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Drosophila as an In Vivo Model for Human Neurodegenerative Disease
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Europe PubMed Central
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4596656
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26447127%20AND%20SRC:MED&resulttype=core&format=json
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26 February 2020
title
Drosophila as an In Vivo Model for Human Neurodegenerative Disease
(English)
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PubMed
stated in
Europe PubMed Central
PMC publication ID
4596656
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26447127%20AND%20SRC:MED&resulttype=core&format=json
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26 February 2020
main subject
Drosophila
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neurodegeneration
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author
Leeanne McGurk
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1
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Europe PubMed Central
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4596656
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26 February 2020
Amit Berson
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2
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Europe PubMed Central
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4596656
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26 February 2020
Nancy M. Bonini
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3
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Nancy M Bonini
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Europe PubMed Central
PMC publication ID
4596656
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26 February 2020
language of work or name
English
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publication date
1 October 2015
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4596656
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26 February 2020
published in
Genetics
2 references
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PubMed
stated in
Europe PubMed Central
PMC publication ID
4596656
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26447127%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 February 2020
volume
201
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Europe PubMed Central
PMC publication ID
4596656
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retrieved
26 February 2020
issue
2
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PubMed
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Europe PubMed Central
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4596656
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26 February 2020
page(s)
377-402
2 references
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PubMed
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Europe PubMed Central
PMC publication ID
4596656
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26 February 2020
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20 March 2017
The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins
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Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy
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20 March 2017
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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
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7 April 2017
Comparative genomics of the eukaryotes
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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
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Parkinson's disease
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7 April 2017
Biological and chemical approaches to diseases of proteostasis deficiency
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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
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7 April 2017
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
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7 April 2017
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
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7 April 2017
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
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7 April 2017
A Drosophila model of Parkinson's disease
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7 April 2017
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
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7 April 2017
The C9orf72 repeat expansion disrupts nucleocytoplasmic transport.
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9 May 2017
GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport
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PubMed Central
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29 September 2017
Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response
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29 September 2017
Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain
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29 September 2017
Histone deacetylase inhibitors in clinical studies as templates for new anticancer agents
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29 September 2017
Improved and expanded Q-system reagents for genetic manipulations
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29 September 2017
Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death
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29 September 2017
α-Synuclein modifies mutant huntingtin aggregation and neurotoxicity in Drosophila
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PubMed Central
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29 September 2017
Potential function for the Huntingtin protein as a scaffold for selective autophagy
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29 September 2017
Compound heterozygous PNPLA6 mutations cause Boucher-Neuhäuser syndrome with late-onset ataxia
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29 September 2017
Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress
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PubMed Central
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29 September 2017
Development and characterization of an aged onset model of Alzheimer's disease in Drosophila melanogaster
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29 September 2017
Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
Poly-A binding protein-1 localization to a subset of TDP-43 inclusions in amyotrophic lateral sclerosis occurs more frequently in patients harboring an expansion in C9orf72
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29 September 2017
C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
The global epidemiology of hereditary ataxia and spastic paraplegia: a systematic review of prevalence studies
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29 September 2017
Chemical mutagens, transposons, and transgenes to interrogate gene function in Drosophila melanogaster
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29 September 2017
Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease
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PubMed Central
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29 September 2017
The neuropathology associated with repeat expansions in the C9ORF72 gene
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29 September 2017
PNPLA6 mutations cause Boucher-Neuhauser and Gordon Holmes syndromes as part of a broad neurodegenerative spectrum
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
Ataxin-3 protein and RNA toxicity in spinocerebellar ataxia type 3: current insights and emerging therapeutic strategies
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
Hexanucleotide repeats in ALS/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72.
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29 September 2017
RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia
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29 September 2017
FlyBase 102--advanced approaches to interrogating FlyBase
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29 September 2017
What's wrong with epigenetics in Huntington's disease?
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29 September 2017
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
Taking a risk: a therapeutic focus on ataxin-2 in amyotrophic lateral sclerosis?
