(Q34459318)

2 August 2017

1 reference

title

The re-emergence of natural products for drug discovery in the genomics era. (English)

1 reference

2 August 2017

0 references

1 reference

1 reference

Ronald J Quinn

3

0 references

RuAngelie Edrada-Ebel

object named as

RuAngelie Edrada-Ebel

series ordinal

2

0 references

author name string

Alan L Harvey

series ordinal

1

1 reference

2 August 2017

publication date

23 January 2015

1 reference

Nature Reviews Drug Discovery

2 August 2017

published in

1 reference

2 August 2017

volume

14

1 reference

2 August 2017

issue

2

1 reference

2 August 2017

page(s)

111-129

1 reference

Natural products in drug discovery

2 August 2017

cites work

1 reference

A historical overview of natural products in drug discovery.

31 March 2020

1 reference

Natural products as sources of new drugs over the 30 years from 1981 to 2010

31 March 2020

1 reference

Natural products: an evolving role in future drug discovery.

31 March 2020

1 reference

Natural products and Pharma 2011: strategic changes spur new opportunities

31 March 2020

1 reference

Natural products: a continuing source of novel drug leads

31 March 2020

1 reference

Antibiotics in the clinical pipeline in 2013.

31 March 2020

1 reference

Natural products as a robust source of new drugs and drug leads: past successes and present day issues

31 March 2020

1 reference

Enhancements of screening collections to address areas of unmet medical need: an industry perspective

31 March 2020

1 reference

Plate-based diversity selection based on empirical HTS data to enhance the number of hits and their chemical diversity

31 March 2020

1 reference

Impact of high-throughput screening in biomedical research

31 March 2020

1 reference

Biology-oriented synthesis

31 March 2020

1 reference

Charting, navigating, and populating natural product chemical space for drug discovery

31 March 2020

1 reference

Scaffold diversity of natural products: inspiration for combinatorial library design

31 March 2020

1 reference

Novel chemical space exploration via natural products

31 March 2020

1 reference

Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective

31 March 2020

1 reference

Quantifying biogenic bias in screening libraries

31 March 2020

1 reference

Target identification and mechanism of action in chemical biology and drug discovery

31 March 2020

1 reference

The why and how of phenotypic small-molecule screens

31 March 2020

1 reference

Targeting the human genome-microbiome axis for drug discovery: inspirations from global systems biology and traditional Chinese medicine.

31 March 2020

1 reference

In-silico studies in Chinese herbal medicines' research: evaluation of in-silico methodologies and phytochemical data sources, and a review of research to date

31 March 2020

1 reference

Collections of traditional Chinese medical literature as resources for systematic searches

31 March 2020

1 reference

Ethnobotanical approach versus random approach in the search for new bioactive compounds: support of a hypothesis

31 March 2020

1 reference

Effect of tannins on screening of plant extracts for enzyme inhibitory activity and techniques for their removal

31 March 2020

1 reference

High-throughput method for the production and analysis of large natural product libraries for drug discovery

31 March 2020

1 reference

A Simple Method for High-Throughput Extract Prefractionation for Biological Screening

31 March 2020

1 reference

Pre-fractionated microbial samples--the second generation natural products library at Wyeth

31 March 2020

1 reference

Marine natural product libraries for high-throughput screening and rapid drug discovery

31 March 2020

1 reference

Automated high-throughput system to fractionate plant natural products for drug discovery

31 March 2020

1 reference

Construction of a microbial natural product library for chemical biology studies

31 March 2020

1 reference

Drug-like properties: guiding principles for the design of natural product libraries.

31 March 2020

1 reference

A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity

31 March 2020

1 reference

Novel in vitro protein fragment complementation assay applicable to high-throughput screening in a 1536-well format

31 March 2020

1 reference

Development of antibiotic activity profile screening for the classification and discovery of natural product antibiotics.

31 March 2020

1 reference

31 March 2020

1 reference

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

31 March 2020

1 reference

Property distribution of drug-related chemical databases.

31 March 2020

1 reference

A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets.

31 March 2020

1 reference

31 March 2020

1 reference

Developing a drug-like natural product library

31 March 2020

1 reference

Statistical Investigation into the Structural Complementarity of Natural Products and Synthetic Compounds

31 March 2020

1 reference

Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry

31 March 2020

1 reference

Natural products as lead structures: chemical transformations to create lead-like libraries.

