(Q51765163)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29514064%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

title

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29514064%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29514064%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Karolina Chwalek

2

0 references

author name string

Luis Rajman

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29514064%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

publication date

1 March 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29514064%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29514064%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

volume

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29514064%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29514064%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

page(s)

529-547

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29514064%20AND%20SRC:MED&resulttype=core&format=json

Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span

19 March 2020

cites work

1 reference

12 December 2020

Increased nicotinamide adenine dinucleotide content and synthesis in Plasmodium falciparum-infected human erythrocytes.

1 reference

12 December 2020

Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae

1 reference

12 December 2020

Map positions of yeast genes SIR1, SIR3 and SIR4.

1 reference

12 December 2020

Nicotinamide mononucleotide pyrophosphorylase activity in animal tissues.

1 reference

12 December 2020

HIV infection decreases intracellular nicotinamide adenine dinucleotide [NAD]

1 reference

12 December 2020

Evidence that vault ribonucleoprotein particles localize to the nuclear pore complex

1 reference

12 December 2020

Diet and Parkinson's disease. II: A possible role for the past intake of specific nutrients. Results from a self-administered food-frequency questionnaire in a case-control study

1 reference

12 December 2020

Prevention of photoimmunosuppression and photocarcinogenesis by topical nicotinamide

1 reference

12 December 2020

Human CD38 is an authentic NAD(P)+ glycohydrolase

1 reference

12 December 2020

An 85-kb tandem triplication in the slow Wallerian degeneration (Wlds) mouse

1 reference

12 December 2020

Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)

1 reference

12 December 2020

Nutritional and occupational factors influencing the risk of Parkinson's disease: a case-control study in southeastern Sweden

1 reference

12 December 2020

Nicotinamide reduces infarction up to two hours after the onset of permanent focal cerebral ischemia in Wistar rats.

1 reference

12 December 2020

Enzymology of NAD+ synthesis

1 reference

12 December 2020

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

1 reference

12 December 2020

The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase

1 reference

12 December 2020

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

1 reference

12 December 2020

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

1 reference

12 December 2020

Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles

1 reference

12 December 2020

Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose

1 reference

12 December 2020

Metabolic fate of extracellular NAD in human skin fibroblasts

1 reference

12 December 2020

A cellular survival switch: poly(ADP-ribosyl)ation stimulates DNA repair and silences transcription

1 reference

12 December 2020

Structure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin

1 reference

12 December 2020

Meningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase

1 reference

12 December 2020

Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels

1 reference

12 December 2020

Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1

1 reference

12 December 2020

Increased neopterin production and tryptophan degradation in advanced Parkinson's disease

1 reference

12 December 2020

Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection.

1 reference

12 December 2020

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

1 reference

12 December 2020

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

1 reference

12 December 2020

Nicotinamide attenuates focal ischemic brain injury in rats: with special reference to changes in nicotinamide and NAD+ levels in ischemic core and penumbra

1 reference

12 December 2020

Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme

1 reference

12 December 2020

Influence of nicotinic acid on serum cholesterol in man.

1 reference

12 December 2020

Hypercholesterolemia. Use of niacin and niacin combinations in therapy

1 reference

12 December 2020

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

1 reference

12 December 2020

Nicotinamide Offers Multiple Protective Mechanisms in Stroke as a Precursor for NAD<sup>+</sup>, as a PARP Inhibitor and by Partial Restoration of Mitochondrial Function

1 reference

12 December 2020

Enzymology of NAD+ homeostasis in man.

1 reference

12 December 2020

Calorie restriction extends yeast life span by lowering the level of NADH.

1 reference

12 December 2020

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

1 reference

12 December 2020

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

1 reference

12 December 2020

A candidate NAD+ transporter in an intracellular bacterial symbiont related to Chlamydiae

1 reference

12 December 2020

Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds: a meta-analysis of randomized controlled trials

1 reference

12 December 2020

Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy.

1 reference

12 December 2020

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

1 reference

12 December 2020

Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.

1 reference

12 December 2020

Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

1 reference

12 December 2020

Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms

1 reference

12 December 2020

Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity

1 reference

12 December 2020

Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus

1 reference

12 December 2020

Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function

1 reference

12 December 2020

Normal patterns of expression of glycosylphosphatidylinositol-anchored proteins on different subsets of peripheral blood cells: a frame of reference for the diagnosis of paroxysmal nocturnal hemoglobinuria.

1 reference

12 December 2020

Niacin improved rigidity and bradykinesia in a Parkinson's disease patient but also caused unacceptable nightmares and skin rash--a case report

1 reference

12 December 2020

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis

1 reference

12 December 2020

Visfatin mRNA expression in human subcutaneous adipose tissue is regulated by exercise

1 reference

12 December 2020

Pharmacologic doses of nicotinamide in the treatment of inflammatory skin conditions: a review.