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29 September 2017
Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
TDP-43 Phosphorylation by casein kinase Iε promotes oligomerization and enhances toxicity in vivo.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
Amyotrophic lateral sclerosis and spinocerebellar ataxia type 2 in a family with full CAG repeat expansions of ATXN2.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
SMA valiant trial: a prospective, double-blind, placebo-controlled trial of valproic acid in ambulatory adults with spinal muscular atrophy
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
Stress granules in neurodegeneration--lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma
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29 September 2017
Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome
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29 September 2017
VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders.
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29 September 2017
A novel α-synuclein missense mutation in Parkinson disease
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29 September 2017
The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.
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29 September 2017
Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes
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29 September 2017
A GAL4-driver line resource for Drosophila neurobiology
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29 September 2017
Probing mechanisms that underlie human neurodegenerative diseases in Drosophila
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29 September 2017
Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS
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29 September 2017
Genome-wide manipulations of Drosophila melanogaster with transposons, Flp recombinase, and ΦC31 integrase.
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29 September 2017
The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
The clinical and pathological phenotype of C9ORF72 hexanucleotide repeat expansions.
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29 September 2017
A yeast functional screen predicts new candidate ALS disease genes
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation
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29 September 2017
Pathogenic polyglutamine proteins cause dendrite defects associated with specific actin cytoskeletal alterations in Drosophila
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29 September 2017
TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies
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29 September 2017
Expression of human FUS protein in Drosophila leads to progressive neurodegeneration
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29 September 2017
Neuronal function and dysfunction of Drosophila dTDP
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29 September 2017
Ataxin-2 repeat-length variation and neurodegeneration
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29 September 2017
A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43.
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29 September 2017
A genome-scale shRNA resource for transgenic RNAi in Drosophila
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29 September 2017
Demise of the flies: why Drosophila models still matter
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29 September 2017
Non-ATG-initiated translation directed by microsatellite expansions
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29 September 2017
Native Functions of the Androgen Receptor Are Essential to Pathogenesis in a Drosophila Model of Spinobulbar Muscular Atrophy
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29 September 2017
HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones
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29 September 2017
Interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila melanogaster
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29 September 2017
In vivo RNAi: today and tomorrow
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29 September 2017
TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97.
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29 September 2017
The propagation of prion-like protein inclusions in neurodegenerative diseases
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29 September 2017
Design principles of insect and vertebrate visual systems
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29 September 2017
100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future
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29 September 2017
New research resources at the Bloomington Drosophila Stock Center
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29 September 2017
Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS).
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29 September 2017
A Drosophila model for TDP-43 proteinopathy
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29 September 2017
Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.
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29 September 2017
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation
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29 September 2017
Preventing Ataxin-3 protein cleavage mitigates degeneration in a Drosophila model of SCA3.
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29 September 2017
TDP-43 is recruited to stress granules in conditions of oxidative insult.
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PubMed Central
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29 September 2017
Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity
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29 September 2017
Maintaining the brain: insight into human neurodegeneration from Drosophila melanogaster mutants
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29 September 2017
Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model
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29 September 2017
Rethinking ALS: the FUS about TDP-43.
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29 September 2017
Clinical and pathological continuum of multisystem TDP-43 proteinopathies
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29 September 2017
Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein
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29 September 2017
Drosophila models of neurodegenerative diseases
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29 September 2017
Therapeutic application of histone deacetylase inhibitors for central nervous system disorders
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29 September 2017
Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease.
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29 September 2017
Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease
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29 September 2017
Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides
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29 September 2017
The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response
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29 September 2017
A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1.
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29 September 2017
Spinocerebellar ataxia 2 (SCA2).
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29 September 2017
A Drosophila model for LRRK2-linked parkinsonism
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29 September 2017
Identification of novel genes that modify phenotypes induced by Alzheimer's beta-amyloid overexpression in Drosophila
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29 September 2017
Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm
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29 September 2017
Hsp104: a weapon to combat diverse neurodegenerative disorders.
