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Protective effects and mechanisms of sirtuins in the nervous system
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PubMed
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Europe PubMed Central
title
Protective effects and mechanisms of sirtuins in the nervous system
(English)
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stated in
PubMed
main subject
nervous system
0 references
author
Michael J. Zigmond
series ordinal
6
object named as
Michael J. Zigmond
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author name string
Feng Zhang
series ordinal
1
1 reference
stated in
Crossref
Suping Wang
series ordinal
2
1 reference
stated in
Crossref
Li Gan
series ordinal
3
1 reference
stated in
Crossref
Peter S. Vosler
series ordinal
4
1 reference
stated in
Crossref
Yanqin Gao
series ordinal
5
1 reference
stated in
Crossref
Michael J. Zigmond
series ordinal
6
1 reference
stated in
Crossref
Jun Chen
series ordinal
7
1 reference
stated in
Crossref
language of work or name
English
1 reference
stated in
PubMed
publication date
November 2011
1 reference
stated in
PubMed
published in
Progress in Neurobiology
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stated in
PubMed
volume
95
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stated in
PubMed
issue
3
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stated in
PubMed
page(s)
373-95
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PubMed
cites work
MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation
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PubMed Central
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Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C
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HDAC3 is negatively regulated by the nuclear protein DBC1
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PubMed Central
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SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator
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PubMed Central
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7 April 2017
SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
SIRT1 Promotes the Central Adaptive Response to Diet Restriction through Activation of the Dorsomedial and Lateral Nuclei of the Hypothalamus
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.
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7 April 2017
A novel pathway regulates memory and plasticity via SIRT1 and miR-134
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells
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PubMed Central
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7 April 2017
DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
JNK1 phosphorylates SIRT1 and promotes its enzymatic activity
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
SIRT1 deacetylates APE1 and regulates cellular base excision repair
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
MicroRNAs: target recognition and regulatory functions
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
miR-34a repression of SIRT1 regulates apoptosis
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation
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PubMed Central
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7 April 2017
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Negative regulation of the deacetylase SIRT1 by DBC1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
DBC1 is a negative regulator of SIRT1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
SIRT1 deacetylates and positively regulates the nuclear receptor LXR
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
SIRT1 regulates the function of the Nijmegen breakage syndrome protein
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Sirtuin functions in health and disease
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
SIRT1 promotes DNA repair activity and deacetylation of Ku70
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Phosphorylation of HuR by Chk2 regulates SIRT1 expression
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
A probability-based approach for high-throughput protein phosphorylation analysis and site localization
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
PCAF modulates PTEN activity
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
A local mechanism mediates NAD-dependent protection of axon degeneration
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Foxo3a induces motoneuron death through the Fas pathway in cooperation with JNK
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Large-scale characterization of HeLa cell nuclear phosphoproteins
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Composition and dynamics of human mitochondrial nucleoids
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Modification with SUMO. A role in transcriptional regulation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Repeat motifs of tau bind to the insides of microtubules in the absence of taxol
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Negative control of p53 by Sir2alpha promotes cell survival under stress
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Structure of the histone deacetylase SIRT2
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Translation by ribosome shunting on adenovirus and hsp70 mRNAs facilitated by complementarity to 18S rRNA
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Resveratrol improves health and survival of mice on a high-calorie diet
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
CBP/p300 in cell growth, transformation, and development
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Resveratrol is not a direct activator of SIRT1 enzyme activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Mitochondrial calcium and the permeability transition in cell death
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Sirtuin activators
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
The SIRT2 deacetylase regulates autoacetylation of p300
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
Mammalian SIRT1 represses forkhead transcription factors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
Identification of a small molecule inhibitor of Sir2p
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
Modulation of SIRT1 expression in different neurodegenerative models and human pathologies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
Sirtuins in mammals: insights into their biological function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
Tau suppression in a neurodegenerative mouse model improves memory function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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7 April 2017
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
HuR and mRNA stability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
Transcriptional silencing in yeast is associated with reduced nucleosome acetylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
7 April 2017
SIRT6 promotes DNA repair under stress by activating PARP1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
Neuronal Sirt3 protects against excitotoxic injury in mouse cortical neuron culture
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
Pathways for ischemic cytoprotection: role of sirtuins in caloric restriction, resveratrol, and ischemic preconditioning
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
Role of Pax3 acetylation in the regulation of Hes1 and Neurog2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
MNB/DYRK1A as a multiple regulator of neuronal development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
FoxO1 mediates an autofeedback loop regulating SIRT1 expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
Oral resveratrol reduces neuronal damage in a model of multiple sclerosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
NF-kappaB signaling in neurite growth and neuronal survival
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
SIRT1, a histone deacetylase, regulates prion protein-induced neuronal cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
Brain molecular aging, promotion of neurological disease and modulation by Sirtuin5 longevity gene polymorphism
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
Acetylation of tau inhibits its degradation and contributes to tauopathy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
Lysine deacetylation in ischaemic preconditioning: the role of SIRT1
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
Can autophagy promote longevity?
