(Q37217958)

19 August 2017

1 reference

title

Biological transgenic mouse models of Alzheimer's disease (English)

1 reference

19 August 2017

0 references

2

Edward Rockenstein

1 reference

19 August 2017

3

Eliezer Masliah

1 reference

19 August 2017

Leslie Crews

1

1 reference

19 August 2017

publication date

1 January 2008

1 reference

Handbook of clinical neurology / edited by P.J. Vinken and G.W. Bruyn

19 August 2017

published in

1 reference

19 August 2017

volume

89

1 reference

19 August 2017

page(s)

291-301

1 reference

Transgenic models of neurodegeneration. Neurodegeneration: of (transgenic) mice and men.

19 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Transgenic and knockout mice in the study of neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Expression of APP in transgenic mice: a comparison of neuron-specific promoters.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Experimental models of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Chasing genes in Alzheimer's and Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Animal models of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Transgenic mouse models of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Increased tau phosphorylation but absence of formation of neurofibrillary tangles in mice double transgenic for human tau and Alzheimer mutant (M146L) presenilin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Neurofibrillary tangles and tau phosphorylation.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Molecular genetics of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Animal models of PD: pieces of the same puzzle?

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Structural correlates of cognition in dementia: quantification and assessment of synapse change.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Apolipoprotein E dose-dependent modulation of beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Dying for a cause: invertebrate genetics takes on human neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Alzheimer transgenic mouse models come of age.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Polyglutamine expansions: proteolysis, chaperones, and the dangers of promiscuity

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Tau and transgenic animal models

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Insights from mouse models into the molecular basis of neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: I. Superior frontal and inferior temporal cortex.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Pathology of presynaptic proteins in Alzheimer's disease: more than simple loss of terminals.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

The presenilins and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Analysis of tauopathies with transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Alzheimer's disease: cell-specific pathology isolates the hippocampal formation

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Co-expression of multiple transgenes in mouse CNS: a comparison of strategies.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Amyloid diseases: abnormal protein aggregation in neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Tau protein and neurodegeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Behavioral disturbances without amyloid deposits in mice overexpressing human amyloid precursor protein with Flemish (A692G) or Dutch (E693Q) mutation.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Evolution of amyloid: what normal protein folding may tell us about fibrillogenesis and disease

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Recent advances in the understanding of the role of synaptic proteins in Alzheimer's Disease and other neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

The role of synaptic proteins in the pathogenesis of disorders of the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Immunoreactivity of CD45, a protein phosphotyrosine phosphatase, in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Neurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Of mice, men and motor neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Regulation of APP cleavage by alpha-, beta- and gamma-secretases

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Molecular genetics of Alzheimer’s disease

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Causative and susceptibility genes for Alzheimer's disease: a review.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Alzheimer's disease-related synapse loss in the cingulate cortex

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Clearing the brain's amyloid cobwebs

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

The role of APP processing and trafficking pathways in the formation of amyloid beta-protein

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Transgenic mouse model for familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Alpha-synuclein in Lewy bodies

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

"Fatal attractions" of proteins. A comprehensive hypothetical mechanism underlying Alzheimer's disease and other neurodegenerative disorders.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Amyotrophic lateral sclerosis/parkinsonism dementia complex: transgenic mice provide insights into mechanisms underlying a common tauopathy in an ethnic minority on Guam

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

A protective role of the low density lipoprotein receptor-related protein against amyloid beta-protein toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Genome and gene therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

The differential involvement of subcortical nuclei in senile dementia of Alzheimer's type

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

The role of synaptic proteins in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

The value of transgenic models for the study of neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0072-9752%2807%2901227-4

7 January 2021

10.1016/S0072-9752(07)01227-4

Identifiers

DOI

1 reference

19 August 2017

1 reference