(Q35645271)

English

Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease

scientific article published on 4 November 2011

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scholarly article

1 reference

Europe PubMed Central

9 August 2017

Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease (English)

1 reference

Europe PubMed Central

9 August 2017

Huntington's disease

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author name string

P Hemachandra Reddy

1

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Europe PubMed Central

9 August 2017

Ulziibat P Shirendeb

2

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Europe PubMed Central

9 August 2017

language of work or name

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publication date

4 November 2011

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Europe PubMed Central

9 August 2017

Biochimica et Biophysica Acta

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Europe PubMed Central

9 August 2017

1822

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Europe PubMed Central

9 August 2017

101-110

1 reference

Europe PubMed Central

9 August 2017

2

1 reference

Europe PubMed Central

9 August 2017

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

1 reference

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12 July 2018

A β-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes

1 reference

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12 July 2018

Optical trapping for the characterization of amyloid-beta aggregation kinetics

1 reference

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12 July 2018

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

1 reference

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12 July 2018

ELISA measurement of specific non-antigen-bound antibodies to Aβ1-42 monomer and soluble oligomers in sera from Alzheimer's disease, mild cognitively impaired, and noncognitively impaired subjects

1 reference

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12 July 2018

Proteasome inhibition induces α-synuclein SUMOylation and aggregate formation

1 reference

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12 July 2018

DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease

1 reference

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12 July 2018

Gene therapy in mouse models of huntington disease.

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12 July 2018

Targeting oligomers in neurodegenerative disorders: lessons from α-synuclein, tau, and amyloid-β peptide

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RNAi medicine for the brain: progresses and challenges.

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Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

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12 July 2018

Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds

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12 July 2018

Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers.

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12 July 2018

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

1 reference

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12 July 2018

Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation

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12 July 2018

Oligonucleotide therapeutic approaches for Huntington disease

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12 July 2018

Differential electrophysiological changes in striatal output neurons in Huntington's disease.

1 reference

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12 July 2018

Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage

1 reference

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12 July 2018

Formation and toxicity of soluble polyglutamine oligomers in living cells

1 reference

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12 July 2018

Huntington's disease: from molecular pathogenesis to clinical treatment

1 reference

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12 July 2018

Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases

1 reference

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12 July 2018

The rise and fall of Dimebon

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Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

1 reference

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12 July 2018

Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis

1 reference

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12 July 2018

Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

1 reference

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12 July 2018

Presynaptic dysfunction in Huntington's disease.

1 reference

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12 July 2018

Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: potential implications for Alzheimer's and Parkinson's diseases

1 reference

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12 July 2018

A randomized, placebo-controlled trial of latrepirdine in Huntington disease

1 reference

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12 July 2018

Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease

1 reference

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12 July 2018

Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

1 reference

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12 July 2018

Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment

1 reference

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12 July 2018

Mitochondrial structural and functional dynamics in Huntington's disease

1 reference

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12 July 2018

Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients

1 reference

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12 July 2018

Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.

1 reference

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12 July 2018

Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models

1 reference

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12 July 2018

Targeting oxidative/nitrergic stress ameliorates motor impairment, and attenuates synaptic mitochondrial dysfunction and lipid peroxidation in two models of Huntington's disease

1 reference

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12 July 2018

Allele-specific silencing of mutant Huntington's disease gene

1 reference

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12 July 2018

Impairing the mitochondrial fission and fusion balance: a new mechanism of neurodegeneration

1 reference

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12 July 2018

Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

1 reference

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12 July 2018

Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo

1 reference

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12 July 2018

Linking SNPs to CAG repeat length in Huntington's disease patients.

1 reference

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12 July 2018

Minimizing variables among hairpin-based RNAi vectors reveals the potency of shRNAs

1 reference

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Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study

1 reference

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12 July 2018

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

1 reference

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12 July 2018

Impaired regulation of brain mitochondria by extramitochondrial Ca2+ in transgenic Huntington disease rats

1 reference

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12 July 2018

Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice

1 reference

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12 July 2018

Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus

1 reference

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12 July 2018

Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi

1 reference

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12 July 2018

N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking

1 reference

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12 July 2018

Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease

1 reference

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12 July 2018

Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits

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12 July 2018

Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity

1 reference

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12 July 2018

Mitochondrial dysfunction in aging and Alzheimer's disease: strategies to protect neurons

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12 July 2018

Cell systems and the toxic mechanism(s) of alpha-synuclein

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12 July 2018

Selective defect of in vivo glycolysis in early Huntington's disease striatum

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12 July 2018

Hypothesis: Huntingtin may function in membrane association and vesicular trafficking

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12 July 2018

Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications

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12 July 2018

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

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12 July 2018

Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.

1 reference

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12 July 2018

Mutant huntingtin expression induces mitochondrial calcium handling defects in clonal striatal cells: functional consequences

1 reference

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12 July 2018

Role of autophagy in the clearance of mutant huntingtin: a step towards therapy?