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
SIRT1 is regulated by a PPAR{γ}-SIRT1 negative feedback loop associated with senescence
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Enhanced Delivery of Erythropoietin Across the Blood-Brain Barrier for Neuroprotection against Ischemic Neuronal Injury
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
Uncoupling of endothelial nitric oxide synthase after experimental subarachnoid hemorrhage
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
p53-mediated neuronal cell death in ischemic brain injury
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
SIRT1 and p53, effect on cancer, senescence and beyond
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Regulation of SIRT1 in cellular functions: role of polyphenols
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 September 2017
The mitochondria permeability transition pore complex in the brain with interacting proteins - promising targets for protection in neurodegenerative diseases
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Resveratrol as a therapeutic agent for neurodegenerative diseases
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Function and metabolism of sirtuin metabolite O-acetyl-ADP-ribose
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28 September 2017
Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria
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PubMed Central
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28 September 2017
Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia
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PubMed Central
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28 September 2017
Activation of liver X receptor reduces global ischemic brain injury by reduction of nuclear factor-kappaB
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28 September 2017
NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10.
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PubMed Central
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28 September 2017
Division and apoptosis of E2f-deficient retinal progenitors
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PubMed Central
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28 September 2017
Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria
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28 September 2017
SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions
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28 September 2017
Hypoxia-inducible factor 1: a new hope to counteract neurodegeneration?
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28 September 2017
Axonal and neuronal pathology in multiple sclerosis: what have we learnt from animal models
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28 September 2017
Biochemical pathways that regulate acetyltransferase and deacetylase activity in mammalian cells
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28 September 2017
Nrf2: friend or foe for chemoprevention?
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28 September 2017
MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1.
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28 September 2017
Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia.
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28 September 2017
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1.
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28 September 2017
Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.
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28 September 2017
Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Wld S protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice
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PubMed Central
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28 September 2017
Regulation of neuronal cell death by MST1-FOXO1 signaling
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28 September 2017
Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Modulation of microglial innate immunity in Alzheimer's disease by activation of peroxisome proliferator-activated receptor gamma
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28 September 2017
The importance of NAD in multiple sclerosis
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28 September 2017
How does SIRT1 affect metabolism, senescence and cancer?
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Phosphorylation regulates SIRT1 function.
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28 September 2017
Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease
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28 September 2017
Post-ischemic brain damage: NF-kappaB dimer heterogeneity as a molecular determinant of neuron vulnerability.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Resveratrol prevents antibody-induced apoptotic death of retinal cells through upregulation of Sirt1 and Ku70
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Leptin is induced in the ischemic cerebral cortex and exerts neuroprotection through NF-kappaB/c-Rel-dependent transcription.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Minireview: the PGC-1 coactivator networks: chromatin-remodeling and mitochondrial energy metabolism
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Brain SIRT1: anatomical distribution and regulation by energy availability
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration
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28 September 2017
SIRTUIN 1: regulating the regulator
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
PTEN acetylation modulates its interaction with PDZ domain
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Leptin protects hippocampal CA1 neurons against ischemic injury
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Enhanced tolerance against early and late apoptotic oxidative stress in mammalian neurons through nicotinamidase and sirtuin mediated pathways
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Dietary oxyresveratrol prevents parkinsonian mimetic 6-hydroxydopamine neurotoxicity
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Cellular NAD replenishment confers marked neuroprotection against ischemic cell death: role of enhanced DNA repair
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Neurological symptoms and natural course of xeroderma pigmentosum
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Resveratrol and ischemic preconditioning in the brain
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Inhibitors of NAD+ dependent histone deacetylases (sirtuins).
