(Q35125093)

6 August 2017

1 reference

title

Aspartic proteases involved in Alzheimer's disease (English)

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6 August 2017

0 references

Boris Schmidt

1

1 reference

6 August 2017

1 May 2003

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6 August 2017

1 reference

6 August 2017

4

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6 August 2017

5

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6 August 2017

366-378

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Prevalence of Alzheimer's disease in very elderly people: a prospective neuropathological study.

6 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Therapeutic approaches to Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Alzheimer's disease: an overview of current and emerging therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Economic evaluation of donepezil treatment for Alzheimer's disease in Japan

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

New hope for Alzheimer disease vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Gene identification in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Genotype and phenotype in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

New frontiers in Alzheimer's disease genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

The Alzheimer family of diseases: many etiologies, one pathogenesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Dancing in the dark? The status of late-onset Alzheimer's disease genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Presenilin structure, function and role in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Mouse models of Alzheimer's disease: a quest for plaques and tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

TACE and other ADAM proteases as targets for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

A phase I study of AIT-082 in healthy elderly volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Beta-amyloid therapies in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

The beta-secretase, BACE: a prime drug target for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Where Notch and Wnt signaling meet. The presenilin hub

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Presenilin-dependent gamma-secretase activity modulates neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Presenilins are not required for A beta 42 production in the early secretory pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Endoproteolysis of presenilin in vitro: inhibition by gamma-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

The Role of presenilins in gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Intramembrane proteolysis by presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

The search for gamma-secretase and development of inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Beta-secretase as a therapeutic target for inhibitor drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Inhibition of BACE, a promising approach to Alzheimer's disease therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Nicastrin binds to membrane-tethered Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Maturation and pro-peptide cleavage of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Protease inhibitors: current status and future prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Mechanism of Inhibition of beta-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

BACE2 functions as an alternative alpha-secretase in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

The protease inhibitor, MG132, blocks maturation of the amyloid precursor protein Swedish mutant preventing cleavage by beta-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

A combinatorial approach to the identification of dipeptide aldehyde inhibitors of beta-amyloid production

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

gamma-Secretase inhibitors as molecular probes of presenilin function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Presenilin-dependent gamma-secretase activity modulates thymocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

A series of C-terminal amino alcohol dipeptide A beta inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Metabolic regulation of brain Abeta by neprilysin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Fenchylamine sulfonamide inhibitors of amyloid beta peptide production by the gamma-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

A new series of potent benzodiazepine gamma-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Treatment of Alzheimer's disease with clioquinol

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

'...and C is for Clioquinol' - the AbetaCs of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

The challenges of developing and validating molecular and biochemical markers of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Diagnostic approaches to Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Biochemical markers related to Alzheimer's dementia in serum and cerebrospinal fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

p97 as a biomarker for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Blood and CSF biomarkers for AD revisited: what's new, what's good, and is this where we should be looking?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Differential increase in cerebrospinal fluid-acetylcholinesterase after treatment with acetylcholinesterase inhibitors in patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Human kallikrein 6 as a biomarker of alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

N(epsilon)(gamma-glutamyl)lysine in cerebrospinal fluid marks Alzheimer type and vascular dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Amyloid probes based on Congo Red distinguish between fibrils comprising different peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Histochemical analysis of senile plaque amyloid and amyloid angiopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Isomerization of (Z,Z) to (E,E)1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene in strong base: probes for amyloid plaques in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Plasma homocysteine as a risk factor for dementia and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Transgenic mouse models of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Gamma -secretase inhibitors repress thymocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Biochemical markers of Alzheimer's disease: wish and reality

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

Development of small molecule probes for the Beta-amyloid protein of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200200532

21 January 2018

Identifiers

DOI

10.1002/CBIC.200200532

1 reference

6 August 2017

1 reference

PubMed ID

12740808