug taxol in an intact tumor environment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Tumor metastasis: mechanistic insights and clinical challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Cancer spread and micrometastasis development: quantitative approaches for in vivo models.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Patient-derived tumour xenografts as models for oncology drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Modeling and predicting clinical efficacy for drugs targeting the tumor milieu

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The APL paradigm and the "co-clinical trial" project

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The ESTRO Breur Lecture 2009. From population to voxel-based radiotherapy: exploiting intra-tumour and intra-organ heterogeneity for advanced treatment of non-small cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxia dose painting by numbers: a planning study.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxia imaging using Positron Emission Tomography in non-small cell lung cancer: implications for radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: results from the DAHANCA 24 trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

PET imaging of tumor hypoxia using 18F-labeled pimonidazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Preclinical evaluation and validation of [18F]HX4, a promising hypoxia marker for PET imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

PET imaging of hypoxia using [18F]HX4: a phase I trial

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxia imaging with [¹⁸F]HX4 PET in NSCLC patients: defining optimal imaging parameters.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Imaging hypoxia to improve radiotherapy outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Prospective technical validation and assessment of intra-tumour heterogeneity of a low density array hypoxia gene profile in head and neck squamous cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Approaching a state shift in Earth’s biosphere

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

A 26-gene hypoxia signature predicts benefit from hypoxia-modifying therapy in laryngeal cancer but not bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

hsa-miR-210 Is induced by hypoxia and is an independent prognostic factor in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Global microRNA expression profiling identifies MiR-210 associated with tumor proliferation, invasion and poor clinical outcome in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxia-induced gene expression in chemoradioresistant cervical cancer revealed by dynamic contrast-enhanced MRI.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxia-independent downregulation of hypoxia-inducible factor 1 targets by androgen deprivation therapy in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Androgen-dependent gene expression of prostate-specific antigen is enhanced synergistically by hypoxia in human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Prognostic significance of [18F]-misonidazole positron emission tomography-detected tumor hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine: a substudy of Trans-Tasman Radiation O

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Development of a hypoxia gene expression classifier with predictive impact for hypoxic modification of radiotherapy in head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Radiosensitivity and effect of hypoxia in HPV positive head and neck cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxia-regulated gene expression and prognosis in loco-regional gastroesophageal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The impact of O2 availability on human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Targeted therapies: how personal should we go?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Prediction of response to preoperative chemoradiotherapy in rectal cancer by multiplex kinase activity profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Tumor kinase activity in locally advanced rectal cancer: angiogenic signaling and early systemic dissemination

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Tumor phosphatidylinositol-3-kinase signaling and development of metastatic disease in locally advanced rectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypoxic tumor kinase signaling mediated by STAT5A in development of castration-resistant prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Differential inhibition of ex-vivo tumor kinase activity by vemurafenib in BRAF(V600E) and BRAF wild-type metastatic malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

An in vivo hypoxia metagene identifies the novel hypoxia inducible factor target gene SLCO1B3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Is high-dose stereotactic body radiotherapy (SBRT) for stage I non-small cell lung cancer (NSCLC) overkill? A systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Is there an oligometastatic state in non-small cell lung cancer? A systematic review of the literature

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Comparison of outcomes in patients with stage III versus limited stage IV non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The role of stereotactic ablative radiotherapy for early-stage and oligometastatic non-small cell lung cancer: evidence for changing paradigms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Hypofractionated image-guided radiation therapy for patients with limited volume metastatic non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

The impact of local and regional disease extent on overall survival in patients with advanced stage IIIB/IV non-small cell lung carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Oligometastases treated with stereotactic body radiotherapy: long-term follow-up of prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Stereotactic body radiotherapy for oligometastases.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Radical treatment of non-small-cell lung cancer patients with synchronous oligometastases: long-term results of a prospective phase II trial (Nct01282450).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Tumor angiogenesis: molecular pathways and therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Imaging and cancer: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Clinical cancer advances 2011: Annual Report on Progress Against Cancer from the American Society of Clinical Oncology.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

'Rapid Learning health care in oncology' - an approach towards decision support systems enabling customised radiotherapy'.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Clinical trials in the era of personalized oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Gene expression profiling in cervical cancer: an exploration of intratumor heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

415 patients with adenosquamous carcinoma of the pancreas: a population-based analysis of prognosis and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Predicting outcomes in radiation oncology--multifactorial decision support systems

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Development of a Novel Automated Cell Isolation, Expansion, and Characterization Platform

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Inhibition of carbonic anhydrase activity modifies the toxicity of doxorubicin and melphalan in tumour cellsin vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Relation of a Hypoxia Metagene Derived from Head and Neck Cancer to Prognosis of Multiple Cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Close and Stable Relationship between Proliferation and a Hypoxia Metagene in Aromatase Inhibitor-Treated ER-Positive Breast Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

microRNA-Associated Progression Pathways and Potential Therapeutic Targets Identified by Integrated mRNA and microRNA Expression Profiling in Breast Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Antiangiogenic Activity of the MDM2 Antagonist Nutlin-3

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

Dithiocarbamates are strong inhibitors of the beta-class fungal carbonic anhydrases from Cryptococcus neoformans, Candida albicans and Candida glabrata

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756366.2014.966704

10.3109/14756366.2014.966704

21 January 2018

Identifiers

DOI

1 reference

1 September 2017

1 reference