31 March 2020

1 reference

The influence of lead discovery strategies on the properties of drug candidates

31 March 2020

1 reference

Forward chemical genetics: library scaffold design

31 March 2020

1 reference

The Drug Discovery Portal: a resource to enhance drug discovery from academia

31 March 2020

1 reference

A global approach to analysis and interpretation of metabolic data for plant natural product discovery.

31 March 2020

1 reference

Expanding small-molecule functional metagenomics through parallel screening of broad-host-range cosmid environmental DNA libraries in diverse proteobacteria

31 March 2020

1 reference

A mass spectrometry-guided genome mining approach for natural product peptidogenomics

31 March 2020

1 reference

Metabolic profiling technologies for biomarker discovery in biomedicine and drug development

31 March 2020

1 reference

Metabolic profiling: pathways in drug discovery

31 March 2020

1 reference

Technical advance: application of high-performance liquid chromatography with photodiode array detection to the metabolic profiling of plant isoprenoids

31 March 2020

1 reference

Metabolomic tools for secondary metabolite discovery from marine microbial symbionts

31 March 2020

1 reference

Metabolic profiling on the right path

31 March 2020

1 reference

Metabolomic profiling and genomic study of a marine sponge-associated Streptomyces sp.

31 March 2020

1 reference

Global phenotypic characterization of bacteria

31 March 2020

1 reference

Fungal metabolite analysis in genomics and phenomics

31 March 2020

1 reference

Application of Fourier-transform ion cyclotron resonance mass spectrometry to metabolic profiling and metabolite identification.

31 March 2020

1 reference

New kids on the block: novel informatics methods for natural product discovery

31 March 2020

1 reference

Essential parameters for structural analysis and dereplication by (1)H NMR spectroscopy.

31 March 2020

1 reference

Recent advances and new strategies in the NMR-based identification of natural products

31 March 2020

1 reference

Identification of natural metabolites in mixture: a pattern recognition strategy based on (13)C NMR.

31 March 2020

1 reference

NMR fingerprints of the drug-like natural-product space identify iotrochotazine A: a chemical probe to study Parkinson's disease.

31 March 2020

1 reference

Metabolomics and dereplication strategies in natural products.

31 March 2020

1 reference

Dereplication strategies for targeted isolation of new antitrypanosomal actinosporins A and B from a marine sponge associated-Actinokineospora sp. EG49.

31 March 2020

1 reference

Methods for isolation, purification and structural elucidation of bioactive secondary metabolites from marine invertebrates

31 March 2020

1 reference

Methods for isolation of marine-derived endophytic fungi and their bioactive secondary products.

31 March 2020

1 reference

Metabolic profiling based on two-dimensional J-resolved 1H NMR data and parallel factor analysis

31 March 2020

1 reference

Natural products isolation in modern drug discovery programs

31 March 2020

1 reference

Strategies in biomarker discovery. Peak annotation by MS and targeted LC-MS micro-fractionation for de novo structure identification by micro-NMR.

31 March 2020

1 reference

Optimised protocols for the metabolic profiling of S. cerevisiae by 1H-NMR and HRMAS spectroscopy

31 March 2020

1 reference

HPLC-NMR revisited: using time-slice high-performance liquid chromatography-solid-phase extraction-nuclear magnetic resonance with database-assisted dereplication

31 March 2020

1 reference

VIZR--an automated chemometric technique for metabolic profiling

31 March 2020

1 reference

Dereplicating nonribosomal peptides using an informatic search algorithm for natural products (iSNAP) discovery.

31 March 2020

1 reference

MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data

31 March 2020

1 reference

MZmine: toolbox for processing and visualization of mass spectrometry based molecular profile data

31 March 2020

1 reference

Highly accurate chemical formula prediction tool utilizing high-resolution mass spectra, MS/MS fragmentation, heuristic rules, and isotope pattern matching

31 March 2020

1 reference

XCMS Online: a web-based platform to process untargeted metabolomic data

31 March 2020

1 reference

XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification

31 March 2020

1 reference

Comprehensive Extraction Method Integrated with NMR Metabolomics: A New Bioactivity Screening Method for Plants, Adenosine A1 Receptor Binding Compounds inOrthosiphon stamineusBenth

31 March 2020

1 reference

Evaluation and characterization of bacterial metabolic dynamics with a novel profiling technique, real-time metabolotyping

31 March 2020

1 reference

Diverse metabolic profiles of a Streptomyces strain isolated from a hyper-arid environment

31 March 2020

1 reference

Enhancement of antibiotic and secondary metabolite detection from filamentous fungi by growth on nutritional arrays

31 March 2020

1 reference

The main byproducts and metabolic flux profiling of γ-PGA-producing strain B. subtilis ZJU-7 under different pH values.

