(Q38073986)

28 August 2017

1 reference

title

Why nature really chose phosphate (English)

1 reference

Shina Caroline Lynn Kamerlin

28 August 2017

series ordinal

1

object named as

Shina C L Kamerlin

1 reference

28 August 2017

4

Arieh Warshel

1 reference

28 August 2017

2

Pankaz K Sharma

1 reference

28 August 2017

Ram B Prasad

3

1 reference

28 August 2017

15 January 2013

1 reference

Quarterly Reviews of Biophysics

28 August 2017

1 reference

28 August 2017

46

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28 August 2017

1

1 reference

28 August 2017

1-132

1 reference

Flexibility, diversity, and cooperativity: pillars of enzyme catalysis

28 August 2017

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Density functional calculations of ATP systems. 2. ATP hydrolysis at the active site of actin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

DNA polymerase beta: effects of gapped DNA substrates on dNTP specificity, fidelity, processivity and conformational changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

GTPase activation of elongation factors Tu and G on the ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Interaction of elongation factors EF-G and EF-Tu with a conserved loop in 23S RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

QM/MM studies of hairpin ribozyme self-cleavage suggest the feasibility of multiple competing reaction mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

A classical and ab initio study of the interaction of the myosin triphosphate binding domain with ATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

GTP hydrolysis mechanism of Ras-like GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Calculations of antibody-antigen interactions: microscopic and semi-microscopic evaluation of the free energies of binding of phosphorylcholine analogs to McPC603

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Two-metal-ion mechanism for hammerhead-ribozyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Biological phosphoryl-transfer reactions: understanding mechanism and catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Promiscuous sulfatase activity and thio-effects in a phosphodiesterase of the alkaline phosphatase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Phosphate ester hydrolysis by hydroxo complexes of trivalent lanthanides stabilized by 4-imidazolecarboxylate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Elongation in translation as a dynamic interaction among the ribosome, tRNA, and elongation factors EF-G and EF-Tu

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Multiscale simulations of protein landscapes: using coarse-grained models as reference potentials to full explicit models

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Structure of bovine mitochondrial F(1)-ATPase with nucleotide bound to all three catalytic sites: implications for the mechanism of rotary catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Kinetic and catalytic mechanisms of protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

DNA polymerase beta catalysis: are different mechanisms possible?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

On the generation of catalytic antibodies by transition state analogues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Insights into Ligand-Protein Binding from Local Mechanical Response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Crystallographic evidence for substrate-assisted GTP hydrolysis by a small GTP binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Theoretical methods for the simulation of nucleic acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Dynamical contributions to enzyme catalysis: critical tests of a popular hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Transition state theory can be used in studies of enzyme catalysis: lessons from simulations of tunnelling and dynamical effects in lipoxygenase and other systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Use of viscogens, dNTPalphaS, and rhodium(III) as probes in stopped-flow experiments to obtain new evidence for the mechanism of catalysis by DNA polymerase beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

A Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Efficient catalytic promiscuity in an enzyme superfamily: an arylsulfatase shows a rate acceleration of 10(13) for phosphate monoester hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Correlation between the conformational states of F1-ATPase as determined from its crystal structure and single-molecule rotation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Recognition of cognate transfer RNA by the 30S ribosomal subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Magnesium-cationic dummy atom molecules enhance representation of DNA polymerase beta in molecular dynamics simulations: improved accuracy in studies of structural features and mutational effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Alkaline phosphatase revisited: hydrolysis of alkyl phosphates

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Functional interrelationships in the alkaline phosphatase superfamily: phosphodiesterase activity of Escherichia coli alkaline phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

In silico evidence for DNA polymerase-beta's substrate-induced conformational change

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Thiolysis and alcoholysis of phosphate tri- and monoesters with alkyl and aryl leaving groups. An ab initio study in the gas phase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Calculations of free energy profiles for the staphylococcal nuclease catalyzed reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Mechanistic alternatives in phosphate monoester hydrolysis: what conclusions can be drawn from available experimental data?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The catalytic power of ketosteroid isomerase investigated by computer simulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Steady-state analysis of kinetic isotope effects in enzymic reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Do electrostatic interactions with positively charged active site groups tighten the transition state for enzymatic phosphoryl transfer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Ras/Rap effector specificity determined by charge reversal