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29 September 2017
Suppression of polyglutamine toxicity by the yeast Sup35 prion domain in Drosophila
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29 September 2017
hVAPB, the causative gene of a heterogeneous group of motor neuron diseases in humans, is functionally interchangeable with its Drosophila homologue DVAP-33A at the neuromuscular junction
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
Myotonic dystrophy: RNA-mediated muscle disease
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29 September 2017
Mechanistic studies on Hsp90 inhibition by ansamycin derivatives
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29 September 2017
A Drosophila melanogaster model of spinal muscular atrophy reveals a function for SMN in striated muscle.
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29 September 2017
Accelerated accumulation of misfolded prion protein and spongiform degeneration in a Drosophila model of Gerstmann-Sträussler-Scheinker syndrome.
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29 September 2017
Drosophila in the study of neurodegenerative disease
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29 September 2017
RNA-mediated neuromuscular disorders
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29 September 2017
Modulation of Hsp90 function in neurodegenerative disorders: a molecular-targeted therapy against disease-causing protein
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29 September 2017
Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies
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29 September 2017
Proteolytic cleavage of polyglutamine-expanded ataxin-3 is critical for aggregation and sequestration of non-expanded ataxin-3.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
Drosophila as a model for human neurodegenerative disease
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29 September 2017
17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila.
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29 September 2017
Drosophila, the golden bug, emerges as a tool for human genetics
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29 September 2017
Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
RNA structure of trinucleotide repeats associated with human neurological diseases
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
From fruit fly to bedside: translating lessons from Drosophila models of neurodegenerative disease
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29 September 2017
Conditional expression of UAS-transgenes in the adult eye with a new gene-switch vector system.
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29 September 2017
Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins
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29 September 2017
Chaperoning brain degeneration
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29 September 2017
The art and design of genetic screens: Drosophila melanogaster
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29 September 2017
A conditional tissue-specific transgene expression system using inducible GAL4.
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29 September 2017
Muscleblind localizes to nuclear foci of aberrant RNA in myotonic dystrophy types 1 and 2.
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29 September 2017
Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease
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29 September 2017
CREB-binding protein sequestration by expanded polyglutamine
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29 September 2017
Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster
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29 September 2017
Tissue-specific expression of dominant negative mutant Drosophila HSC70 causes developmental defects and lethality
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29 September 2017
Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone
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29 September 2017
Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
Spongecake and eggroll: two hereditary diseases in Drosophila resemble patterns of human brain degeneration
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29 September 2017
The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila.
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29 September 2017
A modular misexpression screen in Drosophila detecting tissue-specific phenotypes
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29 September 2017
Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT.
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29 September 2017
Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
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29 September 2017
Expression of Drosophila glass protein and evidence for negative regulation of its activity in non-neuronal cells by another DNA-binding protein.
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29 September 2017
From the gene to behavior
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29 September 2017
Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease
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29 September 2017
Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound
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2 June 2018
Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS.
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2 June 2018
C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration
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2 June 2018
Prevalence of amyotrophic lateral sclerosis - United States, 2010-2011.
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2 June 2018
Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43)
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2 June 2018
Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS.
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2 June 2018
In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.
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2 June 2018
Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching
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2 June 2018
Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism.
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2 June 2018
Early degenerative changes in transgenic mice expressing mutant huntingtin involve dendritic abnormalities but no impairment of mitochondrial energy production
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2 June 2018
Genetic suppression of polyglutamine toxicity in Drosophila
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2 June 2018
Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila
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2 June 2018
Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity
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2 June 2018
Huntingtin localization in brains of normal and Huntington's disease patients
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2 June 2018
Motor neuron disease and dementia reported among 13 members of a single family
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2 June 2018
Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS.
