(Q90706140)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30577483%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

title

Regulators of Oncogenic Mutant TP53 Gain of Function (English)

1 reference

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15 April 2020

author name string

Satomi Yamamoto

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30577483%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

Tomoo Iwakuma

series ordinal

2

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15 April 2020

publication date

20 December 2018

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15 April 2020

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15 April 2020

volume

11

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15 April 2020

issue

1

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Creative Commons Attribution 4.0 International

15 April 2020

copyright license

start time

20 December 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Interaction of heat-shock protein 70 with p53 translated in vitro: evidence for interaction with dimeric p53 and for a role in the regulation of p53 conformation

1 reference

12 December 2020

Mutant p53 proteins bind DNA abnormally in vitro

1 reference

12 December 2020

Mutant p53 proteins bind hsp 72/73 cellular heat shock-related proteins in SV40-transformed monkey cells.

1 reference

12 December 2020

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life

1 reference

12 December 2020

The cellular oncogene p53 can be activated by mutagenesis.

1 reference

12 December 2020

Natural state of mutant p53 protein and heat shock protein 70 in breast cancer tissues

1 reference

12 December 2020

Multiple p53 protein isoforms and formation of oligomeric complexes with heat shock proteins Hsp70 and Hsp90 in the human mammary tumor, T47D, cell line

1 reference

12 December 2020

Interaction between hsp70 and hsp40, eukaryotic homologues of DnaK and DnaJ, in human cells expressing mutant-type p53.

1 reference

12 December 2020

Gain of function mutations in p53.

1 reference

12 December 2020

Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53

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12 December 2020

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

1 reference

12 December 2020

ADP-ribosylation of p53 tumor suppressor protein: mutant but not wild-type p53 is modified

1 reference

12 December 2020

The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent

1 reference

12 December 2020

An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control

1 reference

12 December 2020

p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.

1 reference

12 December 2020

Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy

1 reference

12 December 2020

Inhibition of mutant p53 phosphorylation at serine 15 or serine 315 partially restores the function of wild-type p53.

1 reference

12 December 2020

The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 association

1 reference

12 December 2020

Prognostic significance of mutations to different structural and functional regions of the p53 gene in breast cancer.

1 reference

12 December 2020

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

1 reference

12 December 2020

Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

1 reference

12 December 2020

PML is induced by oncogenic ras and promotes premature senescence

1 reference

12 December 2020

Role of the heat shock response and molecular chaperones in oncogenesis and cell death

1 reference

12 December 2020

Surfing the p53 network

1 reference

12 December 2020

Deacetylation of p53 modulates its effect on cell growth and apoptosis

1 reference

12 December 2020

From p63 to p53 across p73.

1 reference

12 December 2020

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

1 reference

12 December 2020

Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer.

1 reference

12 December 2020

Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool.

1 reference

12 December 2020

Distinct pattern of p53 phosphorylation in human tumors

1 reference

12 December 2020

An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2

1 reference

12 December 2020

Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization

1 reference

12 December 2020

CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation

1 reference

12 December 2020

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

1 reference

12 December 2020

Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53.

1 reference

12 December 2020

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

1 reference

12 December 2020

Assessing TP53 status in human tumours to evaluate clinical outcome

1 reference

12 December 2020

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

1 reference

12 December 2020

p53 mutation arising in Arg72 allele in the tumorigenesis and development of carcinoma of the urinary tract.

1 reference

12 December 2020

Alternative and aberrant splicing of MDM2 mRNA in human cancer

1 reference

12 December 2020

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

1 reference

12 December 2020

p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis

1 reference

12 December 2020

PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains.

1 reference

12 December 2020

Nitric oxide prevents UV-induced phosphorylation of the p53 tumor-suppressor protein at serine 46: a possible role in inhibition of apoptosis

1 reference

12 December 2020

Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants

1 reference

12 December 2020

Mutant p53 is constitutively phosphorylated at Serine 15 in UV-induced mouse skin tumors: involvement of ERK1/2 MAP kinase

1 reference

12 December 2020

TP53 gene mutations predict the response to neoadjuvant treatment with 5-fluorouracil and mitomycin in locally advanced breast cancer

1 reference

12 December 2020

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

1 reference

12 December 2020

Ser392 phosphorylation regulates the oncogenic function of mutant p53.

1 reference

12 December 2020

Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures

1 reference

12 December 2020

Post-translational modification of p53 in tumorigenesis

1 reference

12 December 2020

Prognostic significance of serine 392 phosphorylation in overexpressed p53 protein in human esophageal squamous cell carcinoma

1 reference

12 December 2020

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

1 reference

12 December 2020

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

1 reference

12 December 2020

Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified.

