(Q38704713)

English

Pharmacological targeting of the HIF hydroxylases--A new field in medicine development

scientific article

In more languages

edit

Statements

instance of

scholarly article

1 reference

stated in

Europe PubMed Central

5 September 2017

Pharmacological targeting of the HIF hydroxylases--A new field in medicine development (English)

1 reference

stated in

Europe PubMed Central

5 September 2017

Christopher J. Schofield

series ordinal

3

1 reference

stated in

Europe PubMed Central

5 September 2017

4

1 reference

stated in

Europe PubMed Central

5 September 2017

1

Mun Chiang Chan

1 reference

stated in

Europe PubMed Central

5 September 2017

2

James P Holt-Martyn

1 reference

stated in

Europe PubMed Central

5 September 2017

11 January 2016

1 reference

stated in

Europe PubMed Central

5 September 2017

Molecular Aspects of Medicine

1 reference

stated in

Europe PubMed Central

5 September 2017

47-48

1 reference

stated in

Europe PubMed Central

5 September 2017

54-75

1 reference

stated in

Europe PubMed Central

5 September 2017

PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192

1 reference

2 April 2022

https://opencitations.net/index/coci/api/v1/citations/10.1016/J.DEVCEL.2013.06.014

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/20459

Synopsis of some recent tactical application of bioisosteres in drug design

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Analysis of HIF-prolyl hydroxylases binding to substrates

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Factor inhibiting HIF (FIH) recognizes distinct molecular features within hypoxia-inducible factor-α (HIF-α) versus ankyrin repeat substrates

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Mutations to metabolic enzymes in cancer herald a need to unify genetics and biochemistry.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Inhibition of prolyl hydroxylation and procollagen processing in chick-embryo calvaria by a derivative of pyridine-2,4-dicarboxylate. Characterization of the diethyl ester as a proinhibitor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Secondary analysis of the CHOIR trial epoetin-alpha dose and achieved hemoglobin outcomes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Co-localization of erythropoietin mRNA and ecto-5'-nucleotidase immunoreactivity in peritubular cells of rat renal cortex indicates that fibroblasts produce erythropoietin

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Structural studies on human 2-oxoglutarate dependent oxygenases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Short-term treatment with a novel HIF-prolyl hydroxylase inhibitor (GSK1278863) failed to improve measures of performance in subjects with claudication-limited peripheral artery disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Expanding role of the jumonji C domain as an RNA hydroxylase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

A nonradioactive 96-well plate assay for the detection of hypoxia-inducible factor prolyl hydroxylase activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Erythropoietic effect of cobalt in patients with or without anemia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Increased Turnover at Limiting O2 Concentrations by the Thr(387) → Ala Variant of HIF-Prolyl Hydroxylase PHD2.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Selective inhibition of factor inhibiting hypoxia-inducible factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

From toxicological problem to therapeutic use: the discovery of the mode of action of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC), its toxicology and development as a drug

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Oxygen sensing by HIF hydroxylases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

An oxygen-regulated switch in the protein synthesis machinery

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Anaemia in kidney disease: harnessing hypoxia responses for therapy

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Non-heme Fe(IV)-oxo intermediates

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Plasticity of renal erythropoietin-producing cells governs fibrosis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Inverse solvent isotope effects demonstrate slow aquo release from hypoxia inducible factor-prolyl hydroxylase (PHD2)

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

The effect of altitude on dosing and response to erythropoietin in ESRD

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

TRPA1 underlies a sensing mechanism for O2.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Effect of food and gemfibrozil on the pharmacokinetics of the novel prolyl hydroxylase inhibitor GSK1278863.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Epidermal or dermal specific knockout of PHD-2 enhances wound healing and minimizes ischemic injury.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Intracellular pathogen Leishmania donovani activates hypoxia inducible factor-1 by dual mechanism for survival advantage within macrophage

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Hypoxia signalling in cancer and approaches to enforce tumour regression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Pan-genomic binding of hypoxia-inducible transcription factors

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Inhibition of the catalytic activity of hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2 by a MYND-type zinc finger

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Targeting histone lysine demethylases - progress, challenges, and the future

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Inhibition of 2-oxoglutarate dependent oxygenases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Role of hypoxia inducible factor-1 in keratinocyte inflammatory response and neutrophil recruitment

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Prolyl hydroxylase domain protein 2 regulates the intracellular cyclic AMP level in cardiomyocytes through its interaction with phosphodiesterase 4D

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Hyporesponsiveness to recombinant human erythropoietin

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Interdependence of hypoxic and innate immune responses

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Structural integration in hypoxia-inducible factors

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation-induced anaemia in rats

