(Q47878052)

http://europepmc.org/abstract/MED/27021818

6 February 2018

title

Alzheimer disease: modeling an Aβ-centered biological network. (English)

1 reference

http://europepmc.org/abstract/MED/27021818

6 February 2018

0 references

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27021818%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Kilan Le Guennec

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27021818%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

author name string

D Campion

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27021818%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

C Pottier

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27021818%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

A Rovelet-Lecrux

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27021818%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

language of work or name

English

0 references

publication date

29 March 2016

1 reference

http://europepmc.org/abstract/MED/27021818

6 February 2018

published in

Molecular Psychiatry

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27021818%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

volume

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27021818%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27021818%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

page(s)

861-871

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27021818%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/mp.2016.38

2 June 2020

exact match

0 references

cites work

Frontotemporal dementia with parkinsonism linked to chromosome 17 with the MAPT R406W mutation presenting with a broad distribution of abundant senile plaques.

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A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model

21 January 2018

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Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

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A beta oligomers - a decade of discovery

21 January 2018

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Neuropathological stageing of Alzheimer-related changes

21 January 2018

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https://api.crossref.org/works/10.1038%2FMP.2016.38

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FMP.2016.38

Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FMP.2016.38

Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Neurodegenerative lesions: seeding and spreading

21 January 2018

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https://api.crossref.org/works/10.1038%2FMP.2016.38

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

APOE and Alzheimer disease: a major gene with semi-dominant inheritance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Pathway-based approaches for sequencing-based genome-wide association studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

The contribution of de novo coding mutations to autism spectrum disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

De novo deleterious genetic variations target a biological network centered on Aβ peptide in early-onset Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Trafficking and proteolytic processing of APP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Alzheimer culprits: cellular crossroads and interplay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Homer2 and Homer3 interact with amyloid precursor protein and inhibit Abeta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Interaction between amyloid precursor protein and Nogo receptors regulates amyloid deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

SCG10 promotes non-amyloidogenic processing of amyloid precursor protein by facilitating its trafficking to the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Beta-amyloid precursor protein cleavage by a membrane-bound protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Identification and biology of α-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Maturation and pro-peptide cleavage of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aβ production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Deficiency of the copper chaperone for superoxide dismutase increases amyloid-β production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Structural biology of presenilin 1 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

The ubiquitin ligase synoviolin up-regulates amyloid β production by targeting a negative regulator of γ-secretase, Rer1, for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

TMP21 transmembrane domain regulates gamma-secretase cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Membrane rafts in Alzheimer's disease beta-amyloid production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Mechanisms of disease: new therapeutic strategies for Alzheimer's disease--targeting APP processing in lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

DISC1 regulates trafficking and processing of APP and Aβ generation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Neuronal clearance of amyloid-β by endocytic receptor LRP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Metabolic regulation of brain Abeta by neprilysin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Degradation of soluble and fibrillar amyloid beta-protein by matrix metalloproteinase (MT1-MMP) in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Endothelin-converting enzymes degrade intracellular β-amyloid produced within the endosomal/lysosomal pathway and autophagosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Glutamate carboxypeptidase II: an amyloid peptide-degrading enzyme with physiological function in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Identification of BACE2 as an avid ß-amyloid-degrading protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

The role of microglia in amyloid clearance from the AD brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Innate immunity in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Complement receptor 1 (CR1) and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Neuroinflammation in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Progranulin mutations as risk factors for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

ABCA7 in Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Parkin promotes intracellular Abeta1-42 clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Transglutaminase induces protofibril-like amyloid beta-protein assemblies that are protease-resistant and inhibit long-term potentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Sequestration of toxic oligomers by HspB1 as a cytoprotective mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Small heat shock proteins inhibit amyloid-beta protein aggregation and cerebrovascular amyloid-beta protein toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Agrin binds to beta-amyloid (Abeta), accelerates abeta fibril formation, and is localized to Abeta deposits in Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Butyrylcholinesterase attenuates amyloid fibril formation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Mechanisms of transthyretin inhibition of β-amyloid aggregation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Clusterin: a forgotten player in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Alpha2-macroglobulin associates with beta-amyloid peptide and prevents fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Cystatin C modulates cerebral beta-amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Alpha 1-antichymotrypsin regulates Alzheimer beta-amyloid peptide fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Cross-seeding effects of amyloid β-protein and α-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

TDP-43 is a key player in the clinical features associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Tau is essential to beta -amyloid-induced neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Src kinases: a hub for NMDA receptor regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Tau aggregation and its interplay with amyloid-β.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Tau pathology and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Lost after translation: missorting of Tau protein and consequences for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

The importance of tau phosphorylation for neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Hyperphosphorylation-induced tau oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Neurotoxicity induces cleavage of p35 to p25 by calpain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Ryanodine receptors: physiological function and deregulation in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Involvement of endoplasmic reticulum Ca2+ release through ryanodine and inositol 1,4,5-triphosphate receptors in the neurotoxic effects induced by the amyloid-beta peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

The complex PrP(c)-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Eph receptors: new players in Alzheimer's disease pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

The case for rejecting the amyloid cascade hypothesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.38

Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice.

21 January 2018

1 reference

12 December 2020

Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40).

1 reference

12 December 2020

Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition

1 reference

12 December 2020

The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3

1 reference

12 December 2020

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

1 reference

12 December 2020

Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease.

1 reference

12 December 2020

Perlecan binds to the beta-amyloid proteins (A beta) of Alzheimer's disease, accelerates A beta fibril formation, and maintains A beta fibril stability.

1 reference

12 December 2020

Transient increases in intracellular calcium result in prolonged site-selective increases in Tau phosphorylation through a glycogen synthase kinase 3beta-dependent pathway

1 reference

12 December 2020

Amyloid beta-protein inhibits ubiquitin-dependent protein degradation in vitro

1 reference

12 December 2020

Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry.

1 reference

12 December 2020

Coexistent tau and amyloid pathology in hereditary frontotemporal dementia with tau mutations.

1 reference

12 December 2020

SORL1 rare variants: a major risk factor for familial early-onset Alzheimer's disease.

1 reference

12 December 2020

Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1.

1 reference

12 December 2020

Identifiers

DOI

10.1038/MP.2016.38

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27021818%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1 reference