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TOR signaling

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scholarly article

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Europe PubMed Central

16 June 2017

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Europe PubMed Central

TOR signaling (English)

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Europe PubMed Central

16 June 2017

author name string

Thurl E Harris

1

1 reference

Europe PubMed Central

16 June 2017

John C Lawrence

2

1 reference

Europe PubMed Central

16 June 2017

publication date

9 December 2003

1 reference

Europe PubMed Central

16 June 2017

Science's STKE : signal transduction knowledge environment

1 reference

Europe PubMed Central

16 June 2017

2003

1 reference

Europe PubMed Central

16 June 2017

re15

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Europe PubMed Central

16 June 2017

212

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Europe PubMed Central

16 June 2017

Immunopharmacology of rapamycin

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Technical and immunosuppressive advances in transplantation for insulin-dependent diabetes mellitus

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21 January 2018

Can we prevent in-stent restenosis?

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21 January 2018

Targeting mTOR signaling for cancer therapy

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https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Yeast TOR (DRR) proteins: amino-acid sequence alignment and identification of structural motifs.

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

TOR2 is required for organization of the actin cytoskeleton in yeast

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

A putative sirolimus (rapamycin) effector protein

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Cell cycle checkpoint signaling through the ATM and ATR kinases

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

HEAT repeats in the Huntington's disease protein

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

HEAT repeats mediate plasma membrane localization of Tor2p in yeast

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Predominant nuclear localization of mammalian target of rapamycin in normal and malignant cells in culture

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The TOR signaling cascade regulates gene expression in response to nutrients

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2.

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Tor signalling in bugs, brain and brawn

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Retinoblastoma protein phosphorylation via PI 3-kinase and mTOR pathway regulates adipocyte differentiation

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Control of p70 s6 kinase by kinase activity of FRAP in vivo

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Drosophila S6 kinase: a regulator of cell size.

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The PI3K-PDK1 connection: more than just a road to PKB

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Phosphorylation and activation of p70s6k by PDK1

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Identification of a conserved motif required for mTOR signaling

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Multiple independent inputs are required for activation of the p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Synthesis of the translational apparatus is regulated at the translational level

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Transcription of cloned eukaryotic ribosomal RNA genes

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

PHAS-I as a link between mitogen-activated protein kinase and translation initiation

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Repressor binding to a dorsal regulatory site traps human eIF4E in a high cap-affinity state

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111)

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E.

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Mutational analysis of sites in the translational regulator, PHAS-I, that are selectively phosphorylated by mTOR

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

A quantitative molecular model for modulation of mammalian translation by the eIF4E-binding protein 1.

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Regulation of protein kinase cascades by protein phosphatase 2A.

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Alpha 4 associates with protein phosphatases 2A, 4, and 6

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Regulation of protein phosphatase 2A catalytic activity by alpha4 protein and its yeast homolog Tap42

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR).

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

When is a lipid kinase not a lipid kinase? When it is a protein kinase

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Mammalian TOR: a homeostatic ATP sensor

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Characterization of the phosphoproteins and protein kinase activity in mTOR immunoprecipitates.

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Substrate specificities and identification of putative substrates of ATM kinase family members

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Attenuation of mammalian target of rapamycin activity by increased cAMP in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The FKBP12-rapamycin-binding domain is required for FKBP12-rapamycin-associated protein kinase activity and G1 progression

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

TOR, a central controller of cell growth

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2.

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Regulation of mammalian translation factors by nutrients

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Bidirectional modulation of insulin action by amino acids

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Dealing with energy demand: the AMP-activated protein kinase

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

TSC2 mediates cellular energy response to control cell growth and survival

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Inorganic polyphosphate stimulates mammalian TOR, a kinase involved in the proliferation of mammary cancer cells

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Inorganic polyphosphate: a molecule of many functions

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Ten years of protein kinase B signalling: a hard Akt to follow

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Mechanisms of size control.

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Why size matters: altering cell size

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Tumour suppressors hamartin and tuberin: intracellular signalling

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Identification and characterization of the tuberous sclerosis gene on chromosome 16

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Phenotypes of the tuberous sclerosis complex with a revision of diagnostic criteria

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Akt regulates growth by directly phosphorylating Tsc2

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The GAP-related domain of tuberin, the product of the TSC2 gene, is a target for missense mutations in tuberous sclerosis

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Rheb promotes cell growth as a component of the insulin/TOR signalling network

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Drosophila Rheb GTPase is required for cell cycle progression and cell growth

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Farnesyltransferase inhibitor induces rapid growth arrest and blocks p70s6k activation by multiple stimuli

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

A wat1 mutant of fission yeast is defective in cell morphology.

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Delta mutant

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Sin1: an evolutionarily conserved component of the eukaryotic SAPK pathway.

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

FAT: a novel domain in PIK-related kinases

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2122003RE15

21 January 2018

Identifiers

10.1126/STKE.2122003RE15

1 reference

Europe PubMed Central

16 June 2017

1 reference

Europe PubMed Central

16 June 2017

ResearchGate publication ID

0 references

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