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Use of binding energy by an RNA enzyme for catalysis by positioning and substrate destabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Electrostatic origin of the mechanochemical rotary mechanism and the catalytic dwell of F1-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Electrostatic control of GTP and GDP binding in the oncoprotein p21ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The catalytic effect of dihydrofolate reductase and its mutants is determined by reorganization energies

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Simulating the electrostatic guidance of the vectorial translocations in hexameric helicases and translocases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Energy analysis of chemistry for correct insertion by DNA polymerase beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The tetrahymena ribozyme cleaves a 5'-methylene phosphonate monoester approximately 10(2)-fold faster than a normal phosphate diester: implications for enzyme catalysis of phosphoryl transfer reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Ras catalyzes GTP hydrolysis by shifting negative charges from gamma- to beta-phosphate as revealed by time-resolved FTIR difference spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Monitoring the GAP catalyzed H-Ras GTPase reaction at atomic resolution in real time

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Mismatch-induced conformational distortions in polymerase beta support an induced-fit mechanism for fidelity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Directed evolution of sulfotransferases and paraoxonases by ancestral libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Isotope effects in the study of phosphoryl and sulfuryl transfer reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Role of the arginine finger in Ras.RasGAP revealed by QM/MM calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Evidence that the G2661 region of 23S rRNA is located at the ribosomal binding sites of both elongation factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Protein tyrosine phosphatase 1B inhibitors for diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Role of induced fit in enzyme specificity: a molecular forward/reverse switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Conformational coupling in DNA polymerase fidelity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Enzyme recruitment in evolution of new function

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

A primer for the Bema Hapothle. An empirical approach to the characterization of changing transition-state structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

QM/MM analysis suggests that Alkaline Phosphatase (AP) and nucleotide pyrophosphatase/phosphodiesterase slightly tighten the transition state for phosphate diester hydrolysis relative to solution: implication for catalytic promiscuity in the AP supe

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Protein tyrosine phosphatases as drug targets: PTP1B and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The nature of the transition state for enzyme-catalyzed phosphoryl transfer. Hydrolysis of O-aryl phosphorothioates by alkaline phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Ketosteroid isomerase provides further support for the idea that enzymes work by electrostatic preorganization

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

A molecular dynamics study of WPD-loop flexibility in PTP1B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

A computational study of the hydrolysis of dGTP analogues with halomethylene-modified leaving groups in solution: implications for the mechanism of DNA polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Progress in ab initio QM/MM free-energy simulations of electrostatic energies in proteins: accelerated QM/MM studies of pKa, redox reactions and solvation free energies

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Are mixed explicit/implicit solvation models reliable for studying phosphate hydrolysis? A comparative study of continuum, explicit and mixed solvation models

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Associative versus dissociative mechanisms of phosphate monoester hydrolysis: on the interpretation of activation entropies

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

A superfamily of metalloenzymes unifies phosphopentomutase and cofactor-independent phosphoglycerate mutase with alkaline phosphatases and sulfatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Ab initio study of the role of lysine 16 for the molecular switching mechanism of Ras protein p21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Axle-less F1-ATPase rotates in the correct direction

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Degrees of difficulty of water-consuming reactions in the absence of enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Challenges and advances in validating enzyme design proposals: the case of kemp eliminase catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Did nature also choose arsenic?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Phosphoryl transfer in Ras proteins, conclusive or elusive?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Computer simulations of protein functions: searching for the molecular origin of the replication fidelity of DNA polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Computer simulation studies of the fidelity of DNA polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Computer simulation of the chemical catalysis of DNA polymerases: discriminating between alternative nucleotide insertion mechanisms for T7 DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Models for biological phosphoryl transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Signal transduction pathways involving Ras. Mini review

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Mechanism and transition state structure of aryl methylphosphonate esters doubly coordinated to a dinuclear cobalt(III) center