1 reference

12 December 2020

The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation

1 reference

12 December 2020

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

1 reference

12 December 2020

Li-Fraumeni syndrome: a p53 family affair

1 reference

12 December 2020

Evaluation of the combined effect of p53 codon 72 polymorphism and hotspot mutations in response to anticancer drugs

1 reference

12 December 2020

Blockage of NF-kappaB induces serine 15 phosphorylation of mutant p53 by JNK kinase in prostate cancer cells.

1 reference

12 December 2020

Mortalin-based cytoplasmic sequestration of p53 in a nonmammalian cancer model

1 reference

12 December 2020

Posttranslational phosphorylation of mutant p53 protein in tumor development

1 reference

12 December 2020

Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation

1 reference

12 December 2020

Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4.

1 reference

12 December 2020

C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.

1 reference

12 December 2020

Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination

1 reference

12 December 2020

Transcription regulation by mutant p53.

1 reference

12 December 2020

Structure-function-rescue: the diverse nature of common p53 cancer mutants

1 reference

12 December 2020

p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

1 reference

12 December 2020

Structural biology of the tumor suppressor p53 and cancer-associated mutants

1 reference

12 December 2020

MDM2 splice variants predominantly localize to the nucleoplasm mediated by a COOH-terminal nuclear localization signal

1 reference

12 December 2020

Orchestration of chromatin-based processes: mind the TRRAP.

1 reference

12 December 2020

The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP

1 reference

12 December 2020

Ubiquitination and degradation of mutant p53.

1 reference

12 December 2020

Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells

1 reference

12 December 2020

A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis

1 reference

12 December 2020

Chaperone-dependent stabilization and degradation of p53 mutants

1 reference

12 December 2020

PML enhances the regulation of p53 by CK1 in response to DNA damage

1 reference

12 December 2020

Structural biology of the tumor suppressor p53.

1 reference

12 December 2020

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

1 reference

12 December 2020

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

1 reference

12 December 2020

Oxidation of methionine residue at hydrophobic core destabilizes p53 tetrameric structure

1 reference

12 December 2020

Dissecting roles of ubiquitination in the p53 pathway

1 reference

12 December 2020

A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis

1 reference

12 December 2020

Modes of p53 regulation

1 reference

12 December 2020

Promyelocytic leukemia protein is required for gain of function by mutant p53.

1 reference

12 December 2020

Mutant p53 rescue and modulation of p53 redox state.

1 reference

12 December 2020

Mutant p53 gain of oncogenic function: in vivo evidence, mechanism of action and its clinical implications.

1 reference

12 December 2020

Tid1 is a new regulator of p53 mitochondrial translocation and apoptosis in cancer

1 reference

12 December 2020

USP10 regulates p53 localization and stability by deubiquitinating p53

1 reference

12 December 2020

Modulation of the vitamin D3 response by cancer-associated mutant p53

1 reference

12 December 2020

Mutation at Ser392 specifically sensitizes mutant p53H175 to mdm2-mediated degradation.

1 reference

12 December 2020

p53 Research: the past thirty years and the next thirty years.

1 reference

12 December 2020

Nitration of the tumor suppressor protein p53 at tyrosine 327 promotes p53 oligomerization and activation.

1 reference

12 December 2020

Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway

1 reference

12 December 2020

Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding

1 reference

12 December 2020

p53 post-translational modification: deregulated in tumorigenesis

1 reference

12 December 2020

The role of mutant p53 in human cancer

1 reference

12 December 2020

Reactivation of p53: from peptides to small molecules.

1 reference

12 December 2020

Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy

1 reference

12 December 2020

Direct interaction between p53 and Tid1 proteins affects p53 mitochondrial localization and apoptosis

1 reference

12 December 2020

Role of p53 serine 46 in p53 target gene regulation

1 reference

12 December 2020

Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells

1 reference

12 December 2020

p53 regulation by ubiquitin

1 reference

12 December 2020

SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis

1 reference

12 December 2020

A Pin1/mutant p53 axis promotes aggressiveness in breast cancer

1 reference

12 December 2020

The impact of acetylation and deacetylation on the p53 pathway

1 reference

12 December 2020

Multiple stress signals activate mutant p53 in vivo

1 reference

12 December 2020

Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop.

