(Q49853005)

22 February 2018

title

The spectrum of T cell metabolism in health and disease. (English)

1 reference

22 February 2018

2

Lorenzo Galluzzi

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22 February 2018

3

Guido Kroemer

1 reference

22 February 2018

Glenn R Bantug

1

1 reference

22 February 2018

Christoph Hess

series ordinal

4

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22 February 2018

publication date

25 September 2017

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22 February 2018

Nature Reviews Immunology

published in

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22 February 2018

volume

18

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22 February 2018

issue

1

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22 February 2018

page(s)

19-34

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22 February 2018

T cells in Systemic Lupus Erythematosus

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Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation

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Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion

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TSC2 mediates cellular energy response to control cell growth and survival

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AKT/PKB signaling: navigating downstream

21 January 2018

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The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

21 January 2018

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mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation

21 January 2018

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The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin

21 January 2018

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The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

21 January 2018

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T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming

21 January 2018

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mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.

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Metabolism, migration and memory in cytotoxic T cells

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The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

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c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells

21 January 2018

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Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation

21 January 2018

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Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen.

21 January 2018

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The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2017.99

Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Cell surface Glut1 levels distinguish human CD4 and CD8 T lymphocyte subsets with distinct effector functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2017.99

The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells

21 January 2018

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Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2017.99

Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2017.99

Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Cutting Edge: Hypoxia-Inducible Factor 1 Negatively Regulates Th1 Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

RhoA orchestrates glycolysis for TH2 cell differentiation and allergic airway inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Analysis of thymocyte development reveals that the GTPase RhoA is a positive regulator of T cell receptor responses in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Rho-GTPases as key regulators of T lymphocyte biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Spatiotemporal patterning during T cell activation is highly diverse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Metabolic maintenance of cell asymmetry following division in activated T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Posttranscriptional control of T cell effector function by aerobic glycolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

From Krebs to clinic: glutamine metabolism to cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Sestrin2 is a leucine sensor for the mTORC1 pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2017.99

Serine, glycine and one-carbon units: cancer metabolism in full circle

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2017.99

Serine Is an Essential Metabolite for Effector T Cell Expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Memory CD8+ T cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

mTOR regulates memory CD8 T-cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Diversity in T cell memory: an embarrassment of riches

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Lineage relationship and protective immunity of memory CD8 T cell subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Constitutive Glycolytic Metabolism Supports CD8(+) T Cell Effector Memory Differentiation during Viral Infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Serial transfer of single-cell-derived immunocompetence reveals stemness of CD8(+) central memory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Glycolysis determines dichotomous regulation of T cell subsets in hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

The Immune-Metabolic Basis of Effector Memory CD4+ T Cell Function under Hypoxic Conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Tissue-resident memory T cells: local specialists in immune defence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Memory CD8(+) T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Inflammation, metaflammation and immunometabolic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Type 2 diabetes as an inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

B Lymphocytes in obesity-related adipose tissue inflammation and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Normalization of obesity-associated insulin resistance through immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

IL-17 regulates adipogenesis, glucose homeostasis, and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

T-cell profile in adipose tissue is associated with insulin resistance and systemic inflammation in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Adipose invariant natural killer T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Chromatin decondensation and T cell hyperresponsiveness in diabetes-associated hyperglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Hyperglycemia-induced activation of human T-lymphocytes with de novo emergence of insulin receptors and generation of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Transcriptional coactivator p300 regulates glucose-induced gene expression in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

ATP-citrate lyase is essential for high glucose-induced histone hyperacetylation and fibrogenic gene upregulation in mesangial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

High glucose induced alteration of SIRTs in endothelial cells causes rapid aging in a p300 and FOXO regulated pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

A new link between diabetes and cancer: enhanced WNT/β-catenin signaling by high glucose.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

The nuclear receptor LXR is a glucose sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

LXR signaling couples sterol metabolism to proliferation in the acquired immune response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Saturated fatty acid-mediated inflammation and insulin resistance in adipose tissue: mechanisms of action and implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Obesity Drives Th17 Cell Differentiation by Inducing the Lipid Metabolic Kinase, ACC1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Identification of natural RORγ ligands that regulate the development of lymphoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

The Intracellular Cholesterol Landscape: Dynamic Integrator of the Immune Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Fat poetry: a kingdom for PPAR gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Repression of IFN-gamma expression by peroxisome proliferator-activated receptor gamma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPARgamma co-association with transcription factor NFAT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

The nuclear receptor PPARs as important regulators of T-cell functions and autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