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Allosteric inhibition of protein tyrosine phosphatase 1B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Kinetic consequences of replacing the internucleotide phosphorus atoms in DNA with arsenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Protein kinases--the major drug targets of the twenty-first century?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Enzymatic mechanisms of phosphate and sulfate transfer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Probing the structure and mechanism of Ras protein with an expanded genetic code

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Enhancing activity and controlling stereoselectivity in a designed PLP-dependent aldolase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Probing the role of loop 2 in Ras function with unnatural amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Theoretical examination of Mg(2+)-mediated hydrolysis of a phosphodiester linkage as proposed for the hammerhead ribozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Quantum chemical modeling of the GTP hydrolysis by the RAS-GAP protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

SOME ASPECTS OF PHOSPHATE CHEMISTRY.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Limits to Catalysis by Ribonuclease A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Three protein kinase structures define a common motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Protein kinases: evolution of dynamic regulatory proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Enzymatic GTP hydrolysis: insights from an ab initio molecular dynamics study

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Crystal structure of the adenylyl cyclase activator Gsalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Probing the origin of the compromised catalysis of E. coli alkaline phosphatase in its promiscuous sulfatase reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

DNA polymerase beta fidelity: halomethylene-modified leaving groups in pre-steady-state kinetic analysis reveal differences at the chemical transition state

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Evidence for direct attack by hydroxide in phosphodiester hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Nonstatistical dynamics in thermal reactions of polyatomic molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Converting conformational changes to electrostatic energy in molecular motors: The energetics of ATP synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Phosphate monoester hydrolysis in cyclohexane

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

A general two-metal-ion mechanism for catalytic RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

From the structure and function of the ribosome to new antibiotics (Nobel Lecture).

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The time required for water attack at the phosphorus atom of simple phosphodiesters and of DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

A revised mechanism for the alkaline phosphatase reaction involving three metal ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

What recent ribosome structures have revealed about the mechanism of translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Structural investigation of a high-affinity MnII binding site in the hammerhead ribozyme by EPR spectroscopy and DFT calculations. Effects of neomycin B on metal-ion binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Computational study of the phosphoryl transfer catalyzed by a cyclin-dependent kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Computer simulations of enzyme catalysis: methods, progress, and insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Phospho-proteomic analysis of cellular signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Essential role of histidine 84 in elongation factor Tu for the chemical step of GTP hydrolysis on the ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Energetics of enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Theoretical Studies on the Hydrolysis of Mono-Phosphate and Tri-Phosphate in Gas Phase and Aqueous Solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Torsional elasticity and energetics of F1-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Quantum mechanics/molecular mechanics investigation of the chemical reaction in Dpo4 reveals water-dependent pathways and requirements for active site reorganization

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Energy transduction in the F1 motor of ATP synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The Mechanism for Activation of GTP Hydrolysis on the Ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Nucleoside triphosphate-binding proteins: different scaffolds to achieve phosphoryl transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

An efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Enzymes work by solvation substitution rather than by desolvation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

GTPase activating proteins: structural and functional insights 18 years after discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

On the energetics of translocon-assisted insertion of charged transmembrane helices into membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Studies of proton translocations in biological systems: simulating proton transport in carbonic anhydrase by EVB-based models

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

G proteins, effectors and GAPs: structure and mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The energetics of the primary proton transfer in bacteriorhodopsin revisited: it is a sequential light-induced charge separation after all

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

G protein mechanisms: insights from structural analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The ATP synthase--a splendid molecular machine

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Insights into the phosphoryl transfer mechanism of cyclin-dependent protein kinases from ab initio QM/MM free-energy studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

SV40 large T antigen functions in DNA replication and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Testing Geometrical Discrimination within an Enzyme Active Site: Constrained Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion Hole

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Towards accurate ab initio QM/MM calculations of free-energy profiles of enzymatic reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

On the interpretation of the observed linear free energy relationship in phosphate hydrolysis: a thorough computational study of phosphate diester hydrolysis in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Recent mechanistic insights into eukaryotic ribosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Toward accurate screening in computer-aided enzyme design

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

pKa calculations in solution and proteins with QM/MM free energy perturbation simulations: a quantitative test of QM/MM protocols.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Proton transfer in carbonic anhydrase is controlled by electrostatics rather than the orientation of the acceptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Unraveling the structure of the ribosome (Nobel Lecture).