31 March 2020

1 reference

Metabolic flux profiling of recombinant protein secreting Pichia pastoris growing on glucose:methanol mixtures.

31 March 2020

1 reference

Flux analysis and metabolomics for systematic metabolic engineering of microorganisms

31 March 2020

1 reference

Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology

31 March 2020

1 reference

Toxicogenomics for the prediction of toxicity related to herbs from traditional Chinese medicine.

31 March 2020

1 reference

Advances in translational pharmacological investigations in identifying and validating molecular targets of natural product anticancer agents

31 March 2020

1 reference

Omics and its potential impact on R&D and regulation of complex herbal products

31 March 2020

1 reference

A chemometric study of chromatograms of tea extracts by correlation optimization warping in conjunction with PCA, support vector machines and random forest data modeling

31 March 2020

1 reference

Chemometric resolution of coeluting peaks of eleven antihypertensives from multiple classes in high performance liquid chromatography: a comprehensive research in human serum, health product and Chinese patent medicine samples

31 March 2020

1 reference

Unbiased evaluation of bioactive secondary metabolites in complex matrices

31 March 2020

1 reference

Exploring potential chemical markers by metabolomics method for studying the processing mechanism of traditional Chinese medicine using RPLC-Q-TOF/MS: a case study of Radix Aconiti

31 March 2020

1 reference

UPLC-Q-TOF-HDMS analysis of constituents in the root of two kinds of Aconitum using a metabolomics approach

31 March 2020

1 reference

Target separation of a new anti-tumor saponin and metabolic profiling of leaves of Panax notoginseng by liquid chromatography with eletrospray ionization quadrupole time-of-flight mass spectrometry

31 March 2020

1 reference

Benzaldehyde is a precursor of phenylpropylamino alkaloids as revealed by targeted metabolic profiling and comparative biochemical analyses in Ephedra spp

31 March 2020

1 reference

Effects of combined elicitors on tanshinone metabolic profiling and SmCPS expression in Salvia miltiorrhiza hairy root cultures.

31 March 2020

1 reference

Differential cardioprotective effects of salvianolic acid and tanshinone on acute myocardial infarction are mediated by unique signaling pathways

31 March 2020

1 reference

Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models.

31 March 2020

1 reference

Metagenomic approaches for exploiting uncultivated bacteria as a resource for novel biosynthetic enzymology.

31 March 2020

1 reference

Construction of a metagenomic library for the marine sponge Halichondria okadai

31 March 2020

1 reference

Approaches to capturing and designing biologically active small molecules produced by uncultured microbes

31 March 2020

1 reference

Accessing the hidden majority of marine natural products through metagenomics

31 March 2020

1 reference

Linking chemistry and genetics in the growing cyanobactin natural products family

31 March 2020

1 reference

Metagenomic Approaches to Identify and Isolate Bioactive Natural Products from Microbiota of Marine Sponges

31 March 2020

1 reference

Mining metagenomes for novel cellulase genes

31 March 2020

1 reference

Isolation of high molecular weight DNA from marine sponge bacteria for BAC library construction

31 March 2020

1 reference

Heterologous production of polyketides in bacteria

31 March 2020

1 reference

Metagenomic approaches to exploit the biotechnological potential of the microbial consortia of marine sponges.

31 March 2020

1 reference

Lessons from the past and charting the future of marine natural products drug discovery and chemical biology

31 March 2020

1 reference

Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses.

31 March 2020

1 reference

Detection and quantification of functional genes of cellulose- degrading, fermentative, and sulfate-reducing bacteria and methanogenic archaea

31 March 2020

1 reference

Search and discovery strategies for biotechnology: the paradigm shift

31 March 2020

1 reference

Metagenomic and metabolic profiling of nonlithifying and lithifying stromatolitic mats of Highborne Cay, The Bahamas

31 March 2020

1 reference

Biodiscovery from rare actinomycetes: an eco-taxonomical perspective

31 March 2020

1 reference

Optimization of whole-transcriptome amplification from low cell density deep-sea microbial samples for metatranscriptomic analysis

31 March 2020

1 reference

Drugs from hidden bugs: their discovery via untapped resources

31 March 2020

1 reference

Recent advances in the heterologous expression of microbial natural product biosynthetic pathways

31 March 2020

1 reference

The genome sequence of Streptomyces lividans 66 reveals a novel tRNA-dependent peptide biosynthetic system within a metal-related genomic island.