1 reference

12 December 2020

Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38

1 reference

12 December 2020

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

1 reference

12 December 2020

Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models.

1 reference

12 December 2020

The adipokine visfatin is markedly elevated in obese children

1 reference

12 December 2020

Resveratrol improves health and survival of mice on a high-calorie diet

1 reference

12 December 2020

CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses

1 reference

12 December 2020

Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract

1 reference

12 December 2020

The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals

1 reference

12 December 2020

Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.

1 reference

12 December 2020

The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity.

1 reference

12 December 2020

Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells

1 reference

12 December 2020

Assimilation of NAD(+) precursors in Candida glabrata

1 reference

12 December 2020

Molecular Characteristics of Serum Visfatin and Differential Detection by Immunoassays

1 reference

12 December 2020

UV radiation-induced immunosuppression is greater in men and prevented by topical nicotinamide

1 reference

12 December 2020

Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells

1 reference

12 December 2020

Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival

1 reference

12 December 2020

Poly(ADP-ribose) polymerase-2 [corrected] controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid X receptor/peroxisome proliferator-activated receptor-gamma [corrected] heterodimer

1 reference

12 December 2020

Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme

1 reference

12 December 2020

PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2.

1 reference

12 December 2020

Saccharomyces cerevisiae YOR071C encodes the high affinity nicotinamide riboside transporter Nrt1.

1 reference

12 December 2020

High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease.

1 reference

12 December 2020

Retinol-binding protein 4 and nicotinamide phosphoribosyltransferase/visfatin in rat obesity models

1 reference

12 December 2020

Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)

1 reference

12 December 2020

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

1 reference

12 December 2020

Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition

1 reference

12 December 2020

Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology

1 reference

12 December 2020

SIRT1 regulates circadian clock gene expression through PER2 deacetylation

1 reference

12 December 2020

Life span extension and neuronal cell protection by Drosophila nicotinamidase

1 reference

12 December 2020

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

1 reference

12 December 2020

Oral nicotinamide protects against ultraviolet radiation-induced immunosuppression in humans

1 reference

12 December 2020

Relationship between cerebrospinal fluid visfatin (PBEF/Nampt) levels and adiposity in humans

1 reference

12 December 2020

Nicotinamide phosphoribosyltransferase (Nampt): a link between NAD biology, metabolism, and diseases

1 reference

12 December 2020

Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis

1 reference

12 December 2020

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

1 reference

12 December 2020

Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes.

1 reference

12 December 2020

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

1 reference

12 December 2020

Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity.

1 reference

12 December 2020

Visualization of subcellular NAD pools and intra-organellar protein localization by poly-ADP-ribose formation

1 reference

12 December 2020

Mammalian sirtuins: biological insights and disease relevance

1 reference

12 December 2020

NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death

1 reference

12 December 2020

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

1 reference

12 December 2020

Identification of NAD interacting residues in proteins

1 reference

12 December 2020

Mechanisms of vascular aging: new perspectives.

1 reference

12 December 2020

Discovery of a proneurogenic, neuroprotective chemical

1 reference

12 December 2020

Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

1 reference

12 December 2020

SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production

1 reference

12 December 2020

A fluorometric assay for high-throughput screening targeting nicotinamide phosphoribosyltransferase.

1 reference

12 December 2020

PARP-3 and APLF function together to accelerate nonhomologous end-joining

1 reference

12 December 2020

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

1 reference

12 December 2020

Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and inflammation in humans

1 reference

12 December 2020

SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization

1 reference

12 December 2020

MCP-1-activated monocytes induce apoptosis in human retinal pigment epithelium

1 reference

12 December 2020

PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

1 reference

12 December 2020

Visfatin in overweight/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases: a meta-analysis and systemic review

1 reference

12 December 2020

Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation.

1 reference

12 December 2020

Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm.

1 reference

12 December 2020

Flavonoids as inhibitors of human CD38

1 reference

12 December 2020

SIRT6 promotes DNA repair under stress by activating PARP1

1 reference

12 December 2020

NAD blocks high glucose induced mesangial hypertrophy via activation of the sirtuins-AMPK-mTOR pathway

1 reference

12 December 2020

Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase

1 reference

12 December 2020

Nicotinamide phosphoribosyltransferase/visfatin does not catalyze nicotinamide mononucleotide formation in blood plasma

1 reference

12 December 2020

Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice

1 reference

12 December 2020

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

1 reference

12 December 2020

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

1 reference

12 December 2020

Regulation of poly(ADP-ribose) polymerase-1-dependent gene expression through promoter-directed recruitment of a nuclear NAD+ synthase

1 reference

12 December 2020

dSarm/Sarm1 is required for activation of an injury-induced axon death pathway

1 reference

12 December 2020

The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity

1 reference

12 December 2020

Age-associated changes in oxidative stress and NAD+ metabolism in human tissue.

