(Q38289023)

1 September 2017

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title

Epigenetics in T-cell acute lymphoblastic leukemia (English)

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1 September 2017

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Pieter Van Vlierberghe

7

object named as

Pieter Van Vlierberghe

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Frank Speleman

5

object named as

Frank Speleman

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1 September 2017

4

Tom Taghon

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1 September 2017

Inge Van de Walle

3

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author name string

Sofie Peirs

1

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1 September 2017

Joni Van der Meulen

2

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1 September 2017

Bruce Poppe

6

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1 September 2017

publication date

1 January 2015

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1 September 2017

published in

Immunological Reviews

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1 September 2017

volume

263

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1 September 2017

issue

1

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1 September 2017

page(s)

50-67

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Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?

1 September 2017

cites work

1 reference

A revised definition for cure of childhood acute lymphoblastic leukemia.

21 January 2018

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Modern therapy of acute lymphoblastic leukemia

21 January 2018

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Bone marrow transplants from HLA-identical siblings as compared with chemotherapy for children with acute lymphoblastic leukemia in a second remission.

21 January 2018

1 reference

Childhood T-Cell Acute Lymphoblastic Leukemia: The Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium Experience

21 January 2018

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The molecular basis of T cell acute lymphoblastic leukemia

21 January 2018

1 reference

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

21 January 2018

1 reference

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

21 January 2018

1 reference

Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia.

21 January 2018

1 reference

HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL).

21 January 2018

1 reference

Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia

21 January 2018

1 reference

ETV6 mutations in early immature human T cell leukemias

21 January 2018

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Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors.

21 January 2018

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The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

21 January 2018

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The clonal evolution of leukemic stem cells in T-cell acute lymphoblastic leukemia.

21 January 2018

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The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes.

21 January 2018

1 reference

DNA methylation and chromatin - unraveling the tangled web.

21 January 2018

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Functions of DNA methylation: islands, start sites, gene bodies and beyond

21 January 2018

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Maintenance of DNA methylation: Dnmt3b joins the dance.

21 January 2018

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DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

21 January 2018

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DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells

21 January 2018

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DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.

21 January 2018

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Comprehensive methylome map of lineage commitment from haematopoietic progenitors

21 January 2018

1 reference

A decade of exploring the cancer epigenome - biological and translational implications

21 January 2018

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Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia

21 January 2018

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HSC commitment-associated epigenetic signature is prognostic in acute myeloid leukemia

21 January 2018

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Promoter DNA methylation pattern identifies prognostic subgroups in childhood T-cell acute lymphoblastic leukemia

21 January 2018

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The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL.

21 January 2018

1 reference

A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia

21 January 2018

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Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations

21 January 2018

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Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia

21 January 2018

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Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia

21 January 2018

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DNMT3A Mutations in Acute Myeloid Leukemia

21 January 2018

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Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation

21 January 2018

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Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

21 January 2018

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The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers

21 January 2018

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Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

21 January 2018

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Dnmt3a is essential for hematopoietic stem cell differentiation

21 January 2018

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Large conserved domains of low DNA methylation maintained by Dnmt3a

21 January 2018

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High DNA methyltransferase DNMT3B levels: a poor prognostic marker in acute myeloid leukemia

21 January 2018

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Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis

21 January 2018

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Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins

21 January 2018

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DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis.

21 January 2018

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Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine

21 January 2018

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Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

21 January 2018

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Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

21 January 2018

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Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.

21 January 2018

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Acquired mutations in TET2 are common in myelodysplastic syndromes

21 January 2018

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Mutation in TET2 in myeloid cancers

21 January 2018

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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

21 January 2018

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Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

21 January 2018

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High accuracy mutation detection in leukemia on a selected panel of cancer genes

21 January 2018

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The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases

21 January 2018

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Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value

21 January 2018

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IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication

21 January 2018

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

21 January 2018

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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

21 January 2018

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IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

21 January 2018

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Isocitrate dehydrogenase (IDH)2 R140Q mutation induces myeloid and lymphoid neoplasms in mice.

21 January 2018

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IDH1 and IDH2 mutations in pediatric acute leukemia

21 January 2018

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Mutation analysis of isocitrate dehydrogenase in acute lymphoblastic leukemia

21 January 2018

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Functions of site-specific histone acetylation and deacetylation

21 January 2018

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Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.

21 January 2018

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CREBBP mutations in relapsed acute lymphoblastic leukaemia

21 January 2018

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Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family

21 January 2018

1 reference

ETV6-NCOA2: a novel fusion gene in acute leukemia associated with coexpression of T-lymphoid and myeloid markers and frequent NOTCH1 mutations.

21 January 2018

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MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function

21 January 2018

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Differential expression of HDAC3, HDAC7 and HDAC9 is associated with prognosis and survival in childhood acute lymphoblastic leukaemia

21 January 2018

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The expression of histone deacetylase 4 is associated with prednisone poor-response in childhood acute lymphoblastic leukemia

21 January 2018

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Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice

21 January 2018

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Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

21 January 2018

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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

21 January 2018

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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

21 January 2018

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Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1-driven T cell acute lymphoblastic leukemia

21 January 2018

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The H3K27me3 demethylase UTX in normal development and disease

21 January 2018

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Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

21 January 2018

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Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

21 January 2018

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MLL: a histone methyltransferase disrupted in leukemia

21 January 2018

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Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation.

21 January 2018

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A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias

21 January 2018

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CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes.

21 January 2018

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The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia

21 January 2018

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H3K79 methylation profiles define murine and human MLL-AF4 leukemias

21 January 2018

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Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l.