31 March 2020

1 reference

Toward awakening cryptic secondary metabolite gene clusters in filamentous fungi

31 March 2020

1 reference

Streptomyces coelicolor as an expression host for heterologous gene clusters.

31 March 2020

1 reference

Metabolomics methods for the synthetic biology of secondary metabolism

31 March 2020

1 reference

Luminmycins A-C, cryptic natural products from Photorhabdus luminescens identified by heterologous expression in Escherichia coli.

31 March 2020

1 reference

Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster

31 March 2020

1 reference

Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters

31 March 2020

1 reference

Alternative sigma factor over-expression enables heterologous expression of a type II polyketide biosynthetic pathway in Escherichia coli.

31 March 2020

1 reference

The logic, experimental steps, and potential of heterologous natural product biosynthesis featuring the complex antibiotic erythromycin A produced through E. coli.

31 March 2020

1 reference

Homologous overexpression of RfaH in E. coli K4 improves the production of chondroitin-like capsular polysaccharide.

31 March 2020

1 reference

Production of 7-O-methyl aromadendrin, a medicinally valuable flavonoid, in Escherichia coli.

31 March 2020

1 reference

Multi-factorial engineering of heterologous polyketide production in Escherichia coli reveals complex pathway interactions.

31 March 2020

1 reference

Engineering of a plasmid-free Escherichia coli strain for improved in vivo biosynthesis of astaxanthin

31 March 2020

1 reference

Genome-wide screening and identification of factors affecting the biosynthesis of prodigiosin by Hahella chejuensis, using Escherichia coli as a surrogate host.

31 March 2020

1 reference

Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering

31 March 2020

1 reference

Rapid cloning and heterologous expression of the meridamycin biosynthetic gene cluster using a versatile Escherichia coli-streptomyces artificial chromosome vector, pSBAC.

31 March 2020

1 reference

Biosynthesis of 5-deoxyflavanones in microorganisms.

31 March 2020

1 reference

Production of plant-specific flavanones by Escherichia coli containing an artificial gene cluster

31 March 2020

1 reference

Heterologous expression and characterization of bacterial 2-C-methyl-D-erythritol-4-phosphate pathway in Saccharomyces cerevisiae

31 March 2020

1 reference

DNA assembler: a synthetic biology tool for characterizing and engineering natural product gene clusters

31 March 2020

1 reference

Yeast artificial chromosomes employed for random assembly of biosynthetic pathways and production of diverse compounds in Saccharomyces cerevisiae

31 March 2020

1 reference

From genomes to systems: the path with yeast

31 March 2020

1 reference

Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae

31 March 2020

1 reference

Metabolic pathway engineering for complex polyketide biosynthesis in Saccharomyces cerevisiae.

31 March 2020

1 reference

Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A.

31 March 2020

1 reference

Refactoring the silent spectinabilin gene cluster using a plug-and-play scaffold

31 March 2020

1 reference

Bioactivity-guided genome mining reveals the lomaiviticin biosynthetic gene cluster in Salinispora tropica

31 March 2020

1 reference

Discovery of McbB, an enzyme catalyzing the β-carboline skeleton construction in the marinacarboline biosynthetic pathway

31 March 2020

1 reference

Bioactive compounds synthesized by non-ribosomal peptide synthetases and type-I polyketide synthases discovered through genome-mining and metagenomics

31 March 2020

1 reference

Advances in the arsenal of tools available enabling the discovery of novel lantibiotics with therapeutic potential

31 March 2020

1 reference

Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis.

31 March 2020

1 reference

Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites

31 March 2020

1 reference

Macrolide-induced ribosomal frameshifting: a new route to antibiotic resistance

31 March 2020

1 reference

Removal of frameshift intermediates by mismatch repair proteins in Saccharomyces cerevisiae

31 March 2020

1 reference

Biosynthesis of the antibiotic bacillaene, the product of a giant polyketide synthase complex of the trans-AT family

31 March 2020

1 reference

Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties

31 March 2020

1 reference

Lomaiviticins A and B, potent antitumor antibiotics from Micromonospora lomaivitiensis.