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28 September 2017
Role of Nrf2-dependent ARE-driven antioxidant pathway in neuroprotection
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Molecular mechanisms of prion pathogenesis
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
The human SIRT3 protein deacetylase is exclusively mitochondrial
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Poly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damage
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Neuroprotective effects of adenosine monophosphate-activated protein kinase inhibition and gene deletion in stroke
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Sirtuins: the 'magnificent seven', function, metabolism and longevity
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
SIRT1 activation confers neuroprotection in experimental optic neuritis
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Shut-down of translation, a global neuronal stress response: mechanisms and pathological relevance
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Cytoplasm-localized SIRT1 enhances apoptosis
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Resveratrol stimulates AMP kinase activity in neurons
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
A tale of two mitochondrial channels, MAC and PTP, in apoptosis
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Protection by EGb 761 against beta-amyloid-induced neurotoxicity: involvement of NF-kappaB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
PPAR: a new pharmacological target for neuroprotection in stroke and neurodegenerative diseases
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28 September 2017
The biochemistry of sirtuins.
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28 September 2017
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degeneration
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage
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28 September 2017
SIRT1 stimulation by polyphenols is affected by their stability and metabolism.
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28 September 2017
Stability regulation of mRNA and the control of gene expression
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28 September 2017
Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage
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28 September 2017
Alternative mechanisms of initiating translation of mammalian mRNAs
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28 September 2017
Axon degeneration mechanisms: commonality amid diversity
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28 September 2017
The sirtuin inhibitor nicotinamide enhances neuronal cell survival during acute anoxic injury through AKT, BAD, PARP, and mitochondrial associated "anti-apoptotic" pathways
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress
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28 September 2017
Nuclear genes and mitochondrial translation: a new class of genetic disease
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 September 2017
Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.
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28 September 2017
Cerebral endothelial cell apoptosis after ischemia-reperfusion: role of PARP activation and AIF translocation.
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28 September 2017
Post-ischemic inflammation: molecular mechanisms and therapeutic implications
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28 September 2017
Apoptosis in cerebral ischemia: executional and regulatory signaling mechanisms
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28 September 2017
Regulation of histone deacetylase activities
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28 September 2017
p300/CBP and cancer
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28 September 2017
Calorie restriction extends yeast life span by lowering the level of NADH.
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28 September 2017
Yeast life-span extension by calorie restriction is independent of NAD fluctuation
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28 September 2017
Resveratrol: from grapevines to mammalian biology
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28 September 2017
Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene.
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28 September 2017
Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product
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28 September 2017
A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the slow Wallerian degeneration (WldS) mouse
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28 September 2017
The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
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28 September 2017
The conserved core of a human SIR2 homologue functions in yeast silencing
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28 September 2017
In vivo evidence that erythropoietin protects neurons from ischemic damage
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28 September 2017
Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginine
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28 September 2017
Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells
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31 May 2018
Controlling SIRT1 expression by microRNAs in health and metabolic disease
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31 May 2018
miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues
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PubMed Central
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31 May 2018
Resveratrol is neuroprotective because it is not a direct activator of Sirt1-A hypothesis
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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31 May 2018
Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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31 May 2018
Resveratrol neuroprotective effects during focal cerebral ischemia injury via nitric oxide mechanism in rats
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31 May 2018
Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: a crucial role of tubulin deacetylation
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31 May 2018
The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo
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31 May 2018
Erythropoietin protects CA1 neurons against global cerebral ischemia in rat: potential signaling mechanisms
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31 May 2018
APE1 is the major 3'-phosphoglycolate activity in human cell extracts
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31 May 2018
Sir2 is induced by oxidative stress in a yeast model of Huntington disease and its activation reduces protein aggregation.
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28 November 2018
Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.
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28 November 2018
Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivo.
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28 November 2018
Knockdown of FoxO3a induces increased neuronal apoptosis during embryonic development in zebrafish
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28 November 2018
A single-dose resveratrol treatment in a mouse model of amyotrophic lateral sclerosis
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28 November 2018
Evidence that core histone H3 is targeted to the mitochondria in Brassica oleracea.
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28 November 2018
Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 November 2018
Activation of Akt/FoxO signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hypoxic pre-conditioning in adult rats
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28 November 2018
Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 November 2018
Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha expression in experimental stroke
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 November 2018
Leptin reduces infarct size in association with enhanced expression of CB2, TRPV1, SIRT-1 and leptin receptor
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 November 2018
Mice knock out for the histone acetyltransferase p300/CREB binding protein-associated factor develop a resistance to amyloid toxicity
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28 November 2018
Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1.