The Inflammatory Response in Psoriasis: a Comprehensive Review

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Critical regulation of early Th17 cell differentiation by interleukin-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Induction and molecular signature of pathogenic TH17 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Metabolomics in rheumatic diseases: desperately seeking biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Normalization of CD4+ T cell metabolism reverses lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Amino acids and immune function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Interplay between lipids and branched-chain amino acids in development of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Cytosolic branched chain aminotransferase (BCATc) regulates mTORC1 signaling and glycolytic metabolism in CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

System A amino acid transporters regulate glutamine uptake and attenuate antibody-mediated arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

The methotrexate story: a paradigm for development of cancer chemotherapeutic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Mechanistic diversity of radical S-adenosylmethionine (SAM)-dependent methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Metabolomics in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Simvastatin inhibits IFN regulatory factor 4 expression and Th17 cell differentiation in CD4+ T cells derived from patients with multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Combination cancer immunotherapies tailored to the tumour microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Tumor metabolism as modulator of immune response and tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

T cell metabolic fitness in antitumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Metabolic targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Fueling the Cell Division Cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Rapamycin Impairs Antitumor CD8+ T-cell Responses and Vaccine-Induced Tumor Eradication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Regulation of T cells by mTOR: the known knowns and the known unknowns

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Acetate dependence of tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Cancer metabolism: fatty acid oxidation in the limelight

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Foxp3+ T cells inhibit antitumor immune memory modulated by mTOR inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Blockade of mTOR signaling via rapamycin combined with immunotherapy augments antiglioma cytotoxic and memory T-cell functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Friends not foes: CTLA-4 blockade and mTOR inhibition cooperate during CD8+ T cell priming to promote memory formation and metabolic readiness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Persistent Antigen and Prolonged AKT-mTORC1 Activation Underlie Memory CD8 T Cell Impairment in the Absence of CD4 T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Characterization of the metabolic phenotype of rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Autophagy is essential for effector CD8(+) T cell survival and memory formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Immunological mechanisms of the antitumor effects of supplemental oxygenation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and increases antitumor immunoreactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Ionic immune suppression within the tumour microenvironment limits T cell effector function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Uric acid enhances the antitumor immunity of dendritic cell-based vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

A dual role for autophagy in a murine model of lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

l-Arginine depletion blunts antitumor T-cell responses by inducing myeloid-derived suppressor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Tryptophan hydroxylase-1 regulates immune tolerance and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Trial Watch-Small molecules targeting the immunological tumor microenvironment for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

The key role of IL-6-arginase cascade for inducing dendritic cell-dependent CD4(+) T cell dysfunction in tumor-bearing mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Primary Immunodeficiencies and Inflammatory Disease: A Growing Genetic Intersection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Molecular definitions of autophagy and related processes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Mitochondria and the autophagy-inflammation-cell death axis in organismal aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Compromised autophagy and neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Metabolic control of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Autophagy at the crossroads of catabolism and anabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Autophagy in infection, inflammation, and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Autophagy defends cells against invading group A Streptococcus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Autophagy in malignant transformation and cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Efficient cross-presentation depends on autophagy in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Transcriptional control of cellular metabolism by mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Interferon Regulatory Factor 4 controls TH1 cell effector function and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Bcl-6 directly represses the gene program of the glycolysis pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Adipokines in inflammation and metabolic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Cytokine-mediated programmed proliferation of virus-specific CD8(+) memory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

IL-6, in synergy with IL-7 or IL-15, stimulates TCR-independent proliferation and functional differentiation of CD8+ T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Leptin metabolically licenses T cells for activation to link nutrition and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Pioglitazone, a peroxisome proliferator-activated receptor gamma activator, ameliorates experimental autoimmune myocarditis by modulating Th1/Th2 balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Magnitude of the host nutritional responses to infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Regulation and function of mTOR signalling in T cell fate decisions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Autophagy is a critical regulator of memory CD8(+) T cell formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Stable activation of phosphatidylinositol 3-kinase in the T cell immunological synapse stimulates Akt signaling to FoxO1 nuclear exclusion and cell growth control

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Immunopathology of multiple sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Profile of Circulatory Metabolites in a Relapsing-remitting Animal Model of Multiple Sclerosis using Global Metabolomics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

Amino acid flux and protein synthesis after exposure of rats to either Diplococcus pneumoniae or Salmonella typhimurium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2017.99

inferred from DOI database lookup

7 January 2021

based on heuristic

Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28944771

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI.2017.99

1 reference

22 February 2018

PubMed ID

28944771

1 reference

22 February 2018