31 March 2020

1 reference

Altered TUBB3 expression contributes to the epothilone response of mitotic cells.

31 March 2020

1 reference

Ixabepilone for the treatment of breast cancer

31 March 2020

1 reference

The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90

31 March 2020

1 reference

Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum

31 March 2020

1 reference

Modular construction of a functional artificial epothilone polyketide pathway

31 March 2020

1 reference

Lomaiviticin biosynthesis employs a new strategy for starter unit generation

31 March 2020

1 reference

When the nine-membered enediynes play hide and seek

31 March 2020

1 reference

Guadinomines, Type III secretion system inhibitors, produced by Streptomyces sp. K01-0509. II: physico-chemical properties and structure elucidation

31 March 2020

1 reference

Membrane traffic wardens and protein secretion in gram-negative bacteria

31 March 2020

1 reference

Discovery, biosynthesis, and rational engineering of novel enterocin and wailupemycin polyketide analogues.

31 March 2020

1 reference

Metabolic engineering of flavonoids in plants and microorganisms

31 March 2020

1 reference

Metabolic engineering of plant monoterpenes, sesquiterpenes and diterpenes--current status and future opportunities.

31 March 2020

1 reference

Production of soybean isoflavone genistein in non-legume plants via genetically modified secondary metabolism pathway.

31 March 2020

1 reference

Nicotiana benthamiana as a production platform for artemisinin precursors

31 March 2020

1 reference

Production of the antimalarial drug precursor artemisinic acid in engineered yeast

31 March 2020

1 reference

High-level semi-synthetic production of the potent antimalarial artemisinin

31 March 2020

1 reference

Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development.

31 March 2020

1 reference

A simple conversion of artemisinic acid into artemisinin

31 March 2020

1 reference

Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli

31 March 2020

1 reference

Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting

31 March 2020

1 reference

Genomic mining for novel FADH₂-dependent halogenases in marine sponge-associated microbial consortia.

31 March 2020

1 reference

Diversity of nonribosomal peptide synthetase genes in the microbial metagenomes of marine sponges

31 March 2020

1 reference

Structure-activity relationship and mechanism of action studies of manzamine analogues for the control of neuroinflammation and cerebral infections.

31 March 2020

1 reference

Genetic evidence supports secondary metabolic diversity in Prochloron spp., the cyanobacterial symbiont of a tropical ascidian

31 March 2020

1 reference

Metagenome mining reveals polytheonamides as posttranslationally modified ribosomal peptides

31 March 2020

1 reference

An environmental bacterial taxon with a large and distinct metabolic repertoire

31 March 2020

1 reference

Natural products as a rich source of tau-targeting drugs for Alzheimer's disease

31 March 2020

1 reference

Src kinases as therapeutic targets for cancer

31 March 2020

1 reference

Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model.

31 March 2020

1 reference

Evaluation of DA-9801, a new herbal drug for diabetic neuropathy, on metabolism-mediated interaction

31 March 2020

1 reference

Antifungal drug development: challenges, unmet clinical needs, and new approaches.

31 March 2020

1 reference

Antibacterial resistance worldwide: causes, challenges and responses

31 March 2020

1 reference

The growing burden of antimicrobial resistance.

31 March 2020

1 reference

The global need for effective antibiotics: challenges and recent advances

31 March 2020

1 reference

Frontline antibiotic therapy.

31 March 2020

1 reference

10 x '20 Progress--development of new drugs active against gram-negative bacilli: an update from the Infectious Diseases Society of America

31 March 2020

1 reference

Novel antibacterials: a genomics approach to drug discovery

31 March 2020

1 reference

Challenges of antibacterial discovery revisited

31 March 2020

1 reference

Drugs for bad bugs: confronting the challenges of antibacterial discovery

31 March 2020

1 reference

Challenges of antibacterial discovery

31 March 2020

1 reference

Systems-level antimicrobial drug and drug synergy discovery

31 March 2020

1 reference

Platforms for antibiotic discovery

31 March 2020

1 reference

Recent advances in understanding the antibacterial properties of flavonoids

31 March 2020

1 reference

Systematics-guided bioprospecting for bioactive microbial natural products.

31 March 2020

1 reference

Plants as sources of new antimicrobials and resistance-modifying agents

31 March 2020

1 reference

Plant-derived antimicrobial compounds: alternatives to antibiotics

31 March 2020

1 reference

Medicinal plants: a source of anti-parasitic secondary metabolites.