1 reference

12 December 2020

Aurora A mediates cross-talk between N- and C-terminal post-translational modifications of p53

1 reference

12 December 2020

p53 N-terminal phosphorylation: a defining layer of complex regulation

1 reference

12 December 2020

Mutant p53 cooperates with ETS2 to promote etoposide resistance

1 reference

12 December 2020

The DNA binding and accumulation of p53 from breast cancer cell lines and the link with serine 15 phosphorylation

1 reference

12 December 2020

Functional p53 determines docetaxel sensitivity in prostate cancer cells

1 reference

12 December 2020

Dietary downregulation of mutant p53 levels via glucose restriction: mechanisms and implications for tumor therapy

1 reference

12 December 2020

Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2.

1 reference

12 December 2020

Dissecting the pathways that destabilize mutant p53: the proteasome or autophagy?

1 reference

12 December 2020

Preferential binding of hot spot mutant p53 proteins to supercoiled DNA in vitro and in cells.

1 reference

12 December 2020

Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer.

1 reference

12 December 2020

Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner

1 reference

12 December 2020

Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells

1 reference

12 December 2020

Chaperone-mediated autophagy degrades mutant p53.

1 reference

12 December 2020

The p53 Codon 72 Polymorphism Modifies the Cellular Response to Inflammatory Challenge in the Liver

1 reference

12 December 2020

Id4 dependent acetylation restores mutant-p53 transcriptional activity

1 reference

12 December 2020

Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis

1 reference

12 December 2020

Mutant TP53 posttranslational modifications: challenges and opportunities.

1 reference

12 December 2020

Mutant p53 in cancer: new functions and therapeutic opportunities

1 reference

12 December 2020

Mutant p53 reactivation by small molecules makes its way to the clinic.

1 reference

12 December 2020

USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses

1 reference

12 December 2020

Phosphatases reverse p53-mediated cell cycle checkpoints

1 reference

12 December 2020

Arsenic trioxide reactivates proteasome-dependent degradation of mutant p53 protein in cancer cells in part via enhanced expression of Pirh2 E3 ligase

1 reference

12 December 2020

SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma

1 reference

12 December 2020

Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine

1 reference

12 December 2020

Proteasome inhibitors suppress the protein expression of mutant p53.

1 reference

12 December 2020

p53 Acetylation: Regulation and Consequences

1 reference

12 December 2020

Mutant p53 Amplifies Epidermal Growth Factor Receptor Family Signaling to Promote Mammary Tumorigenesis.

1 reference

12 December 2020

Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment

1 reference

12 December 2020

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

1 reference

12 December 2020

Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer

1 reference

12 December 2020

BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function

1 reference

12 December 2020

Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis

1 reference

12 December 2020

Tetramer formation of tumor suppressor protein p53: Structure, function, and applications

1 reference

12 December 2020

Mutant p53: Multiple Mechanisms Define Biologic Activity in Cancer

1 reference

12 December 2020

The Contrived Mutant p53 Oncogene - Beyond Loss of Functions

1 reference

12 December 2020

Allele-specific silencing of mutant p53 attenuates dominant-negative and gain-of-function activities

1 reference

12 December 2020

Targeting Oncogenic Mutant p53 for Cancer Therapy

1 reference

12 December 2020

Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination

1 reference

12 December 2020

Lack of Immunomodulatory Interleukin-27 Enhances Oncogenic Properties of Mutant p53 In Vivo

1 reference

12 December 2020

Heat Shock Protein 70s as Potential Molecular Targets for Colon Cancer Therapeutics

1 reference

12 December 2020

Suppression of gain-of-function mutant p53 with metabolic inhibitors reduces tumor growth in vivo

1 reference

12 December 2020

DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway.

1 reference

12 December 2020

A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis.

1 reference

12 December 2020

The role of p53 in cancer drug resistance and targeted chemotherapy

1 reference

12 December 2020

p53 as a Regulator of Lipid Metabolism in Cancer

1 reference

12 December 2020

Why are there hotspot mutations in the TP53 gene in human cancers?

1 reference

12 December 2020

Mutant p53 partners in crime

1 reference

12 December 2020

Molecular chaperones in the acquisition of cancer cell chemoresistance with mutated TP53 and MDM2 up-regulation

1 reference

12 December 2020

Targeting mutant p53 for efficient cancer therapy.

1 reference

12 December 2020

Mechanical cues control mutant p53 stability through a mevalonate-RhoA axis.

1 reference

12 December 2020

Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α.

1 reference

12 December 2020

Wild-type and cancer-related p53 proteins are preferentially degraded by MDM2 as dimers rather than tetramers.

1 reference

12 December 2020

USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells.

1 reference

12 December 2020

TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma

1 reference

12 December 2020

CHIP promotes autophagy-mediated degradation of aggregating mutant p53 in hypoxic conditions

1 reference

12 December 2020

Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion

1 reference

12 December 2020

Identifiers

DOI

10.3390/CANCERS11010004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30577483%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30577483%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

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