1 reference

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12 July 2018

Designing siRNA that distinguish between genes that differ by a single nucleotide

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12 July 2018

Protective roles for induction of autophagy in multiple proteinopathies

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12 July 2018

Mitochondrial fusion and fission in mammals

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12 July 2018

Target selectivity in mRNA silencing

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12 July 2018

Brain imaging and cognitive dysfunctions in Huntington's disease

1 reference

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12 July 2018

Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis

1 reference

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12 July 2018

Huntingtin associates with acidic phospholipids at the plasma membrane

1 reference

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12 July 2018

Evidence of a breakdown of corticostriatal connections in Parkinson's disease.

1 reference

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12 July 2018

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

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12 July 2018

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

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12 July 2018

Ca2+-induced permeability transition in human lymphoblastoid cell mitochondria from normal and Huntington's disease individuals.

1 reference

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12 July 2018

Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro

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12 July 2018

Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation

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12 July 2018

Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release

1 reference

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12 July 2018

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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12 July 2018

Magnetic resonance imaging and spectroscopy in assessing 3-nitropropionic acid-induced brain lesions: an animal model of Huntington's disease.

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12 July 2018

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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12 July 2018

Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy

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12 July 2018

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

1 reference

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12 July 2018

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

1 reference

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12 July 2018

Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription

1 reference

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12 July 2018

Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease

1 reference

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12 July 2018

An abnormal striatal synaptic plasticity may account for the selective neuronal vulnerability in Huntington's disease

1 reference

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12 July 2018

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

1 reference

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12 July 2018

Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95.

1 reference

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12 July 2018

Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription

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12 July 2018

Glutamine repeats and neurodegeneration

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12 July 2018

Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.

1 reference

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12 July 2018

Wild-type huntingtin protects from apoptosis upstream of caspase-3.

1 reference

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12 July 2018

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

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12 July 2018

Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease

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12 July 2018

Recent advances in understanding the pathogenesis of Huntington's disease

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12 July 2018

Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

12 July 2018

Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

12 July 2018

Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

12 July 2018

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

12 July 2018

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

12 July 2018

Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

12 July 2018

Single photon emission computed tomographic blood flow and magnetic resonance volume imaging of basal ganglia in Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

12 July 2018

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

12 July 2018

Neuronal loss in the hippocampus in Huntington's disease: a comparison with HIV infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

12 July 2018

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

12 July 2018

Reduced basal ganglia volume associated with the gene for Huntington's disease in asymptomatic at-risk persons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

12 July 2018

Cerebral metabolism and atrophy in huntington's disease determined by18FDG and computed tomographic scan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

12 July 2018

Huntington's disease in children. Neuropathologic study of four cases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

12 July 2018

PET scan investigations of Huntington's disease: cerebral metabolic correlates of neurological features and functional decline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

12 July 2018

Positron emission tomography in the early diagnosis of Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

12 July 2018

Neuropathological classification of Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

12 July 2018

Clinical-pathologic correlation in Huntington's disease: a neuropsychological and computed tomography study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

12 July 2018

Cortical and subcortical glucose consumption measured by PET in patients with Huntington's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

12 July 2018

Cerebral structure on MRI, part II: Specific changes in Alzheimer's and Huntington's diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

12 July 2018

The effects of amyloid-β42 oligomer on the proliferation and activation of astrocytes in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

AMPA-receptor-mediated excitatory synaptic transmission is enhanced by iron-induced α-synuclein oligomers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

α-synuclein induced synapse damage is enhanced by amyloid-β1-42.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Role of adenosine A(2A) receptors in modulating synaptic functions and brain levels of BDNF: a possible key mechanism in the pathophysiology of Huntington's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

In situ mitochondrial Ca2+ buffering differences of intact neurons and astrocytes from cortex and striatum.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Weight loss in Huntington disease increases with higher CAG repeat number

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Hypothalamic involvement in Huntington's disease: an in vivo PET study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Mitochondrial NAD+-linked State 3 respiration and complex-I activity are compromised in the cerebral cortex of 3-nitropropionic acid-induced rat model of Huntington's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Increased caspase-2, calpain activations and decreased mitochondrial complex II activity in cells expressing exogenous huntingtin exon 1 containing CAG repeat in the pathogenic range

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Detection of polyglutamine protein oligomers in cells by fluorescence correlation spectroscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Wild-type huntingtin participates in protein trafficking between the Golgi and the extracellular space

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Rapamycin pre-treatment protects against apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Rapamycin alleviates toxicity of different aggregate-prone proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Differential loss of synaptic proteins in Alzheimer's disease: implications for synaptic dysfunction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Huntington's disease: clinical correlates of disability and progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Expansion of polyglutamine induces the formation of quasi-aggregate in the early stage of protein fibrillization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Coenzyme Q10 and remacemide hydrochloride ameliorate motor deficits in a Huntington's disease transgenic mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Progression of symptoms in the early and middle stages of Huntington disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Biochemical abnormalities and excitotoxicity in Huntington's disease brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Longitudinal change in basal ganglia volume in patients with Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249480

25 September 2018

Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22080977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A toxic monomeric conformer of the polyglutamine protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22080977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BBADIS.2011.10.016

1 reference

Europe PubMed Central

9 August 2017

1 reference

Europe PubMed Central

9 August 2017

1 reference

Europe PubMed Central

9 August 2017

ResearchGate publication ID

0 references

Sitelinks

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