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

What we have learned from ribosome structures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The binding change mechanism for ATP synthase--some probabilities and possibilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The GTPase superfamily: conserved structure and molecular mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Dynamic characterization of a DNA repair enzyme: NMR studies of [methyl-13C]methionine-labeled DNA polymerase beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

GEFs and GAPs: critical elements in the control of small G proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Why does the Ras switch "break" by oncogenic mutations?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Binding and unwinding--how T antigen engages the SV40 origin of DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Mechanism of primary proton transfer in bacteriorhodopsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Mechanistic comparison of high-fidelity and error-prone DNA polymerases and ligases involved in DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Key role of electrostatic interactions in bacteriorhodopsin proton transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5'-triphosphate hydrolysis of p21ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Determining the catalytic role of remote substrate binding interactions in ketosteroid isomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The low barrier hydrogen bond (LBHB) proposal revisited: the case of the Asp... His pair in serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

GTPase activation of elongation factor EF-Tu by the ribosome during decoding

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Reexamination of induced fit as a determinant of substrate specificity in enzymatic reactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Exploring, refining, and validating the paradynamics QM/MM sampling

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Paradynamics: an effective and reliable model for ab initio QM/MM free-energy calculations and related tasks

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Three-dimensional structure of a hammerhead ribozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Enzyme millisecond conformational dynamics do not catalyze the chemical step

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Metal ion catalysis in the Tetrahymena ribozyme reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Electrostatic evaluation of the signature motif (H/V)CX5R(S/T) in protein-tyrosine phosphatases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Inhibition of protein tyrosine phosphatase 1B as a potential treatment of diabetes and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

A perspective on enzyme catalysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

In silico studies of the African swine fever virus DNA polymerase X support an induced-fit mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Double-lock ratchet mechanism revealing the role of alphaSER-344 in FoF1 ATP synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Structural Insights into the Origins of DNA Polymerase Fidelity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Chemo-mechanical coupling in F(1)-ATPase revealed by catalytic site occupancy during catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

What are the roles of substrate-assisted catalysis and proximity effects in peptide bond formation by the ribosome?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Contribution of opening and bending dynamics to specific recognition of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

RanGAP mediates GTP hydrolysis without an arginine finger

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Correct and incorrect nucleotide incorporation pathways in DNA polymerase beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Fidelity discrimination in DNA polymerase beta: differing closing profiles for a mismatched (G:A) versus matched (G:C) base pair

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Orchestration of cooperative events in DNA synthesis and repair mechanism unraveled by transition path sampling of DNA polymerase beta's closing

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Regulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Ribozymes: a distinct class of metalloenzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

How subunit coupling produces the gamma-subunit rotary motion in F1-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Prechemistry versus preorganization in DNA replication fidelity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

A quantum mechanical investigation of possible mechanisms for the nucleotidyl transfer reaction catalyzed by DNA polymerase beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Structural aspects of heterotrimeric G-protein signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

High-resolution analysis of Zn(2+) coordination in the alkaline phosphatase superfamily by EXAFS and x-ray crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Drug discovery and protein tyrosine phosphatases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Mutations in 23 S ribosomal RNA perturb transfer RNA selection and can lead to streptomycin dependence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Biophysical and biochemical investigations of RNA catalysis in the hammerhead ribozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Mechanistic analysis of the observed linear free energy relationships in p21ras and related systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Why have mutagenesis studies not located the general base in ras p21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Interactions between Ras proteins and their effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Converting structural information into an allosteric-energy-based picture for elongation factor Tu activation by the ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Coupling of rotation and catalysis in F(1)-ATPase revealed by single-molecule imaging and manipulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The protein kinase complement of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Ras-catalyzed hydrolysis of GTP: a new perspective from model studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

A DNA polymerase beta mutant from colon cancer cells induces mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The sarcin-ricin loop of 23S rRNA is essential for assembly of the functional core of the 50S ribosomal subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

21 January 2018

DNA replication fidelity

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Catalytic promiscuity in Pseudomonas aeruginosa arylsulfatase as an example of chemistry-driven protein evolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Examining the promiscuous phosphatase activity of Pseudomonas aeruginosa arylsulfatase: a comparison to analogous phosphatases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Function and regulation of ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Promiscuity in alkaline phosphatase superfamily. Unraveling evolution through molecular simulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Theoretical study of phosphodiester hydrolysis in nucleotide pyrophosphatase/phosphodiesterase. Environmental effects on the reaction mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Determinants of reactivity and selectivity in soluble epoxide hydrolase from quantum mechanics/molecular mechanics modeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The Key–Lock Theory and the Induced Fit Theory

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The catalytic mechanism of protein tyrosine phosphatases revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Computational modeling of the rate limiting step in low molecular weight protein tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Folding-based molecular simulations reveal mechanisms of the rotary motor F1-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The importance of structural transitions of the switch II region for the functions of elongation factor Tu on the ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

On the mechanism of hydrolysis of phosphate monoesters dianions in solutions and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

How conformational dynamics of DNA polymerase select correct substrates: experiments and simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

A thymine isostere in the templating position disrupts assembly of the closed DNA polymerase beta ternary complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Rapid segmental and subdomain motions of DNA polymerase beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Reaction mechanism of alkaline phosphatase based on crystal structures. Two-metal ion catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Enzyme promiscuity: a mechanistic and evolutionary perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Enzyme promiscuity: evolutionary and mechanistic aspects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Dineopentyl phosphate hydrolysis: evidence for stepwise water attack

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The effect of leaving group on mechanistic preference in phosphate monoester hydrolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The role of metal ions in phosphate ester hydrolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Multiscale modeling of biological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Signaling--2000 and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

On the energetics of ATP hydrolysis in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Coarse-grained (multiscale) simulations in studies of biophysical and chemical systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Altered mechanisms of reactions of phosphate esters bridging a dinuclear metal center

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Eukaryotic DNA Polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Theoretical comparison of p-nitrophenyl phosphate and sulfate hydrolysis in aqueous solution: implications for enzyme-catalyzed sulfuryl transfer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

DNA polymerase fidelity: kinetics, structure, and checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

A new member of the alkaline phosphatase superfamily with a formylglycine nucleophile: structural and kinetic characterisation of a phosphonate monoester hydrolase/phosphodiesterase from Rhizobium leguminosarum

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Isotope effects and medium effects on sulfuryl transfer reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Intrinsic motions along an enzymatic reaction trajectory

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

A hierarchy of timescales in protein dynamics is linked to enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

How translocons select transmembrane helices

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Conformations of an adenine bulge in a DNA octamer and its influence on DNA structure from molecular dynamics simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Why nature chose phosphates

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Chemical and mechanistic approaches to the study of protein tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Site-directed mutagenesis of Thermus thermophilus elongation factor Tu. Replacement of His85, Asp81 and Arg300.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Alkaline phosphatase mono- and diesterase reactions: comparative transition state analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Structural and functional comparisons of nucleotide pyrophosphatase/phosphodiesterase and alkaline phosphatase: implications for mechanism and evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Conformation and hydrogen ion titration of proteins: a continuum electrostatic model with conformational flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Site-directed mutagenesis, kinetic, and spectroscopic studies of the P-loop residues in a low molecular weight protein tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Catalytic mechanism of F1-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Remarkable rate enhancement of orotidine 5'-monophosphate decarboxylase is due to transition-state stabilization rather than to ground-state destabilization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Fidelity mechanisms in DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Electrostatic basis for enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Multiple pathways in the integration of proteins into the mitochondrial outer membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Modeling electrostatic effects in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The mechanism of GTP hydrolysis by Ras probed by Fourier transform infrared spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Electrostatic contributions to binding of transition state analogues can be very different from the corresponding contributions to catalysis: phenolates binding to the oxyanion hole of ketosteroid isomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Kinetic isotope effects in Ras-catalyzed GTP hydrolysis: evidence for a loose transition state

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Autophosphorylation sites on the epidermal growth factor receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Polar bears, antibiotics, and the evolving ribosome (Nobel Lecture).