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Regulation of cellular levels of Sprouty2 protein by prolyl hydroxylase domain and von Hippel-Lindau proteins

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Randomized placebo-controlled dose-ranging and pharmacodynamics study of roxadustat (FG-4592) to treat anemia in nondialysis-dependent chronic kidney disease (NDD-CKD) patients

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Hypoxia-inducible factors link iron homeostasis and erythropoiesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Regulation of histone methylation by demethylimination and demethylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Cardiovascular toxicity of epoetin-alfa in patients with chronic kidney disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Different modes of inhibitor binding to prolyl hydroxylase by combined use of X-ray crystallography and NMR spectroscopy of paramagnetic complexes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Regulation of the HIV-1 promoter by HIF-1α and Vpr proteins

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Expanding chemical biology of 2-oxoglutarate oxygenases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

A fluorescence polarization-based interaction assay for hypoxia-inducible factor prolyl hydroxylases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Oxygen tension level and human viral infections.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Structural and mechanistic studies on γ-butyrobetaine hydroxylase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Stabilization of hypoxia inducible factor rather than modulation of collagen metabolism improves cardiac function after acute myocardial infarction in rats

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Gene regulation in response to graded hypoxia: the non-redundant roles of the oxygen sensors PHD and FIH in the HIF pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Treatment of sickle cell anemia with cobalt chloride

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Assay for 2-oxoglutarate decarboxylating enzymes based on the determination of [1-14C]succinate: application to prolyl 4-hydroxylase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Activation of hypoxia-inducible factor-1 in bacillary angiomatosis: evidence for a role of hypoxia-inducible factor-1 in bacterial infections

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

A randomized controlled study of iron supplementation in patients treated with erythropoietin

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

JmjC-domain-containing proteins and histone demethylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Inhibition of HIF prolyl-4-hydroxylases by FG-4497 reduces brain tissue injury and edema formation during ischemic stroke

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Ischemia and reperfusion--from mechanism to translation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Regulation of erythropoiesis by hypoxia-inducible factors

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence resonance energy transfer-based assay technology

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Erythropoiesis-stimulating agents--time for a reevaluation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

HIF2α signaling inhibits adherens junctional disruption in acute lung injury.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Elongation Factor 2 Kinase Is Regulated by Proline Hydroxylation and Protects Cells during Hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Prolyl 4-hydroxylases, master regulators of the hypoxia response

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

The interstitial response to renal injury: Fibroblast–like cells show phenotypic changes and have reduced potential for erythropoietin gene expression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Asparaginyl beta-hydroxylation of proteins containing ankyrin repeat domains influences their stability and function.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Structural basis for inhibition of the fat mass and obesity associated protein (FTO)

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Prolyl hydroxylase domain protein 3 targets Pax2 for destruction

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional alpha-KG-dependent non-heme iron enzyme: correlation with mechanisms and reactivities

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

A microRNA signature of hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Treatment of hereditary tyrosinaemia type I by inhibition of 4-hydroxyphenylpyruvate dioxygenase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

A lactate-induced response to hypoxia.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Hypoxia and inflammation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Regulation of erythropoietin production

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Monoclonal antibody-based screening assay for factor inhibiting hypoxia-inducible factor inhibitors

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Stabilization of HIF-2α induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth in a murine melanoma model

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

3-(2,2,2-Trimethylhydrazinium)propionate (THP)--a novel gamma-butyrobetaine hydroxylase inhibitor with cardioprotective properties

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Pharmacological characterization of 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxia-inducible factor prolyl hydroxylase inhibitor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

In vitro inhibition of collagen formation by 2,4-pyridine dicarboxylate and minoxidil in rabbit corneal fibroblasts

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

4-Hydroxyphenylpyruvate dioxygenase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Topical prolyl hydroxylase domain-2 silencing improves diabetic murine wound closure

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Loss of epithelial hypoxia-inducible factor prolyl hydroxylase 2 accelerates skin wound healing in mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

HIF hydroxylase pathways in cardiovascular physiology and medicine

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Oral delivery of prolyl hydroxylase inhibitor: AKB-4924 promotes localized mucosal healing in a mouse model of colitis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Identification of the renal erythropoietin-producing cells using transgenic mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

A fluorescence-based assay for 2-oxoglutarate-dependent oxygenases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.MAM.2016.01.001

Identifiers

DOI

10.1016/J.MAM.2016.01.001

1 reference

stated in

Europe PubMed Central

5 September 2017

1 reference

Europe PubMed Central

PubMed ID

26791432

retrieved

5 September 2017

(Q38704713)

Pharmacological targeting of the HIF hydroxylases--A new field in medicine development

Statements

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)