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Toward the structure of presenilin/γ-secretase and presenilin homologs
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title
Toward the structure of presenilin/γ-secretase and presenilin homologs
(English)
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author name string
Michael S. Wolfe
series ordinal
1
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language of work or name
English
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PubMed
publication date
December 2013
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PubMed
published in
Biochimica et Biophysica Acta
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PubMed
volume
1828
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stated in
PubMed
issue
12
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PubMed
page(s)
2886-97
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PubMed
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Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease
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When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease
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Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations
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Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores
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Purification and characterization of the human gamma-secretase complex
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Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation
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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein
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Purification and cloning of amyloid precursor protein beta-secretase from human brain
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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
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Structure of a presenilin family intramembrane aspartate protease
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PubMed Central
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Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins
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Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes
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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
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PubMed Central
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21 March 2017
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
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Structural investigation of the C-terminal catalytic fragment of presenilin 1
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PubMed Central
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A C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysis
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Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain
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Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs
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A nine-transmembrane domain topology for presenilin 1
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21 March 2017
Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex
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21 March 2017
Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor
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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
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21 March 2017
Endoproteolytic processing and stabilization of wild-type and mutant presenilin
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21 March 2017
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
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21 March 2017
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
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21 March 2017
Identification of an archaeal presenilin-like intramembrane protease
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21 March 2017
The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease
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21 March 2017
Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase
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7 April 2017
Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective
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7 April 2017
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
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7 April 2017
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
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7 April 2017
Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor
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28 September 2017
Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics.
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28 September 2017
Processive proteolysis by γ-secretase and the mechanism of Alzheimer's disease
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28 September 2017
The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
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28 September 2017
Familial Alzheimer disease presenilin-1 mutations alter the active site conformation of γ-secretase
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28 September 2017
Presenilin is the molecular target of acidic γ-secretase modulators in living cells
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28 September 2017
Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations
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28 September 2017
Novel γ-secretase enzyme modulators directly target presenilin protein
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28 September 2017
Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy
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28 September 2017
Activation and intrinsic gamma-secretase activity of presenilin 1.
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28 September 2017
Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase
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PubMed Central
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28 September 2017
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease
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PubMed Central
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28 September 2017
Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
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28 September 2017
Glu-333 of nicastrin directly participates in gamma-secretase activity
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
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28 September 2017
Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
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28 September 2017
Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.
1 reference
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PubMed Central
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28 September 2017
The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.
1 reference
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PubMed Central
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28 September 2017
Substrate-targeting gamma-secretase modulators
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PubMed Central
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28 September 2017
Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Substrate specificity of gamma-secretase and other intramembrane proteases
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Active gamma-secretase complexes contain only one of each component
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Advances in gamma-secretase modulation.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Intra- or intercomplex binding to the gamma-secretase enzyme. A model to differentiate inhibitor classes
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Deducing the transmembrane domain organization of presenilin-1 in gamma-secretase by cysteine disulfide cross-linking
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Secretion of the Notch-1 Abeta-like peptide during Notch signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
The initial substrate-binding site of gamma-secretase is located on presenilin near the active site
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Membrane Topology and Nicastrin-enhanced Endoproteolysis of APH-1, a Component of the γ-Secretase Complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
The role of presenilin cofactors in the gamma-secretase complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Gamma-secretase activity is associated with a conformational change of nicastrin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Membrane topology of gamma-secretase component PEN-2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Identification of a novel family of presenilin homologues
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 September 2017
Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
31 May 2018
BMS-708,163 targets presenilin and lacks notch-sparing activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Crystal structure of a rhomboid family intramembrane protease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Topology of the C-terminal fragment of human presenilin 1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Nicastrin functions as a gamma-secretase-substrate receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Stereochemical analysis of (hydroxyethyl)urea peptidomimetic inhibitors of gamma-secretase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Gamma-secretase: proteasome of the membrane?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Probing pockets S2-S4' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimetics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Designed Helical Peptides Inhibit an Intramembrane Protease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Reconstitution of gamma-secretase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3801419
retrieved
28 November 2018
Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24099007
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24099007
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24099007
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24099007
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Structural biology. Membrane protein insertion and stability
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24099007
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Three-dimensional structure of the γ-secretase complex
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24099007
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Subcellular distribution and turnover of presenilins in transfected cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24099007
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.BBAMEM.2013.04.015
0 references
PMCID
3801419
1 reference
stated in
PubMed
PubMed ID
24099007
1 reference
stated in
PubMed
ResearchGate publication ID
257528851
0 references
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