(Q38896940)

7 September 2017

1 reference

title

To clear, or not to clear (senescent cells)? That is the question (English)

1 reference

7 September 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27417123%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Amaia Lujambio

series ordinal

1

1 reference

7 September 2017

language of work or name

English

0 references

publication date

1 July 2016

1 reference

7 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27417123%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

38 Suppl 1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27417123%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

page(s)

S56-64

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27417123%20AND%20SRC:MED&resulttype=core&format=json

The serial cultivation of human diploid cell strains

10 June 2020

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1 reference

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Forging a signature of in vivo senescence

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Extension of life-span by introduction of telomerase into normal human cells

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

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Cellular senescence: when bad things happen to good cells

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Cellular senescence in cancer and aging

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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Cellular senescence: from physiology to pathology

21 January 2018

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Chemokine signaling via the CXCR2 receptor reinforces senescence

21 January 2018

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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

21 January 2018

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Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

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Senescence-messaging secretome: SMS-ing cellular stress

21 January 2018

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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

21 January 2018

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Lessons from senescence: Chromatin maintenance in non-proliferating cells

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Inside and out: the activities of senescence in cancer.

21 January 2018

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Physiological and pathological consequences of cellular senescence.

21 January 2018

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Telomeres shorten during ageing of human fibroblasts

21 January 2018

1 reference

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Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins

21 January 2018

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Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

21 January 2018

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Functional links between telomeres and proteins of the DNA-damage response

21 January 2018

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Living on a break: cellular senescence as a DNA-damage response

21 January 2018

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

21 January 2018

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Oxidative DNA damage and senescence of human diploid fibroblast cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Feedback between p21 and reactive oxygen production is necessary for cell senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

The regulation of INK4/ARF in cancer and aging

21 January 2018

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Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

BRAFE600-associated senescence-like cell cycle arrest of human naevi

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Rb Regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

A negative feedback signaling network underlies oncogene-induced senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

The role of senescent cells in ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Reversal of human cellular senescence: roles of the p53 and p16 pathways

21 January 2018

1 reference

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Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Microarray analysis of replicative senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Senescence is a developmental mechanism that contributes to embryonic growth and patterning

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Programmed cell senescence during mammalian embryonic development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine 'bystander senescence'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Klotho suppresses RIG-I-mediated senescence-associated inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Senescent cells: SASPected drivers of age-related pathologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Senescence of activated stellate cells limits liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Non-cell-autonomous tumor suppression by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Immunosurveillance of senescent cells: the bright side of the senescence program

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Senescent cells communicate via intercellular protein transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Fibrosis-dependent mechanisms of hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Granule exocytosis mediates immune surveillance of senescent cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Recurrent turnover of senescent cells during regeneration of a complex structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Cellular senescence in aging primates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Accumulation of senescent cells in mitotic tissue of aging primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Genetics of melanoma progression: the rise and fall of cell senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Pulmonary artery smooth muscle cell senescence is a pathogenic mechanism for pulmonary hypertension in chronic lung disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Oncogene-induced senescence as an initial barrier in lymphoma development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Restoration of p53 function leads to tumour regression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Therapeutic efficacy of p53 restoration in Mdm2-overexpressing tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Pro-senescence therapy for cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Palbociclib in Hormone-Receptor-Positive Advanced Breast Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Sunitinib induces cellular senescence via p53/Dec1 activation in renal cell carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Enhancing chemotherapy efficacy by reprogramming the senescence-associated secretory phenotype of prostate tumors: A way to reactivate the antitumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201670910

21 January 2018

Identifiers

DOI

10.1002/BIES.201670910

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27417123%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference