(Q38982458)

8 September 2017

1 reference

title

Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes (English)

1 reference

8 September 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27748555%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Luke Leman

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27748555%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Christian A. Olsen

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27748555%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

author name string

Helle M E Kristensen

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27748555%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

M Reza Ghadiri

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27748555%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

publication date

17 October 2016

1 reference

8 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27748555%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

volume

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27748555%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27748555%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

page(s)

5-49

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27748555%20AND%20SRC:MED&resulttype=core&format=json

ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS

2 June 2020

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The many roles of histone deacetylases in development and physiology: implications for disease and therapy

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Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis.

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Histone deacetylases (HDACs): characterization of the classical HDAC family

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Recent progress in the biology and physiology of sirtuins

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The multifaceted functions of sirtuins in cancer

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Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex

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HDAC3: taking the SMRT-N-CoRrect road to repression

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Insights into the Recruitment of Class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR Transcriptional Repression Complex

21 January 2018

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Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR

21 January 2018

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Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo

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Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

21 January 2018

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21 January 2018

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Structural Basis of the Antiproliferative Activity of Largazole, a Depsipeptide Inhibitor of the Histone Deacetylases

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Total synthesis of bicyclic depsipeptides spiruchostatins C and D and investigation of their histone deacetylase inhibitory and antiproliferative activities

21 January 2018

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Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from Burkholderia thailandensis E264.

21 January 2018

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21 January 2018

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Identification of thiols and glutathione conjugates of depsipeptide FK228 (FR901228), a novel histone protein deacetylase inhibitor, in the blood

21 January 2018

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Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities.

21 January 2018

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Histone deacetylase inhibitors from Burkholderia thailandensis

21 January 2018

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Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A.

21 January 2018

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Total synthesis of the bicyclic depsipeptide HDAC inhibitors spiruchostatins A and B, 5''-epi-spiruchostatin B, FK228 (FR901228) and preliminary evaluation of their biological activity

21 January 2018

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Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs

21 January 2018

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Total synthesis of burkholdacs A and B and 5,6,20-tri-epi-burkholdac A: HDAC inhibition and antiproliferative activity.

21 January 2018

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Total synthesis and stereochemical assignment of burkholdac B, a depsipeptide HDAC inhibitor.

21 January 2018

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21 January 2018

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21 January 2018

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Total synthesis and molecular target of largazole, a histone deacetylase inhibitor

21 January 2018

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Contemporary strategies for peptide macrocyclization

21 January 2018

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Functional characterization and manipulation of the apicidin biosynthetic pathway in Fusarium semitectum

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21 January 2018

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Chemical phylogenetics of histone deacetylases

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Discovery of HDAC Inhibitors That Lack an Active Site Zn(2+)-Binding Functional Group.

21 January 2018

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Synthesis and biological activity of largazole and derivatives

21 January 2018

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Aminosäuren und peptide - XXXXII. Synthese von Chlamydocin + epi-Chlamydocin

21 January 2018

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A concise total synthesis of largazole, solution structure, and some preliminary structure activity relationships

21 January 2018

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Enantioselective total synthesis of (+)-largazole, a potent inhibitor of histone deacetylase

21 January 2018

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Total synthesis and biological evaluation of largazole and derivatives with promising selectivity for cancers cells

21 January 2018

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Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues

21 January 2018

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Concise total synthesis of largazole

21 January 2018

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Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: application of N-heterocyclic carbene mediated acylations in complex molecule synthesis

21 January 2018

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Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation

21 January 2018

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Improved total synthesis of the potent HDAC inhibitor FK228 (FR-901228)

21 January 2018

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Macrolactamization versus macrolactonization: total synthesis of FK228, the depsipeptide histone deacetylase inhibitor.

21 January 2018

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Total synthesis of Spiruchostatin A via chemoselective macrocyclization using an accessible enantiomerically pure latent thioester

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21 January 2018

NEW ALDOL TYPE REACTION

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An effective use of benzoic anhydride and its derivatives for the synthesis of carboxylic esters and lactones: a powerful and convenient mixed anhydride method promoted by basic catalysts

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A Stereoselective Synthesis oftrans-1,2-Disubstituted Alkenes Based on the Condensation of Aldehydes with Metallated 1-Phenyl-1H-tetrazol-5-yl Sulfones

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Oxidation of alcohols by “activated” dimethyl sulfoxide. a preparative, steric and mechanistic study

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Catalytic, Enantioselective Aldol Additions with Methyl and Ethyl Acetate O-Silyl Enolates: A Chiral Tridentate Chelate as a Ligand for Titanium(IV)

21 January 2018

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N-methoxy-n-methylamides as effective acylating agents

21 January 2018

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The Catalyst Precursor, Catalyst, and Intermediate in the RuII-Promoted Asymmetric Hydrogen Transfer between Alcohols and Ketones

21 January 2018

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Zur Reaktionsweise des Pentaphenyl-phosphors und einiger Derivate

21 January 2018

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Synthesis of proteins by native chemical ligation

21 January 2018

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The Utility of Phosphonate Carbanions in Olefin Synthesis

21 January 2018

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Darstellung organischer Jodide aus den entsprechenden Bromiden und Chloriden

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Kinetic resolution of racemic allylic alcohols by enantioselective epoxidation. A route to substances of absolute enantiomeric purity?

