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Mutations in spliceosome genes and therapeutic opportunities in myeloid malignancies
scientific article published on 03 September 2019
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Europe PubMed Central
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6852509
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31334570%20AND%20SRC:MED&resulttype=core&format=json
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26 April 2020
review article
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Europe PubMed Central
title
Mutations in spliceosome genes and therapeutic opportunities in myeloid malignancies
(English)
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Europe PubMed Central
PMCID
6852509
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31334570%20AND%20SRC:MED&resulttype=core&format=json
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26 April 2020
author
Justin Taylor
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1
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Europe PubMed Central
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6852509
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31334570%20AND%20SRC:MED&resulttype=core&format=json
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26 April 2020
Stanley C Lee
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2
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Europe PubMed Central
PMCID
6852509
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26 April 2020
publication date
3 September 2019
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26 April 2020
published in
Genes, Chromosomes and Cancer
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Europe PubMed Central
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6852509
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26 April 2020
volume
58
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Europe PubMed Central
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6852509
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31334570%20AND%20SRC:MED&resulttype=core&format=json
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26 April 2020
issue
12
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Europe PubMed Central
PMCID
6852509
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31334570%20AND%20SRC:MED&resulttype=core&format=json
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26 April 2020
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889-902
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Europe PubMed Central
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26 April 2020
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Transcriptome sequencing reveals potential mechanism of cryptic 3' splice site selection in SF3B1-mutated cancers
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23 February 2021
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23 February 2021
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23 February 2021
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23 February 2021
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23 February 2021
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23 February 2021
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23 February 2021
Synonymous Mutations Frequently Act as Driver Mutations in Human Cancers
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23 February 2021
A pan-cancer analysis of transcriptome changes associated with somatic mutations in U2AF1 reveals commonly altered splicing events
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23 February 2021
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23 February 2021
Splicing factor SRSF6 promotes hyperplasia of sensitized skin
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23 February 2021
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23 February 2021
A phase I, open-label, single-arm, dose-escalation study of E7107, a precursor messenger ribonucleic acid (pre-mRNA) splicesome inhibitor administered intravenously on days 1 and 8 every 21 days to patients with solid tumors
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23 February 2021
High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias
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23 February 2021
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23 February 2021
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23 February 2021
Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery
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23 February 2021
Phase I pharmacokinetic and pharmacodynamic study of the first-in-class spliceosome inhibitor E7107 in patients with advanced solid tumors.
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23 February 2021
SF3B1 mutations are associated with alternative splicing in uveal melanoma
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23 February 2021
Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3
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23 February 2021
Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms
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23 February 2021
Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A
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23 February 2021
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
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23 February 2021
Regulation of splicing by SR proteins and SR protein-specific kinases
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23 February 2021
Alternative splicing: a pivotal step between eukaryotic transcription and translation
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23 February 2021
Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma.
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23 February 2021
The spliceosome as a target of novel antitumour drugs
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23 February 2021
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
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23 February 2021
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23 February 2021
The transporter ABCB7 is a mediator of the phenotype of acquired refractory anemia with ring sideroblasts
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23 February 2021
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing
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23 February 2021
Transcriptional elongation and alternative splicing
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23 February 2021
SRSF2 mutations in primary myelofibrosis: significant clustering with IDH mutations and independent association with inferior overall and leukemia-free survival
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23 February 2021
SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)
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23 February 2021
The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.
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23 February 2021
Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes
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23 February 2021
Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome
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23 February 2021
Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6852509
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23 February 2021
The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation
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23 February 2021
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
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23 February 2021
Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6852509
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23 February 2021
SF3B1 and other novel cancer genes in chronic lymphocytic leukemia
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23 February 2021
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
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23 February 2021
Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts
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PubMed Central
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23 February 2021
Biological validation that SF3b is a target of the antitumor macrolide pladienolide
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23 February 2021
Frequent pathway mutations of splicing machinery in myelodysplasia
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23 February 2021
Increased levels of noisy splicing in cancers, but not for oncogene-derived transcripts
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6852509
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23 February 2021
Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study
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23 February 2021
Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A
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23 February 2021
The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region
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23 February 2021
Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing
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23 February 2021
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23 February 2021
Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones
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23 February 2021
The role of the iron transporter ABCB7 in refractory anemia with ring sideroblasts
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23 February 2021
Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice
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23 February 2021
Splicing factor SF3b as a target of the antitumor natural product pladienolide.
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23 February 2021
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
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23 February 2021
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23 February 2021
Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis
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23 February 2021
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23 February 2021
The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site
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23 February 2021
The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis.
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23 February 2021
A phase II clinical and pharmacodynamic study of E7070 in patients with metastatic, recurrent, or refractory squamous cell carcinoma of the head and neck: modulation of retinoblastoma protein phosphorylation by a novel chloroindolyl sulfonamide cell
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23 February 2021
Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities
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23 February 2021
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23 February 2021
Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors
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23 February 2021
Phase I and pharmacokinetic study of E7070, a chloroindolyl-sulfonamide anticancer agent, administered on a weekly schedule to patients with solid tumors
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23 February 2021
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23 February 2021
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23 February 2021
GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp. I. Taxonomy, production, isolation, physicochemical properties and biological activities
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23 February 2021
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23 February 2021
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23 February 2021
Phase II trial of chloroquinoxaline sulfonamide (CQS) in patients with stage III and IV non-small-cell lung cancer
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23 February 2021
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23 February 2021
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stated in
Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phase I trial of chloroguinoxaline sulfonamide, with correlation of its pharmacokinetics and pharmacodynamics
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6852509
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23 February 2021
Two types of acquired idiopathic sideroblastic anaemia (AISA)
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6852509
retrieved
23 February 2021
Phase I clinical and pharmacological study of chloroquinoxaline sulfonamide
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6852509
retrieved
23 February 2021
A map of cytoplasmic RNA transcripts from lytic adenovirus type 2, determined by electron microscopy of RNA:DNA hybrids
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6852509
retrieved
23 February 2021
Spliced segments at the 5′ terminus of adenovirus 2 late mRNA
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6852509
retrieved
23 February 2021
GEX1 Compounds, Novel Antitumor Antibiotics Related to Herboxidiene, Produced by Streptomyces sp. I. Taxonomy, Production, Isolation, Physicochemical Properties and Biological Activities.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FGCC.22784
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1002/GCC.22784
1 reference
stated in
Europe PubMed Central
PMCID
6852509
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31334570%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 April 2020
PMCID
6852509
1 reference
stated in
Europe PubMed Central
PMCID
6852509
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31334570%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 April 2020
PubMed ID
31334570
1 reference
stated in
Europe PubMed Central
PMCID
6852509
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31334570%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 April 2020
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