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The missing link between thermodynamics and structure in F1-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Highly organized but pliant active site of DNA polymerase beta: compensatory mechanisms in mutant enzymes revealed by dynamics simulations and energy analyses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Simulating the effect of DNA polymerase mutations on transition-state energetics and fidelity: evaluating amino acid group contribution and allosteric coupling for ionized residues in human pol beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Active participation of Mg ion in the reaction coordinate of RNA self-cleavage catalyzed by the hammerhead ribozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Characterization of the reaction path and transition states for RNA transphosphorylation models from theory and experiment

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The depth of chemical time and the power of enzymes as catalysts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Energy considerations show that low-barrier hydrogen bonds do not offer a catalytic advantage over ordinary hydrogen bonds

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

On the Mechanism of ATP Hydrolysis in F1-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Substitution of histidine-84 and the GTPase mechanism of elongation factor Tu.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

A structure-based model for the synthesis and hydrolysis of ATP by F1-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Conserved core structure and active site residues in alkaline phosphatase superfamily enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

21 January 2018

Protein-tyrosine kinases

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The age of crosstalk: phosphorylation, ubiquitination, and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Mechanism of the chemical step for the guanosine triphosphate (GTP) hydrolysis catalyzed by elongation factor Tu

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Mechanism of the myosin catalyzed hydrolysis of ATP as rationalized by molecular modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Mechanism of triphosphate hydrolysis in aqueous solution: QM/MM simulations in water clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

QM/MM modeling the Ras-GAP catalyzed hydrolysis of guanosine triphosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

MgF(3)(-) as a transition state analog of phosphoryl transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Biochemical basis of DNA replication fidelity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Error-prone repair DNA polymerases in prokaryotes and eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Kinetic analysis of beta-phosphoglucomutase and its inhibition by magnesium fluoride

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

How does GAP catalyze the GTPase reaction of Ras? A computer simulation study

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Understanding the rates of certain enzyme-catalyzed reactions: proton abstraction from carbon acids, acyl-transfer reactions, and displacement reactions of phosphodiesters

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Insight into catalysis of a unique GTPase reaction by a combined biochemical and FTIR approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Efficient Calculation of Many Stacking and Pairing Free Energies in DNA from a Few Molecular Dynamics Simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Phosphate ester analogues as probes for understanding enzyme catalysed phosphoryl transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Transient accumulation of elastic energy in proton translocating ATP synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

The empirical valence bond model: theory and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Reactivity of Phosphate Diesters Doubly Coordinated to a Dinuclear Cobalt(III) Complex: Dependence of the Reactivity on the Basicity of the Leaving Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

ATP-dependent assembly of double hexamers of SV40 T antigen at the viral origin of DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

Computer simulations of enzymatic reactions: examination of linear free-energy relationships and quantum-mechanical corrections in the initial proton-transfer step of carbonic anhydrase

21 January 2018

1 reference

12 December 2020

Mechanisms of signaling and related enzymes

1 reference

12 December 2020

Mutagenesis of three residues, isoleucine-60, threonine-61, and aspartic acid-80, implicated in the GTPase activity of Escherichia coli elongation factor Tu

1 reference

12 December 2020

Comment on "The mechanism for activation of GTP hydrolysis on the ribosome"

1 reference

12 December 2020

Exploring the Multidimensional Free Energy Surface of Phosphoester Hydrolysis with Constrained QM/MM Dynamics

1 reference

12 December 2020

On the mechanism of guanosine triphosphate hydrolysis in ras p21 proteins

1 reference

12 December 2020

Alkaline phosphatase is an almost perfect enzyme

1 reference

12 December 2020

Relevance of histidine-84 in the elongation factor Tu GTPase activity and in poly(Phe) synthesis: its substitution by glutamine and alanine

1 reference

12 December 2020

Minimalist active-site redesign: teaching old enzymes new tricks

1 reference

12 December 2020

Mechanism of substrate dephosphorylation in low Mr protein tyrosine phosphatase

1 reference

12 December 2020

How many catalytic RNAs? Ions and the Cheshire cat conjecture.