1 reference

12 December 2020

The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease

1 reference

12 December 2020

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease

1 reference

12 December 2020

PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response

1 reference

12 December 2020

NAD+ biosynthesis ameliorates a zebrafish model of muscular dystrophy

1 reference

12 December 2020

The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.

1 reference

12 December 2020

Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome

1 reference

12 December 2020

Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling

1 reference

12 December 2020

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism

1 reference

12 December 2020

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

1 reference

12 December 2020

Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression.

1 reference

12 December 2020

Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3.

1 reference

12 December 2020

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

1 reference

12 December 2020

Regulation of NF-κB signalling by the mono-ADP-ribosyltransferase ARTD10

1 reference

12 December 2020

CD38 and CD157: a long journey from activation markers to multifunctional molecules

1 reference

12 December 2020

Anti-CD38 antibody therapy: windows of opportunity yielded by the functional characteristics of the target molecule

1 reference

12 December 2020

Measuring CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) activity by reverse-phase HPLC.

1 reference

12 December 2020

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

1 reference

12 December 2020

CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells

1 reference

12 December 2020

Mitigation of gamma-radiation induced abasic sites in genomic DNA by dietary nicotinamide supplementation: metabolic up-regulation of NAD(+) biosynthesis

1 reference

12 December 2020

Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure

1 reference

12 December 2020

Sarm1-mediated axon degeneration requires both SAM and TIR interactions

1 reference

12 December 2020

Association of circulating levels of nicotinamide phosphoribosyltransferase (NAMPT/Visfatin) and of a frequent polymorphism in the promoter of the NAMPT gene with coronary artery disease in diabetic and non-diabetic subjects

1 reference

12 December 2020

The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing

1 reference

12 December 2020

Targeting of NAD metabolism in pancreatic cancer cells: potential novel therapy for pancreatic tumors.

1 reference

12 December 2020

Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway

1 reference

12 December 2020

SIRT6, a protein with many faces

1 reference

12 December 2020

Sirtuin 1 regulates hepatitis B virus transcription and replication by targeting transcription factor AP-1.

1 reference

12 December 2020

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

1 reference

12 December 2020

Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis

1 reference

12 December 2020

Resveratrol differentially regulates NAMPT and SIRT1 in Hepatocarcinoma cells and primary human hepatocytes

1 reference

12 December 2020

Nicotinamide and the skin

1 reference

12 December 2020

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.

1 reference

12 December 2020

NAD+ and sirtuins in aging and disease

1 reference

12 December 2020

Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

1 reference

12 December 2020

Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle

1 reference

12 December 2020

NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease

1 reference

12 December 2020

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

1 reference

12 December 2020

Wallerian degeneration: an emerging axon death pathway linking injury and disease

1 reference

12 December 2020

Rapid evolution of PARP genes suggests a broad role for ADP-ribosylation in host-virus conflicts

1 reference

12 December 2020

Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion

1 reference

12 December 2020

Tankyrases: structure, function and therapeutic implications in cancer

1 reference

12 December 2020

Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.

1 reference

12 December 2020

Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism

1 reference

12 December 2020

P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage

1 reference

12 December 2020

P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury

1 reference

12 December 2020

Novel assay for simultaneous measurement of pyridine mononucleotides synthesizing activities allows dissection of the NAD(+) biosynthetic machinery in mammalian cells

1 reference

12 December 2020

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

1 reference

12 December 2020

Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia.

1 reference

12 December 2020

Cardiovascular disease in Europe 2014: epidemiological update

1 reference

12 December 2020

A review of nicotinamide: treatment of skin diseases and potential side effects

1 reference

12 December 2020

Increasing NAD synthesis in muscle via nicotinamide phosphoribosyltransferase is not sufficient to promote oxidative metabolism

1 reference

12 December 2020

Metabolic profiling of alternative NAD biosynthetic routes in mouse tissues

1 reference

12 December 2020

Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage

1 reference

12 December 2020

Early detection of subclinical visual damage after blast-mediated TBI enables prevention of chronic visual deficit by treatment with P7C3-S243.

1 reference

12 December 2020

Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss

1 reference

12 December 2020

The renoprotective effect of curcumin in cisplatin-induced nephrotoxicity.