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28 November 2018
Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 November 2018
Peroxisome-proliferator-activated receptor-alpha activation protects brain capillary endothelial cells from oxygen-glucose deprivation-induced hyperpermeability in the blood-brain barrier.
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28 November 2018
Sirt1's complex roles in neuroprotection
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 November 2018
Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 November 2018
Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 November 2018
Resveratrol inhibits MMP-9 expression by up-regulating PPAR alpha expression in an oxygen glucose deprivation-exposed neuron model
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 November 2018
Neurodegeneration in xeroderma pigmentosum.
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28 November 2018
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 November 2018
Sirt1 contributes critically to the redox-dependent fate of neural progenitors.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 November 2018
Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia
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28 November 2018
Comparative analysis of the effects of resveratrol in two apoptotic models: inhibition of complex I and potassium deprivation in cerebellar neurons
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28 November 2018
Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models.
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28 November 2018
Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus).
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28 November 2018
Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults
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28 November 2018
Intranasal administration with NAD+ profoundly decreases brain injury in a rat model of transient focal ischemia
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28 November 2018
VEGF overexpression enhances striatal neurogenesis in brain of adult rat after a transient middle cerebral artery occlusion
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28 November 2018
Neuroprotection against focal ischemic brain injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone
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28 November 2018
Resveratrol mimics ischemic preconditioning in the brain
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28 November 2018
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.
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28 November 2018
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling
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28 November 2018
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells
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28 November 2018
Suppressing cancer: the importance of being senescent.
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28 November 2018
DNA-binding proteins of mammalian mitochondria.
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28 November 2018
Ischemic preconditioning in the rat brain enhances the repair of endogenous oxidative DNA damage by activating the base-excision repair pathway
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28 November 2018
Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models
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28 November 2018
Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease
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28 November 2018
Nutrient availability regulates SIRT1 through a forkhead-dependent pathway.
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28 November 2018
NAD+ as a metabolic link between DNA damage and cell death.
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28 November 2018
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis
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28 November 2018
Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain.
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28 November 2018
Mechanism of Nicotinamide Inhibition and Transglycosidation by Sir2 Histone/Protein Deacetylases
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28 November 2018
Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states
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28 November 2018
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons
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28 November 2018
Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
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28 November 2018
Peroxisome proliferator-activated receptor-alpha activation as a mechanism of preventive neuroprotection induced by chronic fenofibrate treatment.
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28 November 2018
Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70.
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28 November 2018
Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt.
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28 November 2018
Neuronal expression of the DNA repair protein Ku 70 after ischemic preconditioning corresponds to tolerance to global cerebral ischemia
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28 November 2018
Early decrease in dna repair proteins, Ku70 and Ku86, and subsequent DNA fragmentation after transient focal cerebral ischemia in mice
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28 November 2018
Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: evidence for a preconditioning mechanism
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28 November 2018
Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease
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28 November 2018
Optimal depth and duration of mild hypothermia in a focal model of transient cerebral ischemia: effects on neurologic outcome, infarct size, apoptosis, and inflammation
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28 November 2018
Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 November 2018
Hibernation in ground squirrels induces state and species-specific tolerance to hypoxia and aglycemia: an in vitro study in hippocampal slices
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 November 2018
'Ischemic tolerance' phenomenon found in the brain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242010
retrieved
28 November 2018
Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21930182
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
SIRT1 markedly extends replicative lifespan if the NAD+ salvage pathway is enhanced
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21930182
retrieved
12 December 2020
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inferred from PubMed ID database lookup
Increase in activity during calorie restriction requires Sirt1
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21930182
retrieved
12 December 2020
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inferred from PubMed ID database lookup
Erratum: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21930182
retrieved
12 December 2020
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Evidence that the Rate of Wallerian Degeneration is Controlled by a Single Autosomal Dominant Gene
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21930182
retrieved
12 December 2020
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Identifiers
DOI
10.1016/J.PNEUROBIO.2011.09.001
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3023230
OpenCitations bibliographic resource ID
3023230
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3023230
PMC publication ID
3242010
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3023230
PubMed publication ID
21930182
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3023230
ResearchGate publication ID
51654472
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