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27 November 2018
A neuroprotective role for microRNA miR-1000 mediated by limiting glutamate excitotoxicity
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27 November 2018
ATXN2 polyQ intermediate repeats are a modifier of ALS survival
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Cas9-based genome editing in Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
A fly model for the CCUG-repeat expansion of myotonic dystrophy type 2 reveals a novel interaction with MBNL1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Deactivation of TBP contributes to SCA17 pathogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
A GAL4 driver resource for developmental and behavioral studies on the larval CNS of Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
ATXN2 CAG repeat expansions increase the risk for Chinese patients with amyotrophic lateral sclerosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
TDP-43 loss-of-function causes neuronal loss due to defective steroid receptor-mediated gene program switching in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
100 years of Lewy pathology
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
ATAXIN2 CAG-repeat length in Italian patients with amyotrophic lateral sclerosis: risk factor or variant phenotype? Implication for genetic testing and counseling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Prion-induced toxicity in PrP transgenic Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Accumulation of insoluble forms of FUS protein correlates with toxicity in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
The modulation of Amyotrophic Lateral Sclerosis risk by ataxin-2 intermediate polyglutamine expansions is a specific effect
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Ataxin-2 intermediate-length polyglutamine: a possible risk factor for Chinese patients with amyotrophic lateral sclerosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Selection of behaviors and segmental coordination during larval locomotion is disrupted by nuclear polyglutamine inclusions in a new Drosophila Huntington's disease-like model
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Anti-androgen treatment for spinal and bulbar muscular atrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
DnaJB6 is present in the core of Lewy bodies and is highly up-regulated in parkinsonian astrocytes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Continuum of frontal lobe impairment in amyotrophic lateral sclerosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
MicroRNA pathways modulate polyglutamine-induced neurodegeneration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Induction of multiple heat shock proteins and neuroprotection in a primary culture model of familial amyotrophic lateral sclerosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
MBNL1 and CUGBP1 modify expanded CUG-induced toxicity in a Drosophila model of myotonic dystrophy type 1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Modeling clinically heterogeneous presenilin mutations with transgenic Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Ubiquitin immunohistochemistry suggests classic motor neuron disease, motor neuron disease with dementia, and frontotemporal dementia of the motor neuron disease type represent a clinicopathologic spectrum.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
A SCA7 CAG/CTG repeat expansion is stable in Drosophila melanogaster despite modulation of genomic context and gene dosage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Myotonic dystrophy associated expanded CUG repeat muscleblind positive ribonuclear foci are not toxic to Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Caspase-mediated proteolysis of the polyglutamine disease protein ataxin-3.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
The spinocerebellar ataxia 8 noncoding RNA causes neurodegeneration and associates with staufen in Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Pilot trial of phenylbutyrate in spinal muscular atrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Neuromuscular defects in a Drosophila survival motor neuron gene mutant.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Pharmacological prevention of Parkinson disease in Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
The overlap of amyotrophic lateral sclerosis and frontotemporal dementia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Tiling of the Drosophila epidermis by multidendritic sensory neurons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
YAC transgenic mice carrying pathological alleles of the MJD1 locus exhibit a mild and slowly progressive cerebellar deficit
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Identification of genes that modify ataxin-1-induced neurodegeneration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Expression of human FALS SOD in motorneurons of Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Purkinje cell expression of a mutant allele of SCA1 in transgenic mice leads to disparate effects on motor behaviors, followed by a progressive cerebellar dysfunction and histological alterations.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596656
retrieved
27 November 2018
Myotonic dystrophy type 1 is associated with nuclear foci of mutant RNA, sequestration of muscleblind proteins and deregulated alternative splicing in neurons
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26447127
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Ataxin-1 and ataxin-2 intermediate-length PolyQ expansions in amyotrophic lateral sclerosis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26447127
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26447127
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26447127
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1534/GENETICS.115.179457
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/6itcikohcrbnne4pvluijy5cmy
retrieved
30 July 2022
based on heuristic
mapped directly with Wikidata item
Fatcat ID
release_6itcikohcrbnne4pvluijy5cmy
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/6itcikohcrbnne4pvluijy5cmy
retrieved
30 July 2022
based on heuristic
mapped directly with Wikidata item
OpenCitations bibliographic resource ID
4616303
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4616303
PMC publication ID
4596656
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/6itcikohcrbnne4pvluijy5cmy
retrieved
30 July 2022
based on heuristic
mapped directly with Wikidata item
PubMed publication ID
26447127
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/6itcikohcrbnne4pvluijy5cmy
retrieved
30 July 2022
based on heuristic
mapped directly with Wikidata item
Sitelinks
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