1 reference

12 December 2020

Catalytic promiscuity and the evolution of new enzymatic activities

1 reference

12 December 2020

DNA polymerase beta mutations in human colorectal cancer

1 reference

12 December 2020

Complex oncogenic signaling networks regulate brain tumor-initiating cells and their progenies: pivotal roles of wild-type EGFR, EGFRvIII mutant and hedgehog cascades and novel multitargeted therapies

1 reference

12 December 2020

Asp129 of low molecular weight protein tyrosine phosphatase is involved in leaving group protonation

1 reference

12 December 2020

Mapping the transition state for ATP hydrolysis: implications for enzymatic catalysis

1 reference

12 December 2020

Density functional study of the in-line mechanism of methanolysis of cyclic phosphate and thiophosphate esters in solution: insight into thio effects in RNA transesterification

1 reference

12 December 2020

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

1 reference

12 December 2020

Catalytic proficiency: the extreme case of S-O cleaving sulfatases

1 reference

12 December 2020

Mechanistic insights into the hydrolysis of a nucleoside triphosphate model in neutral and acidic solution

1 reference

12 December 2020

The physiological relevance of protein phosphatase 1 and its interacting proteins to health and disease.

1 reference

12 December 2020

Exploring the role of large conformational changes in the fidelity of DNA polymerase beta

1 reference

12 December 2020

Dual-specific Cdc25B phosphatase: in search of the catalytic acid

1 reference

12 December 2020

Benchmark reaction rates, the stability of biological molecules in water, and the evolution of catalytic power in enzymes

1 reference

12 December 2020

Examining methods for calculations of binding free energies: LRA, LIE, PDLD-LRA, and PDLD/S-LRA calculations of ligands binding to an HIV protease

1 reference

12 December 2020

Methyl Phosphate Dianion Hydrolysis in Solution Characterized by Path Collective Variables Coupled with DFT-Based Enhanced Sampling Simulations

1 reference

12 December 2020

Addressing open questions about phosphate hydrolysis pathways by careful free energy mapping

1 reference

12 December 2020

Substrate-assisted catalysis: molecular basis and biological significance

1 reference

12 December 2020

A binding free energy decomposition approach for accurate calculations of the fidelity of DNA polymerases

1 reference

12 December 2020

Nucleophilic attack on phosphate diesters: a density functional study of in-line reactivity in dianionic, monoanionic, and neutral systems

1 reference

12 December 2020

Structure-function relationships in the GTP binding domain of EF-Tu: mutation of Val20, the residue homologous to position 12 in p21

1 reference

12 December 2020

Dissecting the catalytic mechanism of protein-tyrosine phosphatases

1 reference

12 December 2020

Electrostatic contributions to protein-protein binding affinities: application to Rap/Raf interaction

1 reference

12 December 2020

Biosynthesis of diphosphopyridine nucleotide. II. Enzymatic aspects

1 reference

12 December 2020

Efficient catalytic promiscuity for chemically distinct reactions

1 reference

12 December 2020

Theoretical evaluation of the substrate-assisted catalysis mechanism for the hydrolysis of phosphate monoester dianions

1 reference

12 December 2020

Mechanisms of guanosine triphosphate hydrolysis by Ras and Ras-GAP proteins as rationalized by ab initio QM/MM simulations

1 reference

12 December 2020

Enzymatic synthesis and properties of 5-phosphoribosylpyrophosphate

1 reference

12 December 2020

Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity

1 reference

12 December 2020

A unified polymerase mechanism for nonhomologous DNA and RNA polymerases

1 reference

12 December 2020

Energetics of nucleophile activation in a protein tyrosine phosphatase

1 reference

12 December 2020

Pentacoordinated phosphorus revisited by high-level QM/MM calculations.