1 reference

12 December 2020

Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injury

1 reference

12 December 2020

Spermatid head elongation with normal nuclear shaping requires ADP-ribosyltransferase PARP11 (ARTD11) in mice

1 reference

12 December 2020

Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment

1 reference

12 December 2020

In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences

1 reference

12 December 2020

Leishmania infantum modulates host macrophage mitochondrial metabolism by hijacking the SIRT1-AMPK axis

1 reference

12 December 2020

Absence of SARM1 rescues development and survival of NMNAT2-deficient axons

1 reference

12 December 2020

Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors

1 reference

12 December 2020

Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer's disease-relevant murine model

1 reference

12 December 2020

SARM1 activation triggers axon degeneration locally via NAD⁺ destruction

1 reference

12 December 2020

ADP-ribosyltransferases and poly ADP-ribosylation

1 reference

12 December 2020

Biology of Poly(ADP-Ribose) Polymerases: The Factotums of Cell Maintenance

1 reference

12 December 2020

RNA Regulation by Poly(ADP-Ribose) Polymerases

1 reference

12 December 2020

Physiological and pathophysiological roles of NAMPT and NAD metabolism

1 reference

12 December 2020

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

1 reference

12 December 2020

Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6.

1 reference

12 December 2020

Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart

1 reference

12 December 2020

PARP1 Inhibitors: antitumor drug design

1 reference

12 December 2020

The NAD(+) salvage pathway modulates cancer cell viability via p73.

1 reference

12 December 2020

Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors

1 reference

12 December 2020

PARP6 is a Regulator of Hippocampal Dendritic Morphogenesis

1 reference

12 December 2020

Weight Loss Is Associated With Increased NAD(+)/SIRT1 Expression But Reduced PARP Activity in White Adipose Tissue.

1 reference

12 December 2020

Safety assessment of nicotinamide riboside, a form of vitamin B3

1 reference

12 December 2020

Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs

1 reference

12 December 2020

Apollo-NADP(+): a spectrally tunable family of genetically encoded sensors for NADP(+).

1 reference

12 December 2020

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice.

1 reference

12 December 2020

PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection.

1 reference

12 December 2020

Mitochondrial protein hyperacetylation in the failing heart

1 reference

12 December 2020

PARP inhibitors: the race is on.

1 reference

12 December 2020

Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk.

1 reference

12 December 2020

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

1 reference

12 December 2020

Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death

1 reference

12 December 2020

Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing.

1 reference

12 December 2020

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism.

1 reference

12 December 2020

Biosensor reveals multiple sources for mitochondrial NAD⁺.

1 reference

12 December 2020

Nicotinamide mononucleotide inhibits post-ischemic NAD(+) degradation and dramatically ameliorates brain damage following global cerebral ischemia

1 reference

12 December 2020

Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds

1 reference

12 December 2020

Genetic Association of PARP15 Polymorphisms with Clinical Outcome of Acute Myeloid Leukemia in a Korean Population

1 reference

12 December 2020

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

1 reference

12 December 2020

SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation

1 reference

12 December 2020

NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice

1 reference

12 December 2020

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

1 reference

12 December 2020

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

1 reference

12 December 2020

NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair.

1 reference

12 December 2020

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion.

1 reference

12 December 2020

Role of Niacin in Current Clinical Practice: A Systematic Review.

1 reference

12 December 2020

PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation

1 reference

12 December 2020

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.

1 reference

12 December 2020

Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration.

1 reference

12 December 2020

Simultaneous quantitation of nicotinamide riboside, nicotinamide mononucleotide and nicotinamide adenine dinucleotide in milk by a novel enzyme-coupled assay

1 reference

12 December 2020

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

1 reference

12 December 2020

Luteolinidin Protects the Postischemic Heart through CD38 Inhibition with Preservation of NAD(P)(H).

1 reference

12 December 2020

PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes

1 reference

12 December 2020

Nicotinamide Mononucleotide, an NAD+ Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1-Dependent Manner

1 reference

12 December 2020

NMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency In Vivo

1 reference

12 December 2020

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration.

1 reference

12 December 2020

A conserved NAD+ binding pocket that regulates protein-protein interactions during aging

1 reference

12 December 2020

Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats

1 reference

12 December 2020

Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway.

1 reference

12 December 2020

Clinical Trials Corner

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12 December 2020

NAD+ loss, a new player in AhR biology: prevention of thymus atrophy and hepatosteatosis by NAD+ repletion

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12 December 2020

PARP inhibitor rucaparib induces changes in NAD levels in cells and liver tissues as assessed by MRS.

1 reference

12 December 2020

Upregulation of mitochondrial NAD+ levels impairs the clonogenicity of SSEA1+ glioblastoma tumor-initiating cells

1 reference

12 December 2020

Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity

1 reference

12 December 2020

The first human clinical study for NMN has started in Japan

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12 December 2020

Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model

1 reference

12 December 2020

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells.

1 reference

12 December 2020

NAD replenishment with nicotinamide mononucleotide protects blood-brain barrier integrity and attenuates delayed tissue plasminogen activator-induced haemorrhagic transformation after cerebral ischaemia.

1 reference

12 December 2020

Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration.

1 reference

12 December 2020

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

1 reference

12 December 2020

An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers.

1 reference

12 December 2020

NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.

1 reference

12 December 2020

10.1016/J.CMET.2018.02.011

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29514064%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29514064%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference