(Q37832902)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21273704%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

review article

1 reference

title

Modifiers and mechanisms of multi-system polyglutamine neurodegenerative disorders: lessons from fly models (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21273704%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21273704%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

author name string

Moushami Mallik

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21273704%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

publication date

1 December 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21273704%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21273704%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

volume

89

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21273704%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21273704%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

page(s)

497-526

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21273704%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s12041-010-0072-4

21 January 2020

exact match

0 references

cites work

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From sequence to phenotype: reverse genetics in Drosophila melanogaster

21 January 2018

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The genome sequence of Drosophila melanogaster

21 January 2018

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The other trinucleotide repeat: polyalanine expansion disorders

21 January 2018

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dAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1

21 January 2018

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A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila

21 January 2018

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

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Hsp60D is essential for caspase-mediated induced apoptosis in Drosophila melanogaster.

21 January 2018

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Heat shock genes - integrating cell survival and death

21 January 2018

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p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

21 January 2018

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Antioxidants cannot suppress the lethal phenotype of a Drosophila melanogaster model of Huntington's disease

21 January 2018

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Huntingtin aggregation and toxicity in Huntington's disease

21 January 2018

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Impairment of the ubiquitin-proteasome system by protein aggregation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Deleterious and protective properties of an aggregate-prone protein with a polyalanine expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Caspase-mediated proteolysis of the polyglutamine disease protein ataxin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Drosophila, the golden bug, emerges as a tool for human genetics

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Drosophila as a model for human neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

MicroRNA pathways modulate polyglutamine-induced neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family member.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Using Drosophila melanogaster to map human cancer pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Expression of expanded polyglutamine targets profilin for degradation and alters actin dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Drosophila: a "model" model system to study neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Dynamic expression of Hsp27 in the presence of mutant ataxin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Homophila: human disease gene cognates in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Co-chaperone CHIP promotes aggregation of ataxin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Polyglutamine-expanded ataxin-7 causes cerebellar dysfunction by inducing transcriptional dysregulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Evolution of the Friedreich's ataxia trinucleotide repeat expansion: founder effect and premutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Progress in pathogenesis studies of spinocerebellar ataxia type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Spinocerebellar ataxia type 8: clinical features in a large family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

A point mutation in the FMR-1 gene associated with fragile X mental retardation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Polyglutamine is not all: the functional role of the AXH domain in the ataxin-1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Prepattern in the developing Drosophila eye revealed by an activated torso--sevenless chimeric receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

G-TRACE: rapid Gal4-based cell lineage analysis in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Trinucleotide repeats and neurodegenerative disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Huntingtin interacts with a family of WW domain proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

A Drosophila model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Identification of genes that modify ataxin-1-induced neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Androgen receptor mutation in Kennedy's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Pseudopupil phenomena in the compound eye of drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Apoptosis and caspases in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

An unstable triplet repeat in a gene related to myotonic muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Heat shock transcription factor 1-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Modulation of prion formation, aggregation, and toxicity by the actin cytoskeleton in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Expanded huntingtin activates the c-Jun terminal kinase/c-Jun pathway prior to aggregate formation in striatal neurons in culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Diseases of unstable repeat expansion: mechanisms and common principles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Identification of the gene FMR2, associated with FRAXE mental retardation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Transcriptional activation modulated by homopolymeric glutamine and proline stretches

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Chromosomal assignment of the second locus for autosomal dominant cerebellar ataxia (SCA2) to chromosome 12q23-24.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Loss of Hsp70 in Drosophila is pleiotropic, with effects on thermotolerance, recovery from heat shock and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG island

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Molecular genetics of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

The fragile-X premutation: a maturing perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Lessons from fragile X regarding neurobiology, autism, and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Molecular chaperones in the cytosol: from nascent chain to folded protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Hereditary dentatorubral-pallidoluysian atrophy: ubiquitinated filamentous inclusions in the cerebellar dentate nucleus neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Transcriptional alterations and chromatin remodeling in polyglutamine diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Molecular chaperone functions of heat-shock proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

SCA12: an unusual mutation leads to an unusual spinocerebellar ataxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

HSP27 and cell death in spinocerebellar ataxia type 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Therapeutic opportunities in polyglutamine disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Expansion of the polyQ repeat in ataxin-2 alters its Golgi localization, disrupts the Golgi complex and causes cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

The art and design of genetic screens: Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Human sat III and Drosophila hsr omega transcripts: a common paradigm for regulation of nuclear RNA processing in stressed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Huntingtin interacting proteins are genetic modifiers of neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Cytosol-endoplasmic reticulum interplay by Sec61alpha translocon in polyglutamine-mediated neurotoxicity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Humanin attenuates apoptosis induced by DRPLA proteins with expanded polyglutamine stretches

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Trinucleotide repeats and long homopeptides in genes and proteins associated with nervous system disease and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Reversible disruption of dynactin 1-mediated retrograde axonal transport in polyglutamine-induced motor neuron degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Genetic suppression of polyglutamine toxicity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Suppression of polyglutamine toxicity by a Drosophila homolog of myeloid leukemia factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Trinucleotide repeat amplification and hypermethylation of a CpG island in FRAXE mental retardation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

DNA analysis in hereditary dentatorubral-pallidoluysian atrophy: correlation between CAG repeat length and phenotypic variation and the molecular basis of anticipation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

An untranslated CTG expansion causes a novel form of spinocerebellar ataxia (SCA8)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

The molecular circuitry governing retinal determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Genome-wide RNAi as a route to gene function in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Polyglutamines placed into context

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Kennedy's disease. Phosphorylation of the polyglutamine-expanded form of androgen receptor regulates its cleavage by caspase-3 and enhances cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Dodecamer repeat expansion in cystatin B gene in progressive myoclonus epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Instability of the EPM1 minisatellite

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Polyglutamine genes interact to modulate the severity and progression of neurodegeneration in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

RNA toxicity is a component of ataxin-3 degeneration in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Interaction of Huntington disease protein with transcriptional activator Sp1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

The effect of neuronal expression of heat shock proteins 26 and 27 on lifespan, neurodegeneration, and apoptosis in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

AKT-sensitive or insensitive pathways of toxicity in glial cells and neurons in Drosophila models of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Expanding our understanding of polyglutamine diseases through mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Expression of polyglutamine-expanded Huntingtin activates the SEK1-JNK pathway and induces apoptosis in a hippocampal neuronal cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Trinucleotide repeat disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Myotonic dystrophy mutation: an unstable CTG repeat in the 3' untranslated region of the gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

RNAi for the large non-coding hsromega transcripts suppresses polyglutamine pathogenesis in Drosophila models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

The developmentally active and stress-inducible noncoding hsromega gene is a novel regulator of apoptosis in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Improved activities of CREB binding protein, heterogeneous nuclear ribonucleoproteins and proteasome following downregulation of noncoding hsromega transcripts help suppress poly(Q) pathogenesis in fly models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Expansion explosion: new clues to the pathogenesis of repeat expansion neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Can flies help humans treat neurodegenerative diseases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Drosophila in the study of neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Animal models of polyglutamine diseases and therapeutic approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Association of ataxin-7 with the proteasome subunit S4 of the 19S regulatory complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Clinical, genetic, molecular, and pathophysiological insights into spinocerebellar ataxia type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Molecular clearance of ataxin-3 is regulated by a mammalian E4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Large expansion of the ATTCT pentanucleotide repeat in spinocerebellar ataxia type 10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

CREB-binding protein sequestration by expanded polyglutamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Polyglutamine-expanded spinocerebellar ataxia-7 protein disrupts normal SAGA and SLIK histone acetyltransferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Polyglutamine expansion induces a protein-damaging stress connecting heat shock protein 70 to the JNK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Aggregation of expanded polyglutamine domain in yeast leads to defects in endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Generating patterned arrays of photoreceptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

A protein trap strategy to detect GFP-tagged proteins expressed from their endogenous loci in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Modulation of neurodegeneration by molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Protective role of Engrailed in a Drosophila model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

FRAXE and mental retardation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Modelling neurodegenerative diseases in Drosophila: a fruitful approach?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

RNA-binding protein hoip accelerates polyQ-induced neurodegeneration in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Dentatorubral and pallidoluysian atrophy expansion of an unstable CAG trinucleotide on chromosome 12p

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Induction of molecular chaperones as a therapeutic strategy for the polyglutamine diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Amino acid sequences flanking polyglutamine stretches influence their potential for aggregate formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Polyglutamine diseases: a transcription disorder?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Beyond the Qs in the polyglutamine diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Trinucleotide Repeat Disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Iron metabolism and mitochondrial abnormalities in Friedreich ataxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Thyroid hormone-induced juxtaposition of regulatory elements/factors and chromatin remodeling of Crabp1 dependent on MED1/TRAP220.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Trinucleotide repeats in neurogenetic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Structure and mechanism of the Hsp90 molecular chaperone machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Repeat instability: mechanisms of dynamic mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Genes with triplet repeats: a new class of mutations causing neurological diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Conditioned behavior in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Mental retardation genes in drosophila: New approaches to understanding and treating developmental brain disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

A modular misexpression screen in Drosophila detecting tissue-specific phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Targeting CREB-binding protein (CBP) loss of function as a therapeutic strategy in neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Comparative genomics of the eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Drosophila models of neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Huntingtin localization in brains of normal and Huntington's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Mechanisms for neuronal cell death and dysfunction in Huntington's disease: pathological cross-talk between the nucleus and the mitochondria?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Bax-like protein Drob-1 protects neurons from expanded polyglutamine-induced toxicity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Altered expressions of the noncoding hsromega gene enhances poly-Q-induced neurotoxicity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Expression analysis of the ataxin-1 protein in tissues from normal and spinocerebellar ataxia type 1 individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

A novel protein with RNA-binding motifs interacts with ataxin-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Interaction of expanded polyglutamine stretches with nuclear transcription factors leads to aberrant transcriptional regulation in polyglutamine diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

RNA-binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

SUMO modification of Huntingtin and Huntington's disease pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Intranuclear ataxin1 inclusions contain both fast- and slow-exchanging components

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Transcriptional abnormalities in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Cognitive decline, neuromotor and behavioural disturbances in a mouse model for fragile-X-associated tremor/ataxia syndrome (FXTAS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Calcium homeostasis and spinocerebellar ataxia-1 (SCA-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Unstable minisatellite expansion causing recessively inherited myoclonus epilepsy, EPM1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Examining polyglutamine peptide length: a connection between collapsed conformations and increased aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Caspase activation during apoptotic cell death induced by expanded polyglutamine in N2a cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Modulation of Hsp90 function in neurodegenerative disorders: a molecular-targeted therapy against disease-causing protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Myotonic dystrophy: RNA-mediated muscle disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Role of heat shock proteins during polyglutamine neurodegeneration: mechanisms and hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the alpha 1A-voltage-dependent calcium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

SCA7 mouse models show selective stabilization of mutant ataxin-7 and similar cellular responses in different neuronal cell types

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

The gene for autosomal dominant cerebellar ataxia with pigmentary macular dystrophy maps to chromosome 3p12–p21.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12041-010-0072-4

Misfolding of proteins with a polyglutamine expansion is facilitated by proteasomal chaperones

21 January 2018

1 reference

12 December 2020

The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster

1 reference

12 December 2020

Expression of baculovirus P35 prevents cell death in Drosophila

1 reference

12 December 2020

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

1 reference

12 December 2020

Yeast as a model system to investigate protein conformational diseases

1 reference

12 December 2020

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1 reference

12 December 2020

Proteasome function is inhibited by polyglutamine-expanded ataxin-1, the SCA1 gene product

1 reference

12 December 2020

Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motor neuronal processes

1 reference

12 December 2020

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

1 reference

12 December 2020

In situ evidence for DNA fragmentation in Huntingtonʼs disease striatum and Alzheimerʼs disease temporal lobes

1 reference

12 December 2020

Dentatorubral-pallidoluysian atrophy (DRPLA). Molecular basis for wide clinical features of DRPLA

1 reference

12 December 2020

Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition.

1 reference

12 December 2020

The molecular basis of Friedreich ataxia.

1 reference

12 December 2020

Friedreich's ataxia: a clinical and genetic study of 90 families with an analysis of early diagnostic criteria and intrafamilial clustering of clinical features

1 reference

12 December 2020

Protein aggregation and neurodegenerative disease

1 reference

12 December 2020

Age of onset in Huntington disease: sex specific influence of apolipoprotein E genotype and normal CAG repeat length.

1 reference

12 December 2020

Implications of protein degradation in aging.

1 reference

12 December 2020

Molecular-clinical correlations in males with an expanded FMR1 mutation

1 reference

12 December 2020

Neuropathological classification of Huntington's disease

1 reference

12 December 2020

Letter: Hereditary ataxia and HL-A genotypes

1 reference

12 December 2020

Neuronal intranuclear inclusions in polyglutamine diseases: nuclear weapons or nuclear fallout?

1 reference

12 December 2020

Genetic variation and evolutionary stability of the FMR1 CGG repeat in six closed human populations

1 reference

12 December 2020

Strong correlation between the number of CAG repeats in androgen receptor genes and the clinical onset of features of spinal and bulbar muscular atrophy

1 reference

12 December 2020

Characterization of the structure and the amyloidogenic properties of the Josephin domain of the polyglutamine-containing protein ataxin-3

1 reference

12 December 2020

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

1 reference

12 December 2020

Caenorhabditis elegans as a model system for triplet repeat diseases

1 reference

12 December 2020

Omega speckles - a novel class of nuclear speckles containing hnRNPs associated with noncoding hsr-omega RNA in Drosophila

1 reference

12 December 2020

1 reference

12 December 2020