21 January 2018

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hDOT1L links histone methylation to leukemogenesis

21 January 2018

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DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis

21 January 2018

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Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L

21 January 2018

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Understanding the language of Lys36 methylation at histone H3.

21 January 2018

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Identification of functional cooperative mutations of SETD2 in human acute leukemia

21 January 2018

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Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia

21 January 2018

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Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia

21 January 2018

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Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies

21 January 2018

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Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP

21 January 2018

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Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

21 January 2018

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GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7

21 January 2018

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Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1

21 January 2018

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The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

21 January 2018

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Mutations in PHF6 are associated with Börjeson-Forssman-Lehmann syndrome

21 January 2018

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PHF6 mutations in T-cell acute lymphoblastic leukemia

21 January 2018

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Mutations of PHF6 are associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214 in T-cell acute lymphoblastic leukemia

21 January 2018

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A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).

21 January 2018

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MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia

21 January 2018

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T-cell acute lymphoblastic leukemia in association with Börjeson-Forssman-Lehmann syndrome due to a mutation in PHF6.

21 January 2018

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PHF6 mutations in adult acute myeloid leukemia

21 January 2018

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Detection of an activated JAK3 variant and a Xq26.3 microdeletion causing loss of PHF6 and miR-424 expression in myelodysplastic syndromes by combined targeted next generation sequencing and SNP array analysis.

21 January 2018

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Somatic mutations of PHF6 in patients with chronic myeloid leukemia in blast crisis

21 January 2018

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Somatic mutation of PHF6 gene in T-cell acute lymphoblatic leukemia, acute myelogenous leukemia and hepatocellular carcinoma

21 January 2018

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Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis

21 January 2018

1 reference

Structural and functional insights into the human Börjeson-Forssman-Lehmann syndrome-associated protein PHF6.

21 January 2018

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PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex

21 January 2018

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Cancer biology and NuRD: a multifaceted chromatin remodelling complex

21 January 2018

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The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development

21 January 2018

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Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression

21 January 2018

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A comprehensive molecular study on Coffin-Siris and Nicolaides-Baraitser syndromes identifies a broad molecular and clinical spectrum converging on altered chromatin remodeling.

21 January 2018

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Numerous BAF complex genes are mutated in Coffin-Siris syndrome.

21 January 2018

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The SWI/SNF complex--chromatin and cancer.

21 January 2018

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The X-linked intellectual disability protein PHF6 associates with the PAF1 complex and regulates neuronal migration in the mammalian brain.

21 January 2018

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PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis

21 January 2018

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Bromodomains as therapeutic targets

21 January 2018

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Master transcription factors and mediator establish super-enhancers at key cell identity genes

21 January 2018

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Super-enhancers in the control of cell identity and disease

21 January 2018

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Selective inhibition of tumor oncogenes by disruption of super-enhancers

21 January 2018

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NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers

21 January 2018

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The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability

21 January 2018

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Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer

21 January 2018

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5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy

21 January 2018

1 reference

Decitabine in patients with newly diagnosed and relapsed acute myeloid leukemia

21 January 2018

1 reference

Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia

21 January 2018

1 reference

Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia

21 January 2018

1 reference

DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia

21 January 2018

1 reference

Zebularine induces chemosensitization to methotrexate and efficiently decreases AhR gene methylation in childhood acute lymphoblastic leukemia cells

21 January 2018

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Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

21 January 2018

1 reference

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

21 January 2018

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IDH1 and IDH2 mutations in gliomas

21 January 2018

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A vaccine targeting mutant IDH1 induces antitumour immunity

21 January 2018

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Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML.

21 January 2018

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Hyper-activation of WNT/β-catenin signaling pathway mediates anti-tumor effects of histone deacetylase inhibitors in acute T lymphoblastic leukemia

21 January 2018

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The histone deacetylase inhibitor AN-9 has selective toxicity to acute leukemia and drug-resistant primary leukemia and cancer cell lines

21 January 2018

1 reference

Therapeutic targeting of c-Myc in T-cell acute lymphoblastic leukemia, T-ALL

21 January 2018

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Histone deacetylase inhibitors potently repress CXCR4 chemokine receptor expression and function in acute lymphoblastic leukaemia

21 January 2018

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New and emerging HDAC inhibitors for cancer treatment

21 January 2018

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A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

21 January 2018

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Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

21 January 2018

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Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

21 January 2018

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Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75).

21 January 2018

1 reference

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

21 January 2018

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Validation and structural characterization of the LEDGF/p75-MLL interface as a new target for the treatment of MLL-dependent leukemia

21 January 2018

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The mechanisms behind the therapeutic activity of BET bromodomain inhibition

21 January 2018

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Targeting bromodomains: epigenetic readers of lysine acetylation

21 January 2018

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c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

21 January 2018

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Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia.

21 January 2018

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Targeting MYCN in neuroblastoma by BET bromodomain inhibition

21 January 2018

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BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia

21 January 2018

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An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

21 January 2018

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Developmental gene networks: a triathlon on the course to T cell identity

21 January 2018

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The chromatin landscape and transcription factors in T cell programming

21 January 2018

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The role of mutations in epigenetic regulators in myeloid malignancies

21 January 2018

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Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

21 January 2018

1 reference

Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia

21 January 2018

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TAL1/SCL is downregulated upon histone deacetylase inhibition in T-cell acute lymphoblastic leukemia cells

21 January 2018

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Involvement of the MLL gene in T-lineage acute lymphoblastic leukemia

21 January 2018

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Adult T-cell progenitors retain myeloid potential

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/IMR.12237

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1 September 2017

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