21 January 2018

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Über Umlagerung von Phenol-allyläthern inC-Allyl-phenole

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Ueber ein Kondensationsprodukt aus Formaldehyd, Ammoniak und Antipyrin

21 January 2018

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Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases

21 January 2018

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Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold

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Synthesis and activity of largazole analogues with linker and macrocycle modification

21 January 2018

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Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups

21 January 2018

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Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties

21 January 2018

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Synthesis and biological evaluation of c7-demethyl largazole analogues

21 January 2018

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Biological evaluation of new largazole analogues: alteration of macrocyclic scaffold with click chemistry

21 January 2018

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Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole

21 January 2018

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Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole

21 January 2018

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Comparative pharmacokinetic properties and antitumor activity of the marine HDACi Largazole and Largazole peptide isostere

21 January 2018

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Evaluation of class I HDAC isoform selectivity of largazole analogues

21 January 2018

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Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor.

21 January 2018

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Largazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1)

21 January 2018

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Total synthesis of (18S)- and (18R)-homolargazole by rhodium-catalyzed hydrocarboxylation.

21 January 2018

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FK228 Analogues Induce Fetal Hemoglobin in Human Erythroid Progenitors

21 January 2018

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Synthesis and biological evaluation of novel FK228 analogues as potential isoform selective HDAC inhibitors.

21 January 2018

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Romidepsin (FK228) and its analogs directly inhibit phosphatidylinositol 3-kinase activity and potently induce apoptosis as histone deacetylase/phosphatidylinositol 3-kinase dual inhibitors

21 January 2018

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The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor

21 January 2018

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Biochemical, biological and structural properties of romidepsin (FK228) and its analogs as novel HDAC/PI3K dual inhibitors

21 January 2018

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Efficient solid-phase synthesis of FK228 analogues as potent antitumoral agents

21 January 2018

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Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones

21 January 2018

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Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides

21 January 2018

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Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework.

21 January 2018

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Cyclic tetrapeptides bearing a sulfhydryl group potently inhibit histone deacetylases.

21 January 2018

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Synthesis, evaluation and molecular modeling of cyclic tetrapeptide histone deacetylase inhibitors as anticancer agents

21 January 2018

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Discovery of potent HDAC inhibitors based on chlamydocin with inhibitory effects on cell migration.

21 January 2018

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Cyclic tetrapeptides with -SS- bridging between amino acid side chains for potent histone deacetylases' inhibition

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Bicyclic tetrapeptides as potent HDAC inhibitors: effect of aliphatic loop position and hydrophobicity on inhibitory activity.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201600519

Chlamydocin-hydroxamic acid analogues as histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Toward an HDAC6 inhibitor: synthesis and conformational analysis of cyclic hexapeptide hydroxamic acid designed from alpha-tubulin sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

CHAP31 induces apoptosis only via the intrinsic pathway in human esophageal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Impact of novel histone deacetylase inhibitors, CHAP31 and FR901228 (FK228), on adenovirus-mediated transgene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Histone deacetylase inhibitors preferentially augment transient transgene expression in human dermal fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor MI-192.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Macrocyclic peptoid-Peptide hybrids as inhibitors of class I histone deacetylases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Solution, solid phase and computational structures of apicidin and its backbone-reduced analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Probing the bioactive conformation of an archetypal natural product HDAC inhibitor with conformationally homogeneous triazole-modified cyclic tetrapeptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Protein prosthesis: 1,5-disubstituted[1,2,3]triazoles as cis-peptide bond surrogates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Non-peptide macrocyclic histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Non-peptide macrocyclic histone deacetylase inhibitors derived from tricyclic ketolide skeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

A structure-activity relationship study of the antimalarial and antileishmanial activities of nonpeptide macrocyclic histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Non-natural macrocyclic inhibitors of histone deacetylases: design, synthesis, and activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Design and synthesis of a potent histone deacetylase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Synthesis, molecular docking and biological evaluation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

A cyclodextrin-capped histone deacetylase inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Surfactants in membrane solubilisation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Stability and equilibria of promiscuous aggregates in high protein milieus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Bispyridinium dienes: histone deacetylase inhibitors with selective activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Variable active site loop conformations accommodate the binding of macrocyclic largazole analogues to HDAC8

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Conformationally homogeneous cyclic tetrapeptides: useful new three-dimensional scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Beta2-amino acids in the design of conformationally homogeneous cyclo-peptide scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Innovative Strategies for Selective Inhibition of Histone Deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Inside HDACs with more selective HDAC inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Constraining cyclic peptides to mimic protein structure motifs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Direct comparison of linear and macrocyclic compound libraries as a source of protein ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Macrocycles: lessons from the distant past, recent developments, and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Quantitative comparison of the relative cell permeability of cyclic and linear peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

N-methylation of peptides: a new perspective in medicinal chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Evaluation of functional groups on amino acids in cyclic tetrapeptides in histone deacetylase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Total Synthesis of Azumamide E and Sugar Amino Acid-Containing Analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Bicyclic peptides as potent inhibitors of histone deacetylases: Optimization of alkyl loop length

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

The synthesis of cyclic tetrapeptoid analogues of the antiprotozoal natural product apicidin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Subunit structure of chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201600519

Diheteropeptin, a new substance with TGF-beta-like activity, produced by a fungus, Diheterospora chlamydosporia. I. Production, isolation and biological activities

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.53.788

Phoenistatin, a new gene expression-enhancing substance produced by Acremonium fusigerum

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.54.187

FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.47.301

Isolation and structural elucidation of new cyclotetrapeptides, trapoxins A and B, having detransformation activities as antitumor agents.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.43.1524

Identifiers

DOI

10.1002/CBIC.201600519

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27748555%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1 reference