1 reference

12 December 2020

Testing electrostatic complementarity in enzyme catalysis: hydrogen bonding in the ketosteroid isomerase oxyanion hole

1 reference

12 December 2020

Comment on "The Pentacovalent Phosphorus Intermediate of a Phosphoryl Transfer Reaction"

1 reference

12 December 2020

Theoretical analyses on the role of Mg2+ ions in ribozyme reactions.

1 reference

12 December 2020

Structure and binding of Mg(II) ions and di-metal bridge complexes with biological phosphates and phosphoranes

1 reference

12 December 2020

How should we think about the ribosome?

1 reference

12 December 2020

Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate.

1 reference

12 December 2020

The Role of Metals in Enzyme-Catalyzed Substitutions at each of the Phosphorus Atoms of ATP

1 reference

12 December 2020

Reaction dynamics of G-protein catalyzed hydrolysis of GTP as viewed by X-ray crystallographic snapshots of Gi alpha 1

1 reference

12 December 2020

Mutation of Arg-166 of Alkaline Phosphatase Alters the Thio Effect but Not the Transition State for Phosphoryl Transfer. Implications for the Interpretation of Thio Effects in Reactions of Phosphatases†

1 reference

12 December 2020

Synthesis in Escherichia coli of GTPase-deficient mutants of Gs alpha.

1 reference

12 December 2020

A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus

1 reference

12 December 2020

A comprehensive pathway map of epidermal growth factor receptor signaling

1 reference

12 December 2020

Dynamics of biochemical and biophysical reactions: insight from computer simulations

1 reference

12 December 2020

Mechanism of the reaction catalyzed by staphylococcal nuclease: identification of the rate-determining step

1 reference

12 December 2020

ras oncogenes in human cancer: a review

1 reference

12 December 2020

Density functional study of the enzymatic reaction catalyzed by a cyclin-dependent kinase

1 reference

12 December 2020

Identification of residues involved in a conformational change accompanying substitutions for glutamate-43 in staphylococcal nuclease

1 reference

12 December 2020

Biosynthesis of the purines. XVI. The synthesis of adenosine 5'-phosphate and 5-amino-4-imidazolecarboxamide ribotide by a nucleotide pyrophosphorylase.

1 reference

12 December 2020

At the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?

1 reference

12 December 2020

gamma-phosphate protonation and pH-dependent unfolding of the Ras.GTP.Mg2+ complex: a vibrational spectroscopy study

1 reference

12 December 2020

Simulation and analysis of single-ribosome translation.

1 reference

12 December 2020

Simian virus 40 large T antigen: the puzzle, the pieces, and the emerging picture

1 reference

12 December 2020

The Hydrolysis of RNA: From Theoretical Calculations to the Hammerhead Ribozyme-Mediated Cleavage of RNA

1 reference

12 December 2020

The performance of hybrid DFT for mechanisms involving transition metal complexes in enzymes

1 reference

12 December 2020

Theoretical studies of the hydroxide-catalyzed P-O cleavage reactions of neutral phosphate triesters and diesters in aqueous solution: examination of the changes induced by H/Me substitution

1 reference

12 December 2020

The quest for free metaphosphate in solution. Racemization at phosphorus in the transfer of the phospho group from aryl phosphate monoesters to tert-butyl alcohol in acetonitrile or in tert-butyl alcohol

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

7 January 2021

Simulation of enzyme reactions using valence bond force fields and other hybrid quantum/classical approaches

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

7 January 2021

Methyl Phosphate Dianion Hydrolysis in Solution Characterized by Path Collective Variables Coupled with DFT-Based Enhanced Sampling Simulations

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

7 January 2021

Mapping catalytic promiscuity in the alkaline phosphatase superfamily

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

7 January 2021

Response to Comment on "The Mechanism for Activation of GTP Hydrolysis on the Ribosome"

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

7 January 2021

Pseudo-rotation in the hydrolysis of phosphate esters

1 reference

https://api.crossref.org/works/10.1017%2FS0033583512000157

7 January 2021

Parameterization of semiempirical methods to treat nucleophilic attacks to biological phosphates: AM1/d parameters for phosphorus

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1017/S0033583512000157

Identifiers

DOI

10.1017/S0033583512000157

1 reference

28 August 2017

1 reference

PubMed ID

23318152