31 March 2020

1 reference

Antifungal screening of endophytic fungi from Ginkgo biloba for discovery of potent anti-phytopathogenic fungicides

31 March 2020

1 reference

Pharmacologically prospective antibiotic agents and their sources: a marine microbial perspective

31 March 2020

1 reference

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

31 March 2020

1 reference

Platensimycin and platencin: promising antibiotics for future application in human medicine

31 March 2020

1 reference

Novel inhibitors of bacterial cytokinesis identified by a cell-based antibiotic screening assay

31 March 2020

1 reference

Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection

31 March 2020

1 reference

Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH)

31 March 2020

1 reference

A survey of yeast genomic assays for drug and target discovery

31 March 2020

1 reference

Combining functional genomics and chemical biology to identify targets of bioactive compounds

31 March 2020

1 reference

Dysregulation of bacterial proteolytic machinery by a new class of antibiotics

31 March 2020

1 reference

Confronting the challenges of natural product-based antifungal discovery

31 March 2020

1 reference

PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products.

31 March 2020

1 reference

Compound prioritization methods increase rates of chemical probe discovery in model organisms

31 March 2020

1 reference

C. elegans: model host and tool for antimicrobial drug discovery

31 March 2020

1 reference

A zebrafish high throughput screening system used for Staphylococcus epidermidis infection marker discovery

31 March 2020

1 reference

High-throughput screen for novel antimicrobials using a whole animal infection model

31 March 2020

1 reference

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

31 March 2020

1 reference

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

31 March 2020

1 reference

Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity

31 March 2020

1 reference

Protein-protein interactions as druggable targets: recent technological advances

31 March 2020

1 reference

Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions

31 March 2020

1 reference

The road less traveled: modulating signal transduction enzymes by inhibiting their protein-protein interactions

31 March 2020

1 reference

Small-molecule stabilization of protein-protein interactions: an underestimated concept in drug discovery?

31 March 2020

1 reference

2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions.

31 March 2020

1 reference

TIMBAL v2: update of a database holding small molecules modulating protein-protein interactions

31 March 2020

1 reference

Targeting protein-protein interactions: lessons from p53/MDM2.

31 March 2020

1 reference

Small molecular weight protein-protein interaction antagonists: an insurmountable challenge?

31 March 2020

1 reference

Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.

31 March 2020

1 reference

Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp.

31 March 2020

1 reference

The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53-mDM2 protein-protein interaction

31 March 2020

1 reference

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

31 March 2020

1 reference

Drugging the p53 pathway: understanding the route to clinical efficacy

31 March 2020

1 reference

A Phase I First-in-Human Pharmacokinetic and Pharmacodynamic Study of Serdemetan in Patients with Advanced Solid Tumors

31 March 2020

1 reference

The novel anticancer agent JNJ-26854165 induces cell death through inhibition of cholesterol transport and degradation of ABCA1

31 March 2020

1 reference

Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions

31 March 2020

1 reference

High-throughput screening for modulators of protein-protein interactions: use of photonic crystal biosensors and complementary technologies

31 March 2020

1 reference

A facile method to screen inhibitors of protein-protein interactions including MDM2-p53 displayed on T7 phage

31 March 2020

1 reference

Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules

31 March 2020

1 reference

Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins

31 March 2020

1 reference

A phase I study of AT-101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensive-stage small cell lung cancer

31 March 2020

1 reference

Bcl-2 antagonists: a proof of concept for CLL therapy

31 March 2020

1 reference

Natural product inhibitors of protein-protein interactions mediated by Src-family SH2 domains.

31 March 2020

1 reference

JBIR-22, an inhibitor for protein-protein interaction of the homodimer of proteasome assembly factor 3.

31 March 2020

1 reference

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

31 March 2020

1 reference

New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action

31 March 2020

1 reference

Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing

31 March 2020

1 reference

An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription

31 March 2020

1 reference

NP/MS since 1970: from the basement to the bench top.

31 March 2020

1 reference

Leveraging biodiversity knowledge for potential phyto-therapeutic applications

31 March 2020

1 reference

Emerging trends in genomic approaches for microbial bioprospecting

31 March 2020

1 reference

Marketed marine natural products in the pharmaceutical and cosmeceutical industries: tips for success

31 March 2020

1 reference

Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain

31 March 2020

1 reference

Eribulin mesylate: a novel halichondrin B analogue for the treatment of metastatic breast cancer

31 March 2020

1 reference

From micrograms to grams: scale-up synthesis of eribulin mesylate

31 March 2020

1 reference

Yondelis (trabectedin, ET-743): the development of an anticancer agent of marine origin

31 March 2020

1 reference

The neuroprotective effects of intrathecal administration of the selective N-type calcium channel blocker ziconotide in a rat model of spinal ischemia

31 March 2020

1 reference

The impact of the United Nations Convention on Biological Diversity on natural products research

31 March 2020

1 reference

Access to and use of marine genetic resources: understanding the legal framework.

31 March 2020

1 reference

Microscale methodology for structure elucidation of natural products

31 March 2020

1 reference

NMR of natural products at the 'nanomole-scale'.

31 March 2020

1 reference

Structure elucidation at the nanomole scale. 3. Phorbasides G-I from Phorbas sp.

31 March 2020

1 reference

Acetylated dammarane-type bisdesmosides from Combretum inflatum.

31 March 2020

1 reference

Cytotoxic and antibacterial beilschmiedic acids from a Gabonese species of Beilschmiedia

31 March 2020

1 reference

Phenylpropanoids from Phragmipedium calurum and their antiproliferative activity

31 March 2020

1 reference

Isolation of apoptosis-inducing stilbenoids from four members of the Orchidaceae family

31 March 2020

1 reference

From single to multiple microcoil flow probe NMR and related capillary techniques: a review

31 March 2020

1 reference

Assigning stereochemistry to single diastereoisomers by GIAO NMR calculation: the DP4 probability

31 March 2020

1 reference

Structure validation of natural products by quantum-mechanical GIAO calculations of 13C NMR chemical shifts

31 March 2020

1 reference

Determination of the relative stereochemistry of flexible organic compounds by Ab initio methods: conformational analysis and Boltzmann-averaged GIAO 13C NMR chemical shifts.

31 March 2020

1 reference

ZINC: a free tool to discover chemistry for biology

31 March 2020

1 reference

Diazo group electrophilicity in kinamycins and lomaiviticin A: potential insights into the molecular mechanism of antibacterial and antitumor activity

31 March 2020

1 reference

Molecular insights into the biosynthesis of guadinomine: a type III secretion system inhibitor

31 March 2020

1 reference

Use of natural products as chemical library for drug discovery and network pharmacology

31 March 2020

1 reference

Pharmacophore-driven identification of PPARγ agonists from natural sources.

31 March 2020

1 reference

iSMART: an integrated cloud computing web server for traditional Chinese medicine for online virtual screening, de novo evolution and drug design

31 March 2020

1 reference

iScreen: world's first cloud-computing web server for virtual screening and de novo drug design based on TCM database@Taiwan

31 March 2020

1 reference

Applications of integrated data mining methods to exploring natural product space for acetylcholinesterase inhibitors

31 March 2020

1 reference

AfroDb: a select highly potent and diverse natural product library from African medicinal plants

31 March 2020

1 reference

Development of a natural products database from the biodiversity of Brazil.

31 March 2020

1 reference

A new antibiotic kills pathogens without detectable resistance

31 March 2020

1 reference

Activation of fungal silent gene clusters: a new avenue to drug discovery.

31 March 2020

1 reference

12 December 2020

Identification and biotechnological application of novel regulatory genes involved in Streptomyces polyketide overproduction through reverse engineering strategy

1 reference

12 December 2020

Antimicrobial plant metabolites: structural diversity and mechanism of action

1 reference

12 December 2020

Medicinal Chemistry: Challenges and Opportunities

1 reference

12 December 2020

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

12 December 2020

Overexpressing transcriptional regulator in Aspergillus oryzae activates a silent biosynthetic pathway to produce a novel polyketide

1 reference

12 December 2020

[Isolation of naringenin from Cynachum vincetoxicum (L.) Pers. 10]

1 reference

12 December 2020

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

1 reference

12 December 2020

Infection of zebrafish embryos with intracellular bacterial pathogens

1 reference

12 December 2020

Metabolomics for bioactivity assessment of natural products.

1 reference

12 December 2020

Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data

1 reference

12 December 2020

The Design of Leadlike Combinatorial Libraries

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD4510

1 reference